ATE323699T1 - Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen - Google Patents
Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussenInfo
- Publication number
- ATE323699T1 ATE323699T1 AT03250563T AT03250563T ATE323699T1 AT E323699 T1 ATE323699 T1 AT E323699T1 AT 03250563 T AT03250563 T AT 03250563T AT 03250563 T AT03250563 T AT 03250563T AT E323699 T1 ATE323699 T1 AT E323699T1
- Authority
- AT
- Austria
- Prior art keywords
- releasing hormone
- gnrh
- affect
- effects
- gonadotropin releasing
- Prior art date
Links
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title abstract 4
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title abstract 3
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title abstract 3
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
- 102000006771 Gonadotropins Human genes 0.000 abstract 1
- 108010086677 Gonadotropins Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 239000002622 gonadotropin Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 239000003270 steroid hormone Substances 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Anesthesiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35656102P | 2002-02-12 | 2002-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE323699T1 true ATE323699T1 (de) | 2006-05-15 |
Family
ID=27613554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03250563T ATE323699T1 (de) | 2002-02-12 | 2003-01-30 | Nicht-peptidische verbindungen, welche die wirkung des gonadotropin-freisetzenden hormons (gnrh) beeinflussen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6833372B2 (de) |
| EP (1) | EP1334972B1 (de) |
| JP (1) | JP2004002309A (de) |
| AT (1) | ATE323699T1 (de) |
| AU (1) | AU2003202115A1 (de) |
| BR (1) | BR0300599A (de) |
| CA (1) | CA2418712A1 (de) |
| DE (1) | DE60304609D1 (de) |
| MX (1) | MXPA03001320A (de) |
| WO (1) | WO2003068769A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7205307B2 (en) * | 2002-02-14 | 2007-04-17 | Icagen, Inc. | Pyrimidines as novel openers of potassium ion channels |
| KR20040090979A (ko) * | 2002-03-13 | 2004-10-27 | 얀센 파마슈티카 엔.브이. | 히스톤 데아세틸레이즈의 신규한 억제제 |
| US7456222B2 (en) | 2002-05-17 | 2008-11-25 | Sequella, Inc. | Anti tubercular drug: compositions and methods |
| CN101404986B (zh) | 2002-05-17 | 2011-09-28 | 赛奎拉公司 | 用于诊断和治疗感染性疾病的组合物和制药方法 |
| US20040033986A1 (en) | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
| EP1560818A1 (de) | 2002-06-13 | 2005-08-10 | Pfizer Inc. | Nicht-peptidische gnrh verbindungen, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
| JP2006510725A (ja) * | 2002-11-20 | 2006-03-30 | パラダイム・セラピューティクス・リミテッド | 複素環式ケイ素化合物、ならびにＧｎＲＨ（ゴナドトロピン放出ホルモン）と関係のある疾患または状態の治療におけるその使用 |
| KR20060037409A (ko) | 2003-07-30 | 2006-05-03 | 제논 파마슈티칼스 인크. | 피페라진 유도체 및 그의 치료제로서의 용도 |
| WO2005034857A2 (en) | 2003-09-05 | 2005-04-21 | Sequella, Inc. | Methods and compositions comprising diamines as new anti-tubercular therapeutics |
| US7799832B2 (en) | 2003-10-23 | 2010-09-21 | Valeant Pharmaceuticals North America | Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| KR100751314B1 (ko) * | 2003-10-14 | 2007-08-22 | 삼성에스디아이 주식회사 | 어드레싱 전력을 최소화한 방전 디스플레이 장치 및 그구동 방법 |
| US20090209522A1 (en) * | 2005-06-28 | 2009-08-20 | Graham Andrew Showell | Heterocyclic Non-Peptide GNRH Antagonists |
| US7683058B2 (en) | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| AU2006322461A1 (en) * | 2005-09-09 | 2007-06-14 | H. Lundbeck A/S | Pyrimidine derivatives and their use as KCNQ potassium channels openers |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8293911B2 (en) | 2006-08-23 | 2012-10-23 | Valeant Pharmaceuticals International | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8722929B2 (en) | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| WO2008066900A1 (en) | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US7737157B2 (en) * | 2008-08-29 | 2010-06-15 | Hutchison Medipharma Enterprises Limited | Pyrimidine compounds |
