AR128556A2 - Polinucleótido aislado adecuado para la expresión condicional de un gen efector en una línea germinal masculina de artrópodos; método para introducir de manera recombinante una proteína efectora en una gónada o esperma, excluyendo la gónada o esperma transformado por este método; método de supresión de una población de artrópodos nativos, excluyendo la población de artrópodos nativos y las gónadas transformadas por este método; método para retardar o revertir la resistencia a insecticidas y/o bioplaguicidas en una población de artrópodos, excluyendo la población de artrópodos y las gónadas transformadas por este método; método de control de calidad, excluyendo los individuos analizados en este método; y método para determinar el estado de apareamiento de un artrópodo hembra - Google Patents
Polinucleótido aislado adecuado para la expresión condicional de un gen efector en una línea germinal masculina de artrópodos; método para introducir de manera recombinante una proteína efectora en una gónada o esperma, excluyendo la gónada o esperma transformado por este método; método de supresión de una población de artrópodos nativos, excluyendo la población de artrópodos nativos y las gónadas transformadas por este método; método para retardar o revertir la resistencia a insecticidas y/o bioplaguicidas en una población de artrópodos, excluyendo la población de artrópodos y las gónadas transformadas por este método; método de control de calidad, excluyendo los individuos analizados en este método; y método para determinar el estado de apareamiento de un artrópodo hembraInfo
- Publication number
- AR128556A2 AR128556A2 ARP230100383A ARP230100383A AR128556A2 AR 128556 A2 AR128556 A2 AR 128556A2 AR P230100383 A ARP230100383 A AR P230100383A AR P230100383 A ARP230100383 A AR P230100383A AR 128556 A2 AR128556 A2 AR 128556A2
- Authority
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- Argentina
- Prior art keywords
- excluding
- population
- transformed
- arthropod
- arthropods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 17
- 108090000623 proteins and genes Proteins 0.000 title abstract 13
- 241000238421 Arthropoda Species 0.000 title abstract 12
- 239000012636 effector Substances 0.000 title abstract 9
- 210000002149 gonad Anatomy 0.000 title abstract 8
- 108091033319 polynucleotide Proteins 0.000 title abstract 6
- 102000040430 polynucleotide Human genes 0.000 title abstract 6
- 239000002157 polynucleotide Substances 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 238000003908 quality control method Methods 0.000 title abstract 3
- 210000004602 germ cell Anatomy 0.000 title abstract 2
- 239000002917 insecticide Substances 0.000 title abstract 2
- 230000013011 mating Effects 0.000 title abstract 2
- 230000001629 suppression Effects 0.000 title 1
- 108091023040 Transcription factor Proteins 0.000 abstract 6
- 102000040945 Transcription factor Human genes 0.000 abstract 6
- 108091026890 Coding region Proteins 0.000 abstract 3
- 238000011144 upstream manufacturing Methods 0.000 abstract 3
- 241000283715 Damaliscus lunatus Species 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 abstract 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 102000004243 Tubulin Human genes 0.000 abstract 1
- 108090000704 Tubulin Proteins 0.000 abstract 1
- 230000000853 biopesticidal effect Effects 0.000 abstract 1
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 229960003722 doxycycline Drugs 0.000 abstract 1
- 239000003269 fluorescent indicator Substances 0.000 abstract 1
- 230000009931 harmful effect Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 231100000518 lethal Toxicity 0.000 abstract 1
- 230000001665 lethal effect Effects 0.000 abstract 1
- 231100000225 lethality Toxicity 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 230000021121 meiosis Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 229960002180 tetracycline Drugs 0.000 abstract 1
- 229930101283 tetracycline Natural products 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/60—New or modified breeds of invertebrates
- A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
- A01K67/65—Genetically modified arthropods
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/60—New or modified breeds of invertebrates
- A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
- A01K67/65—Genetically modified arthropods
- A01K67/68—Genetically modified insects
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/203—Animal model comprising inducible/conditional expression system, e.g. hormones, tet
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/20—Animal model comprising regulated expression system
- A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/70—Invertebrates
- A01K2227/706—Insects, e.g. Drosophila melanogaster, medfly
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
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- A01K2267/0393—Animal model comprising a reporter system for screening tests
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- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/002—Vectors comprising a special translation-regulating system controllable or inducible
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- Pest Control & Pesticides (AREA)
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Abstract
Polinucleótido aislado adecuado para la expresión condicional de un gen efector en una línea germinal masculina de artrópodos, que comprende: una primera unidad de expresión que comprende un gen efector y un promotor para dicho gen operativamente unido a dicho gen y una segunda unidad de expresión que comprende una secuencia codificante para un factor de transcripción y un elemento regulador corriente arriba unido operativamente a dicha secuencia, donde el factor de transcripción es capaz de actuar sobre el promotor en la primera unidad de expresión para dirigir la expresión del gen efector, donde el elemento regulador corriente arriba comprende: un promotor para el factor de transcripción, donde el promotor es de matotopetli (topi), always early (aly) o b-2 tubulin (B2T), o un homólogo del mismo y un 5 UTR adyacente a un sitio de inicio para la secuencia codificante del factor de transcripción, donde el 5 UTR es de la proteína de choque térmico hsp83, topi, aly, o B2T, o un homólogo de la misma, donde, cuando tanto el promotor como el 5 UTR son de B2T, las señales de retraso transcripcional en la secuencia B2T se eliminan del promotor o del 5 UTR y donde el elemento regulador corriente arriba impulsa la expresión del factor de transcripción de tal manera que la proteína del factor de transcripción a su vez impulsa la transcripción del gen efector antes de la meiosis; método para introducir de manera recombinante una proteína efectora en una gónada o esperma, excluyendo la gónada o esperma transformado por este método; método de supresión de una población de artrópodos nativos, excluyendo la población de artrópodos nativos y las gónadas transformadas por este método; método para retardar o revertir la resistencia a insecticidas y/o bioplaguicidas en una población de artrópodos, excluyendo la población de artrópodos y las gónadas transformadas por este método; método de control de calidad, excluyendo los individuos analizados en este método; y método para determinar el estado de apareamiento de un artrópodo hembra. Reivindicación 23: El polinucleótido aislado de acuerdo con la reivindicación 22, caracterizado porque la secuencia codificante heteróloga comprende una secuencia que codifica una proteína que tiene un efecto letal, perjudicial o esterilizante, y/o una secuencia que codifica un marcador seleccionable. Reivindicación 24: El polinucleótido aislado de acuerdo con la reivindicación 22 o 23, caracterizado porque la mediación del empalme alternativo es específica del sexo y confiere una letalidad específica femenina. Reivindicación 25: El polinucleótido aislado de acuerdo con cualquiera de las reivindicaciones 22 - 24, caracterizado porque la tercera unidad de expresión es inducible y la inducción se produce por provisión o ausencia de una entidad química, tal como tetraciclina o uno de sus análogos incluyendo doxiciclina. Reivindicación 30: Un método de control de calidad, excluyendo los individuos analizados en este método, caracterizado porque comprende incluir una proteína fluorescente indicadora como, o además de, la proteína efectora codificada por el polinucleótido aislado de acuerdo con cualquiera de las reivindicaciones 1 - 26, de modo que los individuos en que se ha inducido o des-reprimido la expresión de la proteína efectora se hacen visibles en longitudes de onda adecuadas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1203850.1A GB2500113A (en) | 2012-03-05 | 2012-03-05 | Arthropod male germline gene expression system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR128556A2 true AR128556A2 (es) | 2024-05-22 |
Family
ID=46003145
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100723 AR091314A1 (es) | 2012-03-05 | 2013-03-05 | Biocontrol |
| ARP230100383A AR128556A2 (es) | 2012-03-05 | 2023-02-17 | Polinucleótido aislado adecuado para la expresión condicional de un gen efector en una línea germinal masculina de artrópodos; método para introducir de manera recombinante una proteína efectora en una gónada o esperma, excluyendo la gónada o esperma transformado por este método; método de supresión de una población de artrópodos nativos, excluyendo la población de artrópodos nativos y las gónadas transformadas por este método; método para retardar o revertir la resistencia a insecticidas y/o bioplaguicidas en una población de artrópodos, excluyendo la población de artrópodos y las gónadas transformadas por este método; método de control de calidad, excluyendo los individuos analizados en este método; y método para determinar el estado de apareamiento de un artrópodo hembra |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100723 AR091314A1 (es) | 2012-03-05 | 2013-03-05 | Biocontrol |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9487801B2 (es) |
| EP (2) | EP2823047B1 (es) |
| JP (1) | JP6363023B2 (es) |
| CN (2) | CN104271747B (es) |
| AR (2) | AR091314A1 (es) |
| AU (2) | AU2013229578B2 (es) |
| BR (1) | BR112014021922B1 (es) |
| CA (1) | CA2866411A1 (es) |
| CL (1) | CL2014002369A1 (es) |
| CO (1) | CO7160024A2 (es) |
| CR (1) | CR20140439A (es) |
| CY (1) | CY1120531T1 (es) |
| ES (1) | ES2683039T3 (es) |
| GB (1) | GB2500113A (es) |
| GT (1) | GT201400188A (es) |
| MA (1) | MA37380B1 (es) |
| MX (1) | MX359468B (es) |
| MY (1) | MY169450A (es) |
| PE (1) | PE20142278A1 (es) |
| PH (1) | PH12014501993A1 (es) |
| SG (2) | SG11201405481SA (es) |
| WO (1) | WO2013131920A1 (es) |
| ZA (1) | ZA201406925B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
| GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
| CA2936312A1 (en) * | 2014-01-08 | 2015-07-16 | President And Fellows Of Harvard College | Rna-guided gene drives |
| GB2526867A (en) | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
| BR112019002771A2 (pt) | 2016-08-12 | 2019-05-14 | Oxitec Ltd | polinucleotídeo de módulo de controle de união de doublesex, sistema de expressão de gene, plasmídeo vetor de expressão, inseto geneticamente engenheirado, métodos para produzir insetos geneticamente engenheirados, para cultivar seletivamente insetos macho geneticamente engenheirados, para reduzir uma população de inseto selvagem, para criar um mosquito aedes aegypti transgênico e para detectar a presença de uma molécula de dna, local alvo cromossômico de aedes aegypti, mosquito aedes aegypti geneticamente engenheirado, molécula de dna, e, kit de detecção de dna. |
| AR117409A1 (es) | 2018-03-29 | 2021-08-04 | Oxitec Ltd | Noctuidas autolimitantes |
| GB201810253D0 (en) * | 2018-06-22 | 2018-08-08 | Imperial Innovations Ltd | Gene drive |
| GB201810256D0 (en) * | 2018-06-22 | 2018-08-08 | Imperial Innovations Ltd | Polynucleotide |
| MA52650A1 (fr) * | 2018-08-14 | 2021-12-31 | Oxitec Ltd | Arthropodes mâles stériles à sélection automatique |
| CN109105341A (zh) * | 2018-09-04 | 2019-01-01 | 安徽师范大学 | 一种用于防治斑翅果蝇的辐照不育方法 |
| GB2579224A (en) * | 2018-11-26 | 2020-06-17 | Zyzzle Ltd | Apparatus for producing an improved animal population |
| EP3660053A1 (en) * | 2018-11-27 | 2020-06-03 | Fraunhofer Gesellschaft zur Förderung der Angewand | Multiprotein expression systems for pest control |
| EA202192430A1 (ru) * | 2019-03-05 | 2022-02-11 | Те Стейт Оф Израэл, Министри Оф Эгрикалчер Энд Рурал Дивелопмент, Эгрикалчарал Рисёрч Органайзейшн (Аро) (Волкани Сентер) | Птицы с отредактированным геномом |
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