AR111665A1 - Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp - Google Patents
Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrpInfo
- Publication number
- AR111665A1 AR111665A1 ARP180101138A ARP180101138A AR111665A1 AR 111665 A1 AR111665 A1 AR 111665A1 AR P180101138 A ARP180101138 A AR P180101138A AR P180101138 A ARP180101138 A AR P180101138A AR 111665 A1 AR111665 A1 AR 111665A1
- Authority
- AR
- Argentina
- Prior art keywords
- useful
- pirrolidine
- diona
- antagonists
- derivatives
- Prior art date
Links
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 title 1
- 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000003735 calcitonin gene related peptide receptor antagonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
La presente proporciona un compuesto de fórmula (1) o una sal aceptable para uso farmacéutico o hidrato del mismo, útil como un antagonista del receptor CGRP. Reivindicación 1: Un compuesto de la fórmula (1) o una sal aceptable para uso farmacéutico o hidrato del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506204P | 2017-05-15 | 2017-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR111665A1 true AR111665A1 (es) | 2019-08-07 |
Family
ID=62245454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180101138A AR111665A1 (es) | 2017-05-15 | 2018-05-02 | Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10336726B2 (es) |
| EP (1) | EP3625221B1 (es) |
| JP (1) | JP6794583B2 (es) |
| CN (1) | CN110662741B (es) |
| AR (1) | AR111665A1 (es) |
| CA (1) | CA3061762C (es) |
| CY (1) | CY1124032T1 (es) |
| DK (1) | DK3625221T3 (es) |
| ES (1) | ES2870325T3 (es) |
| HR (1) | HRP20210655T1 (es) |
| HU (1) | HUE054448T2 (es) |
| LT (1) | LT3625221T (es) |
| PL (1) | PL3625221T3 (es) |
| PT (1) | PT3625221T (es) |
| RS (1) | RS61657B1 (es) |
| SI (1) | SI3625221T1 (es) |
| TW (1) | TW201904955A (es) |
| WO (1) | WO2018213059A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3625220B1 (en) | 2017-05-15 | 2021-03-10 | Eli Lilly and Company | Cgrp receptor antagonists |
| CN114746409A (zh) * | 2019-12-12 | 2022-07-12 | 伊莱利利公司 | 可用作正电子发射断层扫描术的示踪剂化合物的cgrp拮抗剂 |
| CN115704811B (zh) * | 2022-12-26 | 2023-03-31 | 南京威凯尔生物医药科技有限公司 | 一种高效液相色谱法检测乌布吉泮及其对映体和非对映体杂质的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| AU2004222328B2 (en) * | 2003-03-14 | 2009-10-08 | Merck Sharp & Dohme Corp. | Aryl spirohydantoin CGRP receptor antagonists |
| EP2846798B1 (en) | 2012-05-09 | 2018-04-04 | Merck Sharp & Dohme Corp. | Aliphatic spirolactam cgrp receptor antagonists |
| TW201718574A (zh) | 2015-08-12 | 2017-06-01 | 美國禮來大藥廠 | Ｃｇｒｐ受體拮抗劑 |
| TWI636041B (zh) | 2015-08-12 | 2018-09-21 | 美國禮來大藥廠 | Ｃｇｒｐ受體拮抗劑 |
-
2018
- 2018-05-02 TW TW107114809A patent/TW201904955A/zh unknown
- 2018-05-02 AR ARP180101138A patent/AR111665A1/es unknown
- 2018-05-08 HU HUE18727529A patent/HUE054448T2/hu unknown
- 2018-05-08 DK DK18727529.2T patent/DK3625221T3/da active
- 2018-05-08 LT LTEP18727529.2T patent/LT3625221T/lt unknown
- 2018-05-08 HR HRP20210655TT patent/HRP20210655T1/hr unknown
- 2018-05-08 CA CA3061762A patent/CA3061762C/en active Active
- 2018-05-08 RS RS20210400A patent/RS61657B1/sr unknown
- 2018-05-08 JP JP2020512768A patent/JP6794583B2/ja not_active Expired - Fee Related
- 2018-05-08 ES ES18727529T patent/ES2870325T3/es active Active
- 2018-05-08 PT PT187275292T patent/PT3625221T/pt unknown
- 2018-05-08 SI SI201830241T patent/SI3625221T1/sl unknown
- 2018-05-08 US US15/973,681 patent/US10336726B2/en not_active Expired - Fee Related
- 2018-05-08 EP EP18727529.2A patent/EP3625221B1/en active Active
- 2018-05-08 WO PCT/US2018/031526 patent/WO2018213059A1/en not_active Ceased
- 2018-05-08 CN CN201880032549.5A patent/CN110662741B/zh not_active Expired - Fee Related
- 2018-05-08 PL PL18727529T patent/PL3625221T3/pl unknown
-
2021
- 2021-04-06 CY CY20211100293T patent/CY1124032T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2020519686A (ja) | 2020-07-02 |
| SI3625221T1 (sl) | 2021-04-30 |
| EP3625221A1 (en) | 2020-03-25 |
| DK3625221T3 (da) | 2021-04-19 |
| US10336726B2 (en) | 2019-07-02 |
| HUE054448T2 (hu) | 2021-09-28 |
| CN110662741B (zh) | 2022-08-16 |
| EP3625221B1 (en) | 2021-03-03 |
| HRP20210655T1 (hr) | 2021-05-28 |
| PL3625221T3 (pl) | 2021-08-23 |
| CA3061762A1 (en) | 2018-11-22 |
| JP6794583B2 (ja) | 2020-12-02 |
| CN110662741A (zh) | 2020-01-07 |
| LT3625221T (lt) | 2021-04-26 |
| CA3061762C (en) | 2021-11-09 |
| RS61657B1 (sr) | 2021-04-29 |
| PT3625221T (pt) | 2021-04-15 |
| US20180327384A1 (en) | 2018-11-15 |
| CY1124032T1 (el) | 2022-05-27 |
| TW201904955A (zh) | 2019-02-01 |
| WO2018213059A1 (en) | 2018-11-22 |
| ES2870325T3 (es) | 2021-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |