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AR127116A2 - Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores - Google Patents

Péptidos y combinación de péptidos novedosos para su uso en inmunoterapia contra diversos tumores

Info

Publication number
AR127116A2
AR127116A2 ARP220102547A ARP220102547A AR127116A2 AR 127116 A2 AR127116 A2 AR 127116A2 AR P220102547 A ARP220102547 A AR P220102547A AR P220102547 A ARP220102547 A AR P220102547A AR 127116 A2 AR127116 A2 AR 127116A2
Authority
AR
Argentina
Prior art keywords
seq
peptide
antigen
cells
chosen
Prior art date
Application number
ARP220102547A
Other languages
English (en)
Inventor
Stevermann Lea Dr
Singh Harpreet Dr
Jens Fritsche
Schoor Oliver Dr
Weinschenk Toni Dr
Mahr Andrea Dr
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of AR127116A2 publication Critical patent/AR127116A2/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

Reivindicación 1: Un péptido caracterizado porque comprende una secuencia de aminoácidos que se elige del grupo que consiste en SEQ ID Nº 243, SEQ ID Nº 1 a SEQ ID Nº 10, SEQ ID Nº 12, SEQ ID Nº 13, SEQ ID Nº 15 a SEQ ID Nº 24, SEQ ID Nº 26 a SEQ ID Nº 28, SEQ ID Nº 30 a SEQ ID Nº 103, SEQ ID Nº 105 a SEQ ID Nº 154, SEQ ID Nº 156, SEQ ID Nº 158 a SEQ ID Nº 167, SEQ ID Nº 169 a SEQ ID Nº 213, SEQ ID Nº 216 a SEQ ID Nº 242, SEQ ID Nº 244 a SEQ ID Nº 263, y SEQ ID Nº 265 a SEQ ID Nº 288, y secuencias variantes de las mismas que son por lo menos 88% homólogas a cualquiera de SEQ ID Nº 243, SEQ ID Nº 1 a SEQ ID Nº 10, SEQ ID Nº 12, SEQ ID Nº 13, SEQ ID Nº 15 a SEQ ID Nº 24, SEQ ID Nº 26 a SEQ ID Nº 28, SEQ ID Nº 30 a SEQ ID Nº 103, SEQ ID Nº 105 a SEQ ID Nº 154, SEQ ID Nº 156, SEQ ID Nº 158 a SEQ ID Nº 167, SEQ ID Nº 169 a SEQ ID Nº 213, SEQ ID Nº 216 a SEQ ID Nº 242, SEQ ID Nº 244 a SEQ ID Nº 263, y SEQ ID Nº 265 a SEQ ID Nº 288, y en donde dicha variante se une a molécula(s) del complejo mayor de histocompatibilidad (MHC) y/o induce a las células T para reaccionar en forma cruzada con dicho péptido variante; y una sal farmacéuticamente aceptable de la misma, en donde dicho péptido no es un polipéptido de longitud completa. Reivindicación 12: Un método in vitro para producir linfocitos T activados, caracterizado porque el método comprende poner en contacto in vitro las células T con moléculas MHC de clase I o II humanas cargadas con antígeno expresadas sobre la superficie de una célula presentadora de antígeno adecuada o una construcción artificial que imita a una célula presentadora de antígeno durante un periodo de tiempo suficiente para activar dichas células T de una forma específica de antígeno, en donde dicho antígeno es un péptido de acuerdo con cualquiera de las Reivindicaciones 1 a 4. Reivindicación 14: Un método para matar células blanco en un paciente caracterizado porque las células blanco presentan un polipéptido que comprende una secuencia de aminoácidos dada en cualquiera de las Reivindicaciones 1 a 4, el método comprende administrar al paciente una cantidad eficaz de células T activadas como se define en la Reivindicación 13. Reivindicación 21: El conjunto de componentes de acuerdo con la Reivindicación 19 o 20, caracterizado porque el mencionado péptido se elige del grupo que consiste en SEQ ID Nº 243, SEQ ID Nº 1 a SEQ ID Nº 10, SEQ ID Nº 12, SEQ ID Nº 13, SEQ ID Nº 15 a SEQ ID Nº 24, SEQ ID Nº 26 a SEQ ID Nº 28, SEQ ID Nº 30 a SEQ ID Nº 103, SEQ ID Nº 105 a SEQ ID Nº 154, SEQ ID Nº 156, SEQ ID Nº 158 a SEQ ID Nº 167, SEQ ID Nº 169 a SEQ ID Nº 213, SEQ ID Nº 216 a SEQ ID Nº 242, SEQ ID Nº 244 a SEQ ID Nº 263, y SEQ ID Nº 265 a SEQ ID Nº 288. Reivindicación 31: El receptor de células T de acuerdo con la Reivindicación 30, caracterizado porque dicha secuencia de aminoácidos es por lo menos 88% idéntica a la SEQ ID Nº 243, SEQ ID Nº 1 a SEQ ID Nº 10, SEQ ID Nº 12, SEQ ID Nº 13, SEQ ID Nº 15 a SEQ ID Nº 24, SEQ ID Nº 26 a SEQ ID Nº 28, SEQ ID Nº 30 a SEQ ID Nº 103, SEQ ID Nº 105 a SEQ ID Nº 154, SEQ ID Nº 156, SEQ ID Nº 158 a SEQ ID Nº 167, SEQ ID Nº 169 a SEQ ID Nº 213, SEQ ID Nº 216 a SEQ ID Nº 242, SEQ ID Nº 244 a SEQ ID Nº 263, y SEQ ID Nº 265 a SEQ ID Nº 288. Reivindicación 39: Una composición farmacéutica caracterizada porque comprende por lo menos un ingrediente activo que se elige del grupo que consiste en el péptido de acuerdo con cualquiera de las Reivindicaciones 1 a 6, el ácido nucleico de acuerdo con la Reivindicación 7, el vector de expresión de acuerdo con la Reivindicación 8, la célula de acuerdo con la Reivindicación 9, el linfocito T activado de acuerdo con la Reivindicación 13 o el anticuerpo de acuerdo con la Reivindicación 15 o 16 receptor de células T de acuerdo con cualquiera de las Reivindicaciones 30 a 32 o el aptámero de acuerdo con la Reivindicación 38, y un transportador farmacéuticamente aceptable, y opcionalmente excipientes y/o estabilizantes adicionales farmacéuticamente aceptables.
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UA124139C2 (uk) 2021-07-28
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SG11201706681VA (en) 2017-10-30
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CA3111059A1 (en) 2016-10-06
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MX2017012427A (es) 2018-01-11
US20200040060A1 (en) 2020-02-06
US20160280759A1 (en) 2016-09-29
CN107531754B (zh) 2024-11-15

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