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AU2001255090A1 - Cdk inhibitors having 3-hydroxychromen-4-one structure - Google Patents

Cdk inhibitors having 3-hydroxychromen-4-one structure

Info

Publication number
AU2001255090A1
AU2001255090A1 AU2001255090A AU5509001A AU2001255090A1 AU 2001255090 A1 AU2001255090 A1 AU 2001255090A1 AU 2001255090 A AU2001255090 A AU 2001255090A AU 5509001 A AU5509001 A AU 5509001A AU 2001255090 A1 AU2001255090 A1 AU 2001255090A1
Authority
AU
Australia
Prior art keywords
hydroxychromen
cdk inhibitors
cdk
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001255090A
Inventor
Sei Hyun Choi
Hyun Ho Chung
Chang Yong Hong
Shin Wu Jeong
Dong Myung Kim
Eunice Eun Kyeong Kim
Jong Hyun Kim
Jin Ho Lee
Tae Sik Park
Seong Gu Ro
Ho Sun Son
Sook Kyung Yoon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Chem Investment Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000023705A external-priority patent/KR20010103188A/en
Priority claimed from KR10-2000-0054573A external-priority patent/KR100399364B1/en
Priority claimed from KR10-2000-0054577A external-priority patent/KR100392468B1/en
Application filed by LG Chem Investment Co Ltd filed Critical LG Chem Investment Co Ltd
Publication of AU2001255090A1 publication Critical patent/AU2001255090A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2001255090A 2000-05-03 2001-05-03 Cdk inhibitors having 3-hydroxychromen-4-one structure Abandoned AU2001255090A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR0023705 2000-05-03
KR1020000023705A KR20010103188A (en) 2000-05-03 2000-05-03 CDK inhibitors having 3-hydroxychromen-4-one structure
KR10-2000-0054573A KR100399364B1 (en) 2000-09-18 2000-09-18 3-Hydroxy-6-aminochromene-4-on derivatives useful as cyclin dependendent kinase inhibitors
KR0054577 2000-09-18
KR0054573 2000-09-18
KR10-2000-0054577A KR100392468B1 (en) 2000-09-18 2000-09-18 3-Hydroxychromene-4-on derivatives useful as cyclin dependendent kinase inhibitors
PCT/KR2001/000725 WO2001083469A1 (en) 2000-05-03 2001-05-03 Cdk inhibitors having 3-hydroxychromen-4-one structure

Publications (1)

Publication Number Publication Date
AU2001255090A1 true AU2001255090A1 (en) 2001-11-12

Family

ID=27350225

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001255090A Abandoned AU2001255090A1 (en) 2000-05-03 2001-05-03 Cdk inhibitors having 3-hydroxychromen-4-one structure

Country Status (7)

Country Link
US (1) US6683095B2 (en)
EP (1) EP1280789A1 (en)
JP (1) JP2003531899A (en)
CN (1) CN1433410A (en)
AU (1) AU2001255090A1 (en)
CA (1) CA2407796A1 (en)
WO (1) WO2001083469A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100399364B1 (en) * 2000-09-18 2003-09-26 주식회사 엘지생명과학 3-Hydroxy-6-aminochromene-4-on derivatives useful as cyclin dependendent kinase inhibitors
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
CN100381437C (en) * 2002-04-17 2008-04-16 赛特凯恩蒂克公司 Compounds, compositions and methods
AU2003245935A1 (en) * 2002-06-13 2003-12-31 Novuspharma S.P.A. Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells
US7884127B2 (en) 2002-07-08 2011-02-08 Pirimal Life Sciences Ltd. Inhibitors of cyclin dependent kinases and their use
US7915301B2 (en) 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
US7271193B2 (en) 2002-07-08 2007-09-18 Nicholas Piramal India, Ltd. Inhibitors of cyclin-dependent kinases and their use
TWI331034B (en) * 2002-07-08 2010-10-01 Piramal Life Sciences Ltd Inhibitors of cyclin-dependent kinases and their use
SE0400759D0 (en) * 2004-03-23 2004-03-23 Astrazeneca Ab Novel amination process
CA2658215C (en) * 2006-07-07 2013-08-27 Piramal Life Sciences Limited An enantioselective synthesis of pyrrolidines-substituted flavones
GB201017315D0 (en) 2010-10-13 2010-11-24 Antoxis Ltd Compound
EP2742033B1 (en) * 2011-08-11 2018-09-19 Armaron Bio Pty Ltd Flavonoid compounds, and methods of use thereof
TWI839690B (en) 2013-07-12 2024-04-21 印度商皮拉馬爾企業有限公司 Use of a pharmaceutical combination for the treatment of melanoma
WO2018073687A1 (en) 2016-10-20 2018-04-26 Pfizer Inc. Anti-proliferative agents for treating pah

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS632925A (en) * 1986-06-23 1988-01-07 Nippon Kayaku Co Ltd C-kinase inhibitor and anti-tumor agent
US5911995A (en) * 1994-08-19 1999-06-15 Regents Of The University Of Minnesota EGF-genistein conjugates for the treatment of cancer
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
KR20010071836A (en) 1998-09-01 2001-07-31 성재갑 Novel Cyclin Dependent Kinase inhibitors having flavone structure

Also Published As

Publication number Publication date
CN1433410A (en) 2003-07-30
CA2407796A1 (en) 2001-11-08
EP1280789A1 (en) 2003-02-05
JP2003531899A (en) 2003-10-28
US20030125356A1 (en) 2003-07-03
WO2001083469A1 (en) 2001-11-08
US6683095B2 (en) 2004-01-27

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