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ATE382039T1 - Benzimidazolone und ihre verwendung als cytokininhibitoren - Google Patents

Benzimidazolone und ihre verwendung als cytokininhibitoren

Info

Publication number
ATE382039T1
ATE382039T1 AT03795649T AT03795649T ATE382039T1 AT E382039 T1 ATE382039 T1 AT E382039T1 AT 03795649 T AT03795649 T AT 03795649T AT 03795649 T AT03795649 T AT 03795649T AT E382039 T1 ATE382039 T1 AT E382039T1
Authority
AT
Austria
Prior art keywords
sub
compounds
benzimidazolones
disclosed
processes
Prior art date
Application number
AT03795649T
Other languages
English (en)
Inventor
Antonio J M Barbosa Jr
Daniel R Goldberg
Abdelhakim Hammach
Pingrong Liu
Neil Moss
Mark Stephen Ralph
Gregory Paul Roth
Christopher Ronald Sarko
Fariba Soleymanzadeh
Andre White
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE382039T1 publication Critical patent/ATE382039T1/de

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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AT03795649T 2002-09-13 2003-09-04 Benzimidazolone und ihre verwendung als cytokininhibitoren ATE382039T1 (de)

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US41042002P 2002-09-13 2002-09-13

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ATE382039T1 true ATE382039T1 (de) 2008-01-15

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US (1) US7115644B2 (de)
EP (1) EP1539708B1 (de)
JP (1) JP4551765B2 (de)
AT (1) ATE382039T1 (de)
AU (1) AU2003265924A1 (de)
CA (1) CA2498754C (de)
DE (1) DE60318320T2 (de)
ES (1) ES2297265T3 (de)
WO (1) WO2004024699A1 (de)

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SG146624A1 (en) * 2003-09-11 2008-10-30 Kemia Inc Cytokine inhibitors
WO2007015877A2 (en) * 2005-07-20 2007-02-08 Kalypsys, Inc. Inhibitors of p38 kinase and methods of treating inflammatory disorders
WO2011021678A1 (ja) * 2009-08-21 2011-02-24 武田薬品工業株式会社 縮合複素環化合物
WO2013186229A1 (en) * 2012-06-11 2013-12-19 Ucb Pharma S.A. Tnf -alpha modulating benzimidazoles
US8901304B1 (en) 2013-11-05 2014-12-02 King Fahd University Of Petroleum And Minerals Benzo[D]imidazole derivatives of piperidine and piperazine
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US7115644B2 (en) 2006-10-03
DE60318320D1 (de) 2008-02-07
CA2498754C (en) 2012-03-06
ES2297265T3 (es) 2008-05-01
JP2006503033A (ja) 2006-01-26
EP1539708B1 (de) 2007-12-26
DE60318320T2 (de) 2008-12-11
AU2003265924A1 (en) 2004-04-30
EP1539708A1 (de) 2005-06-15

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