[go: up one dir, main page]

AU1879597A - Tetraether lipids and liposomes containing said lipids, and use of the same - Google Patents

Tetraether lipids and liposomes containing said lipids, and use of the same

Info

Publication number
AU1879597A
AU1879597A AU18795/97A AU1879597A AU1879597A AU 1879597 A AU1879597 A AU 1879597A AU 18795/97 A AU18795/97 A AU 18795/97A AU 1879597 A AU1879597 A AU 1879597A AU 1879597 A AU1879597 A AU 1879597A
Authority
AU
Australia
Prior art keywords
liposomes
tetraether
lipids
tetraether lipid
gulose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU18795/97A
Inventor
Emmanouil Antonopoulos
Udo Bakowsky
H.-J. Freisleben
Ulrich Rothe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H J FREISLEBEN
Original Assignee
H J FREISLEBEN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7786811&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU1879597(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H J FREISLEBEN filed Critical H J FREISLEBEN
Publication of AU1879597A publication Critical patent/AU1879597A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a tetraether lipid with the general formula (I) in which R1 is a modified or unmodified gulose radical or an oxidation product of said gulose, and R2 is hydrogen, modified or unmodified phosphoglycerine or an oxidation product thereof. It also relates to the use of a tetraether lipid according to the invention and liposomes which contain 0.1 to 100 % by weight, in relation to the whole lipid, of the tetraether lipid according to the invention. Conventional liposomes have a low level of stability in storage and are acid-labile. The use thereof for oral administration of pharmaceuticals which should not be released until they are in the duodenum is therefore not possible. In contrast, liposomes containing the tetraether lipid according to the invention are acid-stable and can therefore move easily through the stomach into the small intestine, and cause resorption therein of active ingredients which are contained in said liposomes and cannot usually be absorbed into the blood stream after oral administration.
AU18795/97A 1996-02-29 1997-02-28 Tetraether lipids and liposomes containing said lipids, and use of the same Abandoned AU1879597A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19607722A DE19607722A1 (en) 1996-02-29 1996-02-29 Tetraether lipids and liposomes containing them and their use
DE19607722 1996-02-29
PCT/EP1997/001011 WO1997031927A1 (en) 1996-02-29 1997-02-28 Tetraether lipids and liposomes containing said lipids, and use of the same

Publications (1)

Publication Number Publication Date
AU1879597A true AU1879597A (en) 1997-09-16

Family

ID=7786811

Family Applications (1)

Application Number Title Priority Date Filing Date
AU18795/97A Abandoned AU1879597A (en) 1996-02-29 1997-02-28 Tetraether lipids and liposomes containing said lipids, and use of the same

Country Status (5)

Country Link
EP (1) EP0883624B1 (en)
AT (1) ATE227304T1 (en)
AU (1) AU1879597A (en)
DE (2) DE19607722A1 (en)
WO (1) WO1997031927A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19736592C2 (en) * 1997-08-22 2002-01-24 Bernina Biosystems Gmbh Tetraether lipid derivative, one or more tetraether lipid derivatives containing liposome or lipid agglomerate and pharmaceutical composition
DE10032329A1 (en) * 2000-07-04 2002-02-07 Kahl Johan Valentin Surface coating on a liquid / solid interface
DE10065561A1 (en) * 2000-12-28 2002-07-11 Bernina Biosystems Gmbh Liposomes and lipid agglomerates containing tetraether lipid derivatives and tetraether lipid derivatives and their use
DE10116197A1 (en) * 2001-03-30 2002-10-17 Bernina Biosystems Gmbh New lipid-soluble methylprednisolone 21-ester derivatives, useful as antiinflammatory, immunosuppressive or antiallergic agents, especially in liposome formulations or lipid coatings on implants
DE10204053A1 (en) * 2002-02-01 2003-08-14 Bernina Biosystems Gmbh New synthetic long-chain tetraether derivatives, useful as components of liposomes for nucleic acid transfection
DE10228857B4 (en) * 2002-06-26 2006-11-16 Surface & Interface Technologies Gmbh Rosenhof Tetraether lipids with small head groups, their preparation and use
DE10249401A1 (en) * 2002-10-23 2004-05-13 Bernina Biosystems Gmbh Liposome forming composition
DE102004033667A1 (en) * 2004-07-01 2006-02-02 Institut für Bioprozess- und Analysenmesstechnik e.V. Composite materials with tetraether lipids and their preparation
WO2006027787A1 (en) 2004-09-09 2006-03-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal compositions of glucocorticoid and glucocorticoid derivatives
DE102012216378B4 (en) * 2012-09-14 2014-05-15 Institut für Bioprozess- und Analysenmesstechnik e.V. Immobilization matrix with tetraether lipid layer, process for its preparation and biosensor chip comprising this immobilization matrix
EP2711369A1 (en) 2012-09-20 2014-03-26 Bernina Plus GmbH Liposomes containing tetraether lipid derivatives
EP3708151A1 (en) 2019-03-15 2020-09-16 Technische Universität Wien Method for producing a composition comprising archaeal lipids from a sulfolobus cell culture
EP4342460A1 (en) 2022-09-21 2024-03-27 NovoArc GmbH Lipid nanoparticle with nucleic acid cargo
WO2025046121A1 (en) 2023-09-01 2025-03-06 Novoarc Gmbh Lipid nanoparticle with nucleic acid cargo and ionizable lipid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098588A (en) * 1989-11-29 1992-03-24 The United States Of America As Represented By The Secretary Of The Navy New class of lubricants derived from archaebacterial lipids
JP3449481B2 (en) * 1991-10-23 2003-09-22 ナショナル リサーチ カウンシル オブ カナダ Formation of stable liposomes from archaeal (Archia) lipid extracts

Also Published As

Publication number Publication date
WO1997031927A1 (en) 1997-09-04
DE59708666D1 (en) 2002-12-12
ATE227304T1 (en) 2002-11-15
DE19607722A1 (en) 1997-09-04
EP0883624B1 (en) 2002-11-06
EP0883624A1 (en) 1998-12-16

Similar Documents

Publication Publication Date Title
AU1879597A (en) Tetraether lipids and liposomes containing said lipids, and use of the same
MY101791A (en) New benzimidazole derivatives
CA2133177A1 (en) Rapamycin formulations for oral administration
CA2112679A1 (en) Dosage form for delivering drug in short-time period
MY101784A (en) Novel pharmacological compounds
IL75070A0 (en) 6-aryl-3(2h)pyridazinones,processes for the preparation thereof and pharmaceutical compositions containing the same
GR1001503B (en) Method for the preparation of pharmaceutical compounds containing carbonic acids containing sulphur and the use thereof in fighting retroviruses.
DE69624711D1 (en) MEANS FOR THE REINFORCEMENT OF POLAR MEDICINAL PRODUCTS FROM THE COLON
IL108625A0 (en) Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives, their prepatation and pharmaceutical compositions containing them
ES2149979T3 (en) STABILIZED COMPOSITION FOR THE ORAL ADMINISTRATION OF PEPTIDES.
GR3006091T3 (en)
HUT38097A (en) Process for preparing substituted benzopyrans and pharmaceutical compositions containing them as active substances
PT996462E (en) PREPARATIONS OF PHARMACEUTICAL COMBINATIONS CONTAINING ERYTHROPOIETIN AND MODIFIED HEMOGLOBINS
HUT53664A (en) Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient
MY129946A (en) Compound with gastric acid inhibitory effect and process for its preparation.
IL85992A0 (en) Dihydropyridinamides,their preparation and pharmaceutical compositions containing them
DE3579471D1 (en) COMPOSITIONS CONTAINING ORAL DEXTRAN.
EP0652755A1 (en) Therapeutic use of phosphoryl-l-serine-n-acyl-sphingosine.
ES8201955A1 (en) 2-Hydroxyoxanilic acid derivatives and salts, their preparation and pharmaceutical compositions containing them.
MY104088A (en) Peptide-drugs compositions containing (alpha)-aminoboroic acid derivatives.
AU2994589A (en) Novel basic-substituted 5-halo-thienoisothiazol-3-(2h)-one-1,1-dioxides, process for the preparation thereof, and pharmaceutical preparations containing these compounds
DE3266072D1 (en) Method for the oral administration of substances in the form of liposomes, and relative pharmaceutical compositions
HK8994A (en) Medicament for treatment of pregnancy-induced hypertension
JPS5793906A (en) Emulsifiable base for mucous membrane
JPS6490133A (en) Pharmaceutical preparation for oral administration