AR124973A1 - Nuevos derivados de pirimidina-2-il sulfonamida - Google Patents
Nuevos derivados de pirimidina-2-il sulfonamidaInfo
- Publication number
- AR124973A1 AR124973A1 ARP220100414A ARP220100414A AR124973A1 AR 124973 A1 AR124973 A1 AR 124973A1 AR P220100414 A ARP220100414 A AR P220100414A AR P220100414 A ARP220100414 A AR P220100414A AR 124973 A1 AR124973 A1 AR 124973A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkoxy
- alkoxy
- heterocycloalkyl
- haloalkyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Compuestos de fórmula (1) en los que R¹ es H, halo, alquilo, alcoxi, alcoxialquilo, alcoxialcoxi, cianoalquilo, haloalquilo, haloalcoxi, tioalquilo, cicloalquilo, cicloalquilalquilo, cicloalcoxi o heterocicloalquilo; R² es ciano, halo, alquilo, alquenilo, alquinilo, alcoxi, alquenilalquilo, alquinilalcoxi, alcoxialquilo, alcoxialcoxi, haloalquilo, haloalcoxi, haloalcoxialquilo, (haloalcoxi)alcoxi, cianoalquilo, cianoalcoxi, tioalquilo, halotioalquilo, halohidroxialcoxi, alquilsulfonilalquilo, cicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalcoxi, heterocicloalquilo, heterocicloalquilalquilo, heterocicloalquilalquinilo o heterocicloalquilalcoxi; R³ es H, halo, alquilo, alcoxi, haloalcoxi o tiolalquilo; X¹ es CR⁵ o N; X² es NH, -N-R⁶, S, -S(O)- o -S(O₂)-; R⁴ es H, halo, alquilo, hidroxialquilo, tioalquilo, cianoalquilo, alcoxi, haloalquilo, haloalcoxi, cicloalquilo o heterocicloalquilo; R⁵ es H, halo, ciano, alquilo, alcoxi, cianoalquilo, cianialcoxi, N-alquilo, dialquilamino, haloalquilo, haloalcoxi, halotioalquilo, alquilsulfinilo, alquilsulfonilo, alquilsulfona, tioalquilo, hidroxialquilo, alcoxicarbonilo, heterocicloalquilo, cicloalquilo o cicloalcoxi; o R⁴ y R⁵ están conectados para formar un cicloalquilo, un heterocicloalquilo, un heterocicloalquilo sustituido de 5 ó 6 miembros que comprende uno o dos sustituyentes seleccionados independientemente de alquilo y oxo o un anillo heteroaromático; R⁶ es H, alquilo, alquilhidroxi o haloalquilo; y sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21159452 | 2021-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR124973A1 true AR124973A1 (es) | 2023-05-24 |
Family
ID=74797733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220100414A AR124973A1 (es) | 2021-02-26 | 2022-02-25 | Nuevos derivados de pirimidina-2-il sulfonamida |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20240025883A1 (es) |
| EP (1) | EP4298092B1 (es) |
| JP (1) | JP2024507176A (es) |
| KR (1) | KR20230152006A (es) |
| CN (1) | CN116829550A (es) |
| AR (1) | AR124973A1 (es) |
| AU (1) | AU2022227183A1 (es) |
| CA (1) | CA3203282A1 (es) |
| CL (1) | CL2023002429A1 (es) |
| CO (1) | CO2023010212A2 (es) |
| CR (1) | CR20230410A (es) |
| IL (1) | IL304450A (es) |
| MX (1) | MX2023009045A (es) |
| PE (1) | PE20240125A1 (es) |
| TW (1) | TW202245749A (es) |
| WO (1) | WO2022180136A1 (es) |
| ZA (1) | ZA202305344B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119585258A (zh) * | 2022-07-28 | 2025-03-07 | 豪夫迈·罗氏有限公司 | 新颖的7-取代的吲哚磺酰胺衍生物 |
| CA3261059A1 (en) * | 2022-07-28 | 2024-02-01 | F. Hoffmann-La Roche Ag | NEW INDOLE SULFONAMIDE DERIVATIVES SUBSTITUTED AT POSITION 7 |
| WO2024104462A1 (en) * | 2022-11-20 | 2024-05-23 | Myrobalan Therapeutics Nanjing Co. Ltd | Gpr17 modulators and uses thereof |
| CN120530103A (zh) | 2023-01-20 | 2025-08-22 | 豪夫迈·罗氏有限公司 | 新颖嘧啶基磺酰胺衍生物 |
| WO2025243044A1 (en) | 2024-05-23 | 2025-11-27 | Pheno Therapeutics Limited | Compounds |
| GB202508014D0 (en) | 2024-05-23 | 2025-07-09 | Pheno Therapeutics Ltd | Compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI754702B (zh) * | 2016-12-28 | 2022-02-11 | 德商Ｕｃｂ製藥有限公司 | （氮雜）吲哚－和苯並呋喃－３－磺醯胺類 |
| TWI857957B (zh) * | 2018-06-19 | 2024-10-11 | 德商Ｕｃｂ製藥有限公司 | 吡啶基及吡基-（氮）吲哚磺醯胺 |
| EP3584244A1 (en) * | 2018-06-20 | 2019-12-25 | UCB Pharma GmbH | Substituted alkoxypyridinyl indolsulfonamides |
-
2022
- 2022-02-24 AU AU2022227183A patent/AU2022227183A1/en active Pending
- 2022-02-24 KR KR1020237028756A patent/KR20230152006A/ko active Pending
- 2022-02-24 WO PCT/EP2022/054586 patent/WO2022180136A1/en not_active Ceased
- 2022-02-24 EP EP22707455.6A patent/EP4298092B1/en active Active
- 2022-02-24 PE PE2023002289A patent/PE20240125A1/es unknown
- 2022-02-24 JP JP2023548875A patent/JP2024507176A/ja active Pending
- 2022-02-24 CA CA3203282A patent/CA3203282A1/en active Pending
- 2022-02-24 MX MX2023009045A patent/MX2023009045A/es unknown
- 2022-02-24 CR CR20230410A patent/CR20230410A/es unknown
- 2022-02-24 CN CN202280013994.3A patent/CN116829550A/zh active Pending
- 2022-02-25 TW TW111107086A patent/TW202245749A/zh unknown
- 2022-02-25 AR ARP220100414A patent/AR124973A1/es unknown
-
2023
- 2023-05-16 ZA ZA2023/05344A patent/ZA202305344B/en unknown
- 2023-07-12 IL IL304450A patent/IL304450A/en unknown
- 2023-07-31 CO CONC2023/0010212A patent/CO2023010212A2/es unknown
- 2023-08-16 CL CL2023002429A patent/CL2023002429A1/es unknown
- 2023-08-24 US US18/455,029 patent/US20240025883A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023009045A (es) | 2023-08-10 |
| PE20240125A1 (es) | 2024-01-22 |
| IL304450A (en) | 2023-09-01 |
| CL2023002429A1 (es) | 2024-01-12 |
| CN116829550A (zh) | 2023-09-29 |
| CR20230410A (es) | 2023-09-25 |
| ZA202305344B (en) | 2024-01-31 |
| EP4298092A1 (en) | 2024-01-03 |
| CO2023010212A2 (es) | 2023-09-08 |
| CA3203282A1 (en) | 2022-09-01 |
| AU2022227183A1 (en) | 2023-06-22 |
| JP2024507176A (ja) | 2024-02-16 |
| EP4298092B1 (en) | 2025-11-26 |
| TW202245749A (zh) | 2022-12-01 |
| AU2022227183A9 (en) | 2024-10-10 |
| WO2022180136A1 (en) | 2022-09-01 |
| KR20230152006A (ko) | 2023-11-02 |
| US20240025883A1 (en) | 2024-01-25 |
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