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AU2009321249B2 - Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan - Google Patents

Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan Download PDF

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Publication number
AU2009321249B2
AU2009321249B2 AU2009321249A AU2009321249A AU2009321249B2 AU 2009321249 B2 AU2009321249 B2 AU 2009321249B2 AU 2009321249 A AU2009321249 A AU 2009321249A AU 2009321249 A AU2009321249 A AU 2009321249A AU 2009321249 B2 AU2009321249 B2 AU 2009321249B2
Authority
AU
Australia
Prior art keywords
seq
amino acid
nos
antibody
light chain
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009321249A
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English (en)
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AU2009321249A1 (en
Inventor
Pascale Lejeune
Patricia Vrignaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40578382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009321249(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of AU2009321249A1 publication Critical patent/AU2009321249A1/en
Assigned to SANOFI reassignment SANOFI Amend patent request/document other than specification (104) Assignors: SANOFI-AVENTIS
Application granted granted Critical
Publication of AU2009321249B2 publication Critical patent/AU2009321249B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2009321249A 2008-11-28 2009-11-27 Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan Active AU2009321249B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08291116A EP2191840A1 (en) 2008-11-28 2008-11-28 Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan
EP08291116.5 2008-11-28
PCT/IB2009/055389 WO2010061357A1 (en) 2008-11-28 2009-11-27 Antitumor combinations containing antibodies recognizing specifically cd38 and melphalan

Publications (2)

Publication Number Publication Date
AU2009321249A1 AU2009321249A1 (en) 2010-06-03
AU2009321249B2 true AU2009321249B2 (en) 2016-06-09

Family

ID=40578382

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009321249A Active AU2009321249B2 (en) 2008-11-28 2009-11-27 Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan

Country Status (32)

Country Link
US (1) US9259406B2 (me)
EP (2) EP2191840A1 (me)
JP (3) JP2012510461A (me)
KR (1) KR101733252B1 (me)
CN (1) CN102264385B (me)
AR (1) AR074219A1 (me)
AU (1) AU2009321249B2 (me)
BR (1) BRPI0921864B1 (me)
CA (1) CA2744990C (me)
CL (1) CL2011001254A1 (me)
CO (1) CO6440557A2 (me)
CR (1) CR20110280A (me)
EA (1) EA026867B1 (me)
EC (1) ECSP11011062A (me)
HN (1) HN2011001417A (me)
IL (1) IL213116B (me)
MA (1) MA32896B1 (me)
ME (1) ME01136B (me)
MX (1) MX342625B (me)
MY (1) MY164577A (me)
NI (1) NI201100105A (me)
NZ (1) NZ593027A (me)
PA (1) PA8850101A1 (me)
PE (1) PE20120340A1 (me)
SG (1) SG171820A1 (me)
SV (1) SV2011003924A (me)
TN (1) TN2011000232A1 (me)
TW (1) TWI454260B (me)
UA (1) UA107069C2 (me)
UY (1) UY32263A (me)
WO (1) WO2010061357A1 (me)
ZA (1) ZA201103925B (me)

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WO2011130624A2 (en) * 2010-04-16 2011-10-20 Immune Disease Institute, Inc. Sustained polypeptide expression from synthetic, modified rnas and uses thereof
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CN103118706B (zh) 2010-09-27 2016-05-18 莫佛塞斯公司 抗cd38抗体与来那度胺或硼替佐米用于治疗多发性骨髓瘤和nhl
EP3590949B1 (en) 2010-10-01 2022-05-18 ModernaTX, Inc. Ribonucleic acids containing n1-methyl-pseudouracils and uses thereof
UA112170C2 (uk) * 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
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AU2012352180A1 (en) 2011-12-16 2014-07-31 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
JP2015513912A (ja) 2012-04-02 2015-05-18 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． タンパク質の産生のための修飾ポリヌクレオチド
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US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
JP6426093B2 (ja) 2012-09-25 2018-11-28 モルフォシス・アーゲー 組み合わせ及びその使用
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UA118255C2 (uk) * 2012-12-07 2018-12-26 Санофі Композиція, яка містить антитіло до cd38 і леналідомід
US10342869B2 (en) 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
CN105980401A (zh) 2013-10-03 2016-09-28 现代治疗公司 编码低密度脂蛋白受体的多核苷酸
CA2927099A1 (en) 2013-10-31 2015-05-07 Sanofi Specific anti-cd38 antibodies for treating human cancers
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
WO2016022589A2 (en) 2014-08-08 2016-02-11 The Regents Of The University Of California Methods for treating multiple myeloma
MX386886B (es) 2014-09-09 2025-03-12 Janssen Biotech Inc Combinación de anticuerpos anti-cd38 y ácido todo-trans retinoico para usarse en terapias.
EA037084B9 (ru) 2014-12-04 2021-08-05 Янссен Байотек, Инк. Антитела к cd38 для лечения острого миелолейкоза
WO2016187546A1 (en) 2015-05-20 2016-11-24 Janssen Biotech, Inc. Anti-cd38 antibodies for treatment of light chain amyloidosis and other cd38-positive hematological malignancies
AU2016282674B2 (en) 2015-06-22 2022-01-13 Janssen Biotech, Inc. Combination therapies for heme malignancies with anti-CD38 antibodies and survivin inhibitors
US20170044265A1 (en) 2015-06-24 2017-02-16 Janssen Biotech, Inc. Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38
CA3004152C (en) 2015-11-03 2024-04-16 Janssen Biotech, Inc. Subcutaneous formulations of anti-cd38 antibodies and their uses
US10781261B2 (en) 2015-11-03 2020-09-22 Janssen Biotech, Inc. Subcutaneous formulations of anti-CD38 antibodies and their uses
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CN117330747A (zh) 2016-07-15 2024-01-02 武田药品工业株式会社 用于评估对于成浆细胞和浆细胞耗竭性疗法的应答的方法和材料
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
CA3079242A1 (en) 2017-10-31 2019-05-09 Janssen Biotech, Inc. Methods of treating high risk multiple myeloma
WO2019130228A1 (en) * 2018-01-01 2019-07-04 Orbicular Pharmaceutical Technologies Pvt. Ltd., Stable liquid compositions of melphalan
JP2021510737A (ja) 2018-01-12 2021-04-30 武田薬品工業株式会社 抗ｃｄ３８抗体の皮下投与
BR112021004670A2 (pt) 2018-09-28 2021-06-01 President And Fellows Of Harvard College reprogramação celular para reverter o envelhecimento e promover a regeneração de órgãos e tecidos
US12274733B2 (en) 2018-09-28 2025-04-15 President And Fellows Of Harvard College Cellular reprogramming to reverse aging and promote organ and tissue regeneration
AU2020242228B2 (en) 2019-03-15 2025-12-11 Morphosys Ag Anti-CD38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease
US11655302B2 (en) 2019-06-10 2023-05-23 Sanofi Anti-CD38 antibodies and formulations
EP4069743A1 (en) 2019-12-05 2022-10-12 Sanofi-Aventis U.S. LLC Formulations of anti-cd38 antibodies for subcutaneous administration
EP4277930A1 (en) 2021-01-14 2023-11-22 MorphoSys AG Anti-cd38 antibodies and their uses
TW202302642A (zh) 2021-03-01 2023-01-16 德商莫菲西斯公司 用於治療抗體介導移植物排斥用途之抗ｃｄ３８抗體
TW202321303A (zh) 2021-07-19 2023-06-01 德商莫菲西斯公司 抗pla2r自體抗體媒介膜性腎病變之治療
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EP2191841A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine
EP2191843A1 (en) 2008-11-28 2010-06-02 Sanofi-Aventis Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide

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WO2006099875A1 (en) * 2005-03-23 2006-09-28 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
EP1914424A2 (en) * 2006-10-16 2008-04-23 Haldex Brake Corporation Installation of middle bearing for a crankshaft

Also Published As

Publication number Publication date
JP2012510461A (ja) 2012-05-10
PE20120340A1 (es) 2012-04-17
AU2009321249A1 (en) 2010-06-03
US20110274686A1 (en) 2011-11-10
UY32263A (es) 2010-06-30
CR20110280A (es) 2011-09-20
MY164577A (en) 2018-01-15
EP2370094A1 (en) 2011-10-05
JP2017141233A (ja) 2017-08-17
EA026867B1 (ru) 2017-05-31
BRPI0921864B1 (pt) 2022-11-16
JP2015205890A (ja) 2015-11-19
NZ593027A (en) 2012-12-21
ME01136B (me) 2013-03-20
SG171820A1 (en) 2011-07-28
BRPI0921864A2 (pt) 2018-10-09
KR20110096550A (ko) 2011-08-30
CN102264385B (zh) 2015-05-20
CA2744990A1 (en) 2010-06-03
ECSP11011062A (es) 2011-07-29
UA107069C2 (uk) 2014-11-25
NI201100105A (es) 2011-12-13
IL213116A0 (en) 2011-07-31
MX2011005670A (es) 2011-09-30
US9259406B2 (en) 2016-02-16
HN2011001417A (es) 2014-01-13
ZA201103925B (en) 2012-09-26
PA8850101A1 (es) 2010-07-27
CA2744990C (en) 2019-05-07
JP6148696B2 (ja) 2017-06-14
EP2191840A1 (en) 2010-06-02
MA32896B1 (fr) 2011-12-01
EA201100864A1 (ru) 2011-12-30
TN2011000232A1 (en) 2012-12-17
CO6440557A2 (es) 2012-05-15
MX342625B (es) 2016-10-06
CN102264385A (zh) 2011-11-30
KR101733252B1 (ko) 2017-05-08
IL213116B (en) 2018-11-29
WO2010061357A1 (en) 2010-06-03
HK1164165A1 (en) 2012-09-21
SV2011003924A (es) 2011-10-07
CL2011001254A1 (es) 2012-01-27
TW201023855A (en) 2010-07-01
AR074219A1 (es) 2010-12-29
TWI454260B (zh) 2014-10-01

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