AR112463A1 - Derivados de propanamina para tratar el dolor y estados relacionados con dolor - Google Patents
Derivados de propanamina para tratar el dolor y estados relacionados con dolorInfo
- Publication number
- AR112463A1 AR112463A1 ARP180102099A AR112463A1 AR 112463 A1 AR112463 A1 AR 112463A1 AR P180102099 A ARP180102099 A AR P180102099A AR 112463 A1 AR112463 A1 AR 112463A1
- Authority
- AR
- Argentina
- Prior art keywords
- radical
- group
- optionally substituted
- unbranched
- branched
- Prior art date
Links
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Reivindicación 1: Compuesto de fórmula general (1), en la que: R¹ se selecciona de un grupo arilo de 5 ó 6 miembros opcionalmente sustituido o un grupo heteroarilo de 5 a 10 miembros opcionalmente sustituido que tiene al menos un heteroátomo seleccionado del grupo de N, O ó S; R² es un compuesto de fórmula (2); n es 1 ó 2; A y B representan independientemente un átomo de carbono que conduce a o bien -CH-, -CR²ᶜ- o bien -CR²ᵈ-; o un átomo de nitrógeno con la condición de que si uno es nitrógeno el otro es un átomo de carbono y con la condición de que cuando A y B son ambos átomos de carbono, R¹ no puede ser fenilo; R²ᵃ y R²ᵇ son independientemente entre sí un átomo de hidrógeno o un radical alquilo C₁₋₆ ramificado o no ramificado; o R²ᵃ y R²ᵇ, estando presentes en el mismo átomo de carbono pueden formar opcionalmente una estructura espirocíclica; R²ᶜ y R²ᵈ son independientemente entre sí un átomo de hidrógeno; un grupo -(CH₂)ₘ-CN siendo m 0 ó 1; un halógeno; un radical alquilo C₁₋₆ ramificado o no ramificado; un radical alquilamino C₁₋₆; un grupo amino; un grupo hidroxilo; un radical alcoxilo C₁₋₆; radical haloalcoxilo C₁₋₆; un radical alcoxialquilo C₁₋₆; un radical cicloalquilo C₃₋₆; un heterocicloalquilo de 5 ó 6 miembros; un heterocicloalquilalquilo C₁₋₆; un radical haloalquilo C₁₋₆; un grupo -CF₃; un grupo arilo opcionalmente sustituido; un radical arilalquilo C₁₋₆; un grupo heteroarilo de 5 a 10 miembros opcionalmente sustituido que tiene al menos un heteroátomo seleccionado del grupo de N, O ó S; o un radical heteroarilalquilo C₁₋₆; R²ᵉ es un átomo de hidrógeno; un grupo =O; o un radical alquilo C₁₋₆ ramificado o no ramificado; R³ y R⁴ son independientemente entre sí un átomo de hidrógeno o un radical alquilo C₁₋₆ ramificado o no ramificado opcionalmente sustituido; o una sal, cocristal, isómero, profármaco o solvato farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382502 | 2017-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR112463A1 true AR112463A1 (es) | 2019-10-30 |
Family
ID=59523044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180102099 AR112463A1 (es) | 2017-07-27 | 2018-07-26 | Derivados de propanamina para tratar el dolor y estados relacionados con dolor |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20200207759A1 (es) |
| EP (1) | EP3658550A1 (es) |
| JP (1) | JP2020530836A (es) |
| KR (1) | KR20200035077A (es) |
| CN (1) | CN111108101A (es) |
| AR (1) | AR112463A1 (es) |
| AU (1) | AU2018305223A1 (es) |
| BR (1) | BR112020001775A2 (es) |
| CA (1) | CA3071074A1 (es) |
| RU (1) | RU2020105027A (es) |
| TW (1) | TW201910327A (es) |
| WO (1) | WO2019020792A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110483509B (zh) * | 2019-09-04 | 2020-08-25 | 温州大学 | 一种合成含氮杂环衍生物的方法 |
| CN110627785B (zh) * | 2019-09-19 | 2021-06-25 | 温州大学 | 一种1,5-四氢萘啶衍生物的制备方法 |
| CN117480161A (zh) | 2021-03-10 | 2024-01-30 | 塔拉森调理公司 | 作为σ配体的新型2,3-二氢-1H-吡咯并[3,2-b]吡啶衍生物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1756054B1 (en) * | 2004-06-01 | 2010-03-31 | F.Hoffmann-La Roche Ag | 3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor |
| TW202026281A (zh) * | 2018-12-12 | 2020-07-16 | 西班牙商艾斯提夫製藥股份有限公司 | 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物 |
-
2018
- 2018-07-26 AR ARP180102099 patent/AR112463A1/es unknown
- 2018-07-27 AU AU2018305223A patent/AU2018305223A1/en not_active Abandoned
- 2018-07-27 KR KR1020207005280A patent/KR20200035077A/ko not_active Withdrawn
- 2018-07-27 TW TW107126150A patent/TW201910327A/zh unknown
- 2018-07-27 WO PCT/EP2018/070418 patent/WO2019020792A1/en not_active Ceased
- 2018-07-27 CN CN201880060537.3A patent/CN111108101A/zh active Pending
- 2018-07-27 RU RU2020105027A patent/RU2020105027A/ru not_active Application Discontinuation
- 2018-07-27 JP JP2020504142A patent/JP2020530836A/ja active Pending
- 2018-07-27 CA CA3071074A patent/CA3071074A1/en not_active Abandoned
- 2018-07-27 US US16/633,595 patent/US20200207759A1/en not_active Abandoned
- 2018-07-27 EP EP18743038.4A patent/EP3658550A1/en not_active Withdrawn
- 2018-07-27 BR BR112020001775-2A patent/BR112020001775A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA3071074A1 (en) | 2019-01-31 |
| KR20200035077A (ko) | 2020-04-01 |
| CN111108101A (zh) | 2020-05-05 |
| BR112020001775A2 (pt) | 2020-07-21 |
| AU2018305223A1 (en) | 2020-02-13 |
| WO2019020792A1 (en) | 2019-01-31 |
| RU2020105027A (ru) | 2021-08-27 |
| US20200207759A1 (en) | 2020-07-02 |
| JP2020530836A (ja) | 2020-10-29 |
| EP3658550A1 (en) | 2020-06-03 |
| TW201910327A (zh) | 2019-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |