AR110001A1 - Derivados heteroarilo bicíclicos - Google Patents
Derivados heteroarilo bicíclicosInfo
- Publication number
- AR110001A1 AR110001A1 ARP170103007A ARP170103007A AR110001A1 AR 110001 A1 AR110001 A1 AR 110001A1 AR P170103007 A ARP170103007 A AR P170103007A AR P170103007 A ARP170103007 A AR P170103007A AR 110001 A1 AR110001 A1 AR 110001A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- lower alkyl
- hydrogen
- lower alkoxy
- compounds
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 206010012289 Dementia Diseases 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 abstract 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 abstract 1
- 201000010374 Down Syndrome Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente se refiere a un compuesto de fórmula (1), (2) ó (3), en las que: R¹ es hidrógeno, alquilo inferior, alquilo inferior sustituido con halógeno, halógeno, alcoxi inferior o alcoxi inferior sustituido con halógeno, R¹ puede ser diferente en el caso de que n = 2 ó 3; n es 1, 2 ó 3; Ar es un grupo heteroarilo de seis elementos, seleccionado de entre los compuestos del grupo de fórmulas (4), en el que R² es hidrógeno, alquilo inferior, alquilo inferior sustituido con halógeno, halógeno o alcoxi inferior; R³ es hidrógeno o halógeno; o a una sal de adición de ácido farmacéuticamente aceptable de los mismos. Los compuestos pueden utilizarse para el tratamiento de la enfermedad de Alzheimer, la angiopatía amiloide cerebral, la hemorragia cerebral hereditaria con amiloidosis de tipo holandés (HCHWA-D), la demencia multiinfarto, la demencia pugilística o el síndrome de Down.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16196720 | 2016-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110001A1 true AR110001A1 (es) | 2019-02-13 |
Family
ID=57218802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170103007A AR110001A1 (es) | 2016-11-01 | 2017-10-30 | Derivados heteroarilo bicíclicos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10941147B2 (es) |
| EP (1) | EP3535266B1 (es) |
| JP (1) | JP7111704B2 (es) |
| CN (1) | CN109641912B (es) |
| AR (1) | AR110001A1 (es) |
| TW (1) | TWI761384B (es) |
| WO (1) | WO2018083050A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7012715B2 (ja) * | 2016-06-27 | 2022-01-28 | エフ．ホフマン－ラ ロシュ アーゲー | γ－セクレターゼモジュレーターとしてのトリアゾロピリジン |
| AR109829A1 (es) * | 2016-09-29 | 2019-01-30 | Hoffmann La Roche | Derivados de piperidina puenteados |
| US11440915B2 (en) | 2017-12-18 | 2022-09-13 | Hoffmann-La Roche Inc. | Triazolo-azepine derivatives |
| WO2019141832A1 (en) * | 2018-01-22 | 2019-07-25 | F. Hoffmann-La Roche Ag | Triazolo-azepine derivatives |
| MA53541B1 (fr) * | 2018-09-03 | 2024-02-29 | Hoffmann La Roche | Dérivés hétéroaryles bicycliques |
| RS65821B1 (sr) * | 2018-12-13 | 2024-09-30 | Hoffmann La Roche | Derivati 7-fenoksi-n-(3-azabiciklo[3.2.1]oktan-8-il)-6,7-dihidro-5h-pirolo[1,2-b][1,2,4]triazol-2-amina i srodna jedinjenja kao modulatori gama-sekretaze za lečenje alchajmerove bolesti |
| AU2019412747B8 (en) | 2018-12-27 | 2025-04-24 | F. Hoffmann-La Roche Ag | Process for the preparation exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate |
| US20230048657A1 (en) * | 2019-11-29 | 2023-02-16 | Hoffmann-La Roche Inc. | Process for the preparation of (9s)-2-bromo-9-(2,3,4-trifluorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[1,5-a]azepine |
| AU2021393968A1 (en) * | 2020-12-11 | 2023-05-11 | F. Hoffmann-La Roche Ag | Process for the preparation of (9s)-n-[3-(6-methylpyrimidin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl]-9-(2,3,4-trifluorophenyl)-6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[1,5-a]azepin-2-amine and its solid form |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201030002A (en) * | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| JPWO2011007756A1 (ja) * | 2009-07-13 | 2012-12-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
| US8486967B2 (en) * | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| US8703763B2 (en) * | 2011-03-02 | 2014-04-22 | Hoffmann-La Roche Inc. | Bridged piperidine derivatives |
| JP6831372B2 (ja) * | 2015-09-09 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋ピペリジン誘導体 |
| JP6872550B2 (ja) * | 2015-12-10 | 2021-05-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋されたピペリジン誘導体 |
| CN109790112B (zh) * | 2016-09-27 | 2022-08-26 | 特殊治疗有限公司 | 具有作为usp30抑制剂活性的氰基吡咯烷衍生物 |
-
2017
- 2017-10-30 JP JP2019522297A patent/JP7111704B2/ja active Active
- 2017-10-30 US US16/346,623 patent/US10941147B2/en active Active
- 2017-10-30 EP EP17788263.6A patent/EP3535266B1/en active Active
- 2017-10-30 CN CN201780052840.4A patent/CN109641912B/zh active Active
- 2017-10-30 AR ARP170103007A patent/AR110001A1/es not_active Application Discontinuation
- 2017-10-30 WO PCT/EP2017/077719 patent/WO2018083050A1/en not_active Ceased
- 2017-10-31 TW TW106137507A patent/TWI761384B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US10941147B2 (en) | 2021-03-09 |
| EP3535266A1 (en) | 2019-09-11 |
| US20190284191A1 (en) | 2019-09-19 |
| CN109641912B (zh) | 2021-10-29 |
| CN109641912A (zh) | 2019-04-16 |
| WO2018083050A1 (en) | 2018-05-11 |
| EP3535266B1 (en) | 2021-12-29 |
| JP2019532972A (ja) | 2019-11-14 |
| JP7111704B2 (ja) | 2022-08-02 |
| TWI761384B (zh) | 2022-04-21 |
| TW201821427A (zh) | 2018-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |