[go: up one dir, main page]

ATE348189T1 - Molekularer nachweis von chromosomalen veränderungen - Google Patents

Molekularer nachweis von chromosomalen veränderungen

Info

Publication number
ATE348189T1
ATE348189T1 AT98924658T AT98924658T ATE348189T1 AT E348189 T1 ATE348189 T1 AT E348189T1 AT 98924658 T AT98924658 T AT 98924658T AT 98924658 T AT98924658 T AT 98924658T AT E348189 T1 ATE348189 T1 AT E348189T1
Authority
AT
Austria
Prior art keywords
probes
molecular detection
relates
chromosomal changes
gene rearrangements
Prior art date
Application number
AT98924658T
Other languages
English (en)
Inventor
Dongen Jacobus Johannus Ma Van
Anthonie Willem Langerak
Original Assignee
Univ Erasmus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus filed Critical Univ Erasmus
Application granted granted Critical
Publication of ATE348189T1 publication Critical patent/ATE348189T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6841In situ hybridisation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT98924658T 1997-05-13 1998-05-13 Molekularer nachweis von chromosomalen veränderungen ATE348189T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201440A EP0878552A1 (de) 1997-05-13 1997-05-13 Molekularer Nachweis von chromosomalen Veränderungen

Publications (1)

Publication Number Publication Date
ATE348189T1 true ATE348189T1 (de) 2007-01-15

Family

ID=8228318

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924658T ATE348189T1 (de) 1997-05-13 1998-05-13 Molekularer nachweis von chromosomalen veränderungen

Country Status (9)

Country Link
US (4) US6730474B1 (de)
EP (1) EP0878552A1 (de)
JP (2) JP2001524832A (de)
AT (1) ATE348189T1 (de)
AU (1) AU7676598A (de)
CA (1) CA2290628C (de)
DE (1) DE69836632T2 (de)
DK (1) DK0981650T3 (de)
WO (1) WO1998051817A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0878552A1 (de) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molekularer Nachweis von chromosomalen Veränderungen
EP1078098A1 (de) 1998-05-04 2001-02-28 Dako A/S Verfahren und sonden zur detektion chromosomaler aberrationen
US7981599B1 (en) 1998-07-31 2011-07-19 Boston Probes, Inc. Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair
WO2000065093A2 (en) * 1999-04-22 2000-11-02 Science And Technology Corporation In situ hybridization methods for reducing the occurrence of false positives and for targeting multiple microorganisms
US7662554B2 (en) * 2002-10-09 2010-02-16 The Trustees Of Boston University Nucleic acid supported protein complementation
EP1745156A2 (de) 2004-05-04 2007-01-24 Dako Denmark A/S Verfahren für den nachweis von chromosomenaberrationen
EP1948825A2 (de) * 2005-10-27 2008-07-30 The Trustees Of Boston University Aktivierte spaltpolypeptide und verfahren zu deren herstellung und verwendung
JP2009513141A (ja) * 2005-10-27 2009-04-02 トラスティーズ オブ ボストン ユニバーシティ タンパク質相補によるリアルタイムインビボ核酸検出
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
KR20090073255A (ko) * 2006-10-27 2009-07-02 트르스티스 오브 보스톤 유니버시티 질병, 악성 종양 및 장애를 치료하기 위한 표적화 분열 생체 분자성 접합체, 및 그의 생성 방법
BRPI0912046B1 (pt) 2008-05-27 2020-11-24 Agilent Technologies, Inc Composições de hibridizaqao e seu uso, bem como metodo de hibridizaqao de sequencias de acido nucleico
US20100068701A1 (en) * 2008-09-12 2010-03-18 Yamada N Alice Chromosome labeling method
EP2401396B1 (de) 2009-02-26 2016-11-23 Dako Denmark A/S Verfahren zur durchführung eines stringenten waschschritts bei hybridisierungsanwendungen
US20130040294A1 (en) 2009-12-02 2013-02-14 Steen H. Matthiesen Compositions and methods for performing hybridizations with no denaturation
WO2012018387A2 (en) 2010-08-02 2012-02-09 Population Diagnotics, Inc. Compositions and methods for discovery of causative mutations in genetic disorders
EP2726628B1 (de) * 2011-07-01 2016-05-11 HTG Molecular Diagnostics, Inc. Verfahren zum nachweis von genfusionen
EP2761028A1 (de) 2011-09-30 2014-08-06 Dako Denmark A/S Hybridisierungszusammensetzungen und -verfahren mit formamid
EP2766483B1 (de) 2011-10-10 2022-03-23 The Hospital For Sick Children Verfahren und zusammensetzungen zum screening und zur behandlung von entwicklungsstörungen
EP3252173A1 (de) 2011-10-21 2017-12-06 Dako Denmark A/S Hybridisierungszusammensetzungen und -verfahren
EP2773779B1 (de) 2011-11-04 2020-10-14 Population Bio, Inc. Verfahren und zusammensetzungen zur diagnose, prognose und behandlung neurologischer erkrankungen
WO2013120018A1 (en) 2012-02-09 2013-08-15 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
WO2014025001A1 (ja) * 2012-08-09 2014-02-13 公益財団法人がん研究会 核酸配列の切断標識方法
US9976180B2 (en) 2012-09-14 2018-05-22 Population Bio, Inc. Methods for detecting a genetic variation in subjects with parkinsonism
WO2014052855A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
DK2891722T3 (en) 2013-11-12 2019-01-07 Population Bio Inc METHODS AND COMPOSITIONS FOR DIAGNOSTICING, PROGRAMMING AND TREATMENT OF ENDOMETRIOSIS
WO2016036403A1 (en) 2014-09-05 2016-03-10 Population Diagnostics Inc. Methods and compositions for inhibiting and treating neurological conditions
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
DK3625368T3 (da) 2018-08-08 2022-12-19 Pml Screening Llc Fremgangsmåder til vurdering af risiko for udvikling af progressiv, multifokal leukoencephalopati forårsaget af john cunningham-virus ved genetisk test
CA3129341A1 (en) 2019-04-25 2020-10-29 Agilent Technologies, Inc. Hybridization compositions and methods for making and using compositions
CN115305178B (zh) * 2022-08-16 2023-02-03 朱哲枭 一种集成式核酸咽拭子单采采样管

Family Cites Families (213)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260433A (en) 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
USRE35491E (en) 1982-11-04 1997-04-08 The Regents Of The University Of California Methods and compositions for detecting human tumors
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4681840A (en) 1984-01-18 1987-07-21 The United States Of America As Represented By The Secretary Of Commerce Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US5013831A (en) 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4849208A (en) 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4843122A (en) 1984-01-30 1989-06-27 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4849505A (en) 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4943523A (en) 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4952685A (en) 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
IL76997A0 (en) 1984-11-14 1986-04-29 Oncogene Science Inc Probes and methods useful for detecting chromosomal translocation
US4785086A (en) 1985-01-17 1988-11-15 Integrated Genetics, Inc. Test for Campylobacter
US6083709A (en) 1985-08-21 2000-07-04 Osi Pharmaceuticals, Inc. Immunoassay for detection of mutant P53 polypeptide in serum
GB8529014D0 (en) 1985-11-25 1986-01-02 Biogen Nv Enhanced secretion of heterologous proteins
US6475720B1 (en) 1986-01-16 2002-11-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US6344315B1 (en) 1986-01-16 2002-02-05 The Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17
US5756696A (en) 1986-01-16 1998-05-26 Regents Of The University Of California Compositions for chromosome-specific staining
US6872817B1 (en) 1986-01-16 2005-03-29 The Regents Of The Univ. Of California Method of staining target interphase chromosomal DNA
US6280929B1 (en) 1986-01-16 2001-08-28 The Regents Of The University Of California Method of detecting genetic translocations identified with chromosomal abnormalities
US5447841A (en) 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5721098A (en) 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
US5015568A (en) 1986-07-09 1991-05-14 The Wistar Institute Diagnostic methods for detecting lymphomas in humans
US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
US4892817A (en) 1987-09-21 1990-01-09 Biogenex Laboratories Stable phosphatase substrate composition
US4912034A (en) 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
NO164622C (no) 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US6203977B1 (en) 1988-11-15 2001-03-20 Yale University Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization
CN1046392A (zh) 1988-11-15 1990-10-24 耶鲁大学 通过原位抑制杂交对人个体中期和间期细胞染色体定位
US5998135A (en) 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
US5079147A (en) 1989-03-13 1992-01-07 The Wistar Institute Of Anatomy And Biology Diagnostic probes and methods for using same to detect breast cancer
US5198338A (en) 1989-05-31 1993-03-30 Temple University Molecular probing for human t-cell leukemia and lymphoma
US5242795A (en) 1989-07-03 1993-09-07 Temple University TCL-5 gene rearrangement involved in T-cell leukemia and melanoma
US8592155B2 (en) 1989-07-19 2013-11-26 The Regents Of The University Of California Method of detecting genetic deletions identified with chromosomal abnormalities
US5149628A (en) 1989-11-15 1992-09-22 Temple University Methods for detecting bcl-3 gene in human leukemias
AU6882791A (en) 1989-11-22 1991-06-13 Children's Hospital Of Los Angeles Bcr/abl transgenic animals as models for philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia
AU647741B2 (en) * 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US6270760B1 (en) 1989-12-18 2001-08-07 Valent Biosciences, Inc. Production of Bacillus thuringiensis integrants
US5695976A (en) 1989-12-18 1997-12-09 Novo Nordisk A/S Stable integration of DNA in bacterial genomes
US5955367A (en) 1989-12-18 1999-09-21 Abbott Laboratories Production of bacillus thuringiensis integrants
US6280721B1 (en) 1989-12-18 2001-08-28 Valent Biosciences, Inc. Production of Bacillus thuringiensis integrants
DK639689D0 (da) 1989-12-18 1989-12-18 Novo Nordisk As Indfoering af dna i celler
EP0515573A1 (de) 1990-02-23 1992-12-02 The Board Of Trustees Of The Leland Stanford Junior University Transkriptionsfaktoren mit einer pathogenen rolle in humanen neoplasias
US20040235039A1 (en) 1990-03-20 2004-11-25 Regents Of The University Of California Chromosome-specific staining to detect genetic rearrangements
CA2037349C (en) 1990-03-26 2008-06-17 James G. Wetmur Branch migration of nucleotides
DK0489149T3 (da) 1990-06-27 2001-12-27 Univ Princeton Prober til påvisning af mutant P53
DE69124522T2 (de) 1990-09-20 1997-09-25 Vysis, Inc., Downers Grove, Ill. Sonde zusammensetzungen für chromosom identifizierung und verfahren
US5491224A (en) 1990-09-20 1996-02-13 Bittner; Michael L. Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture
US5506350A (en) 1990-09-20 1996-04-09 Bittner; Michael L. Production of chromosome region specific DNA sequences and transamination
US6277569B1 (en) 1990-09-20 2001-08-21 Vysis, Inc. Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization
US5789161A (en) 1990-09-20 1998-08-04 Amoco Corporation Methods for genome identification using direct label probe composition
US5512433A (en) 1990-11-08 1996-04-30 Vysis, Inc. Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes
US5258507A (en) 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
JP3122821B2 (ja) 1990-11-21 2001-01-09 ピカー インターナショナル インコーポレイテッド 垂直格納コリメーターを備えた核医学カメラ用ガントリ装置
US5538869A (en) * 1990-12-13 1996-07-23 Board Of Regents, The University Of Texas System In-situ hybridization probes for identification and banding of specific human chromosomes and regions
US5244787A (en) 1991-01-31 1993-09-14 Biogenex Laboratories Antigen retrieval in formalin-fixed tissues using microwave energy
CA2060267A1 (en) * 1991-02-22 1992-08-23 Joe W. Gray Chromosome specific staining to detect genetic rearrangements
AU1779092A (en) 1991-03-20 1992-10-21 Salk Institute For Biological Studies, The Analytical methods for identifying chromosomal aberrations
WO1992021032A1 (en) 1991-05-24 1992-11-26 The Regents Of The University Of California Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients
ATE191512T1 (de) 1991-07-31 2000-04-15 Vysis Inc Nukleinsäure sonden welche bei nachweis von shigellabakterien verwendbar sind
JPH06502079A (ja) 1991-09-19 1994-03-10 ヴァイシス・インコーポレーテッド ゲノム識別用のプローブ組成物および方法
WO1993006246A1 (en) 1991-09-19 1993-04-01 Amoco Corporation Production of chromosome region specific dna sequences and transamination
US6025126A (en) 1991-10-28 2000-02-15 Arch Development Corporation Methods and compositions for the detection of chromosomal aberrations
US5633135A (en) 1991-12-11 1997-05-27 Thomas Jefferson University Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities
US6040140A (en) 1991-12-11 2000-03-21 Thomas Jefferson University Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities
WO1993012136A1 (en) 1991-12-11 1993-06-24 Thomas Jefferson University Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region
CA2107880A1 (en) 1992-02-28 1993-08-29 Douglas J. Taron Methods for detection of chromosomal structure and rearrangements
US5856097A (en) 1992-03-04 1999-01-05 The Regents Of The University Of California Comparative genomic hybridization (CGH)
CA2131543C (en) 1992-03-04 2002-09-17 Daniel Pinkel Comparative genomic hybridization
FR2691475B1 (fr) 1992-05-20 1995-03-24 Centre Nat Rech Scient Séquence d'ADN des produits de fusion résultant de la translocation chromosomique récurrente t(11;22) (q24;q12) associée au développement d'un groupe de tumeurs cancéreuses.
IT1255770B (it) 1992-05-22 1995-11-15 Consiglio Nazionale Ricerche Oligonucleotidi antisenso ad attivita' antitumorale, composizioni farmaceutiche che li comprendono, e loro impieghi
DE4216949C2 (de) 1992-05-22 1997-07-24 Christoph Prof Dr Dr Cremer Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben
WO1993025713A1 (en) * 1992-06-17 1993-12-23 Arch Development Corporation Compositions and methods for detecting gene rearrangements and translocations
US6121419A (en) 1992-06-17 2000-09-19 Arch Development Corp. Compositions and methods for detecting gene rearrangements and translocations
WO1994006936A1 (en) 1992-09-11 1994-03-31 Baylor College Of Medicine Method for the diagnosis of genetic disorders associated with chromosomal abnormalities and uniparental disomy
CA2078377A1 (en) * 1992-09-16 1994-03-17 Henry H. Q. Heng Gene mapping by in situ hybridisation to free chromatin
US5538846A (en) 1992-09-17 1996-07-23 Meeker; Timothy C. BCL-1 locus nucleic acid probes and assay methods
JPH08503604A (ja) 1992-09-18 1996-04-23 アモコ・コーポレーション プローブで用いるための緑色蛍光標識ヌクレオチド
US5547838A (en) 1992-10-01 1996-08-20 Life Technologies, Inc. Method for the rapid and ultra-sensitive detection of leukemic cells
WO1994009022A1 (en) 1992-10-09 1994-04-28 Oncor, Inc. Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue
GB9307754D0 (en) * 1993-04-15 1993-06-02 Perry Robert E Diagnostic probes and therapeutic products
US5492837A (en) 1993-08-27 1996-02-20 Biogenex Laboratories Mounting medium for microscope slide preparations
US5536642A (en) * 1993-09-09 1996-07-16 Barbera-Guillem; Emilio Diagnostic and prognostic methods for solid non-lymphoid tumors and their metastases
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US5472842A (en) 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
WO1995011313A1 (en) 1993-10-18 1995-04-27 Amoco Corporation Control compositions for determination of molecular cytogenetic abnormalities with dna probes
AU1094795A (en) 1993-11-12 1995-05-29 Oncor, Inc. Detection of bladder cancer
US5529925A (en) 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US5622829A (en) 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
US5523204A (en) * 1993-12-10 1996-06-04 Becton Dickinson And Company Detection of nucleic acids in cells by strand displacement amplification
DK145493D0 (da) 1993-12-23 1993-12-23 Dako As Antistof
US6451551B1 (en) 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US5667981A (en) 1994-05-13 1997-09-16 Childrens Hospital Of Los Angeles Diagnostics and treatments for cancers expressing tyrosine phosphorylated CRKL protein
WO1996000234A1 (en) 1994-06-23 1996-01-04 Aprogenex, Inc. Centromere hybridization probes
US5846749A (en) 1994-10-12 1998-12-08 The Regents Of The University Of California Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
DE4444969C1 (de) 1994-12-16 1996-10-24 Orga Med Dr Med Erwin Klopfer Nachweis von Antikörpern gegen p53 in Körperflüssigkeiten
GB9501386D0 (en) 1995-01-23 1995-03-15 Hsc Res Dev Lp Sequence of a af1q cdna
US5731153A (en) 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
EP0727487A1 (de) 1995-02-17 1996-08-21 K.U. Leuven Research & Development Multi-Tumor abweichende Wachstumsgene
IT1275862B1 (it) 1995-03-03 1997-10-24 Consiglio Nazionale Ricerche Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento
US5567586A (en) * 1995-05-18 1996-10-22 Thomas Jefferson University Methods of indentifying solid tumors with chromosome abnormalities in the ALL-1 region
US5684142A (en) 1995-06-07 1997-11-04 Oncor, Inc. Modified nucleotides for nucleic acid labeling
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
US5801032A (en) 1995-08-03 1998-09-01 Abbott Laboratories Vectors and process for producing high purity 6,12-dideoxyerythromycin A by fermentation
US5756294A (en) 1995-09-25 1998-05-26 Oncormed, Inc. Susceptibility mutation for breast and ovarian cancer
DE69637086T2 (de) 1995-10-12 2008-01-10 Lansdorp, Peter M., Vancouver Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
US5892010A (en) 1996-07-15 1999-04-06 The Regents Of The University Of California Genes from the 20Q13 amplicon and their uses
US7049424B2 (en) 1996-07-15 2006-05-23 The Regents Of The University Of California Genes from the 20Q13 amplicon and their uses
US5801021A (en) 1995-10-20 1998-09-01 The Regents Of The University Of California Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer
AU7210196A (en) 1995-11-16 1997-06-05 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
US5700921A (en) 1995-11-27 1997-12-23 Vector Laboratories Labeling nucleic acids
US5759781A (en) 1995-12-22 1998-06-02 Yale University Multiparametric fluorescence in situ hybridization
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
US5654155A (en) 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
DE19610255B4 (de) 1996-03-15 2004-11-04 Universität Heidelberg Verfahren zur Herstellung von Nukleinsäuresequenzen und Verfahren zum Nachweis von Translokationen zwischen Chromosomen
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US5925519A (en) 1996-06-03 1999-07-20 The Regents Of The University Of California Genetic alterations associated with prostate cancer
US6808878B1 (en) 1996-07-15 2004-10-26 The Regents Of The University Of California Genes from the 20Q13 amplicon and their uses
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
EP0825198A1 (de) 1996-08-22 1998-02-25 K.U. Leuven Research & Development Plag Genfamilie und Tumorigenese
WO1998020143A1 (en) 1996-11-05 1998-05-14 Abbott Laboratories Reagents and methods useful for detecting diseases of the lung
US5804384A (en) 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
US5837466A (en) 1996-12-16 1998-11-17 Vysis, Inc. Devices and methods for detecting nucleic acid analytes in samples
GB9626074D0 (en) 1996-12-16 1997-02-05 Cytocell Ltd Nucleic acids amplification assay
US20030096255A1 (en) 1997-02-19 2003-05-22 Felix Carolyn A. Methods and kits for analysis of chromosomal rearrangements associated with cancer
US6368791B1 (en) 1997-02-19 2002-04-09 The Children's Hospital Of Philadelphia Methods and kits for analysis of chromosomal rearrangements associated with leukemia
WO1998037231A2 (de) 1997-02-22 1998-08-27 Ruprecht-Karls-Universität Heidelberg Markierung von nukleinsäuren mit speziellen probengemischen
GB9704054D0 (en) 1997-02-27 1997-04-16 Univ Cambridge Tech Assay
US20020076695A1 (en) 1997-04-04 2002-06-20 Jeffrey S. Ross Methods for treating prostate cancer
US5994071A (en) 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
WO1998049274A1 (fr) 1997-04-29 1998-11-05 Appligene-Oncor Adn polymerase thermostable et inteines de l'espece thermococcus fumicolans
EP0878552A1 (de) * 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molekularer Nachweis von chromosomalen Veränderungen
US6686165B2 (en) 1997-05-20 2004-02-03 Erasmus Universiteit Rotterdam Recognition of tumor-specific gene products in cancer
WO1998053317A1 (en) 1997-05-20 1998-11-26 Erasmus Universiteit Rotterdam Recognition of tumour-specific gene products in cancer
US6352829B1 (en) 1997-05-21 2002-03-05 Clontech Laboratories, Inc. Methods of assaying differential expression
US5994076A (en) 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US6489455B2 (en) 1997-05-21 2002-12-03 Clontech Laboratories, Inc. Methods of assaying differential expression
AU8177398A (en) 1997-06-30 1999-01-19 Government of the United States of America, as represented by The Secretary of the Department of Health and Human Services and His Successors, The Spectral cloning-a new technical approach to the cloning and characterization ofevery chromosomal aberration in cancer samples
US6358682B1 (en) 1998-01-26 2002-03-19 Ventana Medical Systems, Inc. Method and kit for the prognostication of breast cancer
US6043039A (en) 1998-02-17 2000-03-28 Applied Spectral Imaging Method of and composite for in situ fluorescent hybridization
US6150110A (en) 1998-02-28 2000-11-21 The Brigham And Women's Hospital, Inc. HMGI(Y)-LAMA4* fusion oncogene, oncoprotein and methods of use
WO1999051961A2 (en) 1998-04-06 1999-10-14 Scalzi Martin Jane M Improved method for chromosome-specific staining
EP1078098A1 (de) * 1998-05-04 2001-02-28 Dako A/S Verfahren und sonden zur detektion chromosomaler aberrationen
US6037129A (en) 1998-05-28 2000-03-14 Medical University Of South Carolina Multi-marker RT-PCR panel for detecting metastatic breast cancer
JP2002517725A (ja) 1998-06-02 2002-06-18 ヴェンタナ メディカル システムズ インコーポレイテッド 顕微鏡スライド上で不安定試薬を合わせることによる生物学的検体を染色する方法
US5998175A (en) * 1998-07-24 1999-12-07 Lumigen, Inc. Methods of synthesizing and amplifying polynucleotides by ligation of multiple oligomers
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6414133B1 (en) 1998-10-13 2002-07-02 Ventana Medical Systems, Inc. Multiple fusion probes
EP1131470A4 (de) 1998-10-28 2004-11-10 Vysis Inc Zelluläre arrays sowie verfahren zur detektion und verwendung von markern für genetische störungen
DE19855180A1 (de) 1998-11-30 2000-05-31 Metabion Gmbh Ges Fuer Angewan in situ-Hybridisierungsverfahren
EP1415659B9 (de) 1999-01-25 2012-02-15 Biogen Idec MA Inc. Verwendung eines Antikörpers gegen wasserlöslich BAFF zur Krebsbehandlung
US9534254B1 (en) 1999-02-02 2017-01-03 Abbott Molecular Inc. Patient stratification for cancer therapy based on genomic DNA microarray analysis
US6251601B1 (en) 1999-02-02 2001-06-26 Vysis, Inc. Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays
AU3605600A (en) 1999-02-26 2000-09-14 Cellomics, Inc. A system for cell-based screening
US6174681B1 (en) 1999-03-05 2001-01-16 Mayo Foundation For Medical Education And Research Method and probe set for detecting cancer
WO2000060119A2 (en) 1999-04-01 2000-10-12 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for detecting cancer cells
WO2000062804A2 (en) 1999-04-15 2000-10-26 The Regents Of The University Of California Identification of sortase gene
US6689875B1 (en) 1999-06-09 2004-02-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Molecular characterization of chromosome translocation t(11;18)(q21;q21) and its correlation to carcinogenesis
US6284882B1 (en) 1999-06-10 2001-09-04 Abbott Laboratories Myostatin gene promoter and inhibition of activation thereof
DE19932890A1 (de) 1999-07-19 2001-02-01 Deutsches Krebsforsch DNA zum Nachweis von Veränderungen des Chromosoms 8
US20030021813A1 (en) 1999-08-04 2003-01-30 Chovan Linda E. Essential bacteria genes and genome scanning in Haemophilus influenzae for the identification of 'essential genes'
US6429303B1 (en) 1999-09-03 2002-08-06 Curagen Corporation Nucleic acids encoding members of the human B lymphocyte activation antigen B7 family and methods of using the same
FR2798673B1 (fr) 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
AU7844000A (en) 1999-09-30 2001-04-30 Henry M. Jackson Foundation Chromosome alterations in prostate cancer
US6770477B1 (en) 1999-10-06 2004-08-03 The Regents Of The University Of California Differentially expressed genes associated with HER-2/neu overexpression
WO2001029265A1 (en) 1999-10-15 2001-04-26 Ventana Medical Systems, Inc. Method of detecting single gene copies in-situ
DE60044203D1 (de) 1999-12-01 2010-05-27 Medical Res Council Gen das in schizophrenie defekt ist
DE10002803A1 (de) 2000-01-24 2001-08-02 Conbio Lizenzverwertungsgesell System zur internen qualitativen und quantitativen Validierung von Markerindices
WO2001066776A2 (de) 2000-03-10 2001-09-13 Institut für Molekulare Biotechnologie E.V. Neuartige l-form-bakterienstämme, verfahren zu deren herstellung sowie deren verwendung zur herstellung von genprodukten
AU781992B2 (en) 2000-04-04 2005-06-23 Medical Research Council Methods involving induced dimerisation by cellular components
WO2001095860A2 (en) 2000-06-14 2001-12-20 Case Western Reserve University Probes for chondrogenesis
CA2413986A1 (en) 2000-06-22 2001-12-27 Biogen, Inc. Gp354 nucleic acids and polypeptides
US6903187B1 (en) 2000-07-21 2005-06-07 Allergan, Inc. Leucine-based motif and clostridial neurotoxins
US20030039658A1 (en) 2000-08-18 2003-02-27 Mario Estable MCEF, a novel transcription factor
WO2002018601A2 (en) 2000-08-25 2002-03-07 Abbott Laboratories Essential bacteria genes and genome scanning in haemophilus influenzae for the identification of 'essential genes'
US6942970B2 (en) * 2000-09-14 2005-09-13 Zymed Laboratories, Inc. Identifying subjects suitable for topoisomerase II inhibitor treatment
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
AU2001296561A1 (en) 2000-10-04 2002-04-15 Apoxis, S.A. Tach: new tnf-receptor family nucleic acids and polypeptides
WO2002044411A1 (en) 2000-12-01 2002-06-06 Rosetta Inpharmatics, Inc. Use of profiling for detecting aneuploidy
US6391592B1 (en) 2000-12-14 2002-05-21 Affymetrix, Inc. Blocker-aided target amplification of nucleic acids
US7892730B2 (en) 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
EP1362124B1 (de) 2001-02-20 2011-07-06 Vysis, Inc. Verfahren und sonden für den nachweis von krebs
WO2002070747A1 (en) 2001-03-01 2002-09-12 Fujisawa Pharmaceutical Co., Ltd. Method of molecular diagnosis of chronic myelogenous leukemia
EP1379125A4 (de) 2001-03-22 2004-12-08 Abbott Gmbh & Co Kg Transgene tiere, die für interessierende gene spezifische antikörper exprimieren, sowie deren verwendung
AU2002259230A1 (en) 2001-05-14 2002-11-25 Cancer Genetics, Inc. Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (fish)
WO2003004645A1 (en) 2001-07-03 2003-01-16 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Diagnosis and treatment of cancer involving the notch pathway
EP1417297A4 (de) 2001-07-13 2007-08-22 Whitehead Biomedical Inst Leukämogene transkriptionsfaktoren
DE10154827A1 (de) 2001-11-08 2003-05-28 Deutsches Krebsforsch PNA-Konjugat zur Therapie der chronischen myeloischen Leukämie (CML)
WO2003021262A1 (fr) 2001-08-28 2003-03-13 Takeda Chemical Industries, Ltd. Procede de criblage
US20020182701A1 (en) 2001-08-30 2002-12-05 Saint Louis University Dominant negative variants of methionine aminopeptidase 2 (MetAP2) and clinical uses thereof
EP1432826B1 (de) 2001-09-24 2012-12-12 Life Technologies Corporation Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an zufällig verteillten repeat sequenzen in genomischen nukleinsäuren
US7335470B2 (en) 2001-10-12 2008-02-26 Perkinelmer, Las, Inc. Compilations of nucleic acids and arrays and methods of using them
AU2002349956A1 (en) 2001-10-17 2003-04-28 Digital Gene Technologies, Inc. Correlation of gene expression with chromosome abnormalities in ataxia telangiectasia tumorigenesis
FR2832154B1 (fr) 2001-11-09 2007-03-16 Centre Nat Rech Scient Oligonucleotides inhibiteurs et leur utilisation pour reprimer specifiquement un gene
WO2003044486A2 (en) 2001-11-20 2003-05-30 The Regents Of The University Of California Early leukemia diagnostics using microsphere arrays
WO2003048727A2 (en) 2001-12-03 2003-06-12 Invitrogen Corporation Identification of rearrangements in nucleic acid molecules
DE10163167A1 (de) 2001-12-21 2003-07-03 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren und Verwendung coryneformer Bakterien
DE10202419A1 (de) 2002-01-22 2003-08-07 Ribopharma Ag Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
FI113666B (fi) 2002-01-24 2004-05-31 Tapio Visakorpi Menetelmiä, joissa käytetään kromosomin 12 spesifisiä katkoskohtia ja/tai neuroninavigaattori 3 -geeniä ihon primaaristen T-solulymfoomien diagnosoimiseksi ja taudin etenemisen seuraamiseksi tai ennustamiseksi, sekä näiden katkoskohtien ja geenien käyttö
US20030143524A1 (en) 2002-01-31 2003-07-31 Boaz Lerner Method and system for determining the amount, distribution and conformation of genetic material in a cell
US20040029142A1 (en) 2002-02-11 2004-02-12 Schon Eric A. Concatenation-based nucleic acid detection compositions and methods
US20040110227A1 (en) 2002-03-19 2004-06-10 Erez Levanon Methods and systems for identifying putative fusion transcripts, polypeptides encoded therefrom and polynucleotide sequences related thereto and methods and kits utilizing same
EP1362929A3 (de) 2002-05-17 2004-05-19 Affymetrix, Inc. Methoden zur Genotypisierung
EP1369482A1 (de) 2002-06-07 2003-12-10 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Zielgene für die Diagnose und Behandlung von Krebs
EP1394715A1 (de) 2002-08-02 2004-03-03 Europroteome AG Expertensystem zum Voraussagen des klinischen Ergebnisses
EP1388589A1 (de) 2002-08-09 2004-02-11 Bayer HealthCare AG Genetische Polymorphismen die Wirkungen und Nebenwirkungen von Arzneimitteln sensitiv vorhersagen

Also Published As

Publication number Publication date
US20040180366A1 (en) 2004-09-16
US6730474B1 (en) 2004-05-04
DK0981650T3 (da) 2007-05-07
US20110020822A1 (en) 2011-01-27
EP0878552A1 (de) 1998-11-18
WO1998051817A1 (en) 1998-11-19
JP2009148291A (ja) 2009-07-09
CA2290628A1 (en) 1998-11-19
DE69836632D1 (de) 2007-01-25
CA2290628C (en) 2013-01-08
JP2001524832A (ja) 2001-12-04
US20060014199A1 (en) 2006-01-19
AU7676598A (en) 1998-12-08
US7034144B2 (en) 2006-04-25
DE69836632T2 (de) 2007-09-27

Similar Documents

Publication Publication Date Title
ATE348189T1 (de) Molekularer nachweis von chromosomalen veränderungen
Masters et al. Short tandem repeat profiling provides an international reference standard for human cell lines
Wells et al. DNA structure and gene regulation
Perry-O’Keefe et al. Peptide nucleic acid pre-gel hybridization: an alternative to Southern hybridization
Grimanelli et al. Mapping diplosporous apomixis in tetraploid Tripsacum: one gene or several genes?
Körkkö et al. Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing
Haapa et al. An efficient and accurate integration of mini-Mu transposons in vitro: a general methodology for functional genetic analysis and molecular biology applications
Amor et al. Human centromere repositioning “in progress”
Ananiev et al. Oat–maize chromosome addition lines: a new system for mapping the maize genome
Hanson et al. Evolution of interspersed repetitive elements in Gossypium (Malvaceae)
Barber Hybridization and the evolution of plants
ATE293706T1 (de) Spezies-übergreifendes anfärben von chromosomen
Sýkorová et al. Minisatellite telomeres occur in the family Alliaceae but are lost in Allium
Capanna et al. Chromosomes and speciation in Mus musculus domesticus
Achuthan et al. Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma
Marra et al. PCR amplification of the mating‐type idiomorphs in Cryphonectria parasitica
Dray et al. Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1)
Iannuzzi et al. Comparative FISH-mapping of the prion protein gene (PRNP) on cattle, river buffalo, sheep and goat chromosomes
Marchal et al. DNA methylation in mouse gametogenesis
Hegedüs et al. Separation of 1–23-kb complementary DNA strands by urea–agarose gel electrophoresis
Raudsepp et al. Comparative mapping in equids: the asine X chromosome is rearranged compared to horse and Hartmann’s mountain zebra
González et al. Polyploid speciation in Zea (Poaceae): cytogenetic insights
EP0747489A3 (de) Nucleinsäuresonden und Amplifizierungsoligonukleotide für Neisseria Spezies
ATE349541T1 (de) Gen-expressionskonstrukt von hap1 modifiziert für planzenzellen
Salah et al. Chromosomal instability associated with a novel BLM frameshift mutation (c. 1980‐1982delAA) in two unrelated Tunisian families with Bloom syndrome

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties