AU2003283597A1 - Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors - Google Patents
Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitorsInfo
- Publication number
- AU2003283597A1 AU2003283597A1 AU2003283597A AU2003283597A AU2003283597A1 AU 2003283597 A1 AU2003283597 A1 AU 2003283597A1 AU 2003283597 A AU2003283597 A AU 2003283597A AU 2003283597 A AU2003283597 A AU 2003283597A AU 2003283597 A1 AU2003283597 A1 AU 2003283597A1
- Authority
- AU
- Australia
- Prior art keywords
- benzthiazole
- benzoxazole
- acid derivatives
- heparanase inhibitors
- benzimidazole acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
- 102100024025 Heparanase Human genes 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 108010037536 heparanase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0226820.9 | 2002-11-16 | ||
| GB0226820A GB0226820D0 (en) | 2002-11-16 | 2002-11-16 | Novel compounds |
| GB0319542.7 | 2003-08-20 | ||
| GB0319542A GB0319542D0 (en) | 2003-08-20 | 2003-08-20 | Novel compounds |
| PCT/GB2003/004991 WO2004046122A2 (en) | 2002-11-16 | 2003-11-17 | Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003283597A8 AU2003283597A8 (en) | 2004-06-15 |
| AU2003283597A1 true AU2003283597A1 (en) | 2004-06-15 |
Family
ID=32328067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003283597A Abandoned AU2003283597A1 (en) | 2002-11-16 | 2003-11-17 | Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003283597A1 (en) |
| WO (1) | WO2004046122A2 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006044502A2 (en) * | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases |
| EP1688413A1 (en) * | 2005-02-03 | 2006-08-09 | Hikma Pharmaceuticals Co. Ltd. | Benzoxazole derivatives for the prophylaxis and treatment of inflammatory bowel diseases |
| US20090163476A1 (en) * | 2005-03-03 | 2009-06-25 | Sirtris Pharmaceuticals, Inc. | N-Phenyl Benzamide Derivatives as Sirtuin Modulators |
| WO2007042816A1 (en) * | 2005-10-12 | 2007-04-19 | Biolipox Ab | Benzoxazoles useful in the treatment of inflammation |
| US8334290B2 (en) | 2005-10-31 | 2012-12-18 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| CN101541783B (en) | 2006-06-30 | 2014-10-01 | 苏尼西斯制药有限公司 | pyridinonyl PDK1 inhibitors |
| JP2010513253A (en) * | 2006-12-14 | 2010-04-30 | ベーリンガー インゲルハイム インテルナショナール ゲーエムベーハー | Benzoxazoles useful for the treatment of inflammation |
| EP2118069B1 (en) * | 2007-01-09 | 2014-01-01 | Amgen Inc. | Bis-aryl amide derivatives useful for the treatment of cancer |
| JP2012525336A (en) * | 2009-04-27 | 2012-10-22 | エラン ファーマシューティカルズ，インコーポレイテッド | Alpha-4 integrin pyridinone antagonist |
| EP2808014A4 (en) | 2012-01-27 | 2016-01-13 | Nat Univ Corp Univ Toyama | INHIBITOR OF SERINE RACEMASE |
| CN111018790B (en) | 2014-04-29 | 2023-09-19 | Fmc公司 | Pyridazinone herbicides |
| CN104529729B (en) * | 2014-12-31 | 2016-03-30 | 浙江永太科技股份有限公司 | The preparation method of the fluoro-3-chlorobenzaldehyde of a kind of 2- |
| CA3003419C (en) | 2015-10-28 | 2023-01-24 | Thomas Martin Stevenson | Novel pyridazinone herbicides |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| US11718609B2 (en) | 2016-12-13 | 2023-08-08 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| EP3381908A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | 2-(4-(4-(bromo-methoxybenzamido)benzylamino)phenyl)benzazole derivatives and their use as anti-heparanase |
| EP3381907A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | Symmetrical 2-aminophenyl-benzazolyl-5-acetate compounds and their use as anti-heparanase |
| TWI785022B (en) | 2017-03-28 | 2022-12-01 | 美商富曼西公司 | Novel pyridazinone herbicides |
| WO2019018562A1 (en) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | AMIDO COMPOUNDS AS AhR MODULATORS |
| CN114760999B (en) | 2019-11-18 | 2024-08-23 | 外治世拉普提斯株式会社 | Composition for treating spinal cord injury comprising stem cells treated with novel compounds |
| WO2021116820A1 (en) * | 2019-12-10 | 2021-06-17 | Aurobindo Pharma Limited | An improved process for the preparation of benoxaprofen |
| CN117924386B (en) * | 2023-12-22 | 2024-07-12 | 合肥综合性国家科学中心大健康研究院 | HPA1 degradation agent and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3267081A (en) * | 1962-09-19 | 1966-08-16 | Koppers Co Inc | Benzothiazole dicarboxylic acids and polymers derived therefrom |
| GB1435721A (en) * | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
| JPS4943974A (en) * | 1972-09-06 | 1974-04-25 | ||
| DE3443594A1 (en) * | 1984-11-29 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | AMINOPHENYLBENZTHIAZOLE |
| US4659360A (en) * | 1984-11-30 | 1987-04-21 | Fmc Corporation | Plant growth and development modification using benzoxazole derivatives |
| AU2002228317A1 (en) * | 2001-01-29 | 2002-08-12 | Insight Strategy And Marketing Ltd | Benz-1,3-azole derivatives and their uses as heparanase inhibitors |
-
2003
- 2003-11-17 AU AU2003283597A patent/AU2003283597A1/en not_active Abandoned
- 2003-11-17 WO PCT/GB2003/004991 patent/WO2004046122A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003283597A8 (en) | 2004-06-15 |
| WO2004046122A2 (en) | 2004-06-03 |
| WO2004046122A3 (en) | 2004-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |