AR111315A1 - Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue - Google Patents
Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengueInfo
- Publication number
- AR111315A1 AR111315A1 ARP180100777A ARP180100777A AR111315A1 AR 111315 A1 AR111315 A1 AR 111315A1 AR P180100777 A ARP180100777 A AR P180100777A AR P180100777 A ARP180100777 A AR P180100777A AR 111315 A1 AR111315 A1 AR 111315A1
- Authority
- AR
- Argentina
- Prior art keywords
- ch2ch2oh
- trifluoromethyl
- hydrogen
- chlorine
- compounds
- Prior art date
Links
- 208000001490 Dengue Diseases 0.000 title abstract 4
- 206010012310 Dengue fever Diseases 0.000 title abstract 4
- 208000025729 dengue disease Diseases 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000000460 chlorine Substances 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 208000036142 Viral infection Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 230000009385 viral infection Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente se refiere a derivados de indolina sustituidos, a métodos para prevenir o tratar infecciones virales por dengue mediante el uso de dichos compuestos y también se refiere a dichos compuestos para su uso como medicamento, más preferentemente, para su uso como medicamento para tratar o prevenir infecciones virales por dengue. La presente se refiere además a composiciones farmacéuticas o preparados combinados de los compuestos, a las composiciones o preparados para su uso como un medicamento, más preferentemente para la prevención o el tratamiento de infecciones virales por dengue. La presente también se refiere a procesos para la preparación de los compuestos. Reivindicación 1: Un compuesto de fórmula (1), incluida cualquiera de sus formas estereoquímicamente isoméricas, donde R¹ es fluoro, R² es -CH₂CH₂OH, R³ es trifluorometilo, y R⁴ es hidrógeno, o R¹ es fluoro, R² es -CH₂CH₂OH, R³ es trifluorometilo, y R⁴ es metoxi, o R¹ es fluoro, R² es -CH₂CH₂OH, R³ es trifluorometoxi, y R⁴ es hidrógeno, o R¹ es cloro, R² es -CH₂CH₂OH, R³ es trifluorometilo, y R⁴ es hidrógeno, o R¹ es cloro, R² es -CH₂CH₂OH, R³ es trifluorometilo, y R⁴ es metoxi, o R¹ es cloro, R² es -CH₂CH₂OH, R³ es trifluorometoxi, y R⁴ es hidrógeno, o R¹ es cloro, R² es -(CH₂)₃COOH, R³ es trifluorometilo, y R⁴ es hidrógeno, o R¹ es cloro, R² es -(CH₂)₃COOH, R³ es trifluorometilo, y R⁴ es metoxi, o R¹ es cloro, R² es -(CH₂)₃COOH, R³ es trifluorometoxi, y R⁴ es hidrógeno; o una sal, solvato o polimorfo farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17164045 | 2017-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111315A1 true AR111315A1 (es) | 2019-06-26 |
Family
ID=58464339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100777A AR111315A1 (es) | 2017-03-31 | 2018-03-28 | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US11179368B2 (es) |
| EP (1) | EP3601225B1 (es) |
| JP (1) | JP7038733B2 (es) |
| KR (1) | KR102556222B1 (es) |
| CN (1) | CN110612284B (es) |
| AR (1) | AR111315A1 (es) |
| AU (1) | AU2018246299A1 (es) |
| BR (1) | BR112019019928A2 (es) |
| CA (1) | CA3055260A1 (es) |
| CL (1) | CL2019002744A1 (es) |
| CO (1) | CO2019010292A2 (es) |
| CR (1) | CR20190447A (es) |
| DK (1) | DK3601225T3 (es) |
| EA (1) | EA201992334A1 (es) |
| EC (1) | ECSP19070413A (es) |
| ES (1) | ES2887673T3 (es) |
| HR (1) | HRP20211102T1 (es) |
| HU (1) | HUE055576T2 (es) |
| IL (1) | IL269657A (es) |
| JO (1) | JOP20180026A1 (es) |
| LT (1) | LT3601225T (es) |
| MA (1) | MA48987A (es) |
| MX (1) | MX2019011608A (es) |
| NI (1) | NI201900098A (es) |
| PE (1) | PE20191652A1 (es) |
| PH (1) | PH12019502095A1 (es) |
| SG (1) | SG11201908465QA (es) |
| SI (1) | SI3601225T1 (es) |
| TW (1) | TW201900610A (es) |
| UY (1) | UY37646A (es) |
| WO (1) | WO2018178238A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201116559D0 (en) | 2011-09-26 | 2011-11-09 | Univ Leuven Kath | Novel viral replication inhibitors |
| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| HUE054936T2 (hu) | 2016-03-31 | 2021-10-28 | Janssen Pharmaceuticals Inc | Helyettesített indol-származékok mint a dengue-vírus replikációjának inhibitorai |
| MX2018011788A (es) | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2017240076A1 (en) | 2016-04-01 | 2018-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (ar) | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
| ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| CN109485596A (zh) * | 2018-12-19 | 2019-03-19 | 山东理工职业学院 | 一种含吲哚啉的登革病毒抑制剂的制备方法 |
| WO2025248536A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel oxime derivatives to treat viral infections |
| CN119306651B (zh) * | 2024-10-11 | 2025-12-05 | 山东大学 | 一种吲哚3-酰胺类衍生物及其制备方法与应用 |
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| GB0110832D0 (en) | 2001-05-03 | 2001-06-27 | Virogen Ltd | Antiviral compounds |
| JP2005520795A (ja) | 2001-12-12 | 2005-07-14 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害活性を有するプリン類似体 |
| GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
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| GB201305376D0 (en) | 2013-03-25 | 2013-05-08 | Univ Leuven Kath | Novel viral replication inhibitors |
| EP3060547B1 (en) | 2013-10-23 | 2017-10-11 | Janssen Sciences Ireland UC | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
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| JOP20160086B1 (ar) | 2015-05-08 | 2021-08-17 | 2 Katholieke Univ Leuven Ku Leuven Research And Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JO3633B1 (ar) * | 2015-09-16 | 2020-08-27 | Katholieke Univ Leuven Ku Leuven Research & Development | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| JOP20160198B1 (ar) * | 2015-09-16 | 2022-03-14 | Janssen Pharmaceuticals Inc | مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
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| MX2018011788A (es) * | 2016-03-31 | 2019-05-20 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicacion virica de dengue. |
| EP3436444B1 (en) | 2016-03-31 | 2020-05-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CA3018986A1 (en) | 2016-04-01 | 2017-10-05 | Signal Pharmaceuticals, Llc | Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith |
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| CN109641956A (zh) | 2016-04-01 | 2019-04-16 | 美国安进公司 | Flt3的嵌合受体及其使用方法 |
| BR112018068851B1 (pt) | 2016-04-01 | 2022-11-22 | Basf Se | Composto de fórmula i, composição, métodos de combate ou controle de pragas invertebradas e de proteção de plantas, semente revestida e uso de pelo menos um composto |
| JOP20170069B1 (ar) | 2016-04-01 | 2021-08-17 | 1 Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| AU2017240076A1 (en) | 2016-04-01 | 2018-08-09 | Janssen Pharmaceuticals, Inc. | Substituted indole compound derivatives as dengue viral replication inhibitors |
| JOP20180025B1 (ar) * | 2017-03-31 | 2021-08-17 | Janssen Pharmaceuticals Inc | مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك |
| ES2929667T3 (es) | 2017-05-22 | 2022-11-30 | Janssen Pharmaceuticals Inc | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue |
| CN110753682B (zh) | 2017-05-22 | 2023-06-30 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚啉衍生物 |
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2017
- 2017-03-31 JO JOP/2018/0026A patent/JOP20180026A1/ar unknown
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2018
- 2018-03-28 AR ARP180100777A patent/AR111315A1/es unknown
- 2018-03-29 CR CR20190447A patent/CR20190447A/es unknown
- 2018-03-29 AU AU2018246299A patent/AU2018246299A1/en not_active Abandoned
- 2018-03-29 JP JP2019553485A patent/JP7038733B2/ja active Active
- 2018-03-29 DK DK18715611.2T patent/DK3601225T3/da active
- 2018-03-29 MA MA048987A patent/MA48987A/fr unknown
- 2018-03-29 CN CN201880022012.0A patent/CN110612284B/zh active Active
- 2018-03-29 HU HUE18715611A patent/HUE055576T2/hu unknown
- 2018-03-29 ES ES18715611T patent/ES2887673T3/es active Active
- 2018-03-29 CA CA3055260A patent/CA3055260A1/en not_active Abandoned
- 2018-03-29 SG SG11201908465Q patent/SG11201908465QA/en unknown
- 2018-03-29 SI SI201830334T patent/SI3601225T1/sl unknown
- 2018-03-29 US US16/492,667 patent/US11179368B2/en active Active
- 2018-03-29 TW TW107110873A patent/TW201900610A/zh unknown
- 2018-03-29 WO PCT/EP2018/058077 patent/WO2018178238A1/en not_active Ceased
- 2018-03-29 EP EP18715611.2A patent/EP3601225B1/en active Active
- 2018-03-29 LT LTEPPCT/EP2018/058077T patent/LT3601225T/lt unknown
- 2018-03-29 HR HRP20211102TT patent/HRP20211102T1/hr unknown
- 2018-03-29 MX MX2019011608A patent/MX2019011608A/es unknown
- 2018-03-29 KR KR1020197031206A patent/KR102556222B1/ko active Active
- 2018-03-29 BR BR112019019928A patent/BR112019019928A2/pt not_active IP Right Cessation
- 2018-03-29 PE PE2019001919A patent/PE20191652A1/es unknown
- 2018-03-29 EA EA201992334A patent/EA201992334A1/ru unknown
- 2018-04-02 UY UY0001037646A patent/UY37646A/es unknown
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2019
- 2019-09-13 PH PH12019502095A patent/PH12019502095A1/en unknown
- 2019-09-24 CO CONC2019/0010292A patent/CO2019010292A2/es unknown
- 2019-09-25 IL IL26965719A patent/IL269657A/en unknown
- 2019-09-26 CL CL2019002744A patent/CL2019002744A1/es unknown
- 2019-09-27 NI NI201900098A patent/NI201900098A/es unknown
- 2019-09-27 EC ECSENADI201970413A patent/ECSP19070413A/es unknown
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