AU3027199A - 5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists - Google Patents

5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists

Info

Publication number: AU3027199A
Authority: AU; Australia
Prior art keywords: utilization; production; carboxylic acid; same; acid derivatives
Prior art date: 1998-02-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU30271/99A

Inventor

Wilhelm Amberg

Stefan Hergenroder

Rolf Jansen

Andreas Kling

Dagmar Klinge

Manfred Raschack

Hartmut Riechers

Liliane Unger

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BASF SE

Original Assignee

BASF SE

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-17

Filing date

1999-02-05

Publication date

1999-09-06

1999-02-05 Application filed by BASF SE filed Critical BASF SE

1999-09-06 Publication of AU3027199A publication Critical patent/AU3027199A/en

Status Abandoned legal-status Critical Current

Links

-1 5-substituted pyrimidine-2-yloxy carboxylic acid Chemical class 0.000 title 1
102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AU30271/99A 1998-02-17 1999-02-05 5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists Abandoned AU3027199A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19806438		1998-02-17
DE19806438A DE19806438A1 (en)	1998-02-17	1998-02-17	New pyrimidinyloxy-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiac insufficiency, restenosis, hypertension, kidney failure, asthma and prostate cancer
PCT/EP1999/000776 WO1999042453A1 (en)	1998-02-17	1999-02-05	5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists

Publications (1)

Publication Number	Publication Date
AU3027199A true AU3027199A (en)	1999-09-06

Family

ID=7857948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU30271/99A Abandoned AU3027199A (en)	1998-02-17	1999-02-05	5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists

Country Status (20)

Country	Link
EP (1)	EP1066268A1 (en)
JP (1)	JP2002503726A (en)
KR (1)	KR20010086247A (en)
CN (1)	CN1291190A (en)
AR (1)	AR014960A1 (en)
AU (1)	AU3027199A (en)
BG (1)	BG104577A (en)
BR (1)	BR9907911A (en)
CA (1)	CA2321182A1 (en)
DE (1)	DE19806438A1 (en)
HR (1)	HRP20000602A2 (en)
HU (1)	HUP0100957A3 (en)
IL (1)	IL137038A0 (en)
NO (1)	NO20004075D0 (en)
PL (1)	PL342311A1 (en)
SK (1)	SK11512000A3 (en)
TR (1)	TR200002376T2 (en)
TW (1)	TW579376B (en)
WO (1)	WO1999042453A1 (en)
ZA (1)	ZA991214B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19924892A1 (en) *	1999-06-01	2000-12-07	Basf Ag	New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists
US8168616B1 (en) *	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
JP2010535210A (en)	2007-07-31	2010-11-18	ギリード・コロラド・インコーポレーテッド	Metabolites and derivatives of ambrisentan
HUE026195T2 (en) *	2008-01-22	2016-05-30	Dow Agrosciences Llc	4-amino-5-fluoro-pyrimidine derivatives as fungicides
EP2647287A1 (en) *	2008-08-01	2013-10-09	Dow AgroSciences LLC	Use of 5-fluorocytosine and its derivatives as fungicides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4411225A1 (en) *	1994-03-31	1995-10-05	Basf Ag	Use of carboxylic acid derivatives as a drug
DE19533023B4 (en) *	1994-10-14	2007-05-16	Basf Ag	New carboxylic acid derivatives, their preparation and use
DE19614533A1 (en) *	1996-04-12	1997-10-16	Basf Ag	New alpha-hydroxy acid derivatives, their production and use
DE19614534A1 (en) *	1996-04-12	1997-10-16	Basf Ag	New carboxylic acid derivatives, their production and use
KR20000057642A (en) *	1996-12-18	2000-09-25	스타르크, 카르크	Heterocyclic carboxylic acid derivatives, the production and use thereof as endothelin receptor antagonists
DE19726146A1 (en) *	1997-06-19	1998-12-24	Basf Ag	New ß-amino and ß-azidopcarboxylic acid derivatives, their preparation and use as endothelin receptor antagonists
NZ504316A (en) *	1997-10-31	2002-12-20	Basf Ag	Pyrimidine substituted carboxylic acid derivatives which have amido side-chains useful as endothelin receptor antagonists

1998
- 1998-02-17 DE DE19806438A patent/DE19806438A1/en not_active Withdrawn
1999
- 1999-02-05 TR TR2000/02376T patent/TR200002376T2/en unknown
- 1999-02-05 CN CN99803037A patent/CN1291190A/en active Pending
- 1999-02-05 EP EP99911657A patent/EP1066268A1/en not_active Withdrawn
- 1999-02-05 WO PCT/EP1999/000776 patent/WO1999042453A1/en not_active Ceased
- 1999-02-05 PL PL99342311A patent/PL342311A1/en unknown
- 1999-02-05 CA CA002321182A patent/CA2321182A1/en not_active Abandoned
- 1999-02-05 SK SK1151-2000A patent/SK11512000A3/en unknown
- 1999-02-05 KR KR1020007008925A patent/KR20010086247A/en not_active Withdrawn
- 1999-02-05 JP JP2000532405A patent/JP2002503726A/en active Pending
- 1999-02-05 AU AU30271/99A patent/AU3027199A/en not_active Abandoned
- 1999-02-05 HR HR20000602A patent/HRP20000602A2/en not_active Application Discontinuation
- 1999-02-05 HU HU0100957A patent/HUP0100957A3/en unknown
- 1999-02-05 IL IL13703899A patent/IL137038A0/en unknown
- 1999-02-05 BR BR9907911-9A patent/BR9907911A/en not_active IP Right Cessation
- 1999-02-10 TW TW088102031A patent/TW579376B/en active
- 1999-02-16 ZA ZA9901214A patent/ZA991214B/en unknown
- 1999-02-16 AR ARP990100634A patent/AR014960A1/en not_active Application Discontinuation
2000
- 2000-07-04 BG BG104577A patent/BG104577A/en unknown
- 2000-08-15 NO NO20004075A patent/NO20004075D0/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1291190A (en)	2001-04-11
AR014960A1 (en)	2001-04-11
HUP0100957A2 (en)	2002-02-28
TW579376B (en)	2004-03-11
DE19806438A1 (en)	1999-08-19
BG104577A (en)	2001-03-30
NO20004075L (en)	2000-08-15
NO20004075D0 (en)	2000-08-15
HRP20000602A2 (en)	2001-06-30
ZA991214B (en)	2000-08-16
SK11512000A3 (en)	2001-04-09
PL342311A1 (en)	2001-06-04
KR20010086247A (en)	2001-09-10
WO1999042453A1 (en)	1999-08-26
JP2002503726A (en)	2002-02-05
EP1066268A1 (en)	2001-01-10
BR9907911A (en)	2000-10-24
TR200002376T2 (en)	2000-12-21
HUP0100957A3 (en)	2002-03-28
CA2321182A1 (en)	1999-08-26
IL137038A0 (en)	2001-06-14

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HRP970200A2 (en)	1998-04-30	Novel carboxylic acid derivatives, their production and use
AU5208200A (en)	2000-11-21	Screwed connection, fastener for said connection and method for the production thereof
AU3027199A (en)	1999-09-06	5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists
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IL134276A0 (en)	2001-04-30	Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists
PT1133495E (en)	2003-02-28	SEMI-HYDROCHLORIDE OF 8-CYANO-1-CYCLOPROPYL-7- (1S, 6S-2,8-DIAZABICYCLO-4,3,0-NANO-8-YL) -6-FLUORO-1,4-DIHYDRO-4 -OXO-3-KINOLINOCARBOXYLIC ACID
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Legal Events

Date	Code	Title	Description
2003-07-03	MK5	Application lapsed section 142(2)(e) - patent request and compl. specification not accepted