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AU2001272666A1 - 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission - Google Patents

2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission

Info

Publication number
AU2001272666A1
AU2001272666A1 AU2001272666A AU7266601A AU2001272666A1 AU 2001272666 A1 AU2001272666 A1 AU 2001272666A1 AU 2001272666 A AU2001272666 A AU 2001272666A AU 7266601 A AU7266601 A AU 7266601A AU 2001272666 A1 AU2001272666 A1 AU 2001272666A1
Authority
AU
Australia
Prior art keywords
abnormalities
generally associated
conditions generally
adamantylethylamines
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001272666A
Inventor
Claire Elizabeth Dawson
Suneel Gaur
Roger John Gillespie
Steven Michael Mcateer
Michael Frederick Snape
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ligand UK Research Ltd
Original Assignee
Vernalis Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Research Ltd filed Critical Vernalis Research Ltd
Publication of AU2001272666A1 publication Critical patent/AU2001272666A1/en
Abandoned legal-status Critical Current

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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Compounds of formula (1):whereinR1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, aryl and non-aromatic heterocyclic groups, or each of one or more pair(s) of the substituent groups R1 to R6 may together form a 3,4,5,6,7 or 8-membered ring containing 0,1 or 2 heteroatom(s);R7 is selected from alkyl, aryl and non-aromatic heterocyclic groups; andR8 is selected from hydrogen, halogen, alkyl, aryl and non-aromatic heterocyclic groups;and pharmaceutically acceptable salts and prodrugs thereof, are useful for treating conditions generally associated with abnormalities in glutamatergic transmission.
AU2001272666A 2000-07-25 2001-07-25 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Abandoned AU2001272666A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0018272 2000-07-25
GBGB0018272.5A GB0018272D0 (en) 2000-07-25 2000-07-25 Chemical compounds IV
PCT/GB2001/003321 WO2002008219A2 (en) 2000-07-25 2001-07-25 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission

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AU2001272666A1 true AU2001272666A1 (en) 2002-02-05

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US (1) US6828318B2 (en)
EP (1) EP1305306B1 (en)
JP (1) JP2004504395A (en)
AT (1) ATE283268T1 (en)
AU (1) AU2001272666A1 (en)
CA (1) CA2415585A1 (en)
DE (1) DE60107435T2 (en)
ES (1) ES2233664T3 (en)
GB (1) GB0018272D0 (en)
WO (1) WO2002008219A2 (en)

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JP2019527235A (en) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
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