[go: up one dir, main page]

AU2001244713A1 - Transporters and drug delivery system by using the same - Google Patents

Transporters and drug delivery system by using the same

Info

Publication number
AU2001244713A1
AU2001244713A1 AU2001244713A AU4471301A AU2001244713A1 AU 2001244713 A1 AU2001244713 A1 AU 2001244713A1 AU 2001244713 A AU2001244713 A AU 2001244713A AU 4471301 A AU4471301 A AU 4471301A AU 2001244713 A1 AU2001244713 A1 AU 2001244713A1
Authority
AU
Australia
Prior art keywords
transporters
same
delivery system
drug delivery
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001244713A
Inventor
Mitsuaki Kuwano
Masaki Nakagawa
Hiroshi Suhara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of AU2001244713A1 publication Critical patent/AU2001244713A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544Phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Anesthesiology (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001244713A 2000-04-03 2001-04-03 Transporters and drug delivery system by using the same Abandoned AU2001244713A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000101113 2000-04-03
JP2001-56912 2001-03-01
JP2001056912 2001-03-01
JP2000-101113 2001-03-01
PCT/JP2001/002882 WO2001074400A1 (en) 2000-04-03 2001-04-03 Transporters and drug delivery system by using the same

Publications (1)

Publication Number Publication Date
AU2001244713A1 true AU2001244713A1 (en) 2001-10-15

Family

ID=26589355

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001244713A Abandoned AU2001244713A1 (en) 2000-04-03 2001-04-03 Transporters and drug delivery system by using the same

Country Status (7)

Country Link
US (1) US7455855B2 (en)
EP (1) EP1279406A4 (en)
KR (1) KR100777195B1 (en)
CN (1) CN100479862C (en)
AU (1) AU2001244713A1 (en)
CA (1) CA2404737C (en)
WO (1) WO2001074400A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100777195B1 (en) 2000-04-03 2007-11-19 산텐 세이야꾸 가부시키가이샤 Delivery material and drug delivery system using the same
US20040254197A1 (en) * 2001-09-28 2004-12-16 Santen Pharmaceutical Co., Ltd. Injections for eye tissues containing drug bonded to polyethlene glycol
US7279150B2 (en) * 2002-01-24 2007-10-09 Barnes-Jewish Hospital Chelating agents with lipophilic carriers
EP1498420B1 (en) 2002-03-29 2017-02-01 Nof Corporation Phospholipid derivative
JP4808403B2 (en) * 2002-09-30 2011-11-02 日油株式会社 Phospholipid derivative
JP4403303B2 (en) 2003-01-06 2010-01-27 日油株式会社 Phospholipid derivative and method for producing the same
JP4526479B2 (en) 2003-03-20 2010-08-18 日油株式会社 Phospholipid derivative
CA2705785A1 (en) * 2006-11-14 2008-05-22 Saul Yedgar Use of lipid conjugates in the treatment of diseases or disorders of the eye
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
WO2009140246A2 (en) 2008-05-12 2009-11-19 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
EP2370110B1 (en) 2008-12-25 2017-08-02 Canon Kabushiki Kaisha Labeling composition for intraocular tissue, labeling method of intraocular tissue, and screening method
EP2600900A4 (en) 2010-08-06 2014-11-19 Univ Illinois MULTIPLEXED SUPRAMOLECULAR ASSEMBLIES FOR NON-VIRAL ADMINISTRATION OF GENETIC MATERIAL
EP3340982B1 (en) 2015-08-26 2021-12-15 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (en) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc ARYL, HETEROARYL AND HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR THE DEGRADATION OF TARGET PROTEINS
JP7057290B2 (en) 2016-06-27 2022-04-19 アキリオン ファーマシューティカルズ,インコーポレーテッド Quinazoline and indole compounds for the treatment of medical disorders
WO2018160889A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceuticals, Inc. Aryl, heteroary, and heterocyclic pharmaceutical compounds for treatment of medical disorders
WO2018237026A1 (en) 2017-06-20 2018-12-27 C4 Therapeutics, Inc. N / O-LINKED DEGRONS AND DEGRONIMERS FOR DEGRADATION OF PROTEINS
KR20210018199A (en) 2018-03-26 2021-02-17 씨4 테라퓨틱스, 인코포레이티드 Cerevlon binder for decomposition of Ikaros
US20230022157A1 (en) 2018-08-20 2023-01-26 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
WO2020081723A1 (en) 2018-10-16 2020-04-23 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
MA55628A (en) 2019-04-12 2022-02-16 C4 Therapeutics Inc TRICYCLIC DEGRADING AGENTS OF IKAROS AND AIOLOS
JP2023515073A (en) 2020-02-20 2023-04-12 アキリオン ファーマシューティカルズ, インコーポレーテッド Heteroaryl compounds for the treatment of complement factor D-mediated disorders
KR20220166797A (en) 2020-03-05 2022-12-19 씨4 테라퓨틱스, 인코포레이티드 Compounds for targeted degradation of BRD9
CA3193488A1 (en) 2020-09-23 2022-03-31 Jason Allan Wiles Pharmaceutical compounds for the treatment of complement mediated disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4804539A (en) * 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US5411947A (en) * 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
FR2660193B1 (en) * 1990-04-03 1994-11-04 Philippe Maincent OPTHALMIC PRODUCT COMPRISING NANOCAPSULES, PROCESS FOR THE PREPARATION AND USE OF NANOCAPSULES.
DE4120760A1 (en) 1991-06-24 1993-03-04 3 M Medica Gmbh CARRIER SYSTEMS FOR MEDICINAL PRODUCTS
WO1993024476A1 (en) 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
CA2137297C (en) * 1993-12-06 2000-04-18 Tsuyoshi Miyazaki Reactive vesicle and functional substance-fixed vesicle
EP0754046A1 (en) * 1994-04-04 1997-01-22 FREEMAN, William R. Use of phosphonylmethoxyalkyl nucleosides for the treatment of raised intraocular pressure
JP3525516B2 (en) 1994-10-27 2004-05-10 日本油脂株式会社 Reactive endoplasmic reticulum, endoplasmic reticulum modifier, and production method
NZ318472A (en) * 1995-09-21 1999-10-28 Quadrant Healthcare Uk Ltd Composition or conjugate containing a gp60 receptor and a transcytosis enhancer (typically albumin)
US5641750A (en) 1995-11-29 1997-06-24 Amgen Inc. Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
EP1920773B1 (en) * 1996-11-05 2011-01-05 The Children's Medical Center Corporation Thalidomide and dexamethasone for the treatment of tumors
US6258351B1 (en) * 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DK1053012T3 (en) 1998-02-09 2003-11-17 Enzon Pharmaceuticals Inc Pharmaceutical compositions comprising PEG asparaginase for the treatment of HIV infections
IL138221A0 (en) 1998-03-26 2001-10-31 Schering Corp Formulations for protection of peg-interferon alpha conjugates
HU226294B1 (en) 1998-08-06 2008-08-28 Mountain View Pharmaceuticals Peg-urate oxidase conjugates and use thereof
DE69938148T2 (en) 1998-12-18 2009-02-26 Alza Corp., Mountain View METHOD FOR ADMINISTERING A CONNECTION TO MULTIPLE RESISTANT CELLS
JP2002539082A (en) 1999-02-08 2002-11-19 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド Vascular endothelial growth factor 2
NZ514990A (en) 1999-04-23 2004-01-30 Alza Corp Releasable linkage and compositions containing same
US20020064520A1 (en) * 1999-08-19 2002-05-30 Yanina Rozenberg Targeted artificial gene delivery
EP2845596A3 (en) 2000-01-10 2015-07-15 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Use of lipid conjugates in the treatment of disease
WO2001062827A2 (en) * 2000-02-22 2001-08-30 Shearwater Corporation N-maleimidyl polymer derivatives
KR100777195B1 (en) 2000-04-03 2007-11-19 산텐 세이야꾸 가부시키가이샤 Delivery material and drug delivery system using the same
US20040254197A1 (en) * 2001-09-28 2004-12-16 Santen Pharmaceutical Co., Ltd. Injections for eye tissues containing drug bonded to polyethlene glycol
DE10161149B4 (en) * 2001-12-12 2007-03-08 Ursapharm Arzneimittel Gmbh & Co. Kg Use of heparin-containing ophthalmic agent

Also Published As

Publication number Publication date
CA2404737A1 (en) 2001-10-11
US20030144247A1 (en) 2003-07-31
EP1279406A1 (en) 2003-01-29
CN100479862C (en) 2009-04-22
CA2404737C (en) 2010-06-29
US7455855B2 (en) 2008-11-25
KR100777195B1 (en) 2007-11-19
KR20030009414A (en) 2003-01-29
WO2001074400A1 (en) 2001-10-11
CN1420790A (en) 2003-05-28
EP1279406A4 (en) 2007-10-24

Similar Documents

Publication Publication Date Title
AU2001244713A1 (en) Transporters and drug delivery system by using the same
AU2001288388A1 (en) Substance delivery system
AU2123200A (en) Drug delivery device
AU4985600A (en) Drug delivery device
EP1545662B8 (en) Drug delivery system
AU2001264887A1 (en) Drug delivery device
AU1719800A (en) Drug delivery systems and methods
AU2001238386A1 (en) Medication delivery devices
AU2002244142A1 (en) Integrated medication delivery system
AU7839900A (en) Reusable medication delivery device
AU2001235009A1 (en) Drug delivery apparatus
AU2463701A (en) Drug delivery system exhibiting permeability control
AU4947100A (en) Drug delivery device
AU2002343555A1 (en) Eutectic-based self-nanoemulsified drug delivery system
AU2001281171A1 (en) Medication dispensing system
AU4995100A (en) Selectable agent delivery system
AU3837999A (en) Drug delivery device
AU2001270963A1 (en) Transdermal drug delivery system
AU2001260244A1 (en) Product delivery system
AU6196600A (en) Medication reminder system
AU2002222138A1 (en) Drug delivery system
AU2003285550A1 (en) Drug delivery system
AU2001244854A1 (en) Local drug delivery
AU2002210580A1 (en) Drug delivery system
AU2983100A (en) Drug delivery vehicle