AU472127B2 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number: AU472127B2
Authority: AU; Australia
Prior art keywords: heterocyclic compounds; heterocyclic; compounds
Prior art date: 1971-11-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

AU48191/72A

Other versions

AU4819172A (en

Inventor

DAVID HARTLEY LAWRENCE HENRY CHARLES LUNIS and ALEXANDER WILLIAM OXFORD SUSAN CONSTANCE GARSIDE

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Allen and Hanburys Ltd

Original Assignee

Allen and Hanburys Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-11-19

Filing date

1972-10-26

Publication date

1976-05-20

1972-10-26 Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd

1974-05-16 Publication of AU4819172A publication Critical patent/AU4819172A/en

1976-05-20 Application granted granted Critical

1976-05-20 Publication of AU472127B2 publication Critical patent/AU472127B2/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AU48191/72A 1971-11-19 1972-10-26 Heterocyclic compounds Expired AU472127B2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB5375071A GB1400999A (en)	1971-11-19	1971-11-19	Imidazo-triazine compounds and their use in therapeutic compositions
GBGB53750/71		1971-11-19

Publications (2)

Publication Number	Publication Date
AU4819172A AU4819172A (en)	1974-05-16
AU472127B2 true AU472127B2 (en)	1976-05-20

Family

ID=10468856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU48191/72A Expired AU472127B2 (en)	1971-11-19	1972-10-26	Heterocyclic compounds

Country Status (18)

