[go: up one dir, main page]

AU2002228692A1 - 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors - Google Patents

3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors

Info

Publication number
AU2002228692A1
AU2002228692A1 AU2002228692A AU2869202A AU2002228692A1 AU 2002228692 A1 AU2002228692 A1 AU 2002228692A1 AU 2002228692 A AU2002228692 A AU 2002228692A AU 2869202 A AU2869202 A AU 2869202A AU 2002228692 A1 AU2002228692 A1 AU 2002228692A1
Authority
AU
Australia
Prior art keywords
indeno
dimethylthiazol
pyrazol
derivatives
cdk inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002228692A
Inventor
Eddy W. Yue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of AU2002228692A1 publication Critical patent/AU2002228692A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002228692A 2000-12-01 2001-11-30 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors Abandoned AU2002228692A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25121300P 2000-12-01 2000-12-01
US60/251,213 2000-12-01
PCT/US2001/045227 WO2002044174A2 (en) 2000-12-01 2001-11-30 3-(2,4-dimethylthiazol-5-yl) indeno[1,2-c]pyrazol-4-one derivatives as cdk inhibitors

Publications (1)

Publication Number Publication Date
AU2002228692A1 true AU2002228692A1 (en) 2002-06-11

Family

ID=22950958

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002228692A Abandoned AU2002228692A1 (en) 2000-12-01 2001-11-30 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors

Country Status (3)

Country Link
US (1) US6706718B2 (en)
AU (1) AU2002228692A1 (en)
WO (1) WO2002044174A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593356B2 (en) * 1999-10-20 2003-07-15 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US20040048844A1 (en) 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US7605175B2 (en) 2001-03-02 2009-10-20 Gpc Biotech Ag Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
JP2005527560A (en) * 2002-03-27 2005-09-15 サイクラセル・リミテッド A combination comprising a CDK inhibitor and doxorubicin
GB0225873D0 (en) * 2002-11-06 2002-12-11 Cyclacel Ltd Combination
CA2502979A1 (en) * 2002-11-06 2004-05-21 Cyclacel Limited Pharmaceutical composition comprising a cdk inhibitor and gemcitabine
US7456169B2 (en) 2003-02-27 2008-11-25 Abbott Laboratories Inc. Heterocyclic kinase inhibitors
US7320986B2 (en) 2003-03-07 2008-01-22 Abbott Labortories Fused tri and tetra-cyclic pyrazole kinase inhibitors
US7786112B2 (en) 2003-04-07 2010-08-31 Agennix Usa Inc. Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
GB0313511D0 (en) * 2003-06-11 2003-07-16 Cyclacel Ltd Combination
EA013117B1 (en) 2003-12-23 2010-02-26 ДжиПиСи БАЙОТЕК, ИНК. Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
MXPA06010904A (en) 2004-03-24 2007-06-11 Abbott Lab Tricyclic pyrazole kinase inhibitors.
EP1763345A2 (en) * 2004-06-18 2007-03-21 GPC Biotech Inc. Kinase inhibitors for treating cancers
SE0401716D0 (en) * 2004-07-02 2004-07-02 Astrazeneca Ab New compounds
EP2341911A4 (en) * 2008-10-01 2012-10-24 Univ North Carolina HEMATOPOIETIC PROTECTION AGAINST CHEMOTHERAPEUTIC COMPOUNDS USING SELF-ACTIVE CYCLINE-DEPENDENT KINASE-4/6 INHIBITORS
AU2010248886A1 (en) 2009-05-13 2011-12-01 The University Of North Carolina At Chapel Hill Cyclin dependent kinase inhibitors and methods of use
AU2011329763A1 (en) 2010-11-17 2013-05-09 Brigham And Women's Hospital Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6
SI2968290T1 (en) 2013-03-15 2020-02-28 G1 Therapeutics, Inc., Transient protection of normal cells during chemotherapy
EP2967050A4 (en) 2013-03-15 2016-09-28 G1 Therapeutics Inc HIGHLY ACTIVE ANINEEOPLASTIC AND ANTIPROLIFERATIVE AGENTS
US9717735B2 (en) 2014-04-17 2017-08-01 G1 Therapeutics, Inc. Tricyclic lactams for use in HSPC-sparing treatments for RB-positive abnormal cellular proliferation
WO2016040858A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2223946A (en) 1988-10-24 1990-04-25 Shell Int Research Herbicidal compositions and their use
AU747705C (en) * 1997-12-13 2004-09-23 Bristol-Myers Squibb Company Use of pyrazolo (3,4-b) pyridine as cyclin dependent kinase inhibitors
JP4665239B2 (en) * 1998-04-21 2011-04-06 アゲンニクス アーゲー 5-Aminoindeno [1,2-c] pyrazol-4-ones as anticancer and antiproliferative agents
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
US6114365A (en) * 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6849631B2 (en) * 2000-12-08 2005-02-01 Bristol Myers Squibb Pharma Company Semicarbazides and their uses

Also Published As

Publication number Publication date
US6706718B2 (en) 2004-03-16
WO2002044174A2 (en) 2002-06-06
WO2002044174A3 (en) 2003-01-23
US20020107274A1 (en) 2002-08-08

Similar Documents

Publication Publication Date Title
AU2002228692A1 (en) 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors
AU2001230026A1 (en) 2,4-diaminothiazole derivatives
AU2001219185A1 (en) 2-acylaminobenzimidazole derivatives for treating glaucoma
AU2002214505A1 (en) New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
AU2001280099A1 (en) 4-acylaminopyrazole derivatives
AU2001230584A1 (en) 1h-imidazopyridine derivatives
AU2001230537A1 (en) Pyridoxazine derivatives
AU2001231664A1 (en) Indol-3-yl derivatives
AU2001281802A1 (en) 6-phenylpyrrolopyrimidinedione derivatives
AU2002356533A1 (en) Methods using 1, 2-dithiol-3-thiones and their derivatives and metabolites for inhibiting angiogenesis
AU2001284149A1 (en) Aminoalkylbenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same
AU2001278694A1 (en) Avermectin derivatives
AU2002213978A1 (en) Substituted C-cyclohexylmethylamine derivatives
AU2003282804A1 (en) 3-(3,5-disubstituted-4-hydroxyphenyl)propionamide derivatives as cathepsin b inhibitors
AU2001226794A1 (en) Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives
AU2002212301A1 (en) Diazacycloalkanedione derivatives
AU2002212959A1 (en) Cycloalkylfluorosulfonamide derivatives
AU2001289937A1 (en) Substituted 1-aminobutan-3-ol derivatives
AU2001230565A1 (en) Perfluoroisopropylbenzene derivatives
AU2003269949A1 (en) Substituted 1,4-pyrazine derivatives
AU2001234313A1 (en) Novel phenylheteroalkylamine derivatives
AU2002233698A1 (en) Benzo(b)thiophene derivative and process for producing the same
AU2001280470A1 (en) Heterocyclic sulfonamide derivatives
AU2003252467A1 (en) Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives
AU2003258598A1 (en) Substituted 1,2,3,4-tetrahydroquinoline derivatives