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AU2003264060A1 - Phenacyl xanthine derivatives as dpp-iv inhibitor - Google Patents

Phenacyl xanthine derivatives as dpp-iv inhibitor

Info

Publication number
AU2003264060A1
AU2003264060A1 AU2003264060A AU2003264060A AU2003264060A1 AU 2003264060 A1 AU2003264060 A1 AU 2003264060A1 AU 2003264060 A AU2003264060 A AU 2003264060A AU 2003264060 A AU2003264060 A AU 2003264060A AU 2003264060 A1 AU2003264060 A1 AU 2003264060A1
Authority
AU
Australia
Prior art keywords
dpp
phenacyl
inhibitor
xanthine derivatives
tautomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003264060A
Other versions
AU2003264060A8 (en
Inventor
Matthias Eckhardt
Frank Himmelsbach
Elke Langkopf
Ralf Lotz
Roland Maier
Michael Mark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of AU2003264060A8 publication Critical patent/AU2003264060A8/en
Publication of AU2003264060A1 publication Critical patent/AU2003264060A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns substituted xanthines of general formula (I), wherein: R<1> to R<4> are such as defined in Claim 1, and tautomers, stereoisomers, mixtures, prodrugs and salts thereof. Said compounds have advantageous pharmacological properties, in particular an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.
AU2003264060A 2002-08-22 2003-08-16 Phenacyl xanthine derivatives as dpp-iv inhibitor Abandoned AU2003264060A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10238470.3 2002-08-22
DE10238470A DE10238470A1 (en) 2002-08-22 2002-08-22 New xanthine derivatives, their production and their use as medicines
PCT/EP2003/009096 WO2004018467A2 (en) 2002-08-22 2003-08-16 Phenacyl xanthine derivatives as dpp-iv inhibitor

Publications (2)

Publication Number Publication Date
AU2003264060A8 AU2003264060A8 (en) 2004-03-11
AU2003264060A1 true AU2003264060A1 (en) 2004-03-11

Family

ID=31197232

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003264060A Abandoned AU2003264060A1 (en) 2002-08-22 2003-08-16 Phenacyl xanthine derivatives as dpp-iv inhibitor

Country Status (8)

Country Link
EP (1) EP1554278B1 (en)
JP (1) JP2006501227A (en)
AT (1) ATE323093T1 (en)
AU (1) AU2003264060A1 (en)
CA (1) CA2496325A1 (en)
DE (2) DE10238470A1 (en)
ES (1) ES2262008T3 (en)
WO (1) WO2004018467A2 (en)

Families Citing this family (95)

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US7495005B2 (en) 2002-08-22 2009-02-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, their preparation and their use in pharmaceutical compositions
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
US7482337B2 (en) 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
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Also Published As

Publication number Publication date
JP2006501227A (en) 2006-01-12
WO2004018467A3 (en) 2004-05-13
ATE323093T1 (en) 2006-04-15
CA2496325A1 (en) 2004-03-04
EP1554278A2 (en) 2005-07-20
EP1554278B1 (en) 2006-04-12
ES2262008T3 (en) 2006-11-16
DE50302975D1 (en) 2006-05-24
AU2003264060A8 (en) 2004-03-11
WO2004018467A2 (en) 2004-03-04
DE10238470A1 (en) 2004-03-04

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