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AU2000274809A1 - Inhibition of stenosis or restenosis by p-selectin antagonists - Google Patents

Inhibition of stenosis or restenosis by p-selectin antagonists

Info

Publication number
AU2000274809A1
AU2000274809A1 AU2000274809A AU7480900A AU2000274809A1 AU 2000274809 A1 AU2000274809 A1 AU 2000274809A1 AU 2000274809 A AU2000274809 A AU 2000274809A AU 7480900 A AU7480900 A AU 7480900A AU 2000274809 A1 AU2000274809 A1 AU 2000274809A1
Authority
AU
Australia
Prior art keywords
stenosis
restenosis
inhibition
selectin antagonists
selectin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2000274809A
Inventor
Anjali Kumar
Yahye Merhi
Robert G. Schuab
Jean-Francois Tanguay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut de Cardiologie de Montreal
Genetics Institute LLC
Original Assignee
Institut de Cardiologie de Montreal
Genetics Institute LLC
Montreal Heart Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut de Cardiologie de Montreal, Genetics Institute LLC, Montreal Heart Inst filed Critical Institut de Cardiologie de Montreal
Publication of AU2000274809A1 publication Critical patent/AU2000274809A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2000274809A 2000-09-12 2000-09-12 Inhibition of stenosis or restenosis by p-selectin antagonists Abandoned AU2000274809A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/025007 WO2002022820A1 (en) 2000-09-12 2000-09-12 Inhibition of stenosis or restenosis by p-selectin antagonists

Publications (1)

Publication Number Publication Date
AU2000274809A1 true AU2000274809A1 (en) 2002-03-26

Family

ID=21741767

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2000274809A Abandoned AU2000274809A1 (en) 2000-09-12 2000-09-12 Inhibition of stenosis or restenosis by p-selectin antagonists

Country Status (3)

Country Link
EP (1) EP1325123A4 (en)
AU (1) AU2000274809A1 (en)
WO (1) WO2002022820A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2486106C (en) 2002-05-16 2013-07-16 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
DE602004011272T2 (en) 2003-11-19 2008-12-24 Glycomimetics, Inc. SPECIFIC ANTAGONIST BOTH FOR E- AND P-SELECTINS
UY28886A1 (en) 2004-05-10 2005-12-30 Boehringer Ingelheim Int ANTIBODIES CONSISTING IN POLYPEPTIDES AND DERIVATIVES UNDERSTANDING THREE SEQUENCES CONCERNING THE FOLLOWING NUMBERS OF SEQ. ID: 1-3 AND 4-6; 7-9 AND 10-12 AND 13-15 OR 16-18
BRPI0510561A (en) * 2004-05-11 2007-11-20 Abgenomics Corp epitopes that induce t cell death
EP1928892B1 (en) 2005-08-09 2011-10-12 GlycoMimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
ES2651929T3 (en) 2005-09-02 2018-01-30 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
NZ619524A (en) 2011-06-13 2016-10-28 Abgenomics Cooperatief Ua Anti-psgl-1 antibodies and uses thereof
PL2794626T6 (en) 2011-12-22 2020-11-02 Glycomimetics, Inc. E-selectin antagonist compounds
US9867841B2 (en) 2012-12-07 2018-01-16 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
EP3569609A1 (en) 2014-12-03 2019-11-20 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
EP3405473A1 (en) 2016-01-22 2018-11-28 GlycoMimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
EP3522931A1 (en) 2016-10-07 2019-08-14 GlycoMimetics, Inc. Highly potent multimeric e-selectin antagonists
WO2018169853A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CA3085356A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69334350D1 (en) * 1992-10-23 2011-04-21 Genetics Inst Llc P-selectin ligand protein
AU2361395A (en) * 1994-04-28 1995-11-29 Genetics Institute Inc. Novel P-selectin ligand protein
JPH10504527A (en) * 1994-06-03 1998-05-06 センター・フォー・ブラッド・リサーチ・インコーポレーテッド Treatment and prevention of atherosclerosis
CA2228512A1 (en) * 1995-08-03 1997-02-20 The Board Of Regents Of The University Of Oklahoma Peptide and o-glycan inhibitors of selectin mediated inflammation
WO1999043834A2 (en) * 1998-02-27 1999-09-02 Genetics Institute, Inc. P-selectin ligand protein, including tetrameric fusion proteins
AU773542B2 (en) * 1998-06-16 2004-05-27 Board Of Regents Of The University Of Oklahoma, The Glycosulfopeptides and methods of synthesis and use thereof
AU2001247929A1 (en) * 2000-03-31 2001-10-15 Genetics Institute, Llc Inhibition of thrombosis by treatment with p-selectin antagonists

Also Published As

Publication number Publication date
WO2002022820A1 (en) 2002-03-21
EP1325123A1 (en) 2003-07-09
EP1325123A4 (en) 2004-07-21

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