AR241109A2 - Procedimiento para preparar compuestos relacionados con la espergualina que tiene un grupo fenileno y sus sales - Google Patents
Procedimiento para preparar compuestos relacionados con la espergualina que tiene un grupo fenileno y sus salesInfo
- Publication number
- AR241109A2 AR241109A2 AR29964585A AR29964585A AR241109A2 AR 241109 A2 AR241109 A2 AR 241109A2 AR 29964585 A AR29964585 A AR 29964585A AR 29964585 A AR29964585 A AR 29964585A AR 241109 A2 AR241109 A2 AR 241109A2
- Authority
- AR
- Argentina
- Prior art keywords
- group
- indicated
- benciloxicarbonilo
- corresponds
- case
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- GDVNLLJNADMLLR-BBRMVZONSA-N Spergualin Chemical compound NCCCNCCCCNC(=O)[C@H](O)NC(=O)C[C@@H](O)CCCCN=C(N)N GDVNLLJNADMLLR-BBRMVZONSA-N 0.000 title 1
- JBVZQDJNGFOSNX-UHFFFAOYSA-N Spergualin Natural products NCCCNCCCCNC(=O)C(O)NC(=O)CC(O)CCCCNC(=CN)N JBVZQDJNGFOSNX-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 title 1
- -1 BENZYLOXYCARBONYL Chemical class 0.000 abstract 4
- YJTKZCDBKVTVBY-UHFFFAOYSA-N 1,3-Diphenylbenzene Chemical group C1=CC=CC=C1C1=CC=CC(C=2C=CC=CC=2)=C1 YJTKZCDBKVTVBY-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical group CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA PRODUCIR COMPUESTOS RELACIONADOS CON LA ESPERGUALINA Y QUE INCLUYEN UN GRUPO FENILENO, DE FORMULA I, EN DONDE R1 ES UN GRUPO ALQUILENO QUE PUEDE ESTAR SUSTITUIDO POR UN GRUPO HIDROXIMETILO; X ES H O HALOGENO; M Y N SON 0 A 5 Y SALESDE LOS MISMOS, PORQUE SE ELIMINAN LOS GRUPOS PROTECTORES PRESENTES EN COMPUESTOS RELACIONADOS CON LA ESPERGUALINA PROTEGIDOS, REPRESENTADOS POR LA FORMULA II, EN DONDE N, M Y X TIENEN LOS VALORES INDICADOS; R1 ES UN GRUPO ALQUILINO R2 Y R3 SE SELECCIONANENTRE: T-BUTOXICARBONILO 1-METILETOXICARBONILO, CICLOPENTILOXICARBONILO, BENCILO, BENCILOXICARBONILO CON UN REACTIVO. A: H EN CUYO CASO SE SEPARAN LOS GRUPOS BENCILO, BENCILOXICARBONILO, BENCILOXICARBONILO SUSTITUIDO SEGUN SE HA INDICADO, QUE CORRESPONDEN A R'1, R2 Y R3 Y TAMBIEN EL GRUPO TRIFENILO QUE CORRESPONDE A R'1;B) CON HBR O HC1 EN CUYO CASO SE SEPARAN LOS GRUPOS T-BUTILO, BENCILO CARBONILO Y/O BENCILOXICARBONILO SUSTITUIDO SEGUN SE HA INDICADO QUE CORRESPONDE A R'1; R2 Y R3 Y TAMBIEN EL GRUPO 1MTILETOXICARBONILO, T-BUTOXICARBONILO, CICLOPENTILCARBONILO QUE CORRESPONDEN A R'1, R2 Y R3 Y EL GRUPO TRIFENILMETILO QUE CORRESPONDE A R'1; C): CON ACIDO TRIFLUORMETILSULFONICO EN CUYO CASO SE SEPARA EL GRUPO BENCILOXICARBONILO EVENTUALMENTE SUSTITUIDO SEGUN SE HA INDICADO QUE CORRESPONDE A R'1, R'2 Y R3 Y TAMBIEN EL GRUPO T-BUTOXICARBONILO QUE CORRESPONDE A R2 Y R3 Y EL GRUPO T-BUTILO QUE CORRESPONDE A R'1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59038615A JPS60185758A (ja) | 1984-03-02 | 1984-03-02 | フエニレン基を有するスパガリン関連化合物およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR241109A1 AR241109A1 (es) | 1991-11-15 |
| AR241109A2 true AR241109A2 (es) | 1991-11-15 |
Family
ID=12530153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR299645A AR241109A1 (es) | 1984-03-02 | 1985-03-01 | Procedimiento para preparar compuestos relacionados con la espergualina que tiene un grupo fenileno y sus sales |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4556735A (es) |
| EP (1) | EP0153720B1 (es) |
| JP (1) | JPS60185758A (es) |
| KR (1) | KR910004378B1 (es) |
| CN (1) | CN1004351B (es) |
| AR (1) | AR241109A1 (es) |
| AT (1) | ATE38512T1 (es) |
| AU (1) | AU575912B2 (es) |
| CA (1) | CA1242452A (es) |
| DE (1) | DE3566114D1 (es) |
| DK (1) | DK164855C (es) |
| ES (1) | ES8701720A1 (es) |
| GR (1) | GR850531B (es) |
| HU (1) | HU193085B (es) |
| IE (1) | IE57975B1 (es) |
| PT (1) | PT80038B (es) |
| ZA (1) | ZA851567B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61129119A (ja) * | 1984-11-13 | 1986-06-17 | Microbial Chem Res Found | 新規免疫抑制剤 |
| JPS61165322A (ja) * | 1985-01-14 | 1986-07-26 | Microbial Chem Res Found | スパガリン類の注射用凍結乾燥製剤 |
| JPH075538B2 (ja) * | 1985-08-27 | 1995-01-25 | 財団法人微生物化学研究会 | フエニレン基を有するスパガリン関連ニトリル化合物及びその製造法 |
| JPH0742268B2 (ja) * | 1985-08-27 | 1995-05-10 | 財団法人微生物化学研究会 | フエニレン基を有するスパガリン類縁化合物及びその製造法 |
| ATE64378T1 (de) * | 1986-04-04 | 1991-06-15 | Microbial Chem Res Found | Spergualinaehnliche verbindungen und ihr herstellungsverfahren. |
| JP2605762B2 (ja) * | 1986-12-10 | 1997-04-30 | 武田薬品工業株式会社 | δ−ハイドロキシ−β−リジン誘導体およびその製造法 |
| JPH0794424B2 (ja) * | 1987-09-30 | 1995-10-11 | 財団法人微生物化学研究会 | 新スパガリン関連化合物およびその製造法 |
| US5061787A (en) * | 1988-06-24 | 1991-10-29 | Nippon Kayaku Kabushiki Kaisha | Novel spergualin-related compounds and compositions |
| JPH0776204B2 (ja) * | 1988-07-01 | 1995-08-16 | 寳酒造株式会社 | スパガリン類の精製法 |
| US4990536A (en) * | 1989-04-03 | 1991-02-05 | Nippon Kayaku Kabushiki Kaisha | Immunopotentiator and spergualin-related compound therefor |
| US5162581A (en) * | 1989-05-29 | 1992-11-10 | Takaru Shuzo Co., Ltd. | Crystalline deoxyspergualin, process for its preparation and suppository containing the same |
| DE69104291T2 (de) * | 1990-07-20 | 1995-05-18 | Nippon Kayaku Kk | Spergulinähnliche Verbindungen und ihre Verwendung. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5748957A (en) * | 1980-09-08 | 1982-03-20 | Microbial Chem Res Found | Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient |
| JPS57185254A (en) * | 1981-05-11 | 1982-11-15 | Microbial Chem Res Found | Novel carcinostatic substances and their preparation |
| JPS5862152A (ja) * | 1981-10-08 | 1983-04-13 | Microbial Chem Res Found | Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法 |
-
1984
- 1984-03-02 JP JP59038615A patent/JPS60185758A/ja active Granted
-
1985
- 1985-02-25 DE DE8585102039T patent/DE3566114D1/de not_active Expired
- 1985-02-25 EP EP85102039A patent/EP0153720B1/en not_active Expired
- 1985-02-25 AT AT85102039T patent/ATE38512T1/de not_active IP Right Cessation
- 1985-02-25 HU HU85692A patent/HU193085B/hu not_active IP Right Cessation
- 1985-02-27 KR KR1019850001233A patent/KR910004378B1/ko not_active Expired
- 1985-02-27 US US06/706,312 patent/US4556735A/en not_active Expired - Fee Related
- 1985-02-28 CA CA000475473A patent/CA1242452A/en not_active Expired
- 1985-02-28 ES ES540784A patent/ES8701720A1/es not_active Expired
- 1985-03-01 GR GR850531A patent/GR850531B/el unknown
- 1985-03-01 AR AR299645A patent/AR241109A1/es active
- 1985-03-01 IE IE518/85A patent/IE57975B1/en not_active IP Right Cessation
- 1985-03-01 PT PT80038A patent/PT80038B/pt not_active IP Right Cessation
- 1985-03-01 AU AU39296/85A patent/AU575912B2/en not_active Ceased
- 1985-03-01 DK DK097485A patent/DK164855C/da not_active IP Right Cessation
- 1985-03-01 ZA ZA851567A patent/ZA851567B/xx unknown
- 1985-04-01 CN CN85101425.9A patent/CN1004351B/zh not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0254824B2 (es) | 1990-11-22 |
| ZA851567B (en) | 1986-01-29 |
| EP0153720B1 (en) | 1988-11-09 |
| US4556735A (en) | 1985-12-03 |
| IE850518L (en) | 1985-09-02 |
| HU193085B (en) | 1987-08-28 |
| KR910004378B1 (ko) | 1991-06-26 |
| AR241109A1 (es) | 1991-11-15 |
| AU3929685A (en) | 1985-09-05 |
| EP0153720A2 (en) | 1985-09-04 |
| JPS60185758A (ja) | 1985-09-21 |
| CN1004351B (zh) | 1989-05-31 |
| ES8701720A1 (es) | 1986-12-01 |
| PT80038B (pt) | 1987-09-18 |
| CN85101425A (zh) | 1987-01-17 |
| AU575912B2 (en) | 1988-08-11 |
| GR850531B (es) | 1985-07-01 |
| DK97485D0 (da) | 1985-03-01 |
| KR850006932A (ko) | 1985-10-25 |
| PT80038A (en) | 1985-04-01 |
| IE57975B1 (en) | 1993-06-02 |
| EP0153720A3 (en) | 1986-06-11 |
| DK164855B (da) | 1992-08-31 |
| HUT37117A (en) | 1985-11-28 |
| ES540784A0 (es) | 1986-12-01 |
| DK97485A (da) | 1985-09-03 |
| DE3566114D1 (en) | 1988-12-15 |
| CA1242452A (en) | 1988-09-27 |
| DK164855C (da) | 1993-01-11 |
| ATE38512T1 (de) | 1988-11-15 |
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