AR131189A2 - Proceso para producir derivado de diazabiciclooctano y su intermediario - Google Patents
Proceso para producir derivado de diazabiciclooctano y su intermediarioInfo
- Publication number
- AR131189A2 AR131189A2 ARP230103208A ARP230103208A AR131189A2 AR 131189 A2 AR131189 A2 AR 131189A2 AR P230103208 A ARP230103208 A AR P230103208A AR P230103208 A ARP230103208 A AR P230103208A AR 131189 A2 AR131189 A2 AR 131189A2
- Authority
- AR
- Argentina
- Prior art keywords
- producing
- iii
- formula
- compound
- diazabiciclooctone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Reivindicación 1: Un proceso para producir un compuesto intermediario de diazabiciclo[3.2.1]octano-2-carboxamida, en donde el intermediario tiene la fórmula (III) en donde OBn es benciloxi, y R¹ es 2,5-dioxopirrolidin-1-ilo, 1,3-dioxo-3a,4,7,7a-tetrahidro-1H-isoindol-2(3H)-ilo, 1,3-dioxohexahidro-1H-isoindol-2(3H)-ilo o 3,5-dioxo-4-azatriciclo[5.2.1.0²,⁶]dec-8-en-4-ilo, caracterizado porque comprende: (ii) permitir que un agente de carbonilación seleccionado de fosgeno, difosgeno y trifosgeno actúe sobre un compuesto de fórmula (II), en donde R² es hidrógeno y P es un grupo protector NH capaz de ser removido con ácido, seguido de: (iii) eliminación del grupo protector P, y tratamiento con una base para producir el compuesto de fórmula (III).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013197110 | 2013-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR131189A2 true AR131189A2 (es) | 2025-02-26 |
Family
ID=52743343
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140103525A AR097744A1 (es) | 2013-09-24 | 2014-09-24 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103209A AR131190A2 (es) | 2013-09-24 | 2023-11-28 | Derivado de diazabiciclooctano intermediario |
| ARP230103205A AR131186A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103208A AR131189A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103207A AR131188A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140103525A AR097744A1 (es) | 2013-09-24 | 2014-09-24 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| ARP230103209A AR131190A2 (es) | 2013-09-24 | 2023-11-28 | Derivado de diazabiciclooctano intermediario |
| ARP230103205A AR131186A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230103207A AR131188A2 (es) | 2013-09-24 | 2023-11-28 | Proceso para producir derivado de diazabiciclooctano y su intermediario |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10000491B2 (es) |
| EP (1) | EP3050883B1 (es) |
| JP (1) | JP6453222B2 (es) |
| KR (1) | KR102239725B1 (es) |
| CN (2) | CN107501264A (es) |
| AR (5) | AR097744A1 (es) |
| AU (1) | AU2014324302B2 (es) |
| BR (1) | BR112016006246B8 (es) |
| CA (1) | CA2924953C (es) |
| DK (1) | DK3050883T3 (es) |
| ES (1) | ES2793201T3 (es) |
| HK (1) | HK1244487A1 (es) |
| HU (1) | HUE049027T2 (es) |
| IL (1) | IL244740B (es) |
| MX (2) | MX372585B (es) |
| MY (2) | MY193210A (es) |
| NZ (1) | NZ718009A (es) |
| RU (1) | RU2719480C2 (es) |
| SG (1) | SG11201602256UA (es) |
| TW (1) | TWI644908B (es) |
| WO (1) | WO2015046207A1 (es) |
| ZA (1) | ZA201602053B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2857401B8 (en) * | 2012-05-30 | 2019-11-20 | Meiji Seika Pharma Co., Ltd. | NOVEL ß-LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME |
| US10000491B2 (en) | 2013-09-24 | 2018-06-19 | Meiji Seika Pharma Co., Ltd. | Process for producing diazabicyclooctane derivative and intermediate thereof |
| NZ719568A (en) * | 2013-10-08 | 2018-06-29 | Meiji Seika Pharma Co Ltd | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
| AU2015355970B2 (en) | 2014-12-05 | 2020-05-21 | Meiji Seika Pharma Co., Ltd. | Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation |
| CA2944306C (en) | 2015-10-30 | 2023-11-14 | The Toronto-Dominion Bank | Validating encrypted data from a multi-layer token |
| US11216808B2 (en) | 2015-11-04 | 2022-01-04 | The Toronto-Dominion Bank | Token-based system for excising data from databases |
| JP2020011901A (ja) * | 2016-10-20 | 2020-01-23 | 協和キリン株式会社 | ピロリジン化合物の製造方法 |
| CN106699756B (zh) * | 2016-12-30 | 2019-10-29 | 淄博鑫泉医药技术服务有限公司 | β内酰胺酶抑制剂阿维巴坦的合成方法 |
| CN111447924A (zh) | 2017-09-27 | 2020-07-24 | 费多拉制药公司 | 二氮杂二环辛烷衍生物的药物形式及其制备方法 |
| WO2019064071A1 (en) | 2017-09-27 | 2019-04-04 | F. Hoffmann-La Roche Ag | CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| WO2019064066A1 (en) | 2017-09-27 | 2019-04-04 | F. Hoffmann-La Roche Ag | PHARMACEUTICAL FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
| CN109678856B (zh) * | 2017-10-18 | 2020-09-25 | 新发药业有限公司 | 一种阿维巴坦中间体的制备方法 |
| CN111373033A (zh) | 2017-11-23 | 2020-07-03 | 豪夫迈·罗氏有限公司 | 脯氨酸羟化酶及其相关用途、方法和产品 |
| US11957690B2 (en) | 2018-07-16 | 2024-04-16 | Brown University | Chromogenic beta-lactamase substrate |
| CN119707784A (zh) * | 2018-09-21 | 2025-03-28 | 株式会社Api | 氨基酸衍生物的制备方法 |
| US12195755B2 (en) | 2019-05-20 | 2025-01-14 | Brown University | Placental lipid bilayer for cell-free molecular interaction studies |
| US11751775B2 (en) | 2019-08-30 | 2023-09-12 | DePuy Synthes Products, Inc. | Electrical device for monitoring, prevention, and treatment of implant infections |
| US12509559B2 (en) | 2019-10-28 | 2025-12-30 | Brown University | Bacterial beta-lactamase responsive hydrogels |
| CN121021508A (zh) * | 2025-10-29 | 2025-11-28 | 北京耀诚惠仁科技有限公司 | β-内酰胺酶抑制剂中间体共晶或盐及其制备方法和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS5038509B1 (es) | 1970-10-21 | 1975-12-10 | ||
| JPS538509A (en) | 1976-07-13 | 1978-01-26 | Toshiba Corp | Impedance matching system for data transmission circuit |
| JPS6019759B2 (ja) | 1977-11-24 | 1985-05-17 | イ−ライ・リリ−・アンド・カンパニ− | 非経口投予用１１１１５１５２１３９１９９東京都中央区京橋２丁目３番１３号 |
| GB1589317A (en) | 1977-11-24 | 1981-05-13 | Lilly Co Eli | Freeze drying cephalothin sodium |
| JPS60255723A (ja) | 1984-05-31 | 1985-12-17 | Ono Pharmaceut Co Ltd | メシル酸ガベキサートの結晶性凍結乾燥製剤及びその製造方法 |
| JPH07117533B2 (ja) | 1985-08-28 | 1995-12-18 | 株式会社生体科学研究所 | トランスフエリンおよびその用途 |
| US20030220521A1 (en) | 1989-07-27 | 2003-11-27 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
| TW264475B (es) | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
| ATE177099T1 (de) * | 1993-12-29 | 1999-03-15 | Pfizer | Diazabicyclische neurokinin antagonisten |
| JP2843444B2 (ja) | 1994-05-02 | 1999-01-06 | 塩野義製薬株式会社 | ピロリジルチオカルバペネム誘導体の結晶，該結晶を含む凍結乾燥製剤，およびその製造方法 |
| CN1048248C (zh) | 1994-05-02 | 2000-01-12 | 盐野义制药株式会社 | 吡咯烷基硫基碳代青霉烯衍生物的结晶、含该结晶的冷冻干燥制剂及其制造方法 |
| FR2812635B1 (fr) | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| FR2815420B1 (fr) | 2000-10-16 | 2003-05-16 | Cit Alcatel | Compensation de la dispersion chromatique dans un systeme de transmission a fibre optique, et fibre de compensation |
| FR2825705B1 (fr) | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
| FR2835186B1 (fr) | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| FR2921060B1 (fr) | 2007-09-14 | 2012-06-15 | Novexel | Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires |
| ES2533826T3 (es) | 2008-01-18 | 2015-04-15 | Merck Sharp & Dohme Corp. | Inhibidores de beta-lactamasa |
| FR2930553B1 (fr) | 2008-04-29 | 2010-05-21 | Novexel | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases |
| FR2936798B1 (fr) | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
| WO2010126820A2 (en) | 2009-04-30 | 2010-11-04 | Merck Sharp & Dohme Corp. | Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids |
| FR2951171A1 (fr) | 2009-10-09 | 2011-04-15 | Novexel | Nouveau sel de sodium d'un compose azabicyclique sous forme enantiomere cristallisee et nouvelles formes polymorphes et pseudopolymorphes ainsi que leur preparation |
| JP2012122603A (ja) | 2010-11-15 | 2012-06-28 | Nifco Inc | コネクタ装置 |
| SI2657234T1 (sl) * | 2010-12-22 | 2017-06-30 | Meiji Seika Pharma Co., Ltd. | Derivat optično-aktivnega diazabiciklooktana in metoda za njegovo izdelavo |
| US8772490B2 (en) | 2010-12-22 | 2014-07-08 | Meiji Seika Pharma Co., Ltd. | Optically active diazabicyclooctane derivatives and process for preparing the same |
| JP6023800B2 (ja) | 2011-06-17 | 2016-11-09 | アストラゼネカ アクチボラグ | ｔｒａｎｓ−７−オキソ−６−（スルホオキシ）−１，６−ジアザビシクロ［３，２，１］オクタン−２−カルボキサミドとその塩が含まれる複素環式化合物を製造するための方法 |
| EP2748165B1 (en) | 2011-08-27 | 2016-11-02 | Wockhardt Limited | 1,6-diazabicyclo[3,2,1]octan-7-one derivatives and their use in the treatment of bacterial infections. |
| PT2872510T (pt) | 2011-08-30 | 2017-03-01 | Wockhardt Ltd | Derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infeções bacterianas |
| AU2012310136B2 (en) | 2011-09-13 | 2016-07-07 | Wockhardt Limited | Nitrogen containing compounds and their use |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| EP2857401B8 (en) | 2012-05-30 | 2019-11-20 | Meiji Seika Pharma Co., Ltd. | NOVEL ß-LACTAMASE INHIBITOR AND METHOD FOR PRODUCING SAME |
| US10000491B2 (en) | 2013-09-24 | 2018-06-19 | Meiji Seika Pharma Co., Ltd. | Process for producing diazabicyclooctane derivative and intermediate thereof |
| NZ719568A (en) | 2013-10-08 | 2018-06-29 | Meiji Seika Pharma Co Ltd | Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative |
-
2014
- 2014-09-24 US US15/023,976 patent/US10000491B2/en active Active
- 2014-09-24 WO PCT/JP2014/075203 patent/WO2015046207A1/ja not_active Ceased
- 2014-09-24 EP EP14847854.8A patent/EP3050883B1/en active Active
- 2014-09-24 ES ES14847854T patent/ES2793201T3/es active Active
- 2014-09-24 DK DK14847854.8T patent/DK3050883T3/da active
- 2014-09-24 BR BR112016006246A patent/BR112016006246B8/pt active IP Right Grant
- 2014-09-24 MY MYPI2019004461A patent/MY193210A/en unknown
- 2014-09-24 CA CA2924953A patent/CA2924953C/en active Active
- 2014-09-24 SG SG11201602256UA patent/SG11201602256UA/en unknown
- 2014-09-24 TW TW103132937A patent/TWI644908B/zh active
- 2014-09-24 MX MX2019006550A patent/MX372585B/es unknown
- 2014-09-24 MY MYPI2016700980A patent/MY176278A/en unknown
- 2014-09-24 MX MX2016003867A patent/MX367578B/es active IP Right Grant
- 2014-09-24 NZ NZ718009A patent/NZ718009A/en unknown
- 2014-09-24 HU HUE14847854A patent/HUE049027T2/hu unknown
- 2014-09-24 AU AU2014324302A patent/AU2014324302B2/en active Active
- 2014-09-24 JP JP2015539238A patent/JP6453222B2/ja active Active
- 2014-09-24 CN CN201710665418.8A patent/CN107501264A/zh active Pending
- 2014-09-24 RU RU2016115767A patent/RU2719480C2/ru active
- 2014-09-24 CN CN201480052097.9A patent/CN105555787B/zh active Active
- 2014-09-24 AR ARP140103525A patent/AR097744A1/es active IP Right Grant
- 2014-09-24 KR KR1020167009769A patent/KR102239725B1/ko active Active
-
2016
- 2016-03-23 IL IL244740A patent/IL244740B/en active IP Right Grant
- 2016-03-29 ZA ZA2016/02053A patent/ZA201602053B/en unknown
- 2016-06-24 HK HK18103950.2A patent/HK1244487A1/zh unknown
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2017
- 2017-06-05 US US15/613,620 patent/US10000492B2/en active Active
-
2023
- 2023-11-28 AR ARP230103209A patent/AR131190A2/es unknown
- 2023-11-28 AR ARP230103205A patent/AR131186A2/es unknown
- 2023-11-28 AR ARP230103208A patent/AR131189A2/es unknown
- 2023-11-28 AR ARP230103207A patent/AR131188A2/es unknown
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