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AU2001249144A1 - Novel cyclopentene derivatives useful as antagonists of the motilin receptor - Google Patents

Novel cyclopentene derivatives useful as antagonists of the motilin receptor

Info

Publication number
AU2001249144A1
AU2001249144A1 AU2001249144A AU4914401A AU2001249144A1 AU 2001249144 A1 AU2001249144 A1 AU 2001249144A1 AU 2001249144 A AU2001249144 A AU 2001249144A AU 4914401 A AU4914401 A AU 4914401A AU 2001249144 A1 AU2001249144 A1 AU 2001249144A1
Authority
AU
Australia
Prior art keywords
antagonists
derivatives useful
motilin receptor
cyclopentene derivatives
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001249144A
Inventor
Robert H. Chen
Min A. Xiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of AU2001249144A1 publication Critical patent/AU2001249144A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001249144A 2000-03-13 2001-03-09 Novel cyclopentene derivatives useful as antagonists of the motilin receptor Abandoned AU2001249144A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18891700P 2000-03-13 2000-03-13
US60188917 2000-03-13
PCT/US2001/007703 WO2001068620A1 (en) 2000-03-13 2001-03-09 Novel cyclopentene derivatives useful as antagonists of the motilin receptor

Publications (1)

Publication Number Publication Date
AU2001249144A1 true AU2001249144A1 (en) 2001-09-24

Family

ID=22695088

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001249144A Abandoned AU2001249144A1 (en) 2000-03-13 2001-03-09 Novel cyclopentene derivatives useful as antagonists of the motilin receptor

Country Status (4)

Country Link
US (2) US6392040B2 (en)
AR (1) AR029895A1 (en)
AU (1) AU2001249144A1 (en)
WO (1) WO2001068620A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
GB0611907D0 (en) 2006-06-15 2006-07-26 Glaxo Group Ltd Compounds
JP2009501199A (en) 2005-07-12 2009-01-15 グラクソ グループ リミテッド Piperazine heteroaryl derivatives as GPR38 agonists
HRP20120833T1 (en) * 2005-07-26 2012-11-30 Glaxo Group Limited BENZYLPIPERAZINE DERIVATIVES USED IN THE TREATMENT OF GASTROINTESTINAL DISORDERS
JP5028484B2 (en) * 2006-06-28 2012-09-19 グラクソ グループ リミテッド Piperazinyl derivatives useful for the treatment of GPR38 receptor mediated diseases
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
US8697877B2 (en) 2009-02-27 2014-04-15 Raqualia Pharma Inc. Oxyindole derivatives with motilin receptor agonistic activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636628B1 (en) * 1988-08-25 1990-12-28 Sanofi Sa THIADIAZOLE-1,3,4 DERIVATIVES, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
ATE201866T1 (en) * 1994-08-15 2001-06-15 Merck Sharp & Dohme MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS
US5972939A (en) * 1997-10-28 1999-10-26 Ortho-Mcneil Pharmaceutical, Inc. Cyclopentene derivatives useful as antagonists of the motilin receptor

Also Published As

Publication number Publication date
US6624165B2 (en) 2003-09-23
US20010041701A1 (en) 2001-11-15
US6392040B2 (en) 2002-05-21
US20020111484A1 (en) 2002-08-15
WO2001068620A1 (en) 2001-09-20
AR029895A1 (en) 2003-07-23

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