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IT1228288B - Composti ad attivita' antiserotoninica - Google Patents

Composti ad attivita' antiserotoninica

Info

Publication number
IT1228288B
IT1228288B IT8919029A IT1902989A IT1228288B IT 1228288 B IT1228288 B IT 1228288B IT 8919029 A IT8919029 A IT 8919029A IT 1902989 A IT1902989 A IT 1902989A IT 1228288 B IT1228288 B IT 1228288B
Authority
IT
Italy
Prior art keywords
compounds
serotonin activity
formula
serotonin
activity
Prior art date
Application number
IT8919029A
Other languages
English (en)
Other versions
IT8919029A0 (it
Inventor
Giancarlo Benelli
Angelo Carenzi
Dario Chiarino
Mario Fantucci
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Priority to IT8919029A priority Critical patent/IT1228288B/it
Publication of IT8919029A0 publication Critical patent/IT8919029A0/it
Priority to DE69009195T priority patent/DE69009195T2/de
Priority to EP90100162A priority patent/EP0378111B1/en
Priority to AT90100162T priority patent/ATE106403T1/de
Priority to JP2002405A priority patent/JPH0327379A/ja
Priority to US07/461,807 priority patent/US4988691A/en
Application granted granted Critical
Publication of IT1228288B publication Critical patent/IT1228288B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT8919029A 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica IT1228288B (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT8919029A IT1228288B (it) 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica
DE69009195T DE69009195T2 (de) 1989-01-09 1990-01-04 Isoxazol-Derivate mit Anti-Serotonin-Aktivität, deren Herstellungsverfahren und diese enthaltende Zusammensetzungen.
EP90100162A EP0378111B1 (en) 1989-01-09 1990-01-04 Isoxazole derivatives having anti-serotonin activity, their preparation process and compositions containing them
AT90100162T ATE106403T1 (de) 1989-01-09 1990-01-04 Isoxazol-derivate mit anti-serotonin-aktivität, deren herstellungsverfahren und diese enthaltende zusammensetzungen.
JP2002405A JPH0327379A (ja) 1989-01-09 1990-01-08 抗セロトニン活性を有する化合物
US07/461,807 US4988691A (en) 1989-01-09 1990-01-08 Isoxazole containing compounds exhibiting anti-serotonin activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8919029A IT1228288B (it) 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica

Publications (2)

Publication Number Publication Date
IT8919029A0 IT8919029A0 (it) 1989-01-09
IT1228288B true IT1228288B (it) 1991-06-07

Family

ID=11153958

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8919029A IT1228288B (it) 1989-01-09 1989-01-09 Composti ad attivita' antiserotoninica

Country Status (6)

Country Link
US (1) US4988691A (it)
EP (1) EP0378111B1 (it)
JP (1) JPH0327379A (it)
AT (1) ATE106403T1 (it)
DE (1) DE69009195T2 (it)
IT (1) IT1228288B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8923590D0 (en) * 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
CA2073005C (en) * 1990-09-06 1998-11-10 Alan Stobie Antimuscarinic bronchodilators
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
US6492385B2 (en) 2000-08-18 2002-12-10 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
WO2002017358A2 (en) * 2000-08-21 2002-02-28 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
US6599916B2 (en) 2000-08-21 2003-07-29 Pharmacia & Upjohn Company Quinuclidine-substituted heteroaryl moieties for treatment of disease
EP1311505A2 (en) * 2000-08-21 2003-05-21 PHARMACIA &amp; UPJOHN COMPANY Quinuclidine-substituted heteroaryl moieties for treatment of disease ( nicotinic acetylcholine receptor ligands )
WO2003018585A1 (en) 2001-08-24 2003-03-06 Pharmacia & Upjohn Company Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease
CA2466375A1 (en) * 2001-11-08 2003-05-15 Pharmacia & Upjohn Company Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
AU2003253686A1 (en) 2002-08-01 2004-02-23 Pharmacia & Upjohn Company Llc 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
DE10307903A1 (de) * 2003-02-18 2004-09-02 Karl Storz Gmbh & Co. Kg Verfahren zum Montieren eines Endoskopes
CA2564429A1 (en) 2004-05-14 2005-12-01 Irm Llc Compounds and compositions as ppar modulators
NL2000351C2 (nl) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogeen-modulatoren.
US10165772B2 (en) * 2008-08-21 2019-01-01 Édouard Kouassi Methods and compounds for increasing red blood cell survival
EP3193605A4 (en) * 2014-09-10 2018-04-18 Epizyme, Inc. Substituted piperidine compounds
WO2018039386A1 (en) 2016-08-23 2018-03-01 Ardelyx, Inc. Hormone receptor modulators for treating metabolic conditions and disorders
WO2018039384A1 (en) * 2016-08-23 2018-03-01 Ardelyx, Inc. Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as fxr activators
WO2019055808A1 (en) 2017-09-14 2019-03-21 Ardelyx, Inc. HORMONE RECEPTOR MODULATORS FOR THE TREATMENT OF MUTAGENIC AND FIBROTIC METABOLIC CONDITIONS AND DISORDERS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
EP0035285A3 (en) * 1979-08-17 1981-10-14 American Cyanamid Company Novel isoxazole carboxylic acid phenyl esters, pharmaceutical compositions containing certain of said esters, and process for preparing said esters
DE3405727A1 (de) * 1984-02-17 1985-08-22 Hoechst Ag, 6230 Frankfurt Isoxazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0201165B1 (en) * 1985-03-14 1994-07-20 Beecham Group Plc Medicaments for the treatment of emesis

Also Published As

Publication number Publication date
DE69009195T2 (de) 1994-10-06
DE69009195D1 (de) 1994-07-07
EP0378111A1 (en) 1990-07-18
ATE106403T1 (de) 1994-06-15
JPH0327379A (ja) 1991-02-05
US4988691A (en) 1991-01-29
IT8919029A0 (it) 1989-01-09
EP0378111B1 (en) 1994-06-01

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19931210