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AU2002218019A1 - Methods for depleting and isolating alloreactive and antigen-reactive t cells from hematopoietic donor cells - Google Patents

Methods for depleting and isolating alloreactive and antigen-reactive t cells from hematopoietic donor cells

Info

Publication number
AU2002218019A1
AU2002218019A1 AU2002218019A AU1801902A AU2002218019A1 AU 2002218019 A1 AU2002218019 A1 AU 2002218019A1 AU 2002218019 A AU2002218019 A AU 2002218019A AU 1801902 A AU1801902 A AU 1801902A AU 2002218019 A1 AU2002218019 A1 AU 2002218019A1
Authority
AU
Australia
Prior art keywords
cells
alloreactive
depleting
antigen
isolating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218019A
Other languages
English (en)
Inventor
James G Bender
Mohammad Luqman
Dennis E Van Epps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexell Therapeutics Inc
Original Assignee
Nexell Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexell Therapeutics Inc filed Critical Nexell Therapeutics Inc
Publication of AU2002218019A1 publication Critical patent/AU2002218019A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2002218019A 2000-11-03 2001-10-31 Methods for depleting and isolating alloreactive and antigen-reactive t cells from hematopoietic donor cells Abandoned AU2002218019A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70633700A 2000-11-03 2000-11-03
US09/706,337 2000-11-03
PCT/US2001/046333 WO2002036748A2 (fr) 2000-11-03 2001-10-31 Procedes d'affaiblissement et d'isolement de lymphocytes t, alloreactifs et reactifs vis-a-vis d'antigenes, provenant de cellules donneuses hematopoietiques

Publications (1)

Publication Number Publication Date
AU2002218019A1 true AU2002218019A1 (en) 2002-05-15

Family

ID=24837124

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218019A Abandoned AU2002218019A1 (en) 2000-11-03 2001-10-31 Methods for depleting and isolating alloreactive and antigen-reactive t cells from hematopoietic donor cells

Country Status (2)

Country Link
AU (1) AU2002218019A1 (fr)
WO (1) WO2002036748A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035101A1 (fr) * 2001-10-24 2003-05-01 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Methode permettant de moduler l'activite immunitaire d'un greffon immunocompetent au moyen de la progenipoietine
US7332158B2 (en) 2002-05-29 2008-02-19 Demao Yang Compositions and treatments for myelosuppression by ex vivo activated immune cells
US7048922B2 (en) 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
US20070248584A1 (en) * 2003-06-10 2007-10-25 The University Of Melbourne Immunomodulating Compositions, Uses Therefore and Processes for Their Production
AU2008301240B2 (en) 2007-09-20 2014-07-31 St Vincent's Hospital Sydney Limited A method for identifying antigen-specific regulatory T cells
WO2016176193A1 (fr) * 2015-04-27 2016-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Méthode pour la déplétion sélective de lymphocytes t alloréactifs provenant de greffes de cellules souches ou de lymphocytes d'un donneur afin d'empêcher une réaction du greffon contre l'hôte
CN109666640B (zh) * 2019-01-14 2020-06-16 武汉睿健医药科技有限公司 自然杀伤细胞体外纯培养的方法
US20230079454A1 (en) * 2020-02-14 2023-03-16 The General Hospital Corporation Monitoring viability of organs for transplantation
WO2023006982A1 (fr) * 2021-07-29 2023-02-02 Transimmune Ag Procédés pour réduire sélectivement l'immunogénicité dans un transplant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003520563A (ja) * 1997-07-21 2003-07-08 シーラス コーポレイション 白血球を処置する方法、白血球組成物およびそれを使用する方法
AU756962B2 (en) * 1997-07-23 2003-01-30 Rijksuniversiteit Te Leiden The HA-1 antigen
EP2058389B1 (fr) * 1997-10-27 2016-05-18 Rockefeller University Milieu défini pour la maturation des cellules dendritiques comprenand TNF-alpha, IL-1beta, IL-6
WO1999024078A1 (fr) * 1997-11-12 1999-05-20 The Trustees Of The University Of Pennsylvania Prevention d'une immunoreactivite par depletion ou inhibition de cellules presentant l'antigene
JP2004510950A (ja) * 1998-06-30 2004-04-08 ザ　ロックフェラー　ユニバーシティ 免疫免除された抗原に対する細胞性免疫の検出および調整のための方法および薬剤
WO2001030369A1 (fr) * 1999-10-22 2001-05-03 Biotransplant, Inc. Procede d'induction d'une tolerance immunologique pour des greffons heterologues

Also Published As

Publication number Publication date
WO2002036748A3 (fr) 2003-10-02
WO2002036748A2 (fr) 2002-05-10

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