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MX2011008276A - Inhibidores de quinasa jun n-terminal. - Google Patents

Inhibidores de quinasa jun n-terminal.

Info

Publication number
MX2011008276A
MX2011008276A MX2011008276A MX2011008276A MX2011008276A MX 2011008276 A MX2011008276 A MX 2011008276A MX 2011008276 A MX2011008276 A MX 2011008276A MX 2011008276 A MX2011008276 A MX 2011008276A MX 2011008276 A MX2011008276 A MX 2011008276A
Authority
MX
Mexico
Prior art keywords
jun
inhibitors
present disclosure
terminal kinase
compounds
Prior art date
Application number
MX2011008276A
Other languages
English (en)
Inventor
Andrei W Konradi
Simeon Bowers
Roy K Hom
Hing L Sham
Gary D Probst
Anh Truong
R Jeffrey Neitz
Jennifer Sealy
Gergely Toth
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of MX2011008276A publication Critical patent/MX2011008276A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente exposición proporciona inhibidores de quinasas N-term,inale4s c-Jun (JNK) que tienen una e4structura de conformidad con la siguiente fórmula (i) o una sal o solvato del, en donde el anillo A, CaChj, Z, R5, W y Cy se definen 1}en la pre3sete además proporciona composiciones farmacéuticas que incluyen los compuestos de la presente exposición y métodos para hacer y usar los compuesto y composiciones de la presente exposición, vf. Gr., tratamiento y prevención de varios des+ordenes tales como mal de Alzheimer. (ver fórmula (I)).
MX2011008276A 2009-02-06 2010-02-05 Inhibidores de quinasa jun n-terminal. MX2011008276A (es)

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