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AU2002322477A1 - Composite binding polypeptides - Google Patents

Composite binding polypeptides

Info

Publication number
AU2002322477A1
AU2002322477A1 AU2002322477A AU2002322477A AU2002322477A1 AU 2002322477 A1 AU2002322477 A1 AU 2002322477A1 AU 2002322477 A AU2002322477 A AU 2002322477A AU 2002322477 A AU2002322477 A AU 2002322477A AU 2002322477 A1 AU2002322477 A1 AU 2002322477A1
Authority
AU
Australia
Prior art keywords
binding polypeptides
composite binding
composite
polypeptides
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002322477A
Inventor
Yen Choo
Mark Isalan
Michael Moore
Armin Sepp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gendaq Ltd
Original Assignee
Gendaq Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gendaq Ltd filed Critical Gendaq Ltd
Publication of AU2002322477A1 publication Critical patent/AU2002322477A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002322477A 2001-04-04 2002-04-04 Composite binding polypeptides Abandoned AU2002322477A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0108491.2 2001-04-04
GB0108491A GB0108491D0 (en) 2001-04-04 2001-04-04 Engineering zinc fingers
PCT/US2002/022272 WO2002099084A2 (en) 2001-04-04 2002-04-04 Composite binding polypeptides

Publications (1)

Publication Number Publication Date
AU2002322477A1 true AU2002322477A1 (en) 2002-12-16

Family

ID=9912259

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002322477A Abandoned AU2002322477A1 (en) 2001-04-04 2002-04-04 Composite binding polypeptides

Country Status (3)

Country Link
AU (1) AU2002322477A1 (en)
GB (1) GB0108491D0 (en)
WO (1) WO2002099084A2 (en)

Families Citing this family (227)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060054196A (en) * 2003-06-10 2006-05-22 주식회사 툴젠 Deliverable DNA-binding Protein
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
JP4555292B2 (en) 2003-08-08 2010-09-29 サンガモ バイオサイエンシズ インコーポレイテッド Methods and compositions for targeted cleavage and recombination
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
WO2005028630A2 (en) 2003-09-19 2005-03-31 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
PT2071028E (en) 2003-11-05 2012-04-10 Int Inst Cancer Immunology Inc Hla-dr-binding antigen peptide derived from wt1
DE102005026163A1 (en) * 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Antibodies directed against the Marburg I polymorphism of Factor VII activating protease (FSAP), their production and use
KR20070060115A (en) 2004-09-16 2007-06-12 상가모 바이오사이언스 인코포레이티드 Compositions and Methods for Protein Production
WO2007014275A2 (en) 2005-07-26 2007-02-01 Sangamo Biosciences, Inc. Targeted integration and expression of exogenous nucleic acid sequences
ATE462783T1 (en) 2006-05-25 2010-04-15 Sangamo Biosciences Inc VARIANT FOKI CLIP HALF DOMAINS
JP5551432B2 (en) 2006-05-25 2014-07-16 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for gene inactivation
KR101439568B1 (en) 2006-08-11 2014-09-12 다우 아그로사이언시즈 엘엘씨 Zinc finger nuclease-mediated homologous recombination
AU2007319881B2 (en) 2006-11-13 2012-05-17 Sangamo Therapeutics, Inc. Zinc finger nuclease for targeting the human glucocorticoid receptor locus
EP3070169B1 (en) 2006-12-14 2018-05-09 Dow AgroSciences LLC Optimized non-canonical zinc finger proteins
RU2009135802A (en) 2007-02-27 2011-04-10 Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк. (Jp) METHOD FOR ACTIVATION OF HELPER T-CELLS AND COMPOSITION FOR APPLICATION IN THIS METHOD
AU2008244473B2 (en) 2007-04-26 2013-06-20 Sangamo Therapeutics, Inc. Targeted integration into the PPP1R12C locus
CA2691440A1 (en) 2007-06-29 2009-01-08 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
AU2008275649B2 (en) 2007-07-12 2013-09-05 Sangamo Therapeutics, Inc. Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
CA2937438C (en) 2007-09-27 2020-07-07 Dow Agrosciences Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
EP2188384B1 (en) 2007-09-27 2015-07-15 Sangamo BioSciences, Inc. Rapid in vivo identification of biologically active nucleases
JP2011500082A (en) 2007-10-25 2011-01-06 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for targeted integration
EP2281050B1 (en) 2008-04-14 2014-04-02 Sangamo BioSciences, Inc. Linear donor constructs for targeted integration
AU2009260888B2 (en) 2008-05-28 2014-09-11 Sangamo Therapeutics, Inc. Compositions for linking DNA-binding domains and cleavage domains
EP2130836B1 (en) * 2008-06-03 2013-02-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Means and methods for producing zinc fingers and concatemers thereof
KR101794638B1 (en) 2008-06-10 2017-12-04 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for generation of bax- and bak-deficient cell lines
AU2009283194B2 (en) 2008-08-22 2014-10-16 Sangamo Therapeutics, Inc. Methods and compositions for targeted single-stranded cleavage and targeted integration
EP2344660B1 (en) 2008-10-29 2018-01-17 Sangamo Therapeutics, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
EP2352369B1 (en) 2008-12-04 2017-04-26 Sangamo BioSciences, Inc. Genome editing in rats using zinc-finger nucleases
HRP20180074T1 (en) 2008-12-17 2018-04-06 Dow Agrosciences Llc Targeted integration into the zp15 locus
CA2749965C (en) 2009-02-04 2018-09-11 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathies
JP5932632B2 (en) 2009-03-20 2016-06-15 サンガモ バイオサイエンシーズ， インコーポレイテッド Modification of CXCR4 using modified zinc finger protein
US9834787B2 (en) 2009-04-09 2017-12-05 Sangamo Therapeutics, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
EP2449135B1 (en) 2009-06-30 2016-01-06 Sangamo BioSciences, Inc. Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
EP2461819A4 (en) 2009-07-28 2013-07-31 Sangamo Biosciences Inc Methods and compositions for treating trinucleotide repeat disorders
WO2011019385A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
ES2657067T3 (en) 2009-10-22 2018-03-01 Dow Agrosciences Llc Genetically modified zinc finger proteins that target plant genes involved in fatty acid biosynthesis
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
AU2010339481B2 (en) 2009-12-30 2016-02-04 Pioneer Hi-Bred International, Inc. Methods and compositions for targeted polynucleotide modification
MX336846B (en) 2010-01-22 2016-02-03 Sangamo Biosciences Inc Targeted genomic alteration.
EP3594333B1 (en) 2010-02-08 2023-11-01 Sangamo Therapeutics, Inc. Engineered cleavage half-domains
AU2011215557B2 (en) 2010-02-09 2016-03-10 Sangamo Therapeutics, Inc. Targeted genomic modification with partially single-stranded donor molecules
EP2563918B1 (en) 2010-04-26 2016-11-23 Sangamo BioSciences, Inc. Genome editing of a rosa locus using zinc-finger nucleases
PT2566972T (en) 2010-05-03 2020-03-02 Sangamo Biosciences Inc Compositions for linking zinc finger modules
AU2011256838B2 (en) 2010-05-17 2014-10-09 Sangamo Therapeutics, Inc. Novel DNA-binding proteins and uses thereof
CA3157027A1 (en) 2010-07-21 2012-01-26 Sangamo Therapeutics, Inc. Methods and compositions for modification of a t-cell receptor gene
EP2622090B1 (en) 2010-09-27 2019-06-19 Sangamo Therapeutics, Inc. Compositions for inhibiting viral entry into cells
KR102079480B1 (en) 2010-10-05 2020-02-19 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 Method for activating helper t cell
RU2608643C2 (en) 2010-10-12 2017-01-23 Дзе Чилдрен`З Хоспитал Оф Филадельфия Methods and compositions for treating hemophilia b
WO2012094132A1 (en) 2011-01-05 2012-07-12 Sangamo Biosciences, Inc. Methods and compositions for gene correction
CA2825273A1 (en) * 2011-01-20 2012-07-26 Oneday - Biotech And Pharma Ltd. Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof
CA2831144A1 (en) 2011-03-23 2012-09-27 Pioneer Hi-Bred International, Inc. Methods for producing a complex transgenic trait locus
US8685737B2 (en) 2011-04-27 2014-04-01 Amyris, Inc. Methods for genomic modification
CN104080914A (en) 2011-06-21 2014-10-01 先锋国际良种公司 Compositions and methods for producing male sterile plants
EP3461896B1 (en) 2011-07-15 2023-11-29 The General Hospital Corporation Methods of transcription activator like effector assembly
US9161995B2 (en) 2011-07-25 2015-10-20 Sangamo Biosciences, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
IL277027B (en) 2011-09-21 2022-07-01 Sangamo Therapeutics Inc Methods and preparations for regulating transgene expression
CA2852955C (en) 2011-10-27 2021-02-16 Sangamo Biosciences, Inc. Methods and compositions for modification of the hprt locus
EP2780460B1 (en) 2011-11-16 2018-07-11 Sangamo Therapeutics, Inc. Modified dna-binding proteins and uses thereof
CN108285491B (en) 2012-02-29 2021-08-10 桑格摩生物科学股份有限公司 Methods and compositions for treating huntington's disease
UA115875C2 (en) 2012-05-02 2018-01-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Targeted modification of malate dehydrogenase
CN104471067B (en) 2012-05-07 2020-08-14 桑格摩生物治疗股份有限公司 Methods and compositions for nuclease-mediated targeted integration of transgenes
US9890364B2 (en) 2012-05-29 2018-02-13 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
JP6329537B2 (en) 2012-07-11 2018-05-23 サンガモ セラピューティクス， インコーポレイテッド Methods and compositions for delivery of biological agents
HUE030799T2 (en) 2012-07-11 2017-06-28 Sangamo Biosciences Inc Methods and compositions for the treatment of lysosomal storage diseases
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
WO2014016831A1 (en) 2012-07-23 2014-01-30 Oneday - Biotech And Pharma Ltd. Glutathione-elevating compositions and uses thereof
WO2014016837A1 (en) 2012-07-25 2014-01-30 Oneday - Biotech And Pharma Ltd. Compositions and methods for increasing carnitine level in muscle tissues
US9963715B2 (en) 2012-08-29 2018-05-08 Sangamo Therapeutics, Inc. Methods and compositions for treatment of a genetic condition
UA118090C2 (en) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
CA2884162C (en) 2012-09-07 2020-12-29 Dow Agrosciences Llc Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
UA119135C2 (en) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Engineered transgene integration platform (etip) for gene targeting and trait stacking
EP2906684B8 (en) 2012-10-10 2020-09-02 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
US20150267176A1 (en) 2012-10-12 2015-09-24 The General Hospital Corporation Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
AU2013355327A1 (en) 2012-12-05 2015-06-11 Sangamo Therapeutics, Inc. Methods and compositions for regulation of metabolic disorders
CN105378088A (en) 2012-12-13 2016-03-02 陶氏益农公司 Precision gene targeting to a particular locus in maize
SG10201705028WA (en) 2012-12-17 2017-07-28 Otsuka Pharma Co Ltd Method for activating helper t cell
WO2014124284A1 (en) 2013-02-07 2014-08-14 The General Hospital Corporation Tale transcriptional activators
CA2901676C (en) 2013-02-25 2023-08-22 Sangamo Biosciences, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
US9937207B2 (en) 2013-03-21 2018-04-10 Sangamo Therapeutics, Inc. Targeted disruption of T cell receptor genes using talens
AU2014248208C1 (en) 2013-04-05 2023-04-27 Corteva Agriscience Llc Methods and compositions for integration of an exogenous sequence within the genome of plants
EP2994531B1 (en) 2013-05-10 2018-03-28 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
JP2016521975A (en) 2013-05-15 2016-07-28 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for the treatment of genetic conditions
JP6588438B2 (en) 2013-08-28 2019-10-09 サンガモ セラピューティクス， インコーポレイテッド Composition for linking a DNA binding domain and a cleavage domain
US10117899B2 (en) 2013-10-17 2018-11-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
DK3441468T3 (en) 2013-10-17 2021-07-26 Sangamo Therapeutics Inc Delivery methods and compositions for nuclease-mediated genome manipulation
US10273493B2 (en) 2013-11-04 2019-04-30 Dow Agrosciences Llc Optimal maize loci
BR102014027436B1 (en) 2013-11-04 2022-06-28 Dow Agrosciences Llc RECOMBINANT NUCLEIC ACID MOLECULE AND METHOD FOR PRODUCTION OF A TRANSGENIC PLANT CELL
EP3066110B1 (en) 2013-11-04 2021-12-29 Corteva Agriscience LLC Optimal maize loci
KR102269374B1 (en) 2013-11-04 2021-06-28 코르테바 애그리사이언스 엘엘씨 Optimal soybean loci
CN105934524A (en) 2013-11-11 2016-09-07 桑格摩生物科学股份有限公司 Methods and compositions for treating huntington's disease
PL3492593T3 (en) 2013-11-13 2022-04-19 Children's Medical Center Corporation Nuclease-mediated regulation of gene expression
DK3080274T3 (en) 2013-12-09 2020-08-31 Sangamo Therapeutics Inc Methods and compositions for genome manipulation
PT3083958T (en) 2013-12-19 2019-06-27 Amyris Inc Methods for genomic integration
AU2015218576B2 (en) 2014-02-24 2020-02-27 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration
CA2942762C (en) 2014-03-18 2023-10-17 Sangamo Biosciences, Inc. Methods and compositions for regulation of zinc finger protein expression
US9522936B2 (en) 2014-04-24 2016-12-20 Sangamo Biosciences, Inc. Engineered transcription activator like effector (TALE) proteins
CN106413760B (en) 2014-05-08 2020-01-14 桑格摩生物科学股份有限公司 Methods and compositions for treating huntington's disease
WO2015175642A2 (en) 2014-05-13 2015-11-19 Sangamo Biosciences, Inc. Methods and compositions for prevention or treatment of a disease
WO2015188065A1 (en) 2014-06-05 2015-12-10 Sangamo Biosciences, Inc. Methods and compositions for nuclease design
EP3166964A1 (en) 2014-07-08 2017-05-17 Vib Vzw Means and methods to increase plant yield
AU2015289799B2 (en) 2014-07-14 2018-07-26 The University Court Of The University Of Edinburgh NANOS knock-out that ablates germline cells
WO2016011381A1 (en) 2014-07-18 2016-01-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing cxcr4 expression and/or function to enhance engraftment of hematopoietic stem cells
US9816074B2 (en) 2014-07-25 2017-11-14 Sangamo Therapeutics, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
US9757420B2 (en) 2014-07-25 2017-09-12 Sangamo Therapeutics, Inc. Gene editing for HIV gene therapy
WO2016019144A2 (en) 2014-07-30 2016-02-04 Sangamo Biosciences, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
WO2016044416A1 (en) 2014-09-16 2016-03-24 Sangamo Biosciences, Inc. Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
EP3247366A4 (en) 2015-01-21 2018-10-31 Sangamo Therapeutics, Inc. Methods and compositions for identification of highly specific nucleases
EP4335918A3 (en) 2015-04-03 2024-04-17 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
IL284707B2 (en) 2015-05-12 2024-01-01 Sangamo Therapeutics Inc Nuclease-mediated regulation of gene expression
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
CA2991301A1 (en) 2015-07-13 2017-01-19 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
EP3322428B1 (en) * 2015-07-15 2024-04-24 Agency For Science, Technology And Research Modulation of hepatitis b virus replication
HRP20240908T1 (en) 2015-08-06 2024-10-25 The Curators Of The University Of Missouri Porcine reproductive and respiratory syndrome virus (prrsv)-resistant porcine and cells having modified cd163 genes
DK3352776T3 (en) 2015-09-23 2025-06-23 Sangamo Therapeutics Inc HTT REPRESSORS AND THEIR APPLICATION
AU2016361350B2 (en) 2015-11-23 2023-04-06 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
MX2018007519A (en) 2015-12-18 2019-09-04 Sangamo Therapeutics Inc Targeted disruption of the mhc cell receptor.
AU2016369490C1 (en) 2015-12-18 2021-12-23 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
KR20180127319A (en) 2016-01-15 2018-11-28 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for the treatment of neurological disorders
JP7012650B2 (en) 2016-02-02 2022-01-28 サンガモ セラピューティクス， インコーポレイテッド Composition for linking DNA binding domain and cleavage domain
US20190249172A1 (en) 2016-02-18 2019-08-15 The Regents Of The University Of California Methods and compositions for gene editing in stem cells
JP2019515654A (en) 2016-03-16 2019-06-13 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ Methods and compositions for treating obesity and / or diabetes, and methods and compositions for identifying candidate treatment agents
WO2017165655A1 (en) 2016-03-23 2017-09-28 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
JP7093310B2 (en) 2016-05-18 2022-06-29 アミリス， インコーポレイテッド Compositions and Methods for Genome Integration of Nucleic Acids into Exogenous Landing Pads
AU2017295720B2 (en) 2016-07-13 2021-07-22 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
MA53246A (en) 2016-07-27 2021-07-28 Univ Case Western Reserve COMPOUNDS AND METHODS FOR PROMOTING MYELINATION
WO2018029034A1 (en) 2016-08-09 2018-02-15 Vib Vzw Cellulose synthase inhibitors and mutant plants
BR112019003100A2 (en) 2016-08-24 2019-07-09 Sangamo Therapeutics, Inc. regulation of gene expression using engineered nucleases
SG10201913948PA (en) 2016-08-24 2020-03-30 Sangamo Therapeutics Inc Engineered target specific nucleases
AU2017324462B2 (en) 2016-09-07 2024-03-21 Sangamo Therapeutics, Inc. Modulation of liver genes
AU2017338846B2 (en) 2016-10-04 2020-09-24 Precision Biosciences, Inc. Co-stimulatory domains for use in genetically-modified cells
IL266047B2 (en) 2016-10-20 2025-02-01 Sangamo Therapeutics Inc Methods and preparations for the treatment of Fabry disease
US11020492B2 (en) 2016-10-31 2021-06-01 Sangamo Therapeutics, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
KR102674612B1 (en) 2016-12-01 2024-06-14 상가모 테라퓨틱스, 인코포레이티드 Tau modulators and methods and compositions for their delivery
MA49610A (en) 2016-12-08 2020-05-27 Univ Case Western Reserve METHODS AND COMPOSITIONS FOR IMPROVING FUNCTIONAL MYELIN PRODUCTION
CA3045131A1 (en) 2016-12-14 2018-06-21 Ligandal, Inc. Methods and compositions for nucleic acid and protein payload delivery
EP3579858A4 (en) 2017-02-07 2020-12-23 The Regents of The University of California GENE THERAPY FOR HAPLOINSUFFICIENCY
WO2018195418A1 (en) 2017-04-20 2018-10-25 Oregon Health & Science University Human gene correction
CN110869497A (en) 2017-05-03 2020-03-06 桑格摩生物治疗股份有限公司 Methods and compositions for modifying the cystic fibrosis transmembrane conductance regulator (CFTR) gene
WO2018208837A1 (en) 2017-05-08 2018-11-15 Precision Biosciences, Inc. Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
JP2020529834A (en) 2017-06-30 2020-10-15 プレシジョン バイオサイエンシズ，インク． Genetically modified T cells containing modified introns of the T cell receptor alpha gene
WO2019032675A1 (en) 2017-08-08 2019-02-14 Sangamo Therapeutics, Inc. Chimeric antigen receptor mediated cell targeting
KR20200104284A (en) 2017-10-03 2020-09-03 주노 쎄러퓨티크스 인코퍼레이티드 HPV-specific binding molecule
WO2019070856A1 (en) 2017-10-03 2019-04-11 Precision Biosciences, Inc. Modified epidermal growth factor receptor peptides for use in genetically-modified cells
EP3704238B1 (en) 2017-11-01 2024-01-03 Precision Biosciences, Inc. Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
KR102730214B1 (en) 2017-11-09 2024-11-13 상가모 테라퓨틱스, 인코포레이티드 Genetic alterations in the cytokine-inducible SH2-containing protein (CISH) gene
SG11202004926WA (en) 2017-12-01 2020-06-29 Encoded Therapeutics Inc Engineered dna binding proteins
CA3084572A1 (en) 2017-12-18 2019-06-27 Syngenta Participations Ag Targeted insertion sites in the maize genome
BR112020013626A2 (en) 2018-01-17 2020-12-01 Vertex Pharmaceuticals Incorporated quinoxalinone compounds, compositions, methods and kits to increase genome editing efficiency
KR20200110685A (en) 2018-01-17 2020-09-24 버텍스 파마슈티칼스 인코포레이티드 DNA-PK inhibitor
BR112020014140A2 (en) 2018-01-17 2020-12-01 Vertex Pharmaceuticals Incorporated dna-pk inhibitors
US11401512B2 (en) 2018-02-08 2022-08-02 Sangamo Therapeutics, Inc. Engineered target specific nucleases
CN112585277A (en) 2018-04-05 2021-03-30 朱诺治疗学股份有限公司 T cells expressing recombinant receptors, related polynucleotides and methods
AU2019247200A1 (en) 2018-04-05 2020-10-15 Editas Medicine, Inc. Methods of producing cells expressing a recombinant receptor and related compositions
US11421007B2 (en) 2018-04-18 2022-08-23 Sangamo Therapeutics, Inc. Zinc finger protein compositions for modulation of huntingtin (Htt)
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
IL280951B2 (en) 2018-08-23 2024-08-01 Sangamo Therapeutics Inc Engineered target specific base editors
CN113015741A (en) 2018-09-18 2021-06-22 桑格摩生物治疗股份有限公司 Programmed cell death 1(PD1) specific nucleases
CA3113449A1 (en) 2018-09-21 2020-03-26 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
SG11202103316TA (en) 2018-10-02 2021-04-29 Sangamo Therapeutics Inc Methods and compositions for modulation of tau proteins
WO2020132659A1 (en) 2018-12-21 2020-06-25 Precision Biosciences, Inc. Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
PT3908568T (en) 2019-01-11 2024-09-30 Acuitas Therapeutics Inc Lipids for lipid nanoparticle delivery of active agents
AU2019428629A1 (en) 2019-02-06 2021-01-28 Sangamo Therapeutics, Inc. Method for the treatment of mucopolysaccharidosis type I
WO2020163856A1 (en) 2019-02-10 2020-08-13 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Modified mitochondrion and methods of use thereof
BR112021019448A2 (en) 2019-04-02 2021-11-30 Sangamo Therapeutics Inc Methods for treating beta-thalassemia
AU2020253538A1 (en) 2019-04-03 2021-11-18 Precision Biosciences, Inc. Genetically-modified immune cells comprising a microRNA-adapted shRNA (shRNAmiR)
CA3136265A1 (en) 2019-04-05 2020-10-08 Precision Biosciences, Inc. Methods of preparing populations of genetically-modified immune cells
EP3958871A1 (en) 2019-04-23 2022-03-02 Sangamo Therapeutics, Inc. Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
CN114007640A (en) 2019-05-01 2022-02-01 朱诺治疗学股份有限公司 Cells expressing chimeric receptors from modified CD247 loci, related polynucleotides and methods
CN114025788A (en) 2019-05-01 2022-02-08 朱诺治疗学股份有限公司 Cells, related polynucleotides and methods for expressing recombinant receptors from modified TGFBR2 loci
CN114174520B (en) 2019-05-29 2025-07-08 编码治疗公司 Compositions and methods for selective gene modulation
US20220273715A1 (en) 2019-07-25 2022-09-01 Precision Biosciences, Inc. Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
WO2021035054A1 (en) 2019-08-20 2021-02-25 Precision Biosciences, Inc. Lymphodepletion dosing regimens for cellular immunotherapies
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
AU2020356962A1 (en) 2019-10-02 2022-04-14 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for repressing alpha-synuclein expression
WO2021067864A1 (en) 2019-10-02 2021-04-08 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for treatment of prion disease
WO2021087305A1 (en) 2019-10-30 2021-05-06 Precision Biosciences, Inc. Cd20 chimeric antigen receptors and methods of use for immunotherapy
WO2021087358A1 (en) 2019-11-01 2021-05-06 Sangamo Therapeutics, Inc. Gin recombinase variants
US20230036065A1 (en) 2019-12-06 2023-02-02 Precision Biosciences, Inc. Methods for cancer immunotherapy
IL294535A (en) 2020-01-22 2022-09-01 Sangamo Therapeutics Inc Zinc finger protein transcription factors to suppress tau expression
WO2021158915A1 (en) 2020-02-06 2021-08-12 Precision Biosciences, Inc. Recombinant adeno-associated virus compositions and methods for producing and using the same
WO2021188286A2 (en) * 2020-02-28 2021-09-23 The Broad Institute, Inc. Zinc finger degradation domains
CN115697044A (en) 2020-03-31 2023-02-03 艾洛生物系统有限公司 Regulation of endogenous mogroside pathway genes in watermelon and other cucurbitaceae
JP2023525510A (en) 2020-05-06 2023-06-16 セレクティス ソシエテ アノニム Methods of genetically modifying cells for delivery of therapeutic proteins
CA3177093A1 (en) 2020-05-06 2021-11-11 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
US20230183664A1 (en) 2020-05-11 2023-06-15 Precision Biosciences, Inc. Self-limiting viral vectors encoding nucleases
EP4150057A2 (en) 2020-05-13 2023-03-22 Juno Therapeutics, Inc. Process for producing donor-batched cells expressing a recombinant receptor
JP2023531531A (en) 2020-06-26 2023-07-24 ジュノ セラピューティクス ゲーエムベーハー Engineered T Cells Conditionally Expressing Recombinant Receptors, Related Polynucleotides, and Methods
WO2022016070A1 (en) 2020-07-16 2022-01-20 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
WO2022035793A1 (en) 2020-08-10 2022-02-17 Precision Biosciences, Inc. Antibodies and fragments specific for b-cell maturation antigen and uses thereof
EP4501951A3 (en) 2020-08-25 2025-04-30 Kite Pharma, Inc. T cells with improved functionality
US20240043829A1 (en) 2020-09-25 2024-02-08 Sangamo Therapeutics, Inc. Zinc finger fusion proteins for nucleobase editing
UY39450A (en) 2020-10-02 2022-04-29 Sangamo Therapeutics Inc NOVEL ZINC FINGER PROTEIN TRANSCRIPTION FACTORS TO REPRESS ALPHA-SYNUCLEIN EXPRESSION
US20230365995A1 (en) 2020-10-07 2023-11-16 Precision Biosciences, Inc. Lipid nanoparticle compositions
US20240060079A1 (en) 2020-10-23 2024-02-22 Elo Life Systems Methods for producing vanilla plants with improved flavor and agronomic production
JP2023549780A (en) 2020-11-04 2023-11-29 ジュノー セラピューティクス インコーポレイテッド Cells expressing chimeric receptors from engineered invariant CD3 immunoglobulin superfamily chain loci and related polynucleotides and methods
WO2022101641A1 (en) 2020-11-16 2022-05-19 Pig Improvement Company Uk Limited Influenza a-resistant animals having edited anp32 genes
EP4284823A1 (en) 2021-01-28 2023-12-06 Precision BioSciences, Inc. Modulation of tgf beta signaling in genetically-modified eukaryotic cells
WO2022226316A1 (en) 2021-04-22 2022-10-27 Precision Biosciences, Inc. Compositions and methods for generating male sterile plants
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
AU2022371430A1 (en) 2021-10-19 2024-05-30 Precision Biosciences, Inc. Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
US20250009800A1 (en) 2021-11-16 2025-01-09 Precision Biosciences, Inc. Methods for cancer immunotherapy
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023114943A2 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP4453202A1 (en) 2021-12-22 2024-10-30 Sangamo Therapeutics, Inc. Novel zinc finger fusion proteins for nucleobase editing
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
EP4615960A1 (en) 2022-11-09 2025-09-17 C3S2 GmbH Methods for manufacturing engineered immune cells
WO2024161021A1 (en) 2023-02-03 2024-08-08 Juno Therapeutics Gmbh Methods for non-viral manufacturing of engineered immune cells
CN121152635A (en) 2023-03-31 2025-12-16 布里卡尔治疗公司 Methods for enhancing immunogenicity of cellular vaccines
AU2024255934A1 (en) 2023-04-14 2025-11-20 Precision Biosciences, Inc. Muscle-specific expression cassettes
WO2024216116A1 (en) 2023-04-14 2024-10-17 Precision Biosciences, Inc. Muscle-specific expression cassettes
WO2024238726A1 (en) 2023-05-16 2024-11-21 Omega Therapeutics, Inc. Methods and compositions for modulating methylation of a target gene
WO2024238723A1 (en) 2023-05-16 2024-11-21 Omega Therapeutics, Inc. Methods and compositions for modulating pcsk9 expression
WO2025004001A1 (en) 2023-06-30 2025-01-02 Takeda Pharmaceutical Company Limited Htt repressors and uses thereof
WO2025019742A1 (en) 2023-07-19 2025-01-23 Omega Therapeutics, Inc. Methods and compositions for modulating ctnnb1 expression
WO2025194124A1 (en) 2024-03-14 2025-09-18 Tessera Therapeutics, Inc. Modified st1cas9 guide nucleic acids
WO2025235563A1 (en) 2024-05-07 2025-11-13 Omega Therapeutics, Inc. Epigenetic modulation for upregulation of genes
US20250345431A1 (en) 2024-05-10 2025-11-13 Juno Therapeutics, Inc. Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy

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