ATE114118T1 - System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren. - Google Patents
System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren.Info
- Publication number
- ATE114118T1 ATE114118T1 AT91911198T AT91911198T ATE114118T1 AT E114118 T1 ATE114118 T1 AT E114118T1 AT 91911198 T AT91911198 T AT 91911198T AT 91911198 T AT91911198 T AT 91911198T AT E114118 T1 ATE114118 T1 AT E114118T1
- Authority
- AT
- Austria
- Prior art keywords
- level
- current
- iontophoretic
- agent
- drug delivery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50217690A | 1990-03-30 | 1990-03-30 | |
| US07/671,306 US5207752A (en) | 1990-03-30 | 1991-03-21 | Iontophoretic drug delivery system with two-stage delivery profile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE114118T1 true ATE114118T1 (de) | 1994-12-15 |
Family
ID=27054046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91911198T ATE114118T1 (de) | 1990-03-30 | 1991-03-22 | System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5207752A (de) |
| EP (1) | EP0522092B1 (de) |
| JP (1) | JP3181289B2 (de) |
| KR (1) | KR0169084B1 (de) |
| AT (1) | ATE114118T1 (de) |
| AU (1) | AU638581B2 (de) |
| CA (1) | CA2079316C (de) |
| DE (1) | DE69105202T2 (de) |
| DK (1) | DK0522092T3 (de) |
| ES (1) | ES2067939T3 (de) |
| FI (1) | FI110066B (de) |
| GR (1) | GR3015116T3 (de) |
| NO (1) | NO308025B1 (de) |
| WO (1) | WO1991015258A1 (de) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5207752A (en) | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
| MX9206990A (es) | 1991-12-03 | 1993-06-01 | Alza Corp | Dispositivo iontoforetico de surtido y suministro de energia para el mismo. |
| US5505715A (en) * | 1994-02-25 | 1996-04-09 | Bristol-Myers Squibb Company | Iontophoretic transdermal delivery of deoxyspergualin compounds |
| US7027859B1 (en) | 1994-09-26 | 2006-04-11 | Alza Corporation | Electrotransport delivery device having improved safety and reduced abuse potential |
| US5697896A (en) * | 1994-12-08 | 1997-12-16 | Alza Corporation | Electrotransport delivery device |
| US5700481A (en) * | 1995-03-17 | 1997-12-23 | Takeda Chemical Industries, Ltd. | Transdermal drug delivery process |
| AU701737B2 (en) * | 1995-04-07 | 1999-02-04 | Novartis Ag | Iontophoretic transdermal system for the administration of at least two substances |
| IE960312A1 (en) * | 1995-06-02 | 1996-12-11 | Alza Corp | An electrotransport delivery device with voltage boosting¹circuit |
| AU710793B2 (en) * | 1995-06-07 | 1999-09-30 | Alza Corporation | Electrotransport agent delivery method and apparatus |
| US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
| WO1997014473A1 (en) * | 1995-10-18 | 1997-04-24 | Novartis Ag | Thermopile powered transdermal drug delivery device |
| US6718201B1 (en) * | 1996-06-07 | 2004-04-06 | Alza Corporation | Electrotransport agent delivery method and apparatus |
| AU3404197A (en) * | 1996-06-19 | 1998-01-07 | Becton Dickinson & Company | Iontophoretic delivery of cell adhesion inhibitors |
| US5857994A (en) * | 1996-10-01 | 1999-01-12 | Becton, Dickinson And Company | Awakenable iontophoretic/delivery device for reducing electrical sensation upon application thereof |
| FR2766093B1 (fr) * | 1997-07-15 | 1999-09-03 | Lhd Lab Hygiene Dietetique | Procede de commande d'un dispositif d'administration transdermique de medicament sous champ electrique |
| WO1999030773A1 (en) | 1997-12-16 | 1999-06-24 | Alza Corporation | Regulator with artificial load to maintain regulated delivery |
| PT1047475E (pt) | 1997-12-17 | 2007-04-30 | Alza Corp | Ionoforese com ajuste programado de corrente eléctrica |
| UA56256C2 (uk) | 1998-01-30 | 2003-05-15 | Ново Нордіск А/С | Шприц для ін'єкцій |
| BR0008123A (pt) | 1999-02-10 | 2001-11-13 | Gmp Drug Delivery Inc | Dispositivo baseado em emplastro para aumentar aliberação local de um agente de tratamento paradentro de tecidos alvo, e, processo de liberaçãode um agente de tratamento para dentro detecidos alvo de uma vesìcula corporal |
| US6471675B1 (en) | 1999-04-30 | 2002-10-29 | Medtronic, Inc. | Passive flow control devices for implantable pumps |
| TW453884B (en) | 1999-09-16 | 2001-09-11 | Novo Nordisk As | Dose setting limiter |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| AU2002225870B2 (en) | 2000-11-03 | 2006-09-21 | Intarcia Therapeutics, Inc. | Method for short-term and long-term drug dosimetry |
| US20030143197A1 (en) * | 2001-11-09 | 2003-07-31 | Moran S. Mark | Method for treating diseases with omega interferon |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
| EP2210634A1 (de) * | 2009-01-22 | 2010-07-28 | Sanofi-Aventis Deutschland GmbH | Dosierungseinstellungsmechanismus für Arzneimittelabgabevorrichtung |
| GB0308267D0 (en) * | 2003-04-10 | 2003-05-14 | Dca Design Int Ltd | Improvements in and relating to a pen-type injector |
| US7220778B2 (en) * | 2003-04-15 | 2007-05-22 | The General Hospital Corporation | Methods and devices for epithelial protection during photodynamic therapy |
| EP1595542A1 (de) * | 2004-03-26 | 2005-11-16 | Solvay Pharmaceuticals B.V. | Transdermale iontophoretische Verabreichung von Piperazinyl-2(3H)-benzoxazolon-Verbindungen |
| US7596407B2 (en) * | 2004-03-26 | 2009-09-29 | Solvay Pharmaceuticals, B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
| US7686786B2 (en) | 2004-10-21 | 2010-03-30 | Novo Nordiks A/S | Dial-down mechanism for wind-up pen |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006089768A1 (en) * | 2005-02-28 | 2006-08-31 | Novo Nordisk A/S | A dose setting mechanism for an injection device |
| US7856263B2 (en) * | 2005-04-22 | 2010-12-21 | Travanti Pharma Inc. | Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis |
| CN101163514B (zh) | 2005-04-24 | 2012-01-25 | 诺和诺德公司 | 注射装置 |
| EP1931416A2 (de) * | 2005-09-30 | 2008-06-18 | Tti Ellebeau, Inc. | Iontophoreseverfahren und gerät für die systemische abgabe von wirkstoffen |
| US20090221985A1 (en) * | 2005-10-19 | 2009-09-03 | Shmuel Bukshpan | System for iontophoretic transdermal delivery of polymeric agents and methods of use thereof |
| CN101400394B (zh) | 2006-03-10 | 2012-07-04 | 诺沃-诺迪斯克有限公司 | 具有传动部件的注射装置 |
| US8298194B2 (en) | 2006-03-10 | 2012-10-30 | Novo Nordisk A/S | Injection device and a method of changing a cartridge in the device |
| AU2012261753B2 (en) * | 2006-04-13 | 2015-03-05 | Teva Pharmaceuticals International Gmbh | Transdermal methods and systems for the delivery of anti-migraine compounds |
| WO2007120747A2 (en) * | 2006-04-13 | 2007-10-25 | Nupathe Inc. | Transdermal methods and systems for the delivery of anti-migraine compounds |
| US7954624B2 (en) * | 2006-05-16 | 2011-06-07 | Rorze Corporation | Shuttle type conveying device, microplate feeding and collecting device, pickup device for microplate, cassette for microplate, and shelf for containing microplate |
| ATE458517T1 (de) * | 2006-05-16 | 2010-03-15 | Novo Nordisk As | Getriebemechanismus für ein injektionsgerät |
| EP2023982B1 (de) | 2006-05-18 | 2012-07-11 | Novo Nordisk A/S | Injektionsgerät mit modus-arretiermittel |
| WO2007140416A2 (en) | 2006-05-30 | 2007-12-06 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
| JP5048773B2 (ja) | 2006-08-09 | 2012-10-17 | インターシア セラピューティクス,インコーポレイティド | 浸透圧式デリバリーシステム及びピストンアセンブリー |
| US8728059B2 (en) * | 2006-09-29 | 2014-05-20 | Covidien Lp | System and method for assuring validity of monitoring parameter in combination with a therapeutic device |
| ATE483487T1 (de) | 2007-02-05 | 2010-10-15 | Novo Nordisk As | Injektionsknopf |
| RU2468829C2 (ru) | 2007-03-23 | 2012-12-10 | Ново Нордиск А/С | Инъекционное устройство, содержащее стопорную гайку |
| NZ580447A (en) | 2007-04-23 | 2011-06-30 | Intarcia Therapeutics Inc | Suspension formulations of insulinotropic peptides and uses thereof |
| US8197844B2 (en) | 2007-06-08 | 2012-06-12 | Activatek, Inc. | Active electrode for transdermal medicament administration |
| EP2644228A1 (de) * | 2007-06-27 | 2013-10-02 | The General Hospital Corporation | Verfahren und Vorrichtung zur optischen Unterdrückung der photodynamischen Therapie |
| US20090043244A1 (en) * | 2007-08-08 | 2009-02-12 | Inan Omer T | Electrotransport Drug Delivery Device Adaptable to Skin Resistance Change |
| US8862223B2 (en) | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| US20090259176A1 (en) * | 2008-04-09 | 2009-10-15 | Los Gatos Research, Inc. | Transdermal patch system |
| US20090312689A1 (en) * | 2008-06-05 | 2009-12-17 | Alza Corporation | Adjustable Current Electrotransport Fentanyl Delivery Device |
| US8155737B2 (en) * | 2008-06-19 | 2012-04-10 | Nupathe, Inc. | Pharmacokinetics of iontophoretic sumatriptan administration |
| US8366600B2 (en) * | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
| NZ622157A (en) * | 2008-12-30 | 2015-10-30 | Teva Pharmaceuticals Int Gmbh | Electronic control of drug delivery system |
| US8961492B2 (en) | 2009-02-12 | 2015-02-24 | Incube Labs, Llc | System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation |
| US8190252B2 (en) | 2009-02-12 | 2012-05-29 | Incube Labs, Llc | Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes |
| US8903485B2 (en) * | 2009-08-06 | 2014-12-02 | Incube Labs, Llc | Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes |
| CA2770211A1 (en) * | 2009-08-10 | 2011-02-17 | Nupathe Inc. | Methods for iontophoretically treating nausea and migraine |
| RU2753280C2 (ru) | 2009-09-28 | 2021-08-12 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
| US20110087153A1 (en) * | 2009-10-13 | 2011-04-14 | Angelov Angel S | Transdermal Methods And Systems For The Delivery Of Rizatriptan |
| US8685038B2 (en) | 2009-12-07 | 2014-04-01 | Incube Labs, Llc | Iontophoretic apparatus and method for marking of the skin |
| WO2011100376A2 (en) | 2010-02-10 | 2011-08-18 | Incube Labs, Llc | Methods and architecture for power optimization of iontophoretic transdermal drug delivery |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| AU2012230701B2 (en) | 2011-03-24 | 2016-09-29 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents |
| US8428709B1 (en) | 2012-06-11 | 2013-04-23 | Incline Therapeutics, Inc. | Current control for electrotransport drug delivery |
| US8428708B1 (en) | 2012-05-21 | 2013-04-23 | Incline Therapeutics, Inc. | Self-test for analgesic product |
| WO2012154704A2 (en) | 2011-05-06 | 2012-11-15 | Incube Labs, Llc | System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings |
| JP6069351B2 (ja) | 2011-12-29 | 2017-02-01 | ノボ・ノルデイスク・エー/エス | ダイアルアップ/ダイアルダウン投与機構を有するねじりバネ式ねじ巻き自動注射器 |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| ES2968262T3 (es) | 2015-06-03 | 2024-05-08 | I2O Therapeutics Inc | Sistemas de colocación de implantes |
| CN109310743A (zh) | 2016-05-16 | 2019-02-05 | 因塔西亚制药公司 | 胰高血糖素受体选择性多肽及其使用方法 |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| MX2019008006A (es) | 2017-01-03 | 2019-08-29 | Intarcia Therapeutics Inc | Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco. |
| EP4360651A3 (de) | 2017-08-24 | 2024-07-17 | Novo Nordisk A/S | Glp-1-zusammensetzungen und verwendungen davon |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| TWI878456B (zh) | 2020-02-18 | 2025-04-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1組成物及其用途 |
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|---|---|---|---|---|
| US3163166A (en) * | 1961-04-28 | 1964-12-29 | Colgate Palmolive Co | Iontophoresis apparatus |
| US3618601A (en) * | 1969-10-16 | 1971-11-09 | Thatcher W Richardson | Iontophoresis unit |
| US3677268A (en) * | 1969-11-28 | 1972-07-18 | Sherwood Medical Ind Inc | Iontophoresis electrode |
| US3794910A (en) * | 1971-07-26 | 1974-02-26 | Sherwood Medical Ind Inc | Iontophoresis and conductivity analysis circuit |
| DE2339648C3 (de) * | 1973-08-04 | 1979-09-13 | Trebbin, Peter, 8833 Eichstaett | Anästhesiegerät zur Behandlung der Zähne |
| US4141359A (en) * | 1976-08-16 | 1979-02-27 | University Of Utah | Epidermal iontophoresis device |
| US4211222A (en) * | 1976-08-25 | 1980-07-08 | Robert Tapper | Iontophoretic burn-protection method |
| JPS5347192A (en) * | 1976-10-13 | 1978-04-27 | Matsushita Electric Industrial Co Ltd | Device for introducing fluorine ion to tooth |
| US4325367A (en) * | 1977-06-13 | 1982-04-20 | Robert Tapper | Iontophoretic treatment apparatus |
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| US4215696A (en) * | 1978-03-20 | 1980-08-05 | Graphic Controls Corporation | Biomedical electrode with pressurized skin contact |
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| US4301794A (en) * | 1978-10-18 | 1981-11-24 | Robert Tapper | Method for iontophoretic treatment |
| US4292968A (en) * | 1979-11-26 | 1981-10-06 | Sybron Corporation | Electric supply for ion therapy |
| AU546785B2 (en) * | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
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| AU577731B2 (en) * | 1983-04-15 | 1988-09-29 | Jack Kenneth Ibbott | Therapeutic method and appliance employing flat battery |
| US4557723A (en) * | 1983-08-18 | 1985-12-10 | Drug Delivery Systems Inc. | Applicator for the non-invasive transcutaneous delivery of medicament |
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| US4731926A (en) * | 1985-02-19 | 1988-03-22 | Drug Delivery Systems Inc. | Method of manufacturing disposable and/or replenishable transdermal drug applicators |
| US4708716A (en) * | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
| US4640689A (en) * | 1983-08-18 | 1987-02-03 | Drug Delivery Systems Inc. | Transdermal drug applicator and electrodes therefor |
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| US4851229A (en) * | 1983-12-01 | 1989-07-25 | Alza Corporation | Composition comprising a therapeutic agent and a modulating agent |
| KR880001759B1 (ko) * | 1985-06-10 | 1988-09-12 | 드럭 딜리버리 시스템스 인코오퍼레이티드 | 동전학적(動電學的) 의약투여 속도를 제어하는 시스템 및 방법 |
| US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
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| EP0313638A4 (de) * | 1987-05-15 | 1989-06-14 | Martin H Newman | Arzneimittelverabreichungssystem durch inophorese. |
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| US5207752A (en) | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
-
1991
- 1991-03-21 US US07/671,306 patent/US5207752A/en not_active Expired - Lifetime
- 1991-03-22 DE DE69105202T patent/DE69105202T2/de not_active Expired - Fee Related
- 1991-03-22 AU AU79915/91A patent/AU638581B2/en not_active Expired
- 1991-03-22 WO PCT/US1991/001941 patent/WO1991015258A1/en not_active Ceased
- 1991-03-22 CA CA002079316A patent/CA2079316C/en not_active Expired - Lifetime
- 1991-03-22 DK DK91911198.9T patent/DK0522092T3/da active
- 1991-03-22 JP JP51059091A patent/JP3181289B2/ja not_active Expired - Lifetime
- 1991-03-22 EP EP91911198A patent/EP0522092B1/de not_active Revoked
- 1991-03-22 KR KR1019920702381A patent/KR0169084B1/ko not_active Expired - Fee Related
- 1991-03-22 ES ES91911198T patent/ES2067939T3/es not_active Expired - Lifetime
- 1991-03-22 AT AT91911198T patent/ATE114118T1/de not_active IP Right Cessation
-
1992
- 1992-09-28 NO NO923769A patent/NO308025B1/no not_active IP Right Cessation
- 1992-09-28 FI FI924352A patent/FI110066B/fi active
-
1995
- 1995-02-20 GR GR950400340T patent/GR3015116T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR0169084B1 (ko) | 1999-01-15 |
| DE69105202D1 (de) | 1994-12-22 |
| JP3181289B2 (ja) | 2001-07-03 |
| FI924352L (fi) | 1992-09-28 |
| NO308025B1 (no) | 2000-07-10 |
| GR3015116T3 (en) | 1995-05-31 |
| US5207752A (en) | 1993-05-04 |
| FI110066B (fi) | 2002-11-29 |
| EP0522092A1 (de) | 1993-01-13 |
| EP0522092B1 (de) | 1994-11-17 |
| DE69105202T2 (de) | 1995-03-23 |
| WO1991015258A1 (en) | 1991-10-17 |
| CA2079316C (en) | 2002-01-01 |
| ES2067939T3 (es) | 1995-04-01 |
| FI924352A0 (fi) | 1992-09-28 |
| AU638581B2 (en) | 1993-07-01 |
| NO923769D0 (no) | 1992-09-28 |
| DK0522092T3 (da) | 1995-03-13 |
| JPH05505964A (ja) | 1993-09-02 |
| AU7991591A (en) | 1991-10-30 |
| CA2079316A1 (en) | 1991-10-01 |
| KR930700181A (ko) | 1993-03-13 |
| NO923769L (no) | 1992-11-30 |
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