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AU567311B2 - 2(1-piperazinyl) pyrimidine dicarboxylic acid addition salts for pharmaceutical use - Google Patents

2(1-piperazinyl) pyrimidine dicarboxylic acid addition salts for pharmaceutical use

Info

Publication number
AU567311B2
AU567311B2 AU21164/83A AU2116483A AU567311B2 AU 567311 B2 AU567311 B2 AU 567311B2 AU 21164/83 A AU21164/83 A AU 21164/83A AU 2116483 A AU2116483 A AU 2116483A AU 567311 B2 AU567311 B2 AU 567311B2
Authority
AU
Australia
Prior art keywords
piperazinyl
dicarboxylic acid
acid addition
pyrimidine
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU21164/83A
Other versions
AU2116483A (en
Inventor
Jean-Pierre Chambon
Emilio Crisafulli
Marco Frigerio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of AU2116483A publication Critical patent/AU2116483A/en
Application granted granted Critical
Publication of AU567311B2 publication Critical patent/AU567311B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) An acid addition salt of 2-(1-piperazinyl)pyrimidine with a dicarboxylic acid. 1. Claims (for the contracting state : AT) A process for preparing acid salts of 2-(1-piperazinyl)pyrimidine with dicarboxylic acids, characterized in that it comprises reacting 2-(1-piperazinyl)-pyrimidine with the calculated quantity of a dicarboxylic acid in an organic or aqueous organic solvent.
AU21164/83A 1982-11-12 1983-11-11 2(1-piperazinyl) pyrimidine dicarboxylic acid addition salts for pharmaceutical use Ceased AU567311B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8218975 1982-11-12
FR8218975A FR2536071B1 (en) 1982-11-12 1982-11-12 2-PIPERAZINOPYRIMIDINE ACID SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
AU2116483A AU2116483A (en) 1984-05-17
AU567311B2 true AU567311B2 (en) 1987-11-19

Family

ID=9279123

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21164/83A Ceased AU567311B2 (en) 1982-11-12 1983-11-11 2(1-piperazinyl) pyrimidine dicarboxylic acid addition salts for pharmaceutical use

Country Status (10)

Country Link
EP (1) EP0109340B1 (en)
JP (1) JPS59144766A (en)
AT (1) ATE19243T1 (en)
AU (1) AU567311B2 (en)
CA (1) CA1249275A (en)
DE (1) DE3363093D1 (en)
FR (1) FR2536071B1 (en)
IE (1) IE56184B1 (en)
NZ (1) NZ206222A (en)
ZA (1) ZA838423B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959368A (en) * 1986-02-24 1990-09-25 Mitsui Petrochemical Industries Ltd. Therapeutic agent for neurological diseases
JP2561689B2 (en) * 1986-02-24 1996-12-11 三井石油化学工業株式会社 Neurological drug
YU39503A (en) * 2000-11-22 2006-05-25 F. Hoffmann-La Roche Ag. Pyrimidine derivatives
AR038368A1 (en) 2002-02-01 2005-01-12 Novartis Ag N-PYRIMIDIN-2-IL-AMINAS SUBSTITUTED COMPOUNDS AS IGE INHIBITORS, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF A MEDICINAL PRODUCT
JP4726622B2 (en) * 2005-12-14 2011-07-20 三洋電機株式会社 Leaded battery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US985657A (en) * 1910-12-10 1911-02-28 Baldwin Locomotive Works Car-truck.
AU2605784A (en) * 1983-03-25 1984-09-27 Degussa A.G. N-aromatic-n:-cycloalkylalkanoyl-piperazines
AU2929384A (en) * 1983-06-18 1984-12-20 Bayer Aktiengesellschaft 2-pyrimidinyl-1-piperazine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US985657A (en) * 1910-12-10 1911-02-28 Baldwin Locomotive Works Car-truck.
AU2605784A (en) * 1983-03-25 1984-09-27 Degussa A.G. N-aromatic-n:-cycloalkylalkanoyl-piperazines
AU2929384A (en) * 1983-06-18 1984-12-20 Bayer Aktiengesellschaft 2-pyrimidinyl-1-piperazine derivatives

Also Published As

Publication number Publication date
IE56184B1 (en) 1991-05-08
FR2536071A1 (en) 1984-05-18
JPS59144766A (en) 1984-08-18
NZ206222A (en) 1985-09-13
CA1249275A (en) 1989-01-24
EP0109340B1 (en) 1986-04-16
FR2536071B1 (en) 1986-07-11
DE3363093D1 (en) 1986-05-22
ATE19243T1 (en) 1986-05-15
IE832631L (en) 1984-05-12
AU2116483A (en) 1984-05-17
EP0109340A2 (en) 1984-05-23
ZA838423B (en) 1984-06-27
EP0109340A3 (en) 1984-06-27

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