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AR113908A1 - Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson - Google Patents

Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson

Info

Publication number
AR113908A1
AR113908A1 ARP180103436A ARP180103436A AR113908A1 AR 113908 A1 AR113908 A1 AR 113908A1 AR P180103436 A ARP180103436 A AR P180103436A AR P180103436 A ARP180103436 A AR P180103436A AR 113908 A1 AR113908 A1 AR 113908A1
Authority
AR
Argentina
Prior art keywords
formula
substituent
compounds
disease
treatment
Prior art date
Application number
ARP180103436A
Other languages
English (en)
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of AR113908A1 publication Critical patent/AR113908A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Addiction (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente proporciona compuestos de fórmula (1), que son profármacos de catecolamina para uso en el tratamiento de enfermedades y trastornos neurodegenerativos. La presente proporciona también composiciones farmacéuticas que comprenden compuestos de la misma y métodos de tratar enfermedades y trastornos neurodegenerativos o neuropsiquiátricos utilizando los compuestos de la presente, en particular la enfermedad de Parkinson. Por consiguiente, la presente se refiere a compuestos de fórmula (2) donde R¹ es H y R² se selecciona de uno de los sustituyentes de fórmula (3) y (4) que figuran más adelante; o R¹ se selecciona de uno de los sustituyentes de fórmula (3) y (4) que figuran más adelante y R² es H; o R¹ y R² se representan ambos por el sustituyente de fórmula (3) que figura más adelante; o R¹ y R² se representan ambos por el sustituyente de fórmula (4) que figura más adelante; o R¹ es sustituyente de fórmula (3) y R² es sustituyente de fórmula (4); o R¹ es sustituyente de fórmula (4) y R² es sustituyente de fórmula (3); donde * indica el punto de unión; y donde el átomo de carbono en el punto de unión en el sustituyente de fórmula (3) está en la configuración S; o una sal farmacéuticamente aceptable del mismo.
ARP180103436A 2017-11-24 2018-11-23 Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson AR113908A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201700674 2017-11-24

Publications (1)

Publication Number Publication Date
AR113908A1 true AR113908A1 (es) 2020-06-24

Family

ID=64661284

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180103436A AR113908A1 (es) 2017-11-24 2018-11-23 Profármacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson

Country Status (25)

Country Link
US (5) US10729710B2 (es)
EP (1) EP3713933A1 (es)
JP (4) JP7320507B2 (es)
KR (1) KR102712887B1 (es)
CN (3) CN111386267B (es)
AR (1) AR113908A1 (es)
AU (2) AU2018371193B2 (es)
BR (1) BR112019014981A2 (es)
CA (1) CA3082757A1 (es)
CL (1) CL2020001343A1 (es)
CO (1) CO2020006224A2 (es)
CR (1) CR20200225A (es)
EA (1) EA202090987A8 (es)
EC (1) ECSP20030074A (es)
GE (2) GEP20227446B (es)
IL (1) IL274648B2 (es)
JO (1) JOP20200114A1 (es)
MA (1) MA50800A (es)
MX (2) MX2020005366A (es)
PE (1) PE20211290A1 (es)
PH (1) PH12020550631A1 (es)
SG (1) SG11202004461YA (es)
TW (1) TWI816716B (es)
UA (1) UA127575C2 (es)
WO (1) WO2019101917A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020005366A (es) * 2017-11-24 2020-08-13 H Lundbeck As Nuevos profarmacos de catecolamina para uso en el tratamiento de la enfermedad de parkinson.
US11104697B2 (en) * 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) * 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11111263B2 (en) * 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
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EP3972970A1 (en) * 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
JP2023552699A (ja) * 2020-11-17 2023-12-19 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
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WO2023208867A1 (en) 2022-04-25 2023-11-02 Integrative Research Laboratories Sweden Ab NOVEL 1,2,3,4,4a,5,8,9,10,10a-DECAHYDROBENZO[G]QUINOLIN-6(7H)-ONE COMPOUNDS AND USES THEREOF
JP2025520542A (ja) 2022-06-15 2025-07-03 エバー ニューロ ファーマ ゲーエムベーハー アポモルヒネプロドラッグおよびその使用
WO2025078574A1 (en) 2023-10-12 2025-04-17 Integrative Research Laboratories Sweden Ab NOVEL ESTERS OF 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF
WO2025078571A1 (en) 2023-10-12 2025-04-17 Integrative Research Laboratories Sweden Ab NOVEL CARBONATES AND CARBAMATES OF 1,2,3,4,4a,5,6,7,8,9,10,10a- DODECAHYDROBENZO[g]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF

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US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
EP3972970A1 (en) 2019-05-21 2022-03-30 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
CN113727974B (zh) 2019-05-21 2025-01-07 H.隆德贝克有限公司 用于治疗帕金森病的新儿茶酚胺前药
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JP2023552699A (ja) 2020-11-17 2023-12-19 ハー・ルンドベック・アクチエゼルスカベット パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ
JP7693430B2 (ja) * 2021-07-15 2025-06-17 株式会社日立製作所 運行提案システム、及び運行提案作成方法

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GEP20227446B (en) 2022-12-12
US12226428B2 (en) 2025-02-18
IL274648A (en) 2020-06-30
AU2023201741A1 (en) 2023-04-20
US20250381208A1 (en) 2025-12-18
EP3713933A1 (en) 2020-09-30
JP2023055830A (ja) 2023-04-18
CN117599073A (zh) 2024-02-27
UA127575C2 (uk) 2023-10-18
CN117653649A (zh) 2024-03-08
CA3082757A1 (en) 2019-05-31
JP2023145579A (ja) 2023-10-11
AU2018371193B2 (en) 2022-12-22
CN111386267B (zh) 2023-12-12
CN111386267A (zh) 2020-07-07
CO2020006224A2 (es) 2020-05-29
IL274648B2 (en) 2024-10-01
US20220257623A1 (en) 2022-08-18
US11110110B2 (en) 2021-09-07
TWI816716B (zh) 2023-10-01
IL274648B1 (en) 2024-06-01
NZ764717A (en) 2024-08-30
MA50800A (fr) 2020-09-30
US10729710B2 (en) 2020-08-04
WO2019101917A1 (en) 2019-05-31
JOP20200114A1 (ar) 2020-05-17
BR112019014981A2 (pt) 2020-04-07
EA202090987A8 (ru) 2020-09-29
JP7320684B2 (ja) 2023-08-03
US11707476B2 (en) 2023-07-25
US20200338102A1 (en) 2020-10-29
SG11202004461YA (en) 2020-06-29
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PH12020550631A1 (en) 2021-02-22
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