| CA2834199C (en) * | 2011-07-18 | 2020-01-07 | Merck Patent Gmbh | Benzamides as allosteric modulators of the fsh receptor |
| US20160058895A1 (en) * | 2013-04-19 | 2016-03-03 | Oslo Universitetssykehus Hf | Radiolabeled gnrh antagonists as pet imaging agents |
| CN108164397B (zh) * | 2018-01-18 | 2020-11-13 | 暨南大学 | 一类邻苯二酚衍生物及其制备方法 |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| CA3155812A1 (en) | 2019-11-08 | 2021-05-14 | Cynthia Louise HARDEN | Methods of treating depressive disorders |
| CN116847843A (zh) | 2021-02-09 | 2023-10-03 | 泽农医药公司 | 用于治疗快感缺乏的电压门控的钾通道开放剂 |
| JP2024521316A (ja) * | 2021-06-09 | 2024-05-31 | クリネティックス ファーマシューティカルズ，インク． | 非ペプチド標的治療薬及びその使用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993003058A2 (en) | 1991-07-01 | 1993-02-18 | University Technologies International Inc. | NON-DESENSITIZING ANALOGS OF GnRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS |
| AU5514396A (en) | 1995-04-28 | 1996-11-18 | Takeda Chemical Industries Ltd. | Cyclic pentapeptide lh-rh receptor antagonists |
| AU5844896A (en) | 1995-06-01 | 1996-12-18 | Takeda Chemical Industries Ltd. | Tricyclic diazepines useful as gnrh receptor antagonists |
| US6200957B1 (en) | 1995-12-14 | 2001-03-13 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| SK77298A3 (en) | 1995-12-14 | 1999-01-11 | Merck & Co Inc | Nonpeptide derivatives, pharmaceutical composition containing them and their use |
| WO1997021707A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EE9800181A (et) | 1995-12-14 | 1998-12-15 | Merck & Co., Inc. | Gonadotropiini riliisinghormooni antagonist, selle kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod |
| WO1997021435A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| EP1068178A1 (de) | 1998-03-05 | 2001-01-17 | Agouron Pharmaceuticals, Inc. | Nicht-peptidische gnrh wirkstoffe |
| US5972898A (en) | 1998-03-27 | 1999-10-26 | Abbott Laboratories | 3',3-N-bis-substituted macrolide LHRH antagonists |
| ID29244A (id) * | 1998-08-20 | 2001-08-16 | Agouron Pharma | ZAT-ZAT GnRH NON-PEPTIDA, METODE-METODE DAN ZAT-ZAT ANTARA PEMBUATANNYA |
| US6387885B1 (en) | 1998-08-26 | 2002-05-14 | Abbott Laboratories | 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists |
| US6020521A (en) | 1998-08-26 | 2000-02-01 | Abbott Laboratories | Macrolide LHRH antagonists |
| US5981521A (en) * | 1998-11-13 | 1999-11-09 | Abbott Laboratories | Tetrahydroisoquinoline derivatives as LHRH antagonists |
| FR2793594B1 (fr) | 1999-05-11 | 2001-12-07 | Axon Cable Sa | Cable passe-bas |
| EP1220857B1 (de) | 1999-10-15 | 2005-09-21 | Neurocrine Biosciences, Inc. | Gonadotropin freisetzenden hormon rezeptor antagonisten und ihre verwandten verwendungen |
-
2003
- 2003-01-29 WO PCT/IB2003/000316 patent/WO2003068769A1/en not_active Ceased
- 2003-01-29 AU AU2003202115A patent/AU2003202115A1/en not_active Abandoned
- 2003-01-30 AT AT03250563T patent/ATE323699T1/de not_active IP Right Cessation
- 2003-01-30 DE DE60304609T patent/DE60304609D1/de not_active Expired - Lifetime
- 2003-01-30 EP EP03250563A patent/EP1334972B1/de not_active Expired - Lifetime
- 2003-02-10 CA CA002418712A patent/CA2418712A1/en not_active Abandoned
- 2003-02-11 US US10/364,193 patent/US6833372B2/en not_active Expired - Fee Related
- 2003-02-11 MX MXPA03001320A patent/MXPA03001320A/es unknown
- 2003-02-12 BR BR0300599-2A patent/BR0300599A/pt not_active Application Discontinuation
- 2003-02-12 JP JP2003034331A patent/JP2004002309A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004002309A (ja) | 2004-01-08 |
| DE60304609D1 (de) | 2006-05-24 |
| MXPA03001320A (es) | 2003-08-21 |
| US20040053951A1 (en) | 2004-03-18 |
| EP1334972B1 (de) | 2006-04-19 |
| WO2003068769A1 (en) | 2003-08-21 |
| US6833372B2 (en) | 2004-12-21 |
| AU2003202115A1 (en) | 2003-09-04 |
| CA2418712A1 (en) | 2003-08-12 |
| BR0300599A (pt) | 2005-03-29 |
| EP1334972A1 (de) | 2003-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |