AU2001273545A1 - Sildenafil citrate solid dispersions having high water solubility - Google Patents

Sildenafil citrate solid dispersions having high water solubility

Info

Publication number: AU2001273545A1
Authority: AU; Australia
Prior art keywords: dosage form; sildenafil citrate; water soluble; xylitol; soluble sugar
Prior art date: 2000-07-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001273545A

Other languages

English (en)

Inventor

Li-Lan Chen

Li Tao

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lavipharm Laboratories Inc

Original Assignee

Lavipharm Laboratories Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-19

Filing date

2001-07-18

Publication date

2002-01-30

2001-07-18 Application filed by Lavipharm Laboratories Inc filed Critical Lavipharm Laboratories Inc

2002-01-30 Publication of AU2001273545A1 publication Critical patent/AU2001273545A1/en

Status Abandoned legal-status Critical Current

Links

DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 title claims description 204
229960002639 sildenafil citrate Drugs 0.000 title claims description 188
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 140
239000007962 solid dispersion Substances 0.000 title claims description 93
239000002552 dosage form Substances 0.000 claims description 165
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 90
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 90
239000000811 xylitol Substances 0.000 claims description 90
235000010447 xylitol Nutrition 0.000 claims description 90
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 90
229960002675 xylitol Drugs 0.000 claims description 90
235000000346 sugar Nutrition 0.000 claims description 85
238000000034 method Methods 0.000 claims description 44
239000000203 mixture Substances 0.000 claims description 44
230000003232 mucoadhesive effect Effects 0.000 claims description 39
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 22
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 22
229930195725 Mannitol Natural products 0.000 claims description 22
239000000594 mannitol Substances 0.000 claims description 22
235000010355 mannitol Nutrition 0.000 claims description 22
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 21
235000010356 sorbitol Nutrition 0.000 claims description 21
239000000600 sorbitol Substances 0.000 claims description 21
239000007787 solid Substances 0.000 claims description 20
239000003826 tablet Substances 0.000 claims description 20
239000007788 liquid Substances 0.000 claims description 19
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 6
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
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GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
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BNRNXUUZRGQAQC-UHFFFAOYSA-N Sildenafil Natural products CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 40
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 21
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238000004090 dissolution Methods 0.000 description 12
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KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
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235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
239000000770 propane-1,2-diol alginate Substances 0.000 description 1
150000004672 propanoic acids Chemical class 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
235000019423 pullulan Nutrition 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
239000002994 raw material Substances 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
239000000523 sample Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000036332 sexual response Effects 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
229960001462 sodium cyclamate Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
229940001941 soy protein Drugs 0.000 description 1
235000013599 spices Nutrition 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000003892 spreading Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
239000008107 starch Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
235000019408 sucralose Nutrition 0.000 description 1
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
235000010491 tara gum Nutrition 0.000 description 1
239000000213 tara gum Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000006068 taste-masking agent Substances 0.000 description 1
238000005979 thermal decomposition reaction Methods 0.000 description 1
235000019303 thiodipropionic acid Nutrition 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
239000001917 trigonella foenum graecum l. absolute Substances 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
206010046947 vaginismus Diseases 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
235000021119 whey protein Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Zoology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AU2001273545A 2000-07-19 2001-07-18 Sildenafil citrate solid dispersions having high water solubility Abandoned AU2001273545A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US61989900A	2000-07-19	2000-07-19
US09619899		2000-07-19
PCT/US2001/022538 WO2002005820A1 (fr)	2000-07-19	2001-07-18	Dispersions solides de citrate de sildenafil ayant une forte solubilite dans l'eau

Publications (1)

Publication Number	Publication Date
AU2001273545A1 true AU2001273545A1 (en)	2002-01-30

Family

ID=24483782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001273545A Abandoned AU2001273545A1 (en)	2000-07-19	2001-07-18	Sildenafil citrate solid dispersions having high water solubility

Country Status (4)

Country	Link
EP (1)	EP1301186A1 (fr)
AU (1)	AU2001273545A1 (fr)
CA (1)	CA2417736A1 (fr)
WO (1)	WO2002005820A1 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030077229A1 (en) *	1997-10-01	2003-04-24	Dugger Harry A.	Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs
US8765167B2 (en)	2001-10-12	2014-07-01	Monosol Rx, Llc	Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900497B2 (en)	2001-10-12	2014-12-02	Monosol Rx, Llc	Process for making a film having a substantially uniform distribution of components
US20110033542A1 (en)	2009-08-07	2011-02-10	Monosol Rx, Llc	Sublingual and buccal film compositions
US8603514B2 (en)	2002-04-11	2013-12-10	Monosol Rx, Llc	Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20190328679A1 (en)	2001-10-12	2019-10-31	Aquestive Therapeutics, Inc.	Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7357891B2 (en)	2001-10-12	2008-04-15	Monosol Rx, Llc	Process for making an ingestible film
US20070281003A1 (en)	2001-10-12	2007-12-06	Fuisz Richard C	Polymer-Based Films and Drug Delivery Systems Made Therefrom
US20160175199A1 (en) *	2002-04-11	2016-06-23	Monosol Rx, Llc	Film and Drug Delivery System Made Therefrom
US8900498B2 (en)	2001-10-12	2014-12-02	Monosol Rx, Llc	Process for manufacturing a resulting multi-layer pharmaceutical film
US11207805B2 (en)	2001-10-12	2021-12-28	Aquestive Therapeutics, Inc.	Process for manufacturing a resulting pharmaceutical film
US10285910B2 (en)	2001-10-12	2019-05-14	Aquestive Therapeutics, Inc.	Sublingual and buccal film compositions
DE10232113A1 (de)	2002-07-16	2004-01-29	Bayer Ag	Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
SE0202365D0 (sv) *	2002-08-05	2002-08-05	Pharmacia Ab	New formulation and use thereof
US20050042177A1 (en) *	2003-07-23	2005-02-24	Elan Pharma International Ltd.	Novel compositions of sildenafil free base
US20060035905A1 (en) *	2004-02-06	2006-02-16	Becton, Dickinson And Company	Formulations of phosphodiesterase 5 inhibitors and methods of use
EP1753432A1 (fr) *	2004-05-14	2007-02-21	Solvay Pharmaceuticals GmbH	Medicaments renfermant des inhibiteurs a action double de l'endopeptidase neutre et de l'endopeptidase humaine soluble et destines au traitement de la dysfonction sexuelle
PL1804772T3 (pl) *	2004-08-12	2012-03-30	Reckitt Benckiser Healthcare	Granulki zawierające niesteroidowy lek przeciwzapalny i alkohol cukrowy wytwarzane przez wytłaczanie ze stopu
EP1784167A2 (fr) *	2004-08-27	2007-05-16	Spherics, Inc.	Comprimes multicouche et formes posologiques bioadhesives
ES2704482T3 (es)	2004-11-24	2019-03-18	Meda Pharmaceuticals Inc	Composiciones que comprenden azelastina y sus métodos de uso
US20070020330A1 (en)	2004-11-24	2007-01-25	Medpointe Healthcare Inc.	Compositions comprising azelastine and methods of use thereof
BG66010B1 (bg) *	2004-12-08	2010-10-29	"Софарма" Ад	Лекарствена форма на силденафил
WO2006131806A2 (fr) *	2005-06-07	2006-12-14	Pfizer Products Inc.	Formes multiparticulaires comprenant des medicaments a faible solubilite et supports qui entrainent une liberation rapide de medicament
EP1937217A2 (fr) *	2005-09-13	2008-07-02	Elan Pharma International Limited	Formulations nanoparticulaires de tadalafil
CN102582106B (zh) *	2006-05-23	2015-12-16	奥拉黑尔斯公司	具有阿拉伯树胶粘合剂的双层口用粘附性片剂
EP3254676B1 (fr) *	2009-10-30	2018-11-28	IX Biopharma Ltd	Forme de dosage solide à dissolution rapide
US12186426B2 (en)	2009-10-30	2025-01-07	Ix Biopharma Ltd.	Solid dosage form
DE102010024866A1 (de) *	2010-06-24	2011-12-29	Pharmatech Gmbh	Formulierung zur Geschmacksmaskierung
US9149959B2 (en)	2010-10-22	2015-10-06	Monosol Rx, Llc	Manufacturing of small film strips
AU2012241189A1 (en) *	2010-10-26	2014-04-24	Ix Biopharma Pte Ltd	Fast Dissolving Solid Dosage Form
GB2497728A (en)	2011-12-14	2013-06-26	Londonpharma Ltd	Statin formulations for transmucosal delivery
GB2497933B (en) *	2011-12-21	2014-12-24	Londonpharma Ltd	Drug delivery technology
IN2014MN01706A (fr) *	2012-02-28	2015-05-29	Seoul Pharma Co Ltd
EP2649989B1 (fr) *	2012-04-13	2017-10-18	King Saud University	Procédé de préparation d'une dispersion solide, dispersion solide ainsi obtenue et son utilisation
US20150320677A1 (en) *	2012-08-17	2015-11-12	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Effervescent tablet formulations of dapoxetine and a pde5 inhibitor
US20150231092A1 (en) *	2012-08-17	2015-08-20	Sanovell IIac Sanayi Ve Ticaret Anonim Sirketi	Novel effervescent sachet formulations of dapoxetine and a pde5 inhibitor
CA2886573C (fr) *	2012-10-11	2019-04-02	Stephen Lim Chin Beng	Forme de dosage solide
US9370518B2 (en) *	2013-11-08	2016-06-21	Insys Development Company, Inc.	Sildenafil sublingual spray formulation
FR3013221B1 (fr) *	2013-11-19	2020-11-27	Nabil Said	Composition pharmaceutique effervescente a base de sildenafil et son procede de fabrication
NO2723977T3 (fr)	2014-03-19	2018-03-10
GB201411802D0 (en) *	2014-07-02	2014-08-13	Univ Bradford	Effervescent compositions
CN105435232A (zh) *	2014-08-08	2016-03-30	深圳君圣泰生物技术有限公司	一种液体制剂组合物及其制备方法、用途和制剂
AU2015316552C1 (en)	2014-09-17	2018-08-23	Steerlife India Private Limited	Effervescent composition and method of making it
DK3277283T3 (da)	2015-04-03	2021-04-12	Benuvia Therapeutics Llc	Sublinguale sildenafilsprayformuerlinger
US10111833B2 (en)	2015-04-03	2018-10-30	Insys Development Company, Inc.	Sildenafil sublingual spray formulations
WO2017098481A1 (fr)	2015-12-12	2017-06-15	Steerlife India Private Limited	Compositions effervescentes de metformine et leurs procédés de préparation
EP3452023A1 (fr)	2016-05-05	2019-03-13	Aquestive Therapeutics, Inc.	Compositions d'épinéphrine à administration améliorée
US11273131B2 (en)	2016-05-05	2022-03-15	Aquestive Therapeutics, Inc.	Pharmaceutical compositions with enhanced permeation
US12427121B2 (en)	2016-05-05	2025-09-30	Aquestive Therapeutics, Inc.	Enhanced delivery epinephrine compositions
US12433850B2 (en)	2016-05-05	2025-10-07	Aquestive Therapeutics, Inc.	Enhanced delivery epinephrine and prodrug compositions
FR3052641B1 (fr) *	2016-06-20	2018-06-22	Eurotab	Utilisation de xylitol pour ameliorer la dissolution d'une tablette pour boisson froide
CN108125916B (zh) *	2016-12-01	2021-11-30	江苏天士力帝益药业有限公司	一种西地那非滴丸
CA3046725A1 (fr)	2017-01-11	2018-07-19	Ferring B.V.	Composition pharmaceutique a disintegration rapide
IT201800003507A1 (it) *	2018-03-13	2019-09-13	Fulton Medicinali S P A	Compressa sublinguale comprendente sildenafil citrato
US11179331B1 (en)	2020-04-21	2021-11-23	Cure Pharmaceutcai Holding Corp	Oral soluble film containing sildenafil citrate
US12465564B2 (en)	2021-10-25	2025-11-11	Aquestive Therapeutics, Inc.	Oral and nasal compositions and methods of treatment
PL247528B1 (pl) *	2023-04-08	2025-07-21	Sativa Med Spolka Akcyjna	Płynna kompozycja inhibitorów fosfodiesterazy typu 5 (PDE-5), sposób jej wytwarzania oraz jej zastosowanie do leczenia zaburzeń erekcji

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10298062A (ja) *	1997-04-24	1998-11-10	Pfizer Pharmaceut Co Ltd	口腔内速溶型錠剤
KR20010012995A (ko) *	1997-05-29	2001-02-26	모치다 에이	발기부전 치료제

2001
- 2001-07-18 EP EP01952829A patent/EP1301186A1/fr not_active Withdrawn
- 2001-07-18 WO PCT/US2001/022538 patent/WO2002005820A1/fr not_active Ceased
- 2001-07-18 CA CA002417736A patent/CA2417736A1/fr not_active Abandoned
- 2001-07-18 AU AU2001273545A patent/AU2001273545A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2417736A1 (fr)	2002-01-24
WO2002005820A1 (fr)	2002-01-24
EP1301186A1 (fr)	2003-04-16

Publication	Publication Date	Title
AU2001273545A1 (en)	2002-01-30	Sildenafil citrate solid dispersions having high water solubility
TWI594754B (zh)	2017-08-11	口服皮質類固醇組合物
US6552024B1 (en)	2003-04-22	Compositions and methods for mucosal delivery
US8735374B2 (en)	2014-05-27	Oral mucoadhesive dosage form
EP2717852B1 (fr)	2019-05-08	Formes posologiques comestibles à la forme d'une bande de feuille ou d'une tranche contenant les résines échangeuses d'ions pour masquer le goût
US20090047330A1 (en)	2009-02-19	Oral fast dissolving films for erectile dysfunction bioactive agents
US20110250274A1 (en)	2011-10-13	Estriol formulations
EP2560612B1 (fr)	2014-09-03	Procédé de préparation de compositions pharmaceutiques destinées à une administration orale, comprenant un ou plusieurs principes actifs, et compositions les comprenant
PT1998762E (pt)	2010-11-30	Forma farmacêutica sólida contendo um agente activo de sabor mascarado
JP5420535B2 (ja)	2014-02-19	速崩性錠剤製造のための医薬製剤
JP2004535361A (ja)	2004-11-25	生体接着性の徐放性送達独立気泡発泡体フィルム
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