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AR123048A2 - Moduladores de p2x7 - Google Patents

Moduladores de p2x7

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Publication number
AR123048A2
AR123048A2 ARP210102071A ARP210102071A AR123048A2 AR 123048 A2 AR123048 A2 AR 123048A2 AR P210102071 A ARP210102071 A AR P210102071A AR P210102071 A ARP210102071 A AR P210102071A AR 123048 A2 AR123048 A2 AR 123048A2
Authority
AR
Argentina
Prior art keywords
alkyl
compounds
formulas
halo
group
Prior art date
Application number
ARP210102071A
Other languages
English (en)
Inventor
Vaca Manuel Jesus Alcazar
Brett D Allison
Gil Jose Ignacio Andres
Christa C Chrovian
Heather Renee Coate
Angelis Meri De
Xiaohu Deng
Curt A Dvorak
Christine F Gelin
Michael A Letavic
Jimmy T Liang
Neelakandha S Mani
Jason C Rech
Brad M Savall
Akinola Soyode-Johnson
Brice Stenne
Devin M Swanson
Jessica L Wall
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR123048A2 publication Critical patent/AR123048A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

La presente invención se dirige a los compuestos de las fórmulas (1, 1a, 2a y 2b). La invención se refiere, además, a las composiciones farmacéuticas que comprenden los compuestos de las fórmulas (1, 1a, 2a y 2b). Los métodos para preparar y para usar los compuestos de las fórmulas (1, 1a, 2a y 2b) se encuentran, además, dentro del alcance de la invención. Reivindicación 1: Un compuesto de la fórmula (2a) y (2b) en donde: R³, R⁴ y R⁶ son independientemente H o alquilo C₁-C₃; R⁸ es fenilo o piridilo, opcionalmente sustituido con cero a tres sustituyentes Rᵐ en donde Rᵐ se selecciona, independientemente, del grupo que consiste en halo, alquilo C₁-C₃, y perhaloalquilo; R⁷ es (a) fenilo, opcionalmente sustituido con cero a dos grupos seleccionados, independientemente, del grupo que consiste en halo, alquilo C₁-C₃, hidroxi, o (b) heteroarilo, independientemente seleccionado del grupo que consiste en: los compuestos del grupo de fórmulas (3); en donde Rᵏ es halo o alquilo C₁-C₃; Rʲ es H o alquilo C₁-C₃; en donde el alquilo C₁-C₃ está opcionalmente sustituido con un sustituyente halo o un sustituyente alcoxi; y n es un entero entre 0 - 3; y sales aceptables farmacéuticamente de los compuestos de la fórmula (2a y 2b).
ARP210102071A 2013-03-14 2021-07-23 Moduladores de p2x7 AR123048A2 (es)

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US201361786260P 2013-03-14 2013-03-14

Publications (1)

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AR123048A2 true AR123048A2 (es) 2022-10-26

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ARP140101138A AR095530A1 (es) 2013-03-14 2014-03-14 Moduladores de p2x7
ARP210102071A AR123048A2 (es) 2013-03-14 2021-07-23 Moduladores de p2x7

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US (8) US9066946B2 (es)
EP (3) EP3495365A1 (es)
JP (1) JP6293861B2 (es)
KR (5) KR20230049754A (es)
CN (2) CN105209464B (es)
AR (2) AR095530A1 (es)
AU (5) AU2014239291B2 (es)
BR (1) BR112015023142B1 (es)
CA (1) CA2906085C (es)
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DK (2) DK3239151T3 (es)
EA (1) EA028816B1 (es)
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