NO20004075D0 - Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists - Google Patents

Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists

Info

Publication number: NO20004075D0
Authority: NO; Norway
Prior art keywords: yloxy; preparation; carboxylic acid; acid derivatives; endothelin antagonists
Prior art date: 1998-02-17

Application number

NO20004075A

Other languages

Norwegian (no)

Other versions

NO20004075L (en

Inventor

Wilhelm Amberg

Rolf Jansen

Andreas Kling

Dagmar Klinge

Hartmut Riechers

Stefan Hergenroeder

Manfred Raschack

Liliane Unger

Original Assignee

Basf Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-17

Filing date

2000-08-15

Publication date

2000-08-15

2000-08-15 Application filed by Basf Ag filed Critical Basf Ag

2000-08-15 Publication of NO20004075D0 publication Critical patent/NO20004075D0/en

2000-08-15 Publication of NO20004075L publication Critical patent/NO20004075L/en

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
IUBKMGVNAYWGSL-UHFFFAOYSA-N pyrimidin-2-yl hydrogen carbonate Chemical class OC(=O)OC1=NC=CC=N1 IUBKMGVNAYWGSL-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20004075A 1998-02-17 2000-08-15 Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists NO20004075L (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19806438A DE19806438A1 (en)	1998-02-17	1998-02-17	New pyrimidinyloxy-propionic acid derivatives useful as endothelin receptor antagonists in treatment of e.g. cardiac insufficiency, restenosis, hypertension, kidney failure, asthma and prostate cancer
PCT/EP1999/000776 WO1999042453A1 (en)	1998-02-17	1999-02-05	5-substituted pyrimidine-2-yloxy carboxylic acid derivatives, the production of the same and their utilization as endothelin antagonists

Publications (2)

Publication Number	Publication Date
NO20004075D0 true NO20004075D0 (en)	2000-08-15
NO20004075L NO20004075L (en)	2000-08-15

Family

ID=7857948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20004075A NO20004075L (en)	1998-02-17	2000-08-15	Substituted pyrimidin-2-yloxy-carboxylic acid derivatives, their preparation and their use as endothelin antagonists

Country Status (20)

Country	Link
EP (1)	EP1066268A1 (en)
JP (1)	JP2002503726A (en)
KR (1)	KR20010086247A (en)
CN (1)	CN1291190A (en)
AR (1)	AR014960A1 (en)
AU (1)	AU3027199A (en)
BG (1)	BG104577A (en)
BR (1)	BR9907911A (en)
CA (1)	CA2321182A1 (en)
DE (1)	DE19806438A1 (en)
HR (1)	HRP20000602A2 (en)
HU (1)	HUP0100957A3 (en)
IL (1)	IL137038A0 (en)
NO (1)	NO20004075L (en)
PL (1)	PL342311A1 (en)
SK (1)	SK11512000A3 (en)
TR (1)	TR200002376T2 (en)
TW (1)	TW579376B (en)
WO (1)	WO1999042453A1 (en)
ZA (1)	ZA991214B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19924892A1 (en) *	1999-06-01	2000-12-07	Basf Ag	New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists
US8168616B1 (en) *	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
CA2695259C (en) *	2007-07-31	2016-05-24	Gilead Colorado, Inc.	Metabolites and derivatives of ambrisentan
PT2562162E (en) *	2008-01-22	2015-10-21	Dow Agrosciences Llc	N-cyano-4-amino-5-fluoro-pyrimidine derivatives as fungicides
JP5580310B2 (en) *	2008-08-01	2014-08-27	ダウアグロサイエンシィズエルエルシー	Use of 5-fluorocytosine as a fungicide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4411225A1 (en) *	1994-03-31	1995-10-05	Basf Ag	Use of carboxylic acid derivatives as a drug
DE19533023B4 (en) *	1994-10-14	2007-05-16	Basf Ag	New carboxylic acid derivatives, their preparation and use
DE19614533A1 (en) *	1996-04-12	1997-10-16	Basf Ag	New alpha-hydroxy acid derivatives, their production and use
DE19614534A1 (en) *	1996-04-12	1997-10-16	Basf Ag	New carboxylic acid derivatives, their production and use
CN1247533A (en) *	1996-12-18	2000-03-15	Basf公司	Heterocyclic carboxylic acid derivatives, prodn. and use thereof as endothelin receptor antagonists
DE19726146A1 (en) *	1997-06-19	1998-12-24	Basf Ag	New ß-amino and ß-azidopcarboxylic acid derivatives, their preparation and use as endothelin receptor antagonists
EP1027338A2 (en) *	1997-10-31	2000-08-16	Basf Aktiengesellschaft	New carboxylic acid derivatives, carrying amido side-chains; production and use as endothelin receptor antagonists

1998
- 1998-02-17 DE DE19806438A patent/DE19806438A1/en not_active Withdrawn
1999
- 1999-02-05 CN CN99803037A patent/CN1291190A/en active Pending
- 1999-02-05 HR HR20000602A patent/HRP20000602A2/en not_active Application Discontinuation
- 1999-02-05 AU AU30271/99A patent/AU3027199A/en not_active Abandoned
- 1999-02-05 HU HU0100957A patent/HUP0100957A3/en unknown
- 1999-02-05 BR BR9907911-9A patent/BR9907911A/en not_active IP Right Cessation
- 1999-02-05 TR TR2000/02376T patent/TR200002376T2/en unknown
- 1999-02-05 EP EP99911657A patent/EP1066268A1/en not_active Withdrawn
- 1999-02-05 IL IL13703899A patent/IL137038A0/en unknown
- 1999-02-05 PL PL99342311A patent/PL342311A1/en unknown
- 1999-02-05 CA CA002321182A patent/CA2321182A1/en not_active Abandoned
- 1999-02-05 SK SK1151-2000A patent/SK11512000A3/en unknown
- 1999-02-05 JP JP2000532405A patent/JP2002503726A/en active Pending
- 1999-02-05 WO PCT/EP1999/000776 patent/WO1999042453A1/en not_active Ceased
- 1999-02-05 KR KR1020007008925A patent/KR20010086247A/en not_active Withdrawn
- 1999-02-10 TW TW088102031A patent/TW579376B/en active
- 1999-02-16 ZA ZA9901214A patent/ZA991214B/en unknown
- 1999-02-16 AR ARP990100634A patent/AR014960A1/en not_active Application Discontinuation
2000
- 2000-07-04 BG BG104577A patent/BG104577A/en unknown
- 2000-08-15 NO NO20004075A patent/NO20004075L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
TR200002376T2 (en)	2000-12-21
TW579376B (en)	2004-03-11
WO1999042453A1 (en)	1999-08-26
AR014960A1 (en)	2001-04-11
HRP20000602A2 (en)	2001-06-30
EP1066268A1 (en)	2001-01-10
PL342311A1 (en)	2001-06-04
KR20010086247A (en)	2001-09-10
CA2321182A1 (en)	1999-08-26
NO20004075L (en)	2000-08-15
HUP0100957A3 (en)	2002-03-28
JP2002503726A (en)	2002-02-05
CN1291190A (en)	2001-04-11
DE19806438A1 (en)	1999-08-19
BG104577A (en)	2001-03-30
SK11512000A3 (en)	2001-04-09
AU3027199A (en)	1999-09-06
BR9907911A (en)	2000-10-24
HUP0100957A2 (en)	2002-02-28
IL137038A0 (en)	2001-06-14
ZA991214B (en)	2000-08-16

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Legal Events

Date	Code	Title	Description
2003-10-20	FC2A	Withdrawal, rejection or dismissal of laid open patent application