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GB1297398A - - Google Patents

Info

Publication number
GB1297398A
GB1297398A GB1297398DA GB1297398A GB 1297398 A GB1297398 A GB 1297398A GB 1297398D A GB1297398D A GB 1297398DA GB 1297398 A GB1297398 A GB 1297398A
Authority
GB
United Kingdom
Prior art keywords
fatty acid
tetraacylcytidine
aug
derivatives
yakuhun
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1297398A publication Critical patent/GB1297398A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

1297398 Tetraacylcytidine derivatives TAKEDA YAKUHUN KOGYO KK 4 Aug 1970 [6 Aug 1969] 37522/70 Heading C2C Novel N<SP>4</SP>,O<SP>2#</SP>,O<SP>3#</SP>,O<SP>5#</SP>-tetraacylcytidine derivatives wherein the acyl group is derived from a fatty acid containing 3 to 18 carbon atoms are prepared by acylating cytidine with the appropriate fatty acid anhydrides or fatty acid halides. Pharmaceutical compositions, suitable for oral or parenteral administration, and having central nervous system activating effects, contain the above novel compound and pharmaceutically acceptable diluents and carriers.
GB1297398D 1969-08-06 1970-08-04 Expired GB1297398A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6218669 1969-08-06

Publications (1)

Publication Number Publication Date
GB1297398A true GB1297398A (en) 1972-11-22

Family

ID=13192837

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1297398D Expired GB1297398A (en) 1969-08-06 1970-08-04

Country Status (3)

Country Link
DE (1) DE2038807A1 (en)
FR (1) FR2068467B1 (en)
GB (1) GB1297398A (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013687A1 (en) * 1992-12-08 1994-06-23 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
WO1994026761A1 (en) * 1993-05-14 1994-11-24 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US5470838A (en) * 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US5583117A (en) * 1987-10-28 1996-12-10 Pro-Neuron, Inc. Acylated uridine and cytidine for elevating tissue uridine and cytidine
US5691320A (en) * 1987-10-28 1997-11-25 Pro-Neuron, Inc. Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6329350B1 (en) 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
WO2005049633A1 (en) * 2003-11-03 2005-06-02 Cognis Ip Management Gmbh Acyl ribonucleosides and acyl deoxyribonucleosides
US7709459B2 (en) 1994-07-01 2010-05-04 Wellstat Therapeutics Corporation Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US8067392B2 (en) 1998-08-31 2011-11-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
US10500224B2 (en) * 2013-11-14 2019-12-10 Kainos Medicine, Inc. Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment
US12186433B2 (en) 2017-09-08 2025-01-07 Universite D'Angers France Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177348A (en) 1977-12-13 1979-12-04 United States Government Carbocyclic analogs of cytosine nucleosides
US4232154A (en) 1977-12-13 1980-11-04 United States Of America Carbocyclic analogs of cytosine nucleosides exhibiting antiviral and antineoplasticactivity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1539372A (en) * 1966-12-17 1968-09-13 Tokyo Tanabe Co Process for the production of riboflavin esters and new products thus obtained

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274563B1 (en) 1987-10-28 2001-08-14 Pro-Neuron, Inc. Acylated uridine and cytidine and uses thereof
US6232298B1 (en) 1987-10-28 2001-05-15 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5470838A (en) * 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
US5583117A (en) * 1987-10-28 1996-12-10 Pro-Neuron, Inc. Acylated uridine and cytidine for elevating tissue uridine and cytidine
US5691320A (en) * 1987-10-28 1997-11-25 Pro-Neuron, Inc. Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
US5736531A (en) * 1987-10-28 1998-04-07 Pro-Neuron, Inc. Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
US5968914A (en) * 1987-10-28 1999-10-19 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6329350B1 (en) 1987-10-28 2001-12-11 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US6316426B1 (en) 1987-10-28 2001-11-13 Pro-Neuron, Inc. Acylated uridine and cytidine and uses thereof
US6258795B1 (en) 1987-10-28 2001-07-10 Pro-Neuron, Inc. Acylated uridine and cytidine and uses thereof
US7776838B1 (en) 1987-10-28 2010-08-17 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US7173017B1 (en) 1987-10-28 2007-02-06 Wellstat Therapeutics Corporation Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US7166581B1 (en) 1987-10-28 2007-01-23 Wellstat Therapeutics Corporation Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US6344447B2 (en) 1987-10-28 2002-02-05 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US7105498B2 (en) 1987-10-28 2006-09-12 Wellstat Therapeutics Corporation Acylated uridine and cytidine and uses thereof
AU732120B2 (en) * 1992-12-08 2001-04-12 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
WO1994013687A1 (en) * 1992-12-08 1994-06-23 Pro-Neuron, Inc. Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
WO1994026761A1 (en) * 1993-05-14 1994-11-24 Pro-Neuron, Inc. Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
US7709459B2 (en) 1994-07-01 2010-05-04 Wellstat Therapeutics Corporation Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US8067392B2 (en) 1998-08-31 2011-11-29 Wellstat Therapeutics Corporation Compositions and methods for treatment of mitochondrial diseases
WO2005049633A1 (en) * 2003-11-03 2005-06-02 Cognis Ip Management Gmbh Acyl ribonucleosides and acyl deoxyribonucleosides
US10500224B2 (en) * 2013-11-14 2019-12-10 Kainos Medicine, Inc. Mutual prodrug comprising short chain fatty acids and zebularine or 1'-cyano-cytarabine for cancer treatment
US12186433B2 (en) 2017-09-08 2025-01-07 Universite D'Angers France Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof

Also Published As

Publication number Publication date
DE2038807A1 (en) 1971-02-18
FR2068467A1 (en) 1971-08-27
FR2068467B1 (en) 1974-08-23

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees