AR130836A1 - Nuevos compuestos heterocíclicos - Google Patents
Nuevos compuestos heterocíclicosInfo
- Publication number
- AR130836A1 AR130836A1 ARP230102822A ARP230102822A AR130836A1 AR 130836 A1 AR130836 A1 AR 130836A1 AR P230102822 A ARP230102822 A AR P230102822A AR P230102822 A ARP230102822 A AR P230102822A AR 130836 A1 AR130836 A1 AR 130836A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- formula
- cycloalkyl
- haloalkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable de este, en donde: W y Z se seleccionan cada uno independientemente de CH₂ y CH₂CH₂; Y se selecciona de CH y N; U se selecciona de CH y N; V se selecciona de NH, O y S; X se selecciona de NH y O; L se selecciona de CH₂ y O; A se selecciona de: los restos del grupo de fórmulas (2); B se selecciona de: un resto de fórmula (3) y un heteroarilo bicíclico fusionado de 9 miembros que comprende 1 - 3 heteroátomos seleccionados de N, O y S, en donde los átomos del anillo restantes son carbono; R¹ se selecciona de hidrógeno, halógeno, ciano, alquil C₁-C₆, alcoxi C₁-C₆, haloalquil C₁-C₆, haloalcoxi C₁-C₆, cicloalquil C₃-C₁₀, halocicloalquil C₃-C₁₀, cicloalquil C₃-C₁₀-alquil C₁-C₆, haloalquil C₁-C₆-cicloalquil C₃-C₁₀, aril C₆-C₁₄, sulfamoílo, un grupo de fórmula (4), y (alquil C₁-C₆)₂PO-; R¹ᵃ se selecciona de alquil C₁-C₆ y haloalquil C₁-C₆; R² se selecciona de hidrógeno, halógeno, ciano, alquil C₁-C₆, alcoxi C₁-C₆, haloalquil C₁-C₆ y haloalcoxi C₁-C₆; y R³ se selecciona de cicloalquil C₃-C₁₀, hidroxicicloalquil C₃-C₁₀, aminocicloalquil C₃-C₁₀, halocicloalquil C₃-C₁₀, alquil C₁-C₆, haloalquil C₁-C₆, alcoxi C₁-C₆ y haloalcoxi C₁-C₆. Reivindicación 32: Un método para el tratamiento o la profilaxis de enfermedades o trastornos que están asociados con la monoacilglicerol lipasa en un mamífero, en donde el método comprende administrar a dicho mamífero una cantidad terapéuticamente eficaz de un compuesto de fórmula (1) de acuerdo con cualquiera de las reivindicaciones 1 a 27, o de una sal farmacéuticamente aceptable de este, o de una composición farmacéutica de acuerdo con la reivindicación 31.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22203172 | 2022-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR130836A1 true AR130836A1 (es) | 2025-01-22 |
Family
ID=83994880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230102822A AR130836A1 (es) | 2022-10-24 | 2023-10-23 | Nuevos compuestos heterocíclicos |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP4608823A1 (es) |
| JP (1) | JP2025536386A (es) |
| KR (1) | KR20250092179A (es) |
| CN (1) | CN120051466A (es) |
| AR (1) | AR130836A1 (es) |
| AU (1) | AU2023369999A1 (es) |
| CA (1) | CA3264503A1 (es) |
| TW (1) | TW202428574A (es) |
| WO (1) | WO2024088922A1 (es) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3883936T3 (pl) * | 2018-11-22 | 2023-11-20 | F. Hoffmann-La Roche Ag | Nowe związki heterocykliczne |
| CN114401968A (zh) * | 2019-09-24 | 2022-04-26 | 豪夫迈·罗氏有限公司 | 新颖杂环单酰基甘油脂肪酶(magl)抑制剂 |
-
2023
- 2023-10-23 AR ARP230102822A patent/AR130836A1/es unknown
- 2023-10-23 JP JP2025523080A patent/JP2025536386A/ja active Pending
- 2023-10-23 AU AU2023369999A patent/AU2023369999A1/en active Pending
- 2023-10-23 CN CN202380073401.7A patent/CN120051466A/zh active Pending
- 2023-10-23 KR KR1020257011543A patent/KR20250092179A/ko active Pending
- 2023-10-23 WO PCT/EP2023/079392 patent/WO2024088922A1/en not_active Ceased
- 2023-10-23 TW TW112140414A patent/TW202428574A/zh unknown
- 2023-10-23 CA CA3264503A patent/CA3264503A1/en active Pending
- 2023-10-23 EP EP23797713.7A patent/EP4608823A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3264503A1 (en) | 2024-05-02 |
| WO2024088922A1 (en) | 2024-05-02 |
| KR20250092179A (ko) | 2025-06-23 |
| JP2025536386A (ja) | 2025-11-05 |
| AU2023369999A1 (en) | 2025-01-23 |
| EP4608823A1 (en) | 2025-09-03 |
| TW202428574A (zh) | 2024-07-16 |
| CN120051466A (zh) | 2025-05-27 |
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