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AU6081294A - Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides - Google Patents

Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Info

Publication number
AU6081294A
AU6081294A AU60812/94A AU6081294A AU6081294A AU 6081294 A AU6081294 A AU 6081294A AU 60812/94 A AU60812/94 A AU 60812/94A AU 6081294 A AU6081294 A AU 6081294A AU 6081294 A AU6081294 A AU 6081294A
Authority
AU
Australia
Prior art keywords
treatment
pyrimidine nucleosides
toxicity
agent
chemotherapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU60812/94A
Inventor
Michael Kevin Bamat
Reid Warren Von Borstel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pro Neuron Inc
Original Assignee
Pro Neuron Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc
Publication of AU6081294A publication Critical patent/AU6081294A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU60812/94A 1993-05-14 1993-12-30 Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides Abandoned AU6081294A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6138193A 1993-05-14 1993-05-14
US061381 1993-05-14
PCT/US1993/012689 WO1994026761A1 (en) 1993-05-14 1993-12-30 Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Publications (1)

Publication Number Publication Date
AU6081294A true AU6081294A (en) 1994-12-12

Family

ID=22035423

Family Applications (1)

Application Number Title Priority Date Filing Date
AU60812/94A Abandoned AU6081294A (en) 1993-05-14 1993-12-30 Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides

Country Status (2)

Country Link
AU (1) AU6081294A (en)
WO (1) WO1994026761A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5959100A (en) * 1996-03-27 1999-09-28 Nexstar Pharmaceuticals, Inc. Pyrimidine nucleosides as therapeutic and diagnostic agents
US5945527A (en) * 1996-05-30 1999-08-31 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
EP0882734B1 (en) * 1997-06-02 2009-08-26 F. Hoffmann-La Roche Ag 5'-Deoxy-cytidine derivatives
AU8388198A (en) * 1997-08-21 1999-03-08 Basf Aktiengesellschaft Use of uridine to counter 5-fluorouracil toxicity
US20020006913A1 (en) 1997-11-04 2002-01-17 Von Borstel Reid W. Antimutagenic compositions for treatment and prevention of photodamage to skin
US6472378B2 (en) 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US6020483A (en) 1998-09-25 2000-02-01 Nexstar Pharmaceuticals, Inc. Nucleoside modifications by palladium catalyzed methods
HUP0301112A3 (en) 2000-02-18 2005-04-28 Shire Biochem Inc Laval Method for the treatment or prevention of flavivirus infections using nucleoside analogues
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
CA2446620C (en) * 2001-05-18 2013-11-19 Rakesh Kumar Antiviral nucleosides
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
EP2265274B1 (en) * 2008-03-03 2018-11-21 Tosk, Inc. Methotrexate adjuvants to reduce toxicity and methods for using the same
WO2010118010A1 (en) 2009-04-06 2010-10-14 Eisai Inc. Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
ES2628609T3 (en) 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
WO2010118006A1 (en) 2009-04-06 2010-10-14 Eisai Inc. (2 ' -deoxy-ribofuranosyl) -1,3,4, 7-tetrahydro- (1,3) iazepin-2-0ne derivatives for treating cancer
HUE042327T2 (en) 2011-08-30 2019-06-28 Astex Pharmaceuticals Inc Decitabine derivative products
HK1254645A1 (en) 2015-07-02 2019-07-26 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
CA3033867A1 (en) 2016-08-17 2018-02-22 Solstice Biologics, Ltd. Polynucleotide constructs
EP3645546A4 (en) 2017-06-30 2021-12-01 Solstice Biologics, Ltd. CHIRAL PHOSPHORAMIDITE AIDS AND METHOD FOR THEIR USE
SG11202000932XA (en) 2017-08-03 2020-02-27 Otsuka Pharma Co Ltd Drug compound and purification methods thereof
CN112770760A (en) 2018-08-14 2021-05-07 托斯克公司 Methods and compositions for reducing radiation-induced toxicity
CN112789048A (en) * 2018-08-14 2021-05-11 托斯克公司 Methods and compositions for treating mucositis
CN112839663A (en) * 2018-08-14 2021-05-25 托斯克公司 Methods and compositions for reducing fluorouracil-induced toxicity
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions
AU2021306230A1 (en) 2020-07-07 2023-03-02 Tosk, Inc. Uridine phosphorylase inhibitors to treat or prevent pulmonary disease
AU2022244240A1 (en) * 2021-03-26 2023-10-05 The Cleveland Clinic Foundation Treatment of rna virus infection with a cytidine deaminase inhibitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1297398A (en) * 1969-08-06 1972-11-22
DE3481191D1 (en) * 1983-07-20 1990-03-08 Teijin Ltd ANTINEOPLASTIC AGENT.
JPS60174797A (en) * 1984-02-21 1985-09-09 Funai Corp N-aroylthymidine derivative and agent for lowering toxicity of antitumor active substance
US4874602A (en) * 1988-02-22 1989-10-17 Paul Calabresi Reduction of the severity 3'-azido-3'-deoxythymidine-induced anemia using benzylacyclouridine
US4950466A (en) * 1988-06-22 1990-08-21 Paul Calabresi Reduction of the severity of 3'-azido-3'-deoxythymidine-induced anemia using a combination of benzylacyclouridine and dipyridamole
US5077290A (en) * 1990-10-11 1991-12-31 Merck & Co., Inc. Morpholine derivatives compositions and use

Also Published As

Publication number Publication date
WO1994026761A1 (en) 1994-11-24

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