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AU2001292739A1 - 1-oxorapamycins - Google Patents

1-oxorapamycins

Info

Publication number
AU2001292739A1
AU2001292739A1 AU2001292739A AU9273901A AU2001292739A1 AU 2001292739 A1 AU2001292739 A1 AU 2001292739A1 AU 2001292739 A AU2001292739 A AU 2001292739A AU 9273901 A AU9273901 A AU 9273901A AU 2001292739 A1 AU2001292739 A1 AU 2001292739A1
Authority
AU
Australia
Prior art keywords
oxorapamycins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001292739A
Inventor
Tianmin Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Publication of AU2001292739A1 publication Critical patent/AU2001292739A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2001292739A 2000-09-27 2001-09-19 1-oxorapamycins Abandoned AU2001292739A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23575000P 2000-09-27 2000-09-27
US60/235,750 2000-09-27
PCT/US2001/029139 WO2002026746A2 (en) 2000-09-27 2001-09-19 1-oxorapamycins

Publications (1)

Publication Number Publication Date
AU2001292739A1 true AU2001292739A1 (en) 2002-04-08

Family

ID=22886760

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001292739A Abandoned AU2001292739A1 (en) 2000-09-27 2001-09-19 1-oxorapamycins

Country Status (3)

Country Link
US (1) US6399625B1 (en)
AU (1) AU2001292739A1 (en)
WO (1) WO2002026746A2 (en)

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ES2349458T3 (en) 2000-01-14 2011-01-03 The Trustees Of The University Of Pennsylvania O-METHYLATE DERIVATIVES OF RAPAMYCIN TO RELIEF AND INHIBIT DISORDERS.
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AU2003243226A1 (en) * 2002-05-15 2003-12-02 Endocyte, Inc. Vitamin-mitomycin conjugates
US20040167165A1 (en) * 2003-01-16 2004-08-26 Geetha Shankar Methods of treating conditions associated with an Edg-7 receptor
WO2004069159A2 (en) 2003-01-27 2004-08-19 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
AR042938A1 (en) * 2003-02-06 2005-07-06 Wyeth Corp USE OF CCI-779 IN THE TREATMENT OF HEPATIC FIBROSIS
BRPI0412659A (en) 2003-07-16 2006-09-26 Wyeth Corp cci-779 isomer c, its preparation process, pharmaceutical composition comprising the same and pharmaceutical package containing said compound
RU2345772C2 (en) * 2003-07-25 2009-02-10 Уайт Lyophilised compositions cci-779
US8288557B2 (en) * 2004-07-23 2012-10-16 Endocyte, Inc. Bivalent linkers and conjugates thereof
US8313763B2 (en) 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
US20060210604A1 (en) * 2004-10-04 2006-09-21 Eric Dadey Ocular delivery of polymeric delivery formulations
WO2006096325A1 (en) * 2005-03-07 2006-09-14 Wyeth Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin
JP5289935B2 (en) * 2005-03-16 2013-09-11 エンドサイト，インコーポレイテッド Synthesis and purification of pteroic acid and its conjugates
US20100087474A1 (en) * 2005-04-27 2010-04-08 University Of Florida Materials and methods for enhanced degradation of mutant proteins associated with human disease
JP2009504783A (en) * 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド Ligand conjugates of vinca alkaloids, analogues and derivatives
EP2374480A3 (en) * 2005-08-19 2013-05-01 Endocyte, Inc. Mutli-drug ligand conjugates
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
NZ599239A (en) * 2007-03-14 2013-10-25 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins
EP2176293B1 (en) * 2007-06-25 2019-04-03 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
AU2008316835B2 (en) 2007-10-25 2015-07-16 Endocyte, Inc. Tubulysins and processes for preparing
CA2743491C (en) 2008-11-11 2016-10-11 Zelton Dave Sharp Inhibition of mammalian target of rapamycin
US20170079962A1 (en) 2009-11-11 2017-03-23 Rapamycin Holdings, Llc Oral Rapamycin Preparation and Use for Stomatitus
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
WO2013013708A1 (en) 2011-07-26 2013-01-31 Fundació Institut D'investigació Biomèdica De Bellvitge Treatment of acute rejection in renal transplant
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
US9750728B2 (en) 2012-09-29 2017-09-05 Targeted Therapeutics, Llc Method and pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
CN103705925B (en) 2012-09-29 2018-03-30 段磊 Pharmaceutical composition for inhibiting PI3K/AKT/mTOR signaling pathway
CA2926747A1 (en) 2012-10-12 2014-04-17 Arlan RICHARDSON Use of mtor inhibitors to treat vascular cognitive impairment
IN2015DN04147A (en) 2012-10-16 2015-10-16 Endocyte Inc
DK2968281T3 (en) 2013-03-13 2020-11-02 Univ Texas MTOR INHIBITORS FOR PREVENTING THE GROWTH OF THE INTESTINAL POLYPH
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
DK3089737T3 (en) 2013-12-31 2021-12-13 Rapamycin Holdings Llc ORAL RAPAMYCIN NANOPARTICLE PREPARATIONS AND USE.
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
EP3848065B1 (en) 2017-05-15 2023-07-26 C. R. Bard, Inc. Medical device with drug-eluting coating and intermediate layer
WO2020101675A1 (en) 2018-11-14 2020-05-22 Lutonix, Inc. Medical device with drug-eluting coating on modified device surface
CN113939324A (en) 2019-04-08 2022-01-14 巴德外周血管股份有限公司 Medical devices having drug eluting coatings on modified device surfaces

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US4885171A (en) 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
US5206018A (en) 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
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US4650803A (en) 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
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US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
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US5321009A (en) 1991-04-03 1994-06-14 American Home Products Corporation Method of treating diabetes
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
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US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
ATE135583T1 (en) 1991-06-18 1996-04-15 American Home Prod USE OF RAPAMYCIN TO TREAT T-CELL LYMPHOMA/LEUKEMIA IN ADULTS
IL102414A (en) 1991-07-25 1996-08-04 Univ Louisville Res Found Pharmaceutical compositions for treating ocular inflammation comprising rapamycin
US5162333A (en) 1991-09-11 1992-11-10 American Home Products Corporation Aminodiesters of rapamycin
US5286731A (en) 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory bowel disease
US5286730A (en) 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory disease
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US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
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US5385910A (en) 1993-11-22 1995-01-31 American Home Products Corporation Gem-distributed esters of rapamycin
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Also Published As

Publication number Publication date
US6399625B1 (en) 2002-06-04
WO2002026746A3 (en) 2002-08-15
WO2002026746A2 (en) 2002-04-04
US20020061903A1 (en) 2002-05-23

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