ATE35506T1 - Selektive methode zum blockieren von 5ht2 rezeptoren. - Google Patents

Selektive methode zum blockieren von 5ht2 rezeptoren.

Info

Publication number: ATE35506T1
Authority: AT; Austria
Prior art keywords: receptors; blocking; selective method; dihydroxyalkyl; hydroxyalkyl
Prior art date: 1983-03-10

Application number

AT84301586T

Other languages

English (en)

Inventor

Marlene Lois Cohen

Ray Ward Fuller

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-10

Filing date

1984-03-09

Publication date

1988-07-15

1984-03-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1988-07-15 Application granted granted Critical

1988-07-15 Publication of ATE35506T1 publication Critical patent/ATE35506T1/de

Links

102000056834 5-HT2 Serotonin Receptors Human genes 0.000 title abstract 2
108091005479 5-HT2 receptors Proteins 0.000 title abstract 2
230000000903 blocking effect Effects 0.000 title 1
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006699 (C1-C3) hydroxyalkyl group Chemical group 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Neurology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Investigation Of Foundation Soil And Reinforcement Of Foundation Soil By Compacting Or Drainage (AREA)
Prostheses (AREA)
Holo Graphy (AREA)
Eye Examination Apparatus (AREA)

AT84301586T 1983-03-10 1984-03-09 Selektive methode zum blockieren von 5ht2 rezeptoren. ATE35506T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/473,882 US4563461A (en)	1983-03-10	1983-03-10	Selective method for blocking 5HT2 receptors
EP84301586A EP0122044B1 (de)	1983-03-10	1984-03-09	Selektive Methode zum Blockieren von 5HT2 Rezeptoren

Publications (1)

Publication Number	Publication Date
ATE35506T1 true ATE35506T1 (de)	1988-07-15

Family

ID=23881404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84301586T ATE35506T1 (de)	1983-03-10	1984-03-09	Selektive methode zum blockieren von 5ht2 rezeptoren.

Country Status (6)

Country	Link
US (1)	US4563461A (de)
EP (1)	EP0122044B1 (de)
JP (1)	JPS59175431A (de)
AT (1)	ATE35506T1 (de)
DE (2)	DE3408730A1 (de)
IT (1)	IT1209512B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4675322A (en) *	1984-12-10	1987-06-23	Eli Lilly And Company	1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4906639A (en) *	1985-10-01	1990-03-06	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
US4713384A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4847261A (en) *	1985-10-01	1989-07-11	Eli Lilly And Company	Alkoxy cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonists properties
US4772709A (en) *	1985-10-01	1988-09-20	Eli Lilly And Company	Process of making ketoalkanol esters of dihydrolysergic acid
US4820713A (en) *	1985-10-01	1989-04-11	Eli Lilly And Company	Ketoalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
US4713385A (en) *	1985-10-01	1987-12-15	Eli Lilly And Company	Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists
US4714704A (en) *	1985-10-01	1987-12-22	Eli Lilly And Company	Alkoxy cycloalkanol esters of dihydrolysergic acid useful as 5HT receptor antagonists
NZ217724A (en) *	1985-10-01	1989-02-24	Lilly Co Eli	Esters of dihydrolysergic acid and pharmaceutical composition
US4810710A (en) *	1985-10-01	1989-03-07	Eli Lilly And Company	4-hydroxycyclohexyl 1-isopropyl-9,10-dihydro-lysergate for the treatment of migraine
US4762842A (en) *	1985-10-01	1988-08-09	Eli Lilly And Company	Selective method for blocking 5HT2 receptors
US4683236A (en) *	1985-10-01	1987-07-28	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid useful as 5Ht2 receptor antagonists
US4968802A (en) *	1985-10-01	1990-11-06	Eli Lilly And Company	Process of making alkoxy cycloalkanol esters of dihydrolysergic acid
US4845224A (en) *	1985-10-01	1989-07-04	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid having peripheral serotonin antagonist properties
US4939258A (en) *	1985-10-01	1990-07-03	Eli Lilly And Company	Cycloalkanol esters of dihydrolysergic acid
EP0228876A3 (de) *	1985-12-20	1989-03-22	Eli Lilly And Company	Ester von Dihydrolysergsäure und verwandte Verbindungen
US4683237A (en) *	1985-12-20	1987-07-28	Eli Lilly And Company	Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists
US4704396A (en) *	1985-12-20	1987-11-03	Eli Lilly And Company	Phenacyl esters of 1-substituted-6-(substituted and unsubstituted) dihydrolysergic acids useful as 5HT receptor antagonists
US4704395A (en) *	1985-12-20	1987-11-03	Eli Lilly And Company	Cyclic ether esters of 2-substituted-6-(substituted and unsubstituted) dihydrolysergic acid useful as 5HT receptor antagonists
US5006526A (en) *	1988-10-17	1991-04-09	Louisiana State University	Method of treating a vertebrate animal to reduce plasma triglycerides and cholesterol levels and to alleviate and prevent atherosclerosis
US5688807A (en) *	1994-03-11	1997-11-18	Eli Lilly And Company	Method for treating 5HT2B receptor related conditions
US5886003A (en) *	1996-03-25	1999-03-23	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of venomous bites and stings
DE10212564B4 (de) *	2002-03-12	2007-04-19	Neurobiotec Gmbh	1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3228941A (en) *		1966-01-11		Methyl and i,g-dimethyl-ergoline i derivatives
US3249617A (en) *		1966-05-03		Alkylated d-lyserglc acid
CH344731A (de) *	1956-05-18	1960-02-29	Sandoz Ag	Verfahren zur Herstellung von neuen, am Indolstickstoff alkylierten Derivaten der Lysergsäure-Reihe
US3580916A (en) *	1969-02-20	1971-05-25	Lilly Co Eli	Hydroxyesters of hexa- and octahydroindoloquinolines
US3879554A (en) *	1970-03-20	1975-04-22	Farmaceutici Italia	Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
GB1290203A (de) *	1970-09-01	1972-09-20
BE792515A (fr) *	1971-12-10	1973-06-08	Sandoz Sa	Nouveaux derives de l'acide lysergique, leur preparation et leur application comme medicaments
JPS5443649B2 (de) *	1973-06-05	1979-12-21
US4153700A (en) *	1975-08-27	1979-05-08	Lake Shore Roentgenology Ltd.	Treatment of the acute after-effects resulting from alcohol ingestion
YU40004B (en) *	1977-07-21	1985-06-30	Lek Tovarna Farmacevtskih	Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds

1983
- 1983-03-10 US US06/473,882 patent/US4563461A/en not_active Expired - Fee Related
1984
- 1984-03-09 IT IT8419995A patent/IT1209512B/it active
- 1984-03-09 JP JP59046388A patent/JPS59175431A/ja active Pending
- 1984-03-09 DE DE19843408730 patent/DE3408730A1/de not_active Withdrawn
- 1984-03-09 EP EP84301586A patent/EP0122044B1/de not_active Expired
- 1984-03-09 AT AT84301586T patent/ATE35506T1/de not_active IP Right Cessation
- 1984-03-09 DE DE8484301586T patent/DE3472529D1/de not_active Expired

Also Published As

Publication number	Publication date
US4563461A (en)	1986-01-07
DE3408730A1 (de)	1984-09-13
IT8419995A0 (it)	1984-03-09
JPS59175431A (ja)	1984-10-04
EP0122044B1 (de)	1988-07-06
EP0122044A1 (de)	1984-10-17
DE3472529D1 (en)	1988-08-11
IT1209512B (it)	1989-08-30

Publication	Publication Date	Title
ATE35506T1 (de)	1988-07-15	Selektive methode zum blockieren von 5ht2 rezeptoren.
BG60249B2 (en)	1994-03-24	Thiazole compound for treatment of ulcers
DK0640592T3 (da)	1999-08-30	N-acylerede tricycliske azaheteroringe anvendelige som vasopressin-antagonister
KR930703311A (ko)	1993-11-29	물질 p의 길항제인 n-알킬 퀴누클리디늄염
MX9504349A (es)	1997-03-29	Derivados de aroilpiperidina.
ATE31307T1 (de)	1987-12-15	Benzofuran- und benzopyrancarboxamid-derivate.
IT1171880B (it)	1987-06-10	Derivati di 2-ammino-3-acilammino-6-benzilammino-piridina aventi azione antiepilettica e procedimento per la loro produzione
DK577584D0 (da)	1984-12-04	Substituerede 2-pyridylmethyl-thio og -sulfinylbenzimidazoler til brug som gastriske antisekretoriske midler
DE3360904D1 (de)	1985-11-07	A fungicidal indanylbenzamide
ES8601951A1 (es)	1985-11-16	Un procedimiento para la preparacion de nuevos cinamil-2,3-dihidro-benzofuranos sustituidos y sus analagos.
CU34216A (es)	1980-10-30	Derivados de dibenzofurano
DK422183A (da)	1984-03-18	Fremgangsmaade til fremstilling af 5-halogenvinyl-2'-deoxyuridinderivater
PT76558A (en)	1983-05-01	Process for the preparation of imidazoline derivatives
DK156396C (da)	1990-01-08	2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse
ATE45575T1 (de)	1989-09-15	Prostacycline.
JPS5293771A (en)	1977-08-06	Benzotriazoles
NO914074D0 (no)	1991-10-17	Polyvinylkloridsammensetninger med forbedret bearbeidelses stabilite
ES2004215A6 (es)	1988-12-16	Procedimiento para preparar quinazolinas tetraciclicas
DK535388A (da)	1989-03-29	Anvendelse af piperidinopropiophenonforbindelse til fremstilling af et hypotensivt middel
DE3362723D1 (en)	1986-04-30	Pyrido-triazoloquinazolines, their preparation and use
JPS53147086A (en)	1978-12-21	Novel imidazothiazolium salts
ES442327A1 (es)	1977-08-16	Procedimiento para la preparacion de nuevos compuestos de hidrodipiranoftalazina.

Legal Events

Date	Code	Title	Description
1988-10-15	UEP	Publication of translation of european patent specification
1993-12-15	REN	Ceased due to non-payment of the annual fee