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AU2001272666A1 - 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission - Google Patents

2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission

Info

Publication number
AU2001272666A1
AU2001272666A1 AU2001272666A AU7266601A AU2001272666A1 AU 2001272666 A1 AU2001272666 A1 AU 2001272666A1 AU 2001272666 A AU2001272666 A AU 2001272666A AU 7266601 A AU7266601 A AU 7266601A AU 2001272666 A1 AU2001272666 A1 AU 2001272666A1
Authority
AU
Australia
Prior art keywords
abnormalities
generally associated
conditions generally
adamantylethylamines
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001272666A
Other languages
English (en)
Inventor
Claire Elizabeth Dawson
Suneel Gaur
Roger John Gillespie
Steven Michael Mcateer
Michael Frederick Snape
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand UK Research Ltd
Original Assignee
Vernalis Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Research Ltd filed Critical Vernalis Research Ltd
Publication of AU2001272666A1 publication Critical patent/AU2001272666A1/en
Abandoned legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

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  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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AU2001272666A 2000-07-25 2001-07-25 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Abandoned AU2001272666A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0018272 2000-07-25
GBGB0018272.5A GB0018272D0 (en) 2000-07-25 2000-07-25 Chemical compounds IV
PCT/GB2001/003321 WO2002008219A2 (fr) 2000-07-25 2001-07-25 Nouvelles 2-adamantylethylamines et leur utilisation dans le traitement d'etats generalement associes a des anomalies de la transmission glutamatergique

Publications (1)

Publication Number Publication Date
AU2001272666A1 true AU2001272666A1 (en) 2002-02-05

Family

ID=9896338

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001272666A Abandoned AU2001272666A1 (en) 2000-07-25 2001-07-25 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission

Country Status (10)

Country Link
US (1) US6828318B2 (fr)
EP (1) EP1305306B1 (fr)
JP (1) JP2004504395A (fr)
AT (1) ATE283268T1 (fr)
AU (1) AU2001272666A1 (fr)
CA (1) CA2415585A1 (fr)
DE (1) DE60107435T2 (fr)
ES (1) ES2233664T3 (fr)
GB (1) GB0018272D0 (fr)
WO (1) WO2002008219A2 (fr)

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BR112015018087B1 (pt) 2013-01-29 2022-09-20 Aptinyx Inc Compostos moduladores de receptor n-metil-d-aspartato (nmda) de espiro-lactama, composição farmacêutica e uso dos mesmos
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CN109415372B (zh) 2016-05-19 2021-01-15 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
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JP2019527235A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
CA3031539C (fr) 2016-08-01 2023-11-28 Aptinyx Inc. Modulateurs spirolactames des recepteurs nmda et leurs utilisations
ES2972533T3 (es) 2016-08-01 2024-06-13 Tenacia Biotechnology Hong Kong Co Ltd Moduladores del receptor de NMDA a base de espirolactama, y sus usos
CN109937204B (zh) 2016-08-01 2022-11-25 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
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WO1997023202A1 (fr) * 1995-12-22 1997-07-03 STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON Ligands du recepteur n-methyl-d-aspartate selectifs de sous-type
ATE275552T1 (de) 1997-12-16 2004-09-15 Warner Lambert Co 1-substituierte-1-aminomethyl-cycloalkan derivate (= gabapentin analoga), deren herstellung und deren verwendung bei der behandlung von neurologischen erkrankungen
GB9802225D0 (en) 1998-02-02 1998-04-01 Cerebrus Ltd Chemical compounds
GB9901691D0 (en) 1999-01-26 1999-03-17 Cerebrus Ltd Chemical compounds

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ATE283268T1 (de) 2004-12-15
US6828318B2 (en) 2004-12-07
JP2004504395A (ja) 2004-02-12
DE60107435T2 (de) 2005-12-15
EP1305306B1 (fr) 2004-11-24
WO2002008219A3 (fr) 2002-06-13
WO2002008219A2 (fr) 2002-01-31
GB0018272D0 (en) 2000-09-13
US20030207881A1 (en) 2003-11-06
EP1305306A2 (fr) 2003-05-02

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