AR111878A1 - Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue - Google Patents
Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengueInfo
- Publication number
- AR111878A1 AR111878A1 ARP180101342A ARP180101342A AR111878A1 AR 111878 A1 AR111878 A1 AR 111878A1 AR P180101342 A ARP180101342 A AR P180101342A AR P180101342 A ARP180101342 A AR P180101342A AR 111878 A1 AR111878 A1 AR 111878A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- dengue
- medicament
- refers
- viral infections
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 4
- 206010012310 Dengue fever Diseases 0.000 title abstract 4
- 208000025729 dengue disease Diseases 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- -1 bicyclo [1.1.1] pentanyl Chemical group 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a derivados de indolina sustituidos, a métodos para prevenir o tratar infecciones virales por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferentemente, para su uso como medicamento para tratar o prevenir infecciones virales por dengue. La presente se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como un medicamento, más preferentemente para la prevención o el tratamiento de infecciones virales por dengue. También se refiere a procesos para la preparación de los compuestos. Reivindicación 1: Un compuesto de fórmula (1), incluida cualquiera de sus formas estereoquimicamente isoméricas, donde R¹ es trifluorometilo, trifluorometoxi, o cloro; R² es hidrógeno, flúor, o metoxi; R³ es hidrógeno, o metoxi; A representa -(CH₂)ₙ-, donde n es 3 ó 4; -O-(CH₂)ₙ-, donde n es 2 ó 4; -O-(CH₂)ₙ-, donde n es 3 y uno o dos CH₂ están sustituidos con uno o dos CH₃; el resto de fórmula (2) ó (3); -CH₂-O-(CH₂)ₙ-, donde n es 2; o -X-Y-, donde- X es -O-, -OCH₂-, o -NH-; e Y es cicloalquilo C₃₋₄ opcionalmente sustituido con flúor, o Y es biciclo[1.1.1]pentanilo; o una sal, solvato o polimorfo farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17172237 | 2017-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111878A1 true AR111878A1 (es) | 2019-08-28 |
Family
ID=58745157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101342A AR111878A1 (es) | 2017-05-22 | 2018-05-21 | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11407715B2 (es) |
| EP (1) | EP3630723B1 (es) |
| JP (1) | JP7203764B2 (es) |
| KR (1) | KR102625988B1 (es) |
| CN (1) | CN110691773B (es) |
| AR (1) | AR111878A1 (es) |
| AU (1) | AU2018274100B2 (es) |
| BR (1) | BR112019024195A2 (es) |
| CA (1) | CA3060583C (es) |
| CL (1) | CL2019003294A1 (es) |
| CO (1) | CO2019012035A2 (es) |
| CR (1) | CR20190530A (es) |
| EA (1) | EA201992782A1 (es) |
| EC (1) | ECSP19083640A (es) |
| ES (1) | ES2929667T3 (es) |
| IL (1) | IL270726B2 (es) |
| MA (1) | MA48943A (es) |
| MX (1) | MX393586B (es) |
| NI (1) | NI201900119A (es) |
| PE (1) | PE20200604A1 (es) |
| PH (1) | PH12019502559A1 (es) |
| TW (1) | TWI758480B (es) |
| UA (1) | UA125407C2 (es) |
| UY (1) | UY37742A (es) |
| WO (1) | WO2018215315A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| MX2018011788A (es) | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2017240076A1 (en) | 2016-04-01 | 2018-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| WO2024252254A1 (en) * | 2023-06-05 | 2024-12-12 | Zydus Lifesciences Limited | Novel compounds to treat viral infections |
| WO2025248536A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel oxime derivatives to treat viral infections |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69830335T2 (de) | 1997-10-27 | 2006-02-02 | Eli Lilly And Co., Indianapolis | MORPHOLINO-N-ETHYL ESTER PRODROGEN VON INDOL sPLA 2 HEMMER |
| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| JP2005520795A (ja) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害活性を有するプリン類似体 |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| EP1844042A1 (en) | 2005-01-14 | 2007-10-17 | Genelabs Technologies, Inc. | Indole derivatives for treating viral infections |
| KR20070102741A (ko) | 2005-02-09 | 2007-10-19 | 미게닉스 인코포레이티드 | 플라비비리대 감염증을 치료하거나 예방하기 위한 조성물및 방법 |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
| JP5559174B2 (ja) * | 2008-08-19 | 2014-07-23 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 冷感−メントール受容体拮抗剤 |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| WO2010091413A1 (en) | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US8993604B2 (en) | 2009-06-30 | 2015-03-31 | Siga Technologies, Inc. | Treatment and prevention of dengue virus infections |
| US7948798B1 (en) | 2009-07-22 | 2011-05-24 | Marvell International Ltd. | Mixed multi-level cell and single level cell storage device |
| AU2011205797B2 (en) | 2010-01-15 | 2015-07-16 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| US20130023532A1 (en) | 2010-03-26 | 2013-01-24 | Casillas Linda N | Indazolyl-pyrimidines as kinase inhibitors |
| JP5716205B2 (ja) | 2011-03-29 | 2015-05-13 | 学校法人日本大学 | グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法 |
| GB201116559D0 (en) * | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| KR20140054425A (ko) * | 2011-09-30 | 2014-05-08 | 후아웨이 테크놀러지 컴퍼니 리미티드 | 네트워크 발호 방법 및 장치 |
| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| EP3060547B1 (en) | 2013-10-23 | 2017-10-11 | Janssen Sciences Ireland UC | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| CN106132962B (zh) | 2014-01-31 | 2018-09-07 | 百时美施贵宝公司 | 作为凝血因子xia抑制剂的具有芳族p2’基团的大环化合物 |
| TWI681951B (zh) * | 2014-10-01 | 2020-01-11 | 美商健生醫藥公司 | 作為登革熱病毒複製抑制劑之單-或二-取代的吲哚衍生物 |
| NO2721243T3 (es) | 2014-10-01 | 2018-10-20 | ||
| HRP20190139T1 (hr) | 2014-10-01 | 2019-03-22 | Janssen Pharmaceuticals, Inc. | Mono- ili di-supstituirani indoli kao inhibitori replikacije denga virusa |
| PH12017501272B1 (en) | 2015-01-16 | 2023-01-11 | Janssen Pharmaceuticals Inc | Indole derivatives as dengue viral replication inhibitors |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| JOP20160086B1 (ar) * | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2016350868B2 (en) | 2015-11-03 | 2022-03-31 | Zoetis Services Llc | Sol-gel polymer composites and uses thereof |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| EP3436444B1 (en) | 2016-03-31 | 2020-05-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| MX2018011788A (es) * | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| CN109641956A (zh) | 2016-04-01 | 2019-04-16 | 美国安进公司 | Flt3的嵌合受体及其使用方法 |
| CA3018986A1 (en) | 2016-04-01 | 2017-10-05 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
| PL3436030T3 (pl) | 2016-04-01 | 2022-12-19 | Kite Pharma, Inc. | Receptory chimeryczne i sposoby ich zastosowania |
| CA3019149A1 (en) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Chimeric antigen and t cell receptors and methods of use |
| BR112018068851B1 (pt) | 2016-04-01 | 2022-11-22 | Basf Se | Composto de fórmula i, composição, métodos de combate ou controle de pragas invertebradas e de proteção de plantas, semente revestida e uso de pelo menos um composto |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2017240076A1 (en) | 2016-04-01 | 2018-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180026A1 (ar) | 2017-03-31 | 2019-01-30 | Univ Leuven Kath | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
-
2018
- 2018-05-18 ES ES18728541T patent/ES2929667T3/es active Active
- 2018-05-18 PE PE2019002404A patent/PE20200604A1/es unknown
- 2018-05-18 TW TW107116924A patent/TWI758480B/zh not_active IP Right Cessation
- 2018-05-18 CR CR20190530A patent/CR20190530A/es unknown
- 2018-05-18 WO PCT/EP2018/063028 patent/WO2018215315A1/en not_active Ceased
- 2018-05-18 CN CN201880033697.9A patent/CN110691773B/zh active Active
- 2018-05-18 CA CA3060583A patent/CA3060583C/en active Active
- 2018-05-18 MX MX2019013893A patent/MX393586B/es unknown
- 2018-05-18 AU AU2018274100A patent/AU2018274100B2/en active Active
- 2018-05-18 KR KR1020197036401A patent/KR102625988B1/ko active Active
- 2018-05-18 EP EP18728541.6A patent/EP3630723B1/en active Active
- 2018-05-18 US US16/612,670 patent/US11407715B2/en active Active
- 2018-05-18 EA EA201992782A patent/EA201992782A1/ru unknown
- 2018-05-18 JP JP2019564166A patent/JP7203764B2/ja active Active
- 2018-05-18 MA MA048943A patent/MA48943A/fr unknown
- 2018-05-18 UA UAA201912024A patent/UA125407C2/uk unknown
- 2018-05-18 BR BR112019024195-7A patent/BR112019024195A2/pt active Search and Examination
- 2018-05-21 AR ARP180101342A patent/AR111878A1/es not_active Application Discontinuation
- 2018-05-22 UY UY0001037742A patent/UY37742A/es unknown
-
2019
- 2019-10-28 CO CONC2019/0012035A patent/CO2019012035A2/es unknown
- 2019-11-15 CL CL2019003294A patent/CL2019003294A1/es unknown
- 2019-11-15 PH PH12019502559A patent/PH12019502559A1/en unknown
- 2019-11-18 IL IL270726A patent/IL270726B2/en unknown
- 2019-11-21 NI NI201900119A patent/NI201900119A/es unknown
- 2019-11-22 EC ECSENADI201983640A patent/ECSP19083640A/es unknown
-
2022
- 2022-06-16 US US17/842,367 patent/US11795149B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR111878A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
| AR111315A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
| AR111820A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación de virus del dengue | |
| AR111314A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
| AR108046A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue | |
| PE20180232A1 (es) | Derivados de indol mono o disustituidos como inhibidores de la replicacion viral del dengue | |
| JOP20190229A1 (ar) | مركبات تثبط بروتين mcl-1 | |
| CO2017008862A2 (es) | Composiciones farmacéuticas que comprenden n-(3,5-dimetoxifenil)-n’-(1-metiletil)-n-[3-(1-metil-1h-pirazol-4-il-quinoxalin-6-il]etano-1,2-diamina | |
| MX2021006552A (es) | Antagonista del receptor del factor de liberacion de corticotropina 1 (crf1), formulaciones farmaceuticas y formas solidas del mismo para el tratamiento de hiperplasia suprarrenal congenita. | |
| CR20150628A (es) | Derivados de la pirazolopirrolidina y su uso en el tratamiento de enfermedades | |
| AR111233A1 (es) | Inhibidores de tyk2, usos y métodos para la producción de los mismos | |
| ECSP18073245A (es) | Derivados de indol sustituidos como inhibidores de la replicación vírica del dengue | |
| EA201692249A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| HRP20200408T1 (hr) | Mono- ili di-supstituirani derivati indola kao inhibitori replikacije denga virusa | |
| UY36903A (es) | Derivados de indol mono- o disustituidos como inhibidores de la replicación viral del dengue | |
| EA201692266A1 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| CR20180496A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
| AR081261A1 (es) | Metodos para tratar afecciones virales | |
| AR103412A1 (es) | Derivados de indol mono o disustituido como inhibidores de la replicación del virus del dengue | |
| UY36124A (es) | Derivados de carboxamida | |
| MX2019006612A (es) | Derivados de imidazo[1,5-a]pirazina como inhibidores de fosfatidilinositol-4,5-bisfosfato 3-quinasadelta (pi3kdelta). | |
| EA201991595A1 (ru) | Активатор nrf2 | |
| UY36123A (es) | Derivados de carboxamida | |
| AR101696A1 (es) | Compuestos de azetidiniloxifenilpirrolidina | |
| CO2017005806A2 (es) | Nuevos derivados de bencimidazol como agentes antihistamínicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |