AU2598897A - Inhibitors of farnesyl-protein transferase - Google Patents

Inhibitors of farnesyl-protein transferase

Info

Publication number: AU2598897A
Authority: AU; Australia
Prior art keywords: farnesyl; inhibitors; protein transferase; transferase; protein
Prior art date: 1996-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU25988/97A

Other versions

AU715603B2 (en

Inventor

Christopher J. Dinsmore

Theresa M. Williams

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-03

Filing date

1997-03-27

Publication date

1997-10-22

1996-05-09 Priority claimed from GBGB9609666.4A external-priority patent/GB9609666D0/en

1997-03-27 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1997-10-22 Publication of AU2598897A publication Critical patent/AU2598897A/en

2000-02-03 Application granted granted Critical

2000-02-03 Publication of AU715603B2 publication Critical patent/AU715603B2/en

2017-03-27 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Virology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AU25988/97A 1996-04-03 1997-03-27 Inhibitors of farnesyl-protein transferase Ceased AU715603B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1479896P	1996-04-03	1996-04-03
US60/014798		1996-04-03
GBGB9609666.4A GB9609666D0 (en)	1996-05-09	1996-05-09	Inhibitors of farnesyl-protein transferase
GB9609666		1996-05-09
PCT/US1997/005235 WO1997036900A1 (en)	1996-04-03	1997-03-27	Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number	Publication Date
AU2598897A true AU2598897A (en)	1997-10-22
AU715603B2 AU715603B2 (en)	2000-02-03

Family

ID=26309289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU25988/97A Ceased AU715603B2 (en)	1996-04-03	1997-03-27	Inhibitors of farnesyl-protein transferase

Country Status (5)

Country	Link
EP (1)	EP0891360A4 (en)
JP (1)	JP2000507585A (en)
AU (1)	AU715603B2 (en)
CA (1)	CA2250353A1 (en)
WO (1)	WO1997036900A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5972966A (en) *	1996-12-05	1999-10-26	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
WO1999027928A1 (en) *	1997-12-04	1999-06-10	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
DE69904302T2 (en) *	1998-02-02	2003-08-14	Lg Chemical Ltd., Seoul/Soul	FARNESYL TRANSFERASE INHIBITORS WITH PIPERID STRUCTURE AND METHOD FOR THE PRODUCTION THEREOF
KR100388790B1 (en) *	1998-03-06	2003-10-04	주식회사 엘지생명과학	Pyridin-2-one derivative useful as farnesyl transferase inhibitor
NZ509241A (en)	1998-08-07	2003-08-29	Du Pont Pharm Co	Succinoylamino lactams as inhibitors of alpha-beta protein production
HRP990246A2 (en)	1998-08-07	2000-06-30	Du Pont Pharm Co	Succinoylamino benzodiazepines as inhibitors of a beta protein production
IL142816A0 (en)	1998-12-24	2002-03-10	Du Pont Pharm Co	SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
EP1165546A2 (en)	1999-04-02	2002-01-02	Du Pont Pharmaceuticals Company	Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
US6960576B2 (en)	1999-09-13	2005-11-01	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en)	1999-09-13	2003-01-07	Bristol-Myers Squibb Pharma Company	Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
WO2001027108A1 (en)	1999-10-08	2001-04-19	Bristol-Myers Squibb Pharma Company	AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6525044B2 (en)	2000-02-17	2003-02-25	Bristol-Myers Squibb Company	Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
US6495540B2 (en)	2000-03-28	2002-12-17	Bristol - Myers Squibb Pharma Company	Lactams as inhibitors of A-β protein production
EP1268433A1 (en)	2000-04-03	2003-01-02	Bristol-Myers Squibb Pharma Company	Cyclic lactams as inhibitors of a-beta-protein production
BR0110051A (en)	2000-04-03	2004-12-07	Bristol Myers Squibb Pharma Co	Compound, Compound Use, Pharmaceutical Composition and Method of Treatment of Alzheimer's Disease
US6632812B2 (en)	2000-04-11	2003-10-14	Dupont Pharmaceuticals Company	Substituted lactams as inhibitors of Aβ protein production
WO2001092235A1 (en)	2000-06-01	2001-12-06	Bristol-Myers Squibb Pharma Company	LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US6974869B2 (en)	2001-09-18	2005-12-13	Bristol-Myers Squibb Pharma Company	Piperizinones as modulators of chemokine receptor activity
TW200307667A (en)	2002-05-06	2003-12-16	Bristol Myers Squibb Co	Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
EP1626961B1 (en) *	2003-05-17	2011-11-02	Korea Research Institute of Bioscience and Biotechnology	Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
ATE531693T1 (en) *	2003-05-17	2011-11-15	Korea Res Inst Of Bioscience	NEW HETEROCYCLIC 2-OXO COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
JP4799408B2 (en) *	2003-07-15	2011-10-26	コリアリサーチインスティテュートオブバイオサイエンスアンドバイオテクノロジー	Use of novel 2-oxoheterocyclic compounds and pharmaceutical compositions containing them
US20070123508A1 (en) *	2005-05-27	2007-05-31	Roger Olsson	PAR2-modulating compounds and their use
CN102548986A (en)	2009-06-05	2012-07-04	链接医药公司	Aminopyrrolidinone derivatives and uses thereof
WO2015130958A1 (en) *	2014-02-26	2015-09-03	Howard University	5-oxopyrrolidine derivatives as hiv integrase inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL69407A (en) *	1982-08-23	1987-10-20	Warner Lambert Co	2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them
DE3336024A1 (en) *	1983-10-04	1985-04-18	Boehringer Ingelheim KG, 6507 Ingelheim	4-AMINO-L-BENZYL-PYRROLIDINONE AND ITS ACID ADDITION SALTS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS
DE3433953A1 (en) *	1984-09-15	1986-03-27	A. Nattermann & Cie GmbH, 5000 Köln	NEW, 3,4-DIHYDRO-2 (1H) -PYRIDONE AND 2 (1H) -PYRIDONE, INCLUDING AN IMIDAZOLE GROUP, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
US4749713A (en) *	1986-03-07	1988-06-07	Ciba-Geigy Corporation	Alpha-heterocycle substituted tolunitriles
US5015653A (en) *	1989-07-10	1991-05-14	Hoffmann-La Roche Inc.	[(5-oxo)-2-pyrrolidinyl)methyl]cyclohexaneacetamides, compositions and use
US5055467A (en) *	1989-11-13	1991-10-08	Allergan, Inc.	Pharmaceutical epinephrine-pilocarpine compounds
US5264449A (en) *	1989-11-13	1993-11-23	Allergan, Inc.	N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl]-2-pyrrolidinone
WO1993012107A1 (en) *	1991-12-18	1993-06-24	Schering Corporation	Imidazoylalkyl substituted with a six membered nitrogen containing heterocyclic ring
ZA929788B (en) *	1991-12-18	1993-06-22	Schering Corp	Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring.
TW218017B (en) *	1992-04-28	1993-12-21	Takeda Pharm Industry Co Ltd

1997
- 1997-03-27 CA CA002250353A patent/CA2250353A1/en not_active Abandoned
- 1997-03-27 AU AU25988/97A patent/AU715603B2/en not_active Ceased
- 1997-03-27 WO PCT/US1997/005235 patent/WO1997036900A1/en not_active Ceased
- 1997-03-27 JP JP9535510A patent/JP2000507585A/en active Pending
- 1997-03-27 EP EP97917738A patent/EP0891360A4/en not_active Withdrawn

Also Published As

Publication number	Publication date
EP0891360A4 (en)	2002-05-15
WO1997036900A1 (en)	1997-10-09
EP0891360A1 (en)	1999-01-20
JP2000507585A (en)	2000-06-20
CA2250353A1 (en)	1997-10-09
AU715603B2 (en)	2000-02-03

Publication	Publication Date	Title
AU703203B2 (en)	1999-03-18	Inhibitors of farnesyl-protein transferase
AU2734797A (en)	1997-11-07	Inhibitors of farnesyl-protein transferase
AU2670297A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2593097A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2253097A (en)	1997-08-22	Inhibitors of farnesyl-protein transferase
AU2430197A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU1988495A (en)	1995-10-03	Inhibitors of farnesyl-protein transferase
AU2555997A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU3373195A (en)	1996-03-22	Inhibitors of farnesyl-protein transferase
GB9604311D0 (en)	1996-05-01	Inhibitors of farnesyl-protein transferase
AU2605897A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2598897A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2552497A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2605797A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2587597A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU1851697A (en)	1997-08-22	Inhibitors of farnesyl-protein transferase
AU2432697A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2432597A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2430397A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2554897A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2600597A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2602097A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU2593297A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase
AU1952697A (en)	1997-08-22	Inhibitors of farnesyl-protein transferase
AU2587997A (en)	1997-10-22	Inhibitors of farnesyl-protein transferase

Legal Events

Date	Code	Title	Description
2000-06-01	FGA	Letters patent sealed or granted (standard patent)
2002-10-31	MK14	Patent ceased section 143(a) (annual fees not paid) or expired