AR130477A1 - C5AR1 ANTAGONISTS AND THEIR USES - Google Patents
C5AR1 ANTAGONISTS AND THEIR USESInfo
- Publication number
- AR130477A1 AR130477A1 ARP230102436A ARP230102436A AR130477A1 AR 130477 A1 AR130477 A1 AR 130477A1 AR P230102436 A ARP230102436 A AR P230102436A AR P230102436 A ARP230102436 A AR P230102436A AR 130477 A1 AR130477 A1 AR 130477A1
- Authority
- AR
- Argentina
- Prior art keywords
- c5ar1
- compounds
- antagonists
- receptor
- antagonize
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En la presente memoria se proporcionan compuestos que modulan (por ejemplo, antagonizan) el receptor para el componente 5a del complemento 1 (C5aR1), un receptor acoplado a la proteína G para C5a que se asocia con trastornos autoinmunitarios, inflamatorios y neurodegenerativos. Además, se proporcionan composiciones farmacéuticas y kits que comprenden los compuestos y los métodos para tratar enfermedades y trastornos relacionados con el C5aR1 con los compuestos en un sujeto, mediante la administración de los compuestos y/o las composiciones que se describen en la presente memoria. Un compuesto con la fórmula (1).Provided herein are compounds that modulate (e.g., antagonize) the complement component 5a receptor 1 (C5aR1), a G protein-coupled receptor for C5a that is associated with autoimmune, inflammatory, and neurodegenerative disorders. Furthermore, provided are pharmaceutical compositions and kits comprising the compounds and methods for treating diseases and disorders related to C5aR1 with the compounds in a subject, by administering the compounds and/or compositions described herein. A compound of formula (1).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263406501P | 2022-09-14 | 2022-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR130477A1 true AR130477A1 (en) | 2024-12-11 |
Family
ID=90275968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP230102436A AR130477A1 (en) | 2022-09-14 | 2023-09-13 | C5AR1 ANTAGONISTS AND THEIR USES |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4587014A2 (en) |
| AR (1) | AR130477A1 (en) |
| TW (1) | TW202425978A (en) |
| WO (1) | WO2024059096A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025176748A1 (en) * | 2024-02-22 | 2025-08-28 | F. Hoffmann-La Roche Ag | Condensed pyrazines or pyrimidines als trem2 agoonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100828982B1 (en) * | 2000-12-28 | 2008-05-14 | 시오노기세이야쿠가부시키가이샤 | Pyridone derivative having affinity for cannabinoid 2-type receptor |
| WO2017014201A1 (en) * | 2015-07-17 | 2017-01-26 | 富士フイルム株式会社 | Nitrogen-containing heterocyclic compound |
| KR102476818B1 (en) * | 2019-05-31 | 2022-12-13 | 주식회사 종근당 | 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same |
-
2023
- 2023-09-13 AR ARP230102436A patent/AR130477A1/en unknown
- 2023-09-13 EP EP23866136.7A patent/EP4587014A2/en active Pending
- 2023-09-13 TW TW112134871A patent/TW202425978A/en unknown
- 2023-09-13 WO PCT/US2023/032581 patent/WO2024059096A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024059096A3 (en) | 2024-04-25 |
| TW202425978A (en) | 2024-07-01 |
| EP4587014A2 (en) | 2025-07-23 |
| WO2024059096A2 (en) | 2024-03-21 |
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