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AR123701A1 - Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2 - Google Patents

Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2

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Publication number
AR123701A1
AR123701A1 ARP210102767A ARP210102767A AR123701A1 AR 123701 A1 AR123701 A1 AR 123701A1 AR P210102767 A ARP210102767 A AR P210102767A AR P210102767 A ARP210102767 A AR P210102767A AR 123701 A1 AR123701 A1 AR 123701A1
Authority
AR
Argentina
Prior art keywords
alkyl
independently selected
halogen
substituted
unsubstituted
Prior art date
Application number
ARP210102767A
Other languages
English (en)
Inventor
Yeon Lim
- Bao Jianming Hee
James P Roane
Original Assignee
Merck Sharp & Dohme
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Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR123701A1 publication Critical patent/AR123701A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se inventan compuestos de fórmula [1] y sales farmacéuticamente aceptables, ésteres y profármacos de los mismos, que son inhibidores de DGAT2. También se proporcionan métodos de preparación de compuestos de fórmula [1], composiciones farmacéuticas que comprenden compuestos de fórmula [1] y métodos de uso de estos compuestos para tratar la esteatosis hepática, esteatohepatitis no alcohólica (EHNA), fibrosis, diabetes mellitus de tipo 2, obesidad, hiperlipidemia, hipercolesterolemia, ateroesclerosis, declive cognitivo, demencia, enfermedades cardiorrenales tales como enfermedades renales crónicas e insuficiencia cardíaca y enfermedades y afecciones relacionadas, que comprenden administrar un compuesto de fórmula [1] a un paciente que lo necesita. Reivindicación 1: Un compuesto de fórmula [1], o una sal farmacéuticamente aceptable del mismo en donde: X, Y y Z se seleccionan independientemente entre N o C(R⁵); R¹ es (1) fenilo sin sustituir o sustituido con 1, 2 ó 3 R⁶, (2) heteroarilo de 5 ó 6 miembros que contiene 1, 2, 3 ó 4 heteroátomos seleccionados independientemente entre N, O y S, en donde el heteroarilo está sin sustituir o sustituido con 1, 2 ó 3 R⁶, o (3) heteroarilo condensado de 8 a 10 miembros que contiene 1, 2, 3 heteroátomos seleccionados independientemente entre N, O y S, en donde el heteroarilo está sin sustituir o sustituido con 1, 2 ó 3 R⁶; R²ᵃ y R²ᵇ se seleccionan independientemente entre (1) hidrógeno, (2) halógeno, (3) hidroxi, (4) alquilo (C₁₋₆), (5) haloalquilo (C₁₋₆), (6) R²ᵃ y R²ᵇ se unen para formar espirocicloalquilo (C₃₋₈) sin sustituir u opcionalmente monosustituido, disustituido con alquilo C₁₋₃, halógeno, OH, o (7) R²ᵃ y R²ᵇ se unen para formar espiro heterociclilo de 4 a 8 miembros que contiene 1 ó 2 heteroátomos seleccionados independientemente entre N, O y S en donde el heterociclilo está sin sustituir o sustituido con 1, 2 ó 3 R⁷; R³ es (1) heterociclilo de 4 a 7 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre N, O y S, (2) heteroarilo de 5 ó 6 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre N, O y S, (3) -alquil (C₁₋₆)-heteroarilo, en donde el heteroarilo es un heteroarilo de 5 ó 6 miembros que contiene 1, 2 ó 3 heteroátomos seleccionados independientemente entre N, O y S, (4) -alquil (C₁₋₆)-arilo, (5) -alquil (C₁₋₆)-heterociclilo, en donde el heterociclilo es un anillo de 3 a 6 miembros que contiene 1 ó 2 heteroátomos seleccionados independientemente entre N, O y S, (6) -alquilo (C₁₋₆), (7) -cicloalquilo (C₃₋₆), (8) -hidroxialquilo (C₁₋₆), (9) -alquil (C₁₋₆)-S(O)₂-NR⁸ᵃR⁸ᵇ, o (10) -alquil (C₁₋₆)-S(O)₂-alquilo (C₁₋₃), en donde cada cicloalquilo o heterociclilo está sin sustituir o sustituido con 1, 2 ó 3 R⁹, y en donde cada alquilo, arilo o heteroarilo está sin sustituir o sustituido con 1, 2 ó 3 R¹⁰; R⁴ es (1) hidrógeno, (2) alquilo (C₁₋₃), o R³ y R⁴ se combinan junto con el átomo de nitrógeno al que están unidos para formar un anillo heterociclilo mono- o bicíclico que contiene 1 ó 2 heteroátomos seleccionados independientemente entre N, O y S, en donde el anillo heterociclilo está sin sustituir o sustituido con 1, 2 ó 3 R¹¹; cuando está presente, cada R⁵ se selecciona entre (1) hidrógeno, (2) alquilo (C₁₋₃), (3) haloalquilo (C₁₋₃), (4) ciano, o (5) halógeno; cuando está presente, cada R⁶ se selecciona independientemente entre (1) ciano, (2) halógeno, (3) -O-alquilo C₁₋₆, (4) cicloalquilo (C₃₋₆), opcionalmente sustituido con halógeno u OH, (5) -(C=O)NH₂, (6) cicloalquiloxi (C₃₋₆) en donde el cicloalquilo está opcionalmente sustituido con halógeno u OH, (7) hidroxi, (8) -NR¹¹R¹¹, (9) -NH(C=O)alquilo (C₁₋₆), (10) amina cíclica (C₂₋₆), opcionalmente sustituida con uno o dos sustituyentes halógeno, (11) haloalquil (C₁₋₆)-, (12) O-haloalquil (C₁₋₆)- opcionalmente sustituido con OH, (13) -O-alquil (C₀₋₃)-cicloalquilo (C₃₋₆) opcionalmente sustituido con uno o dos halógeno, (14) -SO₂alquilo (C₁₋₆), (15) -SO₂NHalquilo (C₁₋₆), (16) -S-alquilo C₁₋₆, (17) -S-haloalquilo C₁₋₆, o (18) alquilo (C₁₋₆); cuando está presente, cada R⁷ se selecciona independientemente entre (1) alquilo (C₁₋₃), (2) halógeno, (3) alcoxi (C₁₋₃)-, (4) haloalquil (C₁₋₃)-, o (5) hidroxi; cuando están presentes, R⁸ᵃ y R⁸ᵇ se seleccionan independientemente entre (1) hidrógeno, (2) alquilo (C₁₋₃), o (3) cicloalquilo (C₃₋₇); cuando está presente, cada R⁹ se selecciona independientemente entre (1) alquilo (C₁₋₃), (2) haloalquil (C₁₋₃)-, (3) oxo, (4) cicloalquilo (C₃₋₆), (5) -N(R¹¹)₂, (6) hidroxi, (7) alcoxil (C₁₋₃)-, (8) ciano, (9) halógeno, (10) -SO₂alquilo (C₁₋₆), (11) -alquil (C₁₋₆)-SO₂alquilo (C₁₋₆), (12) -C(O)alquilo (C₁₋₃), o (13) O-alquilo (C₁₋₃); cuando está presente, R¹⁰ se selecciona independientemente entre (1) hidrógeno, (2) alquilo (C₁₋₃), (3) alcoxi (C₁₋₃)-, (4) hidroxi, (5) halógeno, (6) alquil (C₁₋₃)-S-, (7) haloalquil (C₁₋₃)-, o (8) N(R¹¹)₂; R¹¹, cuando está presente, es independientemente (1) hidrógeno, o (2) alquilo (C₁₋₃).
ARP210102767A 2020-10-08 2021-10-06 Preparación de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2 AR123701A1 (es)

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EP (1) EP4225735A1 (es)
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KR (1) KR20230079427A (es)
CN (1) CN116457346A (es)
AR (1) AR123701A1 (es)
AU (1) AU2021358946A1 (es)
CA (1) CA3195032A1 (es)
CL (1) CL2023000978A1 (es)
CO (1) CO2023004366A2 (es)
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DO (1) DOP2023000068A (es)
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MX (1) MX2023003844A (es)
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