Country	Link
US (1)	US3840537A (en)
JP (1)	JPS563873B2 (en)
AT (1)	AT321923B (en)
AU (1)	AU472127B2 (en)
BE (1)	BE791025A (en)
CA (1)	CA990292A (en)
CH (1)	CH594671A5 (en)
DE (1)	DE2255172A1 (en)
DK (1)	DK138691B (en)
ES (1)	ES408736A1 (en)
FR (1)	FR2160407B1 (en)
GB (1)	GB1400999A (en)
IE (1)	IE37046B1 (en)
IL (1)	IL40686A (en)
NL (1)	NL7215646A (en)
PH (1)	PH9669A (en)
SE (1)	SE402915B (en)
ZA (1)	ZA727532B (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1457873A (en) *	1973-01-04	1976-12-08	Allen & Hanburys Ltd	Imidazotriazines
DE2314488C3 (en) *	1973-03-23	1979-01-04	C.H. Boehringer Sohn, 6507 Ingelheim	8- (2,6-Dichlorophenyl) -7- (4-chlorophenyl) -5-oxo-233,8-tetrahydro-imidazo [1,2-a] -s-triazine, process for its preparation and medicament containing it
DE2335193A1 (en) *	1973-07-11	1975-01-30	Hoechst Ag	BIS-TRIAZINOBENZIMIDAZOLE AND THEIR PRODUCTION
US4115572A (en) *	1977-02-03	1978-09-19	American Cyanamid Company	Imidazo-[1,5-d]-as-triazin-1(2H)-ones and method of ameliorating asthma
USRE30511E (en) *	1977-02-03	1981-02-10	American Cyanamid Company	Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
US4107307A (en) *	1977-02-03	1978-08-15	American Cyanamid Company	Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
DK109578A (en) *	1977-03-25	1978-09-26	Allen & Hanburys Ltd	PROCEDURE FOR MAKING HETEROCYCLIC COMPOUNDS
US4107308A (en) *	1977-10-18	1978-08-15	American Cyanamid Company	Imidazo[1,5-d]-as-triazines
US4308384A (en) *	1978-09-18	1981-12-29	Glaxo Group Limited	Production of triazinones
HU187474B (en) *	1981-11-18	1986-01-28	Gyogyszerkutato Intezet,Hu	Process for producing new spiro-pyrazole-square bracket-1,5-d-square bracket closed-square bracket-1,2,4-square bracket closed-triazine derivatives
US4395547A (en) *	1982-02-10	1983-07-26	American Cyanamid Co.	Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
AU622330B2 (en) *	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
US6624181B1 (en) *	1997-02-28	2003-09-23	Altana Pharma Ag	Synergistic combination
IL135462A0 (en)	1997-11-12	2001-05-20	Bayer Ag	2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
DE19827640A1 (en) *	1998-06-20	1999-12-23	Bayer Ag	New imidazotriazine derivatives useful as smooth muscle relaxants for treating e.g. cardiovascular disorders, cerebrovascular disorders, or erectile dysfunction
JP2002523452A (en)	1998-08-26	2002-07-30	スミスクライン・ビーチャム・コーポレイション	How to treat lung disease
AU777012B2 (en) *	1999-08-21	2004-09-30	Takeda Gmbh	Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist
BR0209541A (en) *	2001-05-09	2004-04-20	Bayer Healthcare Ag	Use of 2-phenyl-substituted imidazotriazinones
GB0113343D0 (en) *	2001-06-01	2001-07-25	Bayer Ag	Novel Heterocycles 2
GB0113344D0 (en) *	2001-06-01	2001-07-25	Bayer Ag	Novel heterocycles 3
DE10135815A1 (en)	2001-07-23	2003-02-06	Bayer Ag	Use of imidazo-triazinone derivative phosphodiesterase 5 inhibitors e.g. for treatment of cardiac insufficiency, psoriasis, diabetes, cancer, glaucoma, bladder disease, Parkinson's disease or pain
DE10232113A1 (en) *	2002-07-16	2004-01-29	Bayer Ag	Medicinal products containing vardenafil hydrochloride trihydrate
JP2006522127A (en) *	2003-04-01	2006-09-28	スミスクラインビーチャムコーポレーション	Imidazotriazine compounds
EP2308879A1 (en)	2004-04-02	2011-04-13	OSI Pharmaceuticals, Inc.	6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
DE102005001989A1 (en) *	2005-01-15	2006-07-20	Bayer Healthcare Ag	Intravenous formulations of PDE inhibitors
DE102005009241A1 (en) *	2005-03-01	2006-09-07	Bayer Healthcare Ag	Dosage forms with controlled bioavailability
DE102005009240A1 (en) *	2005-03-01	2006-09-07	Bayer Healthcare Ag	Dosage forms with improved pharmacokinetic properties
RU2435588C2 (en) *	2005-09-29	2011-12-10	Байер Шеринг Фарма Акциенгезельшафт	Pde inhibitors and their combinations for treatment of urologic disorders
RS51843B (en)	2005-11-17	2012-02-29	Osi Pharmaceuticals Llc.	CONDENSED BICYCLIC m TOR INHIBITORS
JP2010532319A (en) *	2007-06-13	2010-10-07	バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト	PDE inhibitors for the treatment of hearing impairment
JP2012524119A (en)	2009-04-20	2012-10-11	オーエスアイ・ファーマシューティカルズ，エルエルシー	Preparation of C-pyrazine-methylamine
CN103374002B (en) *	2012-04-19	2015-07-15	山东轩竹医药科技有限公司	Phosphodiesterase-5 inhibitor
TW201639851A (en) *	2015-03-16	2016-11-16	大日本住友製藥股份有限公司	Bicyclic imidazolo derivative
WO2017000276A1 (en) *	2015-07-01	2017-01-05	Merck Sharp & Dohme Corp.	Bicyclic heterocyclic compounds as pde2 inhibitors
WO2017204316A1 (en) *	2016-05-27	2017-11-30	塩野義製薬株式会社	5-oxo-1,2,4-triazine derivative, and pharmaceutical composition thereof

0
- BE BE791025D patent/BE791025A/en unknown
1971
- 1971-11-19 GB GB5375071A patent/GB1400999A/en not_active Expired
1972
- 1972-10-23 DK DK525172AA patent/DK138691B/en unknown
- 1972-10-23 IE IE1433/72A patent/IE37046B1/en unknown
- 1972-10-23 ZA ZA727532A patent/ZA727532B/en unknown
- 1972-10-25 US US00300749A patent/US3840537A/en not_active Expired - Lifetime
- 1972-10-26 AU AU48191/72A patent/AU472127B2/en not_active Expired
- 1972-10-27 IL IL40686A patent/IL40686A/en unknown
- 1972-11-01 CA CA155,720A patent/CA990292A/en not_active Expired
- 1972-11-06 SE SE7214358A patent/SE402915B/en unknown
- 1972-11-08 FR FR7239498A patent/FR2160407B1/fr not_active Expired
- 1972-11-10 DE DE2255172A patent/DE2255172A1/en not_active Withdrawn
- 1972-11-16 CH CH1668372A patent/CH594671A5/xx not_active IP Right Cessation
- 1972-11-16 PH PH14090*UA patent/PH9669A/en unknown
- 1972-11-17 AT AT982372A patent/AT321923B/en not_active IP Right Cessation
- 1972-11-17 ES ES408736A patent/ES408736A1/en not_active Expired
- 1972-11-17 NL NL7215646A patent/NL7215646A/xx not_active Application Discontinuation
- 1972-11-17 JP JP11549572A patent/JPS563873B2/ja not_active Expired

Also Published As

Publication number	Publication date
DK138691B (en)	1978-10-16
IE37046L (en)	1973-05-19
CA990292A (en)	1976-06-01
ZA727532B (en)	1973-07-25
GB1400999A (en)	1975-07-16
IL40686A0 (en)	1972-12-29
JPS563873B2 (en)	1981-01-27
AU4819172A (en)	1974-05-16
PH9669A (en)	1976-02-10
US3840537A (en)	1974-10-08
IL40686A (en)	1975-12-31
ES408736A1 (en)	1976-03-01
IE37046B1 (en)	1977-04-27
DK138691C (en)	1979-03-26
DE2255172A1 (en)	1973-05-24
CH594671A5 (en)	1978-01-13
BE791025A (en)	1973-05-07
SE402915B (en)	1978-07-24
FR2160407A1 (en)	1973-06-29
NL7215646A (en)	1973-05-22
FR2160407B1 (en)	1975-10-17
JPS4857993A (en)	1973-08-14
AT321923B (en)	1975-04-25

Publication	Publication Date	Title
AU472127B2 (en)	1976-05-20	Heterocyclic compounds
CA1017336A (en)	1977-09-13	Divinyl-diphenyl compounds
AU459132B2 (en)	1975-02-26	Etrachlorophthalide compounds
AU466025B2 (en)	1975-01-09	Aminohalopyridyloxy compounds
CA1026346A (en)	1978-02-14	Triazolyphosphorus compounds
CA1006163A (en)	1977-03-01	Arylaminopyridine compounds
AU466453B2 (en)	1973-12-20	Triaszolothienodiazepine compounds
AU468514B2 (en)	1976-01-15	Heterocyclic compounds
CA1019871A (en)	1977-10-25	Arc- and track - resistant polyepoxide - polysiloxane compounds
AU4356572A (en)	1974-01-03	New heterocyclic compounds
CA863349A (en)	1971-02-09	Heterocyclic compounds
CA993445A (en)	1976-07-20	Heterocyclic triglycidyl compounds
CA1001641A (en)	1976-12-14	Polyhalobenzylic disulfooxonium compounds
CA924724A (en)	1973-04-17	Heterocyclic compounds
CA879695A (en)	1971-08-31	Heterocyclic compounds
AU460576B2 (en)	1973-08-23	Heterocyclic compounds
AU3920372A (en)	1973-08-23	Heterocyclic compounds
CA878540A (en)	1971-08-17	Heterocyclic organoborines
CA875568A (en)	1971-07-13	Heterocyclic derivatives
CA880906A (en)	1971-09-14	Aryl-substituted heterocyclic compounds
AU461803B2 (en)	1972-12-07	Substituted guamidine compounds
CA1015751A (en)	1977-08-16	Substituted pyridopyrimidinone compounds
CA877313A (en)	1971-08-03	Heterocyclic spiro compounds
AU445230B2 (en)	1972-08-17	Halogenated heterocyclic compounds
AU477713B2 (en)	1974-07-04	Metallised heterocyclic compounds