ATE288414T1 - Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolen - Google Patents
Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolenInfo
- Publication number
- ATE288414T1 ATE288414T1 AT99971797T AT99971797T ATE288414T1 AT E288414 T1 ATE288414 T1 AT E288414T1 AT 99971797 T AT99971797 T AT 99971797T AT 99971797 T AT99971797 T AT 99971797T AT E288414 T1 ATE288414 T1 AT E288414T1
- Authority
- AT
- Austria
- Prior art keywords
- alkylphenyl
- diols
- amino
- ethyl
- propane
- Prior art date
Links
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
- C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
- C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
- C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
- C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9824705.9A GB9824705D0 (en) | 1998-11-11 | 1998-11-11 | Organic compounds |
| GBGB9824706.7A GB9824706D0 (en) | 1998-11-11 | 1998-11-11 | Organic compounds |
| PCT/EP1999/008577 WO2000027798A1 (en) | 1998-11-11 | 1999-11-09 | Production of 2-amino-2-[2-(4-c2-20-alkyl-phenyl)ethyl]propane-1,3-diols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288414T1 true ATE288414T1 (de) | 2005-02-15 |
Family
ID=26314659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99971797T ATE288414T1 (de) | 1998-11-11 | 1999-11-09 | Herstellung von 2-amino-2(2-(4- alkylphenyl)äthyl)propan-1,3-diolen |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6605744B2 (de) |
| EP (2) | EP1457478B1 (de) |
| JP (1) | JP4503184B2 (de) |
| AT (1) | ATE288414T1 (de) |
| AU (1) | AU1161400A (de) |
| DE (1) | DE69923579T2 (de) |
| DK (1) | DK1129066T3 (de) |
| ES (2) | ES2237970T3 (de) |
| PT (2) | PT1129066E (de) |
| WO (1) | WO2000027798A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004507552A (ja) | 2000-08-31 | 2004-03-11 | メルク エンド カムパニー インコーポレーテッド | 免疫調節剤としてのリン酸誘導体 |
| IL162874A0 (en) | 2002-01-11 | 2005-11-20 | Sankyo Co | Amino alcohol and phosphonic acid derivatives and pharmaceutical compositions containing the same |
| AU2005215320B2 (en) | 2004-02-24 | 2008-04-17 | Sankyo Company, Limited | Amino alcohol compound |
| JP5214966B2 (ja) | 2004-07-30 | 2013-06-19 | ノバルティス アーゲー | ２−アミノ−１，３−プロパンジオール化合物およびその類似体の製剤 |
| WO2007022718A1 (fr) * | 2005-08-25 | 2007-03-01 | Chunde Liu | Alcools alkylaryle, leurs derives et leur procede de preparation |
| EP2217561A2 (de) * | 2007-11-02 | 2010-08-18 | Concert Pharmaceuticals, Inc. | Deuteriertes fingolimod |
| KR101641742B1 (ko) | 2008-03-19 | 2016-07-21 | 노파르티스 아게 | 2-아미노-2-[2-(4-ｃ3-ｃ21-알킬-페닐)에틸]프로판-1,3-디올의 제조 방법 |
| CA2743232C (en) * | 2008-11-11 | 2015-12-29 | Novartis Ag | Crystalline forms of fingolimod hcl |
| US8680146B2 (en) * | 2008-11-11 | 2014-03-25 | Novartis Ag | Organic compounds |
| JP5593164B2 (ja) * | 2010-06-29 | 2014-09-17 | 株式会社クラレ | 第１級アルキルハライドの製造方法 |
| WO2012041358A1 (en) | 2010-10-01 | 2012-04-05 | Synthon B.V. | Process for making fingolimod hydrochloride crystals |
| WO2012056458A2 (en) | 2010-10-28 | 2012-05-03 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of fingolimod |
| WO2012071524A1 (en) | 2010-11-24 | 2012-05-31 | Ratiopharm Gmbh | Arylsulfonate salts of fingolimod and processes for preparation thereof |
| EP2658840B1 (de) | 2010-12-28 | 2019-07-03 | Synthon BV | Verfahren zur herstellung von fingolimod-hydrochloridkristallen |
| EP2702034A4 (de) | 2011-04-29 | 2015-03-25 | Reddys Lab Ltd Dr | Herstellung von fingolimod und dessen salzen |
| CN103539683A (zh) * | 2012-07-17 | 2014-01-29 | 广东东阳光药业有限公司 | 治疗硬化病的药物的新晶型及其制备方法 |
| CN102796022B (zh) * | 2012-08-27 | 2015-03-25 | 南京华威医药科技开发有限公司 | 制备2-氨基-2-[2-(4-烷基苯基)乙基]-1,3-丙二醇盐酸盐的方法 |
| EP2945927A4 (de) * | 2013-01-17 | 2017-01-18 | Shilpa Medicare Limited | Herstellung von fingolimod und seinen salzen |
| AU2014224237B2 (en) * | 2013-03-05 | 2017-07-20 | Biocon Limited | A process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
| IN2013MU03696A (de) | 2013-11-25 | 2015-07-31 | Emcure Pharmaceuticals Ltd | |
| EP4173623A4 (de) | 2020-06-26 | 2024-07-24 | Osaka University | Therapeutisches mittel gegen arzneimittelinduzierte bradykardie und bradyarrhythmie |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE269856C (de) | ||||
| JPS5912643B2 (ja) | 1975-04-03 | 1984-03-24 | 和光純薬工業 （株） | フエネチルブロマイド類の製法 |
| JPS52108943A (en) | 1976-03-10 | 1977-09-12 | Teikoku Hormone Mfg Co Ltd | Alkyl phenyl ketone derivative |
| JPS5951932B2 (ja) | 1980-04-14 | 1984-12-17 | 東ソー株式会社 | ハロベンゼン類とオレフィン類との付加化合物の製造方法 |
| DD269856A1 (de) * | 1988-03-03 | 1989-07-12 | Univ Halle Wittenberg | Fluessig-kristalline amphiphile |
| EP0627406B1 (de) * | 1992-10-21 | 1998-10-28 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| IT1265101B1 (it) * | 1993-07-23 | 1996-10-30 | Erba Carlo Spa | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
| ATE211726T1 (de) | 1994-08-22 | 2002-01-15 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| GB9624038D0 (en) | 1996-11-19 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| WO1999001420A1 (en) | 1997-07-03 | 1999-01-14 | Taito Co., Ltd. | Process for the preparation of 2-aminomalonic acid derivatives and intermediates used in the process |
| JP4079505B2 (ja) | 1998-04-28 | 2008-04-23 | 田辺三菱製薬株式会社 | ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法 |
-
1999
- 1999-11-09 PT PT99971797T patent/PT1129066E/pt unknown
- 1999-11-09 EP EP04005240.9A patent/EP1457478B1/de not_active Expired - Lifetime
- 1999-11-09 ES ES99971797T patent/ES2237970T3/es not_active Expired - Lifetime
- 1999-11-09 DK DK99971797T patent/DK1129066T3/da active
- 1999-11-09 JP JP2000580978A patent/JP4503184B2/ja not_active Expired - Lifetime
- 1999-11-09 PT PT4005240T patent/PT1457478T/pt unknown
- 1999-11-09 AU AU11614/00A patent/AU1161400A/en not_active Abandoned
- 1999-11-09 DE DE69923579T patent/DE69923579T2/de not_active Expired - Lifetime
- 1999-11-09 AT AT99971797T patent/ATE288414T1/de active
- 1999-11-09 ES ES04005240.9T patent/ES2644413T3/es not_active Expired - Lifetime
- 1999-11-09 EP EP99971797A patent/EP1129066B1/de not_active Expired - Lifetime
- 1999-11-09 WO PCT/EP1999/008577 patent/WO2000027798A1/en not_active Ceased
-
2001
- 2001-05-08 US US09/850,851 patent/US6605744B2/en not_active Expired - Lifetime
-
2003
- 2003-06-18 US US10/464,294 patent/US7026522B2/en not_active Expired - Lifetime
-
2005
- 2005-11-29 US US11/288,549 patent/US20060079715A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1457478B1 (de) | 2017-07-19 |
| DK1129066T3 (da) | 2005-03-29 |
| US20060079715A1 (en) | 2006-04-13 |
| ES2644413T3 (es) | 2017-11-28 |
| EP1129066B1 (de) | 2005-02-02 |
| US6605744B2 (en) | 2003-08-12 |
| JP4503184B2 (ja) | 2010-07-14 |
| EP1457478A2 (de) | 2004-09-15 |
| DE69923579T2 (de) | 2006-01-12 |
| US20020072635A1 (en) | 2002-06-13 |
| ES2237970T3 (es) | 2005-08-01 |
| US7026522B2 (en) | 2006-04-11 |
| DE69923579D1 (de) | 2005-03-10 |
| WO2000027798A1 (en) | 2000-05-18 |
| EP1457478A3 (de) | 2004-12-22 |
| PT1457478T (pt) | 2017-10-26 |
| JP2002529441A (ja) | 2002-09-10 |
| EP1129066A1 (de) | 2001-09-05 |
| US20030229251A1 (en) | 2003-12-11 |
| AU1161400A (en) | 2000-05-29 |
| PT1129066E (pt) | 2005-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69923579D1 (de) | Herstellung von 2-amino-2(2-(4-alkylphenyl)äthyl)propan-1,3-diolen | |
| DE69514950D1 (de) | Herstellung von imitierten Kunstwerken | |
| DE69822186D1 (de) | Herstellung von mustern | |
| DE69833701D1 (de) | Maschine zur Herstellung von Beuteln | |
| NO307332B1 (no) | Rensing av 1,3-propandiol | |
| CY2004003I2 (el) | Παραγωγα 2-(2-αμινο-1, 6-διϋδρο-6-οξο-πυρινο-9-υλο)-μεθοδυ-1,3-προπανεδιολης | |
| NO962497L (no) | Fluoridert micellært kasein | |
| DE59806703D1 (de) | Herstellung von Formteilen | |
| ATE227723T1 (de) | Eintopfverfahren zur herstellung von 2- oxazolidinonderivate | |
| BR9611339A (pt) | Processo de preparação de 1,3-propanediol | |
| KR970706335A (ko) | 올리고아민 또는 폴리아민의 제조 방법(process eor producing oligoamines of polyamines) | |
| DE69624959D1 (de) | Herstellung von Pentafluorphenylverbindungen | |
| DE59912915D1 (de) | Herstellung von 4,4'-Diketo-carotinoiden | |
| DE60225595D1 (de) | Herstellung von siliziumverbrückten metallocenverbindungen | |
| DE59805764D1 (de) | Verfahren zur selektiven Herstellung von racemischen ansa-Metallocenkomplexen | |
| DE69502001D1 (de) | Herstellung von uranoxid | |
| IT1293777B1 (it) | Processo per la preparazione di tetraazamacrocicli | |
| IT1274675B (it) | Processo per la preparazione di 2- ammino-1,3-propandiolo | |
| ATE181047T1 (de) | Verfahren zur herstellung von 1,1,1-trifluorethan | |
| DE69702961D1 (de) | Herstellung von 1,1-difluorethan | |
| ATE238261T1 (de) | Verfahren zur herstellung von orthoestern | |
| IT1318650B1 (it) | 1,3-diossolani ad attivita' antitosse. | |
| DE59802280D1 (de) | Herstellung von Oxazolderivaten | |
| DE59812729D1 (de) | Verfahren zur Herstellung von 1,3-Dioxanverbindungen | |
| DE69802312D1 (de) | Verfahren zur Herstellung von 3,3',5,5'-Tetra-b-Butylbiphenol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1129066 Country of ref document: EP |