AR110783A1 - Derivados de heterociclos bicíclicos condensados como pesticidas - Google Patents
Derivados de heterociclos bicíclicos condensados como pesticidasInfo
- Publication number
- AR110783A1 AR110783A1 ARP180100191A ARP180100191A AR110783A1 AR 110783 A1 AR110783 A1 AR 110783A1 AR P180100191 A ARP180100191 A AR P180100191A AR P180100191 A ARP180100191 A AR P180100191A AR 110783 A1 AR110783 A1 AR 110783A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- cycloalkyl
- amino
- alkylsulfinyl
- Prior art date
Links
- 239000000575 pesticide Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 46
- -1 C2−6 cyanoalkynyl Chemical group 0.000 abstract 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 11
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 5
- 125000004670 alkyl amino thio carbonyl group Chemical group 0.000 abstract 5
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 4
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 4
- 125000006642 (C1-C6) cyanoalkyl group Chemical group 0.000 abstract 4
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 4
- 125000005089 alkenylaminocarbonyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 3
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 3
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 abstract 3
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 abstract 3
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 abstract 2
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 abstract 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 abstract 2
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 2
- 125000005103 alkyl silyl group Chemical group 0.000 abstract 2
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 abstract 2
- 125000004682 aminothiocarbonyl group Chemical group NC(=S)* 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003636 chemical group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005159 cyanoalkoxy group Chemical group 0.000 abstract 2
- 125000005167 cycloalkylaminocarbonyl group Chemical group 0.000 abstract 2
- 125000004993 haloalkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 abstract 2
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N thiocyanic acid Chemical compound SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- LCOHXBYKSRYXEY-UHFFFAOYSA-N 1-(4-amino-8-butylsulfanylquinazolin-7-yl)-3,6-dimethyl-6,7-dihydro-5h-indol-4-one Chemical compound C1=C(C)C(C(CC(C)C2)=O)=C2N1C1=C(SCCCC)C2=NC=NC(N)=C2C=C1 LCOHXBYKSRYXEY-UHFFFAOYSA-N 0.000 abstract 1
- SLVJWAFNWIUVSU-UHFFFAOYSA-N 1-(4-amino-8-ethylsulfanylquinazolin-7-yl)-3,6,6-trimethyl-5,7-dihydroindol-4-one Chemical compound C1=C(C)C(C(CC(C)(C)C2)=O)=C2N1C1=C(SCC)C2=NC=NC(N)=C2C=C1 SLVJWAFNWIUVSU-UHFFFAOYSA-N 0.000 abstract 1
- IKNRMHDLWNIURV-UHFFFAOYSA-N 1-(4-amino-8-ethylsulfinylquinazolin-7-yl)-3,6,6-trimethyl-5,7-dihydroindol-4-one Chemical compound C1=C(C)C(C(CC(C)(C)C2)=O)=C2N1C1=C(S(=O)CC)C2=NC=NC(N)=C2C=C1 IKNRMHDLWNIURV-UHFFFAOYSA-N 0.000 abstract 1
- NQWBUWUQAFIFSB-UHFFFAOYSA-N 1-(4-amino-8-methylsulfanylquinazolin-7-yl)-3,6,6-trimethyl-5,7-dihydroindol-4-one Chemical compound C1=C(C)C(C(CC(C)(C)C2)=O)=C2N1C1=C(SC)C2=NC=NC(N)=C2C=C1 NQWBUWUQAFIFSB-UHFFFAOYSA-N 0.000 abstract 1
- XFHITHSBIRZMDH-UHFFFAOYSA-N 1-(4-amino-8-propan-2-ylsulfanylquinazolin-7-yl)-3,6,6-trimethyl-5,7-dihydroindol-4-one Chemical compound C1=C(C)C(C(CC(C)(C)C2)=O)=C2N1C1=C(SC(C)C)C2=NC=NC(N)=C2C=C1 XFHITHSBIRZMDH-UHFFFAOYSA-N 0.000 abstract 1
- TXDLSWKHWHIQFF-UHFFFAOYSA-N 1-[4-amino-8-(2-hydroxyethylsulfanyl)quinazolin-7-yl]-3,6,6-trimethyl-5,7-dihydroindol-4-one Chemical compound NC1=NC=NC2=C(SCCO)C(N3C=C(C=4C(=O)CC(C)(C)CC=43)C)=CC=C21 TXDLSWKHWHIQFF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 230000000895 acaricidal effect Effects 0.000 abstract 1
- 239000000642 acaricide Substances 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 1
- 125000005347 halocycloalkyl group Chemical group 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001272 nitrous oxide Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Su uso como acaricidas y/o insecticidas para el control de plagas animales. Reivindicación 1: Los compuestos de la fórmula (1), en la que Aa es nitrógeno o =C(R⁷)-; Ab es nitrógeno o =C(R⁸)-; Ac es nitrógeno o =C(R⁹)-; Ad es nitrógeno o =C(R¹⁰)-, donde los grupos químicos Aa, Ab, Ac y Ad no pueden ser simultáneamente nitrógeno y en donde al menos uno de los grupos químicos Aa, Ab, Ac y Ad debe ser nitrógeno; R¹ es C₁₋₆ alquilo, C₁₋₆ haloalquilo, C₁₋₆ cianoalquilo, C₁₋₆ hidroxialquilo, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₁₋₆ haloalcoxi-C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alqueniloxi-C₁₋₆ alquilo, C₂₋₆ haloalqueniloxi-C₁₋₆ alquilo, C₂₋₆ haloalquenil-C₂₋₆ cianoalquenil-C₂₋₆ alquinil-C₂₋₆ alquiniloxi-C₁₋₆ alquilo, C₂₋₆ haloalquiniloxi-C₁₋₆ alquilo, C₂₋₆ haloalquinilo, C₂₋₆ cianoalquinilo, C₃₋₈ cicloalquilo, C₃₋₈ cicloalquilo-C₃₋₈ cicloalquilo, C₁₋₆ alquil-C₃₋₈ cicloalquilo, halo-C₃₋₈ cicloalquilo, amino, C₁₋₆ alquilamino, di-C₁₋₆ alquil-amino, C₃₋₈ cicloalquilamino, C₁₋₆ alquilcarbonil-amino, C₁₋₆ alquiltio-C₁₋₆ alquilo, C₁₋₆ haloalquiltio-C₁₋₆ alquilo, C₁₋₆ alquilsulfinil-C₁₋₆ alquilo, C₁₋₆ haloalquilsulfinil-C₁₋₆ alquilo, C₁₋₆ alquilsulfonil-C₁₋₆ alquilo, C₁₋₆ haloalquilsulfonil-C₁₋₆ alquilo, C₁₋₆ alcoxi-C₁₋₆ alquiltio-C₁₋₆ alquilo, C₁₋₆ alcoxi-C₁₋₆ alquilsulfinil-C₁₋₆ alquilo, C₁₋₆ alcoxi-C₁₋₆ alquilsulfonil-C₁₋₆ alquilo, C₁₋₆ alquilcarbonil-C₁₋₆ alquilo, C₁₋₆ haloalquilcarbonil-C₁₋₆ alquilo, C₁₋₆ alcoxicarbonil-C₁₋₆ alquilo, C₁₋₆ haloalcoxicarbonil-C₁₋₆ alquilo, C₁₋₆ alquilsulfonilamino, aminosulfonil-C₁₋₆ alquilo, C₁₋₆ alquilaminosulfonil-C₁₋₆ alquilo, di-C₁₋₆ alquil-aminosulfonil-C₁₋₆ alquilo, o es C₁₋₆ alquilo, C₁₋₆ alcoxi, C₂₋₆ alquenilo, C₂₋₆ alquinil-C₃₋₈ cicloalquilo cada uno opcionalmente mono- o polisustituido de manera idéntica o diferente con arilo, hetarilo o heterociclilo, donde arilo, hetarilo o heterociclilo puede estar cada uno opcionalmente mono- o polisustituido de manera idéntica o diferente con halógeno, ciano, nitro, hidroxi, amino, carboxi, carbamoil, aminosulfonilo, C₁₋₆ alquilo, C₃₋₆ cicloalquilo, C₁₋₆ alcoxi, C₁₋₆ haloalquilo, C₁₋₆ haloalcoxi, C₁₋₆ alquiltio, C₁₋₆ alquilsulfinilo, C₁₋₆ alquilsulfonilo, C₁₋₆ alquilsulfimino, C₁₋₆ alquilsulfimino-C₁₋₆ alquilo, C₁₋₆ alquilsulfimino-C₂₋₆ alquilcarbonilo, C₁₋₆ alquilsulfoximino, C₁₋₆ alquilsulfoximino-C₁₋₆ alquilo, C₁₋₆ alquilsulfoximino-C₂₋₆ alquilcarbonilo, C₁₋₆ alcoxicarbonilo, C₁₋₆ alquilcarbonilo, C₃₋₆ trialquilsililo o bencilo; R², R³ son independientemente el uno del otro hidrógeno, ciano, halógeno, acetilo, hidroxi, amino, C₃₋₈ cicloalquilo, halo-C₃₋₈ cicloalquilo, C₁₋₆ alquilo, C₁₋₆ haloalquilo, C₁₋₆ cianoalquilo, C₂₋₆ alquenilo, C₂₋₆ haloalquenil-C₂₋₆ alquinil-C₂₋₆ haloalquinilo, C₁₋₆ alcoxi, C₁₋₆ haloalcoxi, C₁₋₆ alquiltio, C₁₋₆ haloalquiltio, C₁₋₆ alquilsulfinilo, C₁₋₆ haloalquilsulfinilo, C₁₋₆ alquilsulfonilo o C₁₋₆ haloalquilsulfonilo, donde solo uno de los radicales R² o R³ es un sustituyente diferente al hidrógeno; R⁷, R⁸, R⁹, R¹⁰ son independientemente el uno del otro hidrógeno, ciano, halógeno, nitro, acetilo, hidroxi, amino, SCN, tri-C₁₋₆ alquilsililo, C₃₋₈ cicloalquilo, C₃₋₈ cicloalquilo-C₃₋₈ cicloalquilo, C₁₋₆ alquil-C₃₋₈ cicloalquilo, halo-C₃₋₈ cicloalquilo, C₁₋₆ alquilo, C₁₋₆ haloalquilo, C₁₋₆ cianoalquilo, C₁₋₆ hidroxialquilo, hidroxicarbonil-C₁₋₆ alcoxi, C₁₋₆ alcoxicarbonil-C₁₋₆ alquilo, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ haloalquenil-C₂₋₆ cianoalquenil-C₂₋₆ alquinil-C₂₋₆ haloalquinilo, C₂₋₆ cianoalquinilo, C₁₋₆ alcoxi, C₁₋₆ haloalcoxi, C₁₋₆ cianoalcoxi, C₁₋₆ alcoxicarbonil-C₁₋₆ alcoxi, C₁₋₆ alcoxi-C₁₋₆ alcoxi, C₁₋₆ alquilhidroxiimino, C₁₋₆ alcoxiimino, C₁₋₆ alquil-C₁₋₆ alcoxiimino, C₁₋₆ haloalquil-C₁₋₆ alcoxiimino, C₁₋₆ alquiltio, C₁₋₆ haloalquiltio, C₁₋₆ alcoxi-C₁₋₆ alquiltio, C₁₋₆ alquiltio-C₁₋₆ alquilo, C₁₋₆ alquilsulfinilo, C₁₋₆ haloalquilsulfinilo, C₁₋₆ alcoxi-C₁₋₆ alquilsulfinilo, C₁₋₆ alquilsulfinil-C₁₋₆ alquilo, C₁₋₆ alquilsulfonilo, C₁₋₆ haloalquilsulfonilo, C₁₋₆ alcoxi-C₁₋₆ alquilsulfonilo, C₁₋₆ alquilsulfonil-C₁₋₆ alquilo, C₁₋₆ alquilsulfoniloxi, C₁₋₆ alquilcarbonilo, C₁₋₆ alquiltiocarbonilo, C₁₋₆ haloalquilcarbonilo, C₁₋₆ alquilcarboniloxi, C₁₋₆ alcoxicarbonilo, C₁₋₆ haloalcoxicarbonilo, aminocarbonilo, C₁₋₆ alquilaminocarbonilo, C₁₋₆ alquilaminotiocarbonilo, di-C₁₋₆ alquil-aminocarbonilo, di-C₁₋₆ alquil-aminotiocarbonilo, C₂₋₆ alquenilaminocarbonilo, di-C₂₋₆ alquenilaminocarbonilo, C₃₋₈ cicloalquilaminocarbonilo, C₁₋₆ alquilsulfonilamino, C₁₋₆ alquilamino, di-C₁₋₆ alquilamino, aminosulfonilo, C₁₋₆ alquilaminosulfonilo, di-C₁₋₆ alquil-aminosulfonilo, C₁₋₆ alquilsulfoximino, aminotiocarbonilo, C₁₋₆ alquilaminotiocarbonilo, di-C₁₋₆ alquil-aminotiocarbonilo, C₃₋₈ cicloalquilamino o NHCO-C₁₋₆ alquil-(C₁₋₆ alquilcarbonilamino); Q es un sistema de anillos bicíclico o tricíclico fusionado de 8, 9, 10, 11 ó 12 miembros heterocíclico o heteroaromático saturado o parcialmente saturado, donde opcionalmente al menos un grupo carbonilo puede estar presente y / o donde el sistema de anillos puede estar opcionalmente mono- o polisustituido de manera idéntica o diferente y donde los sustituyentes se pueden seleccionar de manera independiente entre ciano, halógeno, nitro, acetilo, hidroxi, amino, SCN, tri-C₁₋₆ alquilsililo, C₃₋₈ cicloalquilo, C₃₋₈ cicloalquilo-C₃₋₈ cicloalquilo, C₁₋₆ alquil-C₃₋₈ cicloalquilo, halo-C₃₋₈ cicloalquilo, C₁₋₆ alquilo, C₁₋₆ haloalquilo, C₁₋₆ cianoalquilo, C₁₋₆ hidroxialquilo, hidroxicarbonil-C₁₋₆ alcoxi, C₁₋₆ alcoxicarbonil-C₁₋₆ alquilo, C₁₋₆ alcoxi-C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ haloalquenil-C₂₋₆ cianoalquenil-C₂₋₆ alquinil-C₂₋₆ alquiniloxi-C₁₋₄ alquilo, C₂₋₆ haloalquinilo, C₂₋₆ cianoalquinilo, C₁₋₆ alcoxi, C₁₋₆ haloalcoxi, C₁₋₆ haloalcoxi-C₁₋₆ alquilo, C₂₋₆ alqueniloxi-C₁₋₆ alquilo, C₂₋₆ haloalqueniloxi-C₁₋₆ alquilo, C₁₋₆ cianoalcoxi, C₁₋₆ alcoxicarbonil-C₁₋₆ alcoxi, C₁₋₆ alcoxi-C₁₋₆ alcoxi, C₁₋₆ alquilhidroxiimino, C₁₋₆ alcoxiimino, C₁₋₆ alquil-C₁₋₆ alcoxiimino, C₁₋₆ haloalquil-C₁₋₆ alcoxiimino, C₁₋₆ alquiltio, C₁₋₆ haloalquiltio, C₁₋₆ alcoxi-C₁₋₆ alquiltio, C₁₋₆ alquiltio-C₁₋₆ alquilo, C₁₋₆ alquilsulfinilo, C₁₋₆ haloalquilsulfinilo, C₁₋₆ alcoxi-C₁₋₆ alquilsulfinilo, C₁₋₆ alquilsulfinil-C₁₋₆ alquilo, C₁₋₆ alquilsulfonilo, C₁₋₆ haloalquilsulfonilo, C₁₋₆ alcoxi-C₁₋₆ alquilsulfonilo, C₁₋₆ alquilsulfonil-C₁₋₆ alquilo, C₁₋₆ alquilsulfoniloxi, C₁₋₆ alquilcarbonilo, C₁₋₆ alquilcarbonil-C₁₋₆ alquilo, C₁₋₆ alquiltiocarbonilo, C₁₋₆ haloalquilcarbonilo, C₁₋₆ alquilcarboniloxi, C₁₋₆ alcoxicarbonilo, C₁₋₆ haloalcoxicarbonilo, aminocarbonilo, C₁₋₆ alquilaminocarbonilo, C₁₋₆ alquilaminotiocarbonilo, di-C₁₋₆ alquil-aminocarbonilo, di-C₁₋₆ alquil-aminotiocarbonilo, C₂₋₆ alquenilaminocarbonilo, di-C₂₋₆ alquenilaminocarbonilo, C₃₋₈ cicloalquilaminocarbonilo, C₁₋₆ alquilsulfonilamino, C₁₋₆ alquilamino, di-C₁₋₆ alquilamino, aminosulfonilo, C₁₋₆ alquilaminosulfonilo, di-C₁₋₆ alquil-aminosulfonilo, C₁₋₆ alquilsulfoximino, aminotiocarbonilo, C₁₋₆ alquilaminotiocarbonilo, di-C₁₋₆ alquil-aminotiocarbonilo, C₃₋₈ cicloalquilamino, NHCO-C₁₋₆ alquil-(C₁₋₆ alquilcarbonilamino), o donde los sustituyentes se pueden seleccionar de manera independiente entre fenilo o un anillo heteroaromático de 5 ó 6 miembros, donde el fenilo o el anillo puede estar opcionalmente mono- o polisustituido de manera idéntica o diferente con C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alquinilo, C₃₋₆ cicloalquilo, C₁₋₆ haloalquilo, C₂₋₆ haloalquenilo, C₂₋₆ haloalquinilo, C₃₋₆ halocicloalquilo, halógeno, CN, NO₂, C₁₋₄ alcoxi, C₁₋₄ haloalcoxi; n es 0, 1 ó 2; y óxido nitroso de los compuestos de la fórmula (1); a excepción de 1-(8-(aliltio)-4-aminoquinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(butiltio)quinazolin-7-il)-3,6-dimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(2-hidroxietiltio)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(piridin-2-ilmetiltio)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indazol-4(5H)-ona, 1-(4-amino-8-(etiltio)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(metiltio)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(etilsulfinilo)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(isopropiltio)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona, 1-(4-amino-8-(ciclopentiltio)quinazolin-7-il)-3,6,6-trimetil-6,7-dihidro-1H-indol-4(5H)-ona; donde Q no puede representar los sistemas de anillos del grupo de fórmulas (2).
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-
2018
- 2018-01-22 WO PCT/EP2018/051442 patent/WO2018138050A1/de not_active Ceased
- 2018-01-24 TW TW107102451A patent/TW201838990A/zh unknown
- 2018-01-26 UY UY0001037582A patent/UY37582A/es not_active Application Discontinuation
- 2018-01-26 AR ARP180100191A patent/AR110783A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201838990A (zh) | 2018-11-01 |
| WO2018138050A1 (de) | 2018-08-02 |
| UY37582A (es) | 2018-08-31 |
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