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AR102492A1 - Cromanos sustituidos y métodos para su uso - Google Patents

Cromanos sustituidos y métodos para su uso

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Publication number
AR102492A1
AR102492A1 ARP150103536A ARP150103536A AR102492A1 AR 102492 A1 AR102492 A1 AR 102492A1 AR P150103536 A ARP150103536 A AR P150103536A AR P150103536 A ARP150103536 A AR P150103536A AR 102492 A1 AR102492 A1 AR 102492A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
alkylenyl
independently
case
Prior art date
Application number
ARP150103536A
Other languages
English (en)
Inventor
R Koenig John
Bogdan Andrew
Voigth Eric
Liu Bo
J Altenbach Robert
C Yeung Ming
B Searle Xenia
Wang Xueqing
R Kym Philip
Original Assignee
Abbvie Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55858309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR102492(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of AR102492A1 publication Critical patent/AR102492A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Agentes en el tratamiento de enfermedades y condiciones mediadas y moduladas por CFTR, que incluyen fibrosis quística, síndrome de Sjögren, insuficiencia pancreática, enfermedad pulmonar obstructiva crónica y enfermedad obstructiva crónica del flujo aéreo. También se proveen composiciones farmacéuticas que comprenden uno o más de los compuestos de fórmula (1). Reivindicación 1: Un compuesto de fórmula (1) o una sal aceptable farmacéuticamente del mismo, donde X es CR² e Y es CR³; o X es N e Y es CR³; o X es CR² e Y es N; m es 0, 1, 2, ó 3; R son sustituyentes opcionales en el anillo ciclopropilo, y en cada caso, son en forma independiente entre sí halógeno, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; R¹ y R², son en forma independiente entre sí hidrógeno, halógeno, C₁₋₆ haloalquilo, C₁₋₆ alquilo, -OR¹A, -C(O)OR¹B, -NR¹AR²A, o -C(O)NR¹AR²A; R¹A y R²A, en cada caso, son en forma independiente entre sí hidrógeno, C₁₋₆ haloalquilo, G¹A, o C₁₋₆ alquilo; donde el C₁₋₆ haloalquilo y el C₁₋₆ alquilo está cada uno opcionalmente sustituido con uno o dos sustituyentes seleccionados en forma independiente entre el grupo que consiste en -ORZA, -SRZA, -S(O)₂RZA, -C(O)RZA, -C(O)ORZA, -C(O)N(RZA)₂, -N(RZA)₂, -N(RZA)C(O)RZB, -N(RZA)S(O)₂RZB, -N(RZA)C(O)ORZB, -N(RZA)C(O)N(RZA), -CN, y G¹A; o R¹A y R²A junto con el átomo de nitrógeno al cual están unidos forman un heterociclo de 4 - 6 miembros donde el heterociclo de 4 - 6 miembros está opcionalmente sustituido con 1, 2, ó 3 sustituyentes seleccionados en forma independiente entre el grupo que consiste en halógeno, C₁₋₆ alquilo, C₁₋₆ haloalquilo, -ORʲ, y N(Rʲ)₂; donde RZA, en cada caso, es en forma independiente hidrógeno, C₁₋₆, haloalquilo, C₁₋₆ alquilo, G¹A, o -(C₁₋₆ alquilenilo)-G¹A; y RZB, en cada caso, es en forma independiente C₁₋₆ haloalquilo, C₁₋₆ alquilo, G¹A, o -(C₁₋₆ alquilenilo)-G¹A; R¹B es hidrógeno, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; R³ y R¹⁴, son en forma independiente entre sí hidrógeno, halógeno, C₁₋₆ haloalquilo, C₁₋₆ alquilo, -OH, o -O-(C₁₋₆ alquilo); R⁴ es hidrógeno, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; R⁵ es hidrógeno, -C(O)Rⁱ, -C(O)OH, -C(O)O(C₁₋₆ alquilo), -C(O)N(Rʰ)₂, C₁₋₆ haloalquilo, C₁₋₆ alquilo, o G²A; donde el C₁₋₆ haloalquilo y el C₁₋₆ alquilo está cada uno opcionalmente sustituido con uno o dos sustituyentes seleccionados en forma independiente entre el grupo que consiste en -ORʰ, -OC(O)N(Rʰ)₂, -C(O)Rʰ, -C(O)ORʰ, -C(O)N(Rʰ)₂, -N(Rʰ)₂, -N(Rʰ)C(O)Rⁱ, -N(Rʰ)S(O)₂Rⁱ, -N(Rʰ)C(O)O(Rⁱ), -N(Rʰ)C(O)N(Rʰ)₂, y G²A; o R⁴ y R⁵, junto con el átomo de carbono al cual se encuentran unidos, forman un cicloalquilo C₃₋₆ o un heterociclo de 4 - 6 miembros; donde el C₃₋₆ cicloalquilo y el heterociclo de 4 - 6 miembros está cada uno opcionalmente sustituido con 1, 2, ó 3 grupos Rᵖ seleccionados en forma independiente; G²A, en cada caso, es en forma independiente cicloalquilo, cicloalquenilo, heterociclo, arilo, o heteroarilo, cada uno de los cuales no está sustituido o está sustituido en forma independiente con 1, 2, ó 3 grupos Rq seleccionados en forma independiente; Rᵖ y Rq, en cada caso, son en forma independiente entre sí C₁₋₆ alquilo, halógeno, C₁₋₆ haloalquilo, -CN, oxo, NO₂, -ORʰ, -OC(O)Rⁱ, -OC(O)N(Rʰ)₂, -SRʰ, -S(O)₂Rʰ, -S(O)₂N(Rʰ)₂, -C(O)Rʰ, -C(O)ORʰ, -C(O)N(Rʰ)₂, -C(O)N(Rʰ)S(O)₂Rʰ, -N(Rʰ)₂, -N(Rʰ)C(O)Rⁱ, -N(Rʰ)S(O)₂Rⁱ, -N(Rʰ)C(O)O(Rⁱ), -N(Rʰ)C(O)N(Rʰ)₂, o GA, donde C₁₋₆, haloalquilo y el C₁₋₆ alquilo está cada uno opcionalmente sustituido con uno o dos sustituyentes seleccionados en forma independiente entre el grupo que consiste en -ORʰ, -OC(O)Rⁱ, -OC(O)N(Rʰ)₂, -SRʰ, -S(O)₂Rʰ, -S(O)₂N(Rʰ)₂, -C(O)Rʰ, -C(O)ORʰ, -C(O)N(Rʰ)₂, -C(O)N(Rʰ)S(O)₂Rʰ, -N(Rʰ)₂, -N(Rʰ)C(O)Rⁱ, -N(Rʰ)S(O)₂Rⁱ, -N(Rʰ)C(O)O(Rⁱ), -N(Rʰ)C(O)N(Rʰ)₂, -CN, y GA; Rʰ, en cada caso, es en forma independiente hidrógeno, C₁₋₆ haloalquilo, C₁₋₆ alquilo, o GA, donde el C₁₋₆ haloalquilo y el C₁₋₆ alquilo está cada uno opcionalmente sustituido con uno o dos sustituyentes seleccionados en forma independiente entre el grupo que consiste en -ORʲ, -OC(O)N(Rʲ)₂, -SRʲ, -C(O)ORʲ, -C(O)N(Rʲ)₂, -N(Rʲ)₂, -CN, y GA; Rⁱ, en cada caso, es en forma independiente C₁₋₆ haloalquilo, C₁₋₆ alquilo, o GA, donde el C₁₋₆ haloalquilo y el C₁₋₆ alquilo está cada uno opcionalmente sustituido con uno o dos sustituyentes seleccionados en forma independiente entre el grupo que consiste en -ORʲ, -OC(O)N(Rʲ)₂, -SRʲ, -C(O)ORʲ, -C(O)N(Rʲ)₂, -N(Rʲ)₂, -CN, y GA; R⁶ es hidrógeno, halógeno, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; R⁷ es hidrógeno, halógeno, -ORʲ, -N(Rʲ)₂, -N(Rʲ)C(O)Rᵏ, C₁₋₆ haloalquilo, C₁₋₆ alquilo, C₂₋₆ alquenilo, o -(C₁₋₆ alquilenilo)-G³A; R⁸ es hidrógeno, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; R⁹, R¹⁰, y R¹³, son en forma independiente entre sí hidrógeno, halógeno, -ORʲ, C₁₋₆ haloalquilo, o C₁₋₆ alquilo; R¹¹ y R¹² son en forma independiente entre sí hidrógeno, C₁₋₃ alquilo, o halógeno; G¹A, G³A, y GA, en cada caso, son en forma independiente entre sí cicloalquilo, cicloalquenilo, heterociclo, arilo, o heteroarilo, cada uno de los cuales no está sustituido o está sustituido en forma independiente con 1, 2, ó 3 grupos Rˢ seleccionados en forma independiente; donde Rˢ, en cada caso, es en forma independiente C₁₋₆ alquilo, C₂₋₆ alquenilo, C₂₋₆ alquinilo, halógeno, C₁₋₆ haloalquilo, -CN, oxo, NO₂, -ORʲ, -OC(O)Rᵏ, -OC(O)N(Rʲ)₂, -SRʲ, -S(O)₂Rʲ, -S(O)₂N(Rʲ)₂, -C(O)Rʲ, -C(O)ORʲ, -C(O)N(Rʲ)₂, -N(Rʲ)₂, -N(Rʲ)C(O)Rᵏ, -N(Rʲ)S(O)₂Rᵏ, -N(Rʲ)C(O)O(Rᵏ), -N(Rʲ)C(O)N(Rʲ)₂, -(C₁₋₆ alquilenilo)-ORʲ, -(C₁₋₆ alquilenilo)-OC(O)Rᵏ, -(C₁₋₆ alquilenilo)-OC(O)N(Rʲ)₂, -(C₁₋₆ alquilenilo)-SRʲ, -(C₁₋₆ alquilenilo)-S(O)₂Rʲ, -(C₁₋₆ alquilenilo)-S(O)₂N(Rʲ)₂, -(C₁₋₆ alquilenilo)-C(O)Rʲ, -(C₁₋₆ alquilenilo)-C(O)ORʲ, -(C₁₋₆ alquilenilo)-C(O)N(Rʲ)₂, -(C₁₋₆ alquilenilo)-N(Rʲ)₂, -(C₁₋₆ alquilenilo)-N(Rʲ)C(O)Rᵏ, -(C₁₋₆ alquilenilo)-N(Rʲ)S(O)₂Rᵏ, -(C₁₋₆ alquilenilo)-N(Rʲ)C(O)O(Rᵏ), -(C₁₋₆ alquilenilo)-N(Rʲ)C(O)N(Rʲ)₂, o -(C₁₋₆ alquilenilo)-CN; Rʲ, en cada caso, es en forma independiente hidrógeno, C₁₋₆ alquilo, o C₁₋₆ haloalquilo; y Rᵏ, en cada caso, es en forma independiente C₁₋₆ alquilo o C₁₋₆ haloalquilo.
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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079139A2 (en) 2005-12-28 2007-07-12 Vertex Pharmaceuticals, Inc. Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
EP3381899B1 (en) 2010-04-22 2021-01-06 Vertex Pharmaceuticals Incorporated Intermediate compound for process of producing cycloalkylcarboxamido-indole compounds
JP6543268B2 (ja) 2014-04-15 2019-07-10 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物
US9840513B2 (en) 2015-07-16 2017-12-12 Abbvie S.Á.R.L. Substituted tricyclics and method of use
PE20181348A1 (es) 2015-10-09 2018-08-22 Abbvie Sarl PIRAZOLO[3,4-b]PIRIDIN-6-CARBOXAMIDAS N-SULFONILADAS Y METODO DE USO
WO2017060873A1 (en) 2015-10-09 2017-04-13 AbbVie S.à.r.l. Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use
BR112018007165A2 (pt) 2015-10-09 2019-01-22 AbbVie S.à.r.l. novos compostos para tratamento da fibrose cística
CN109219602A (zh) 2016-04-26 2019-01-15 艾伯维公司 囊性纤维化跨膜传导调节物蛋白的调节剂
US10138227B2 (en) 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use
US9981910B2 (en) 2016-10-07 2018-05-29 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
US10399940B2 (en) 2016-10-07 2019-09-03 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
WO2018116185A1 (en) 2016-12-20 2018-06-28 AbbVie S.à.r.l. Deuterated cftr modulators and methods of use
TW201831471A (zh) 2017-02-24 2018-09-01 盧森堡商艾伯維公司 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法
CN106977483A (zh) * 2017-06-02 2017-07-25 遵义医学院 一种二氟烷基取代的黄酮醇、异黄酮醇和香豆素类化合物的合成方法
EP3645538A1 (en) * 2017-06-28 2020-05-06 GlaxoSmithKline Intellectual Property Development Limited Modulators of indoleamine 2,3-dioxygenase
US10988454B2 (en) 2017-09-14 2021-04-27 Abbvie Overseas S.À.R.L. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
WO2019070492A1 (en) * 2017-10-02 2019-04-11 Merck Sharp & Dohme Corp. CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS
WO2019193062A1 (en) 2018-04-03 2019-10-10 Abbvie S.Á.R.L Substituted pyrrolidines and their use
US11345691B2 (en) 2019-06-03 2022-05-31 AbbVie Global Enterprises Ltd. Prodrug modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
TW202115014A (zh) 2019-07-12 2021-04-16 美商奧佛麥德公司 用於治療囊腫纖維化之化合物
CR20230120A (es) 2020-08-07 2023-09-01 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
US12324802B2 (en) 2020-11-18 2025-06-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
WO2022150173A1 (en) 2021-01-06 2022-07-14 AbbVie Global Enterprises Ltd. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
US20220211692A1 (en) 2021-01-06 2022-07-07 AbbVie Global Enterprises Ltd. Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
CN113234113B (zh) * 2021-05-31 2023-09-01 江西师范大学 一种构建1,2-顺式-2-硝基-葡萄糖苷和半乳糖糖苷的方法
CN113372318A (zh) * 2021-07-02 2021-09-10 贵州中医药大学 7-甲氧基-4’-甲酸甲酯二氢黄酮的制备方法及装置
AU2023215272A1 (en) 2022-02-03 2024-08-15 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
KR20240155228A (ko) 2022-02-03 2024-10-28 버텍스 파마슈티칼스 인코포레이티드 (6a,12a)-17-아미노-12-메틸-6,15-비스(트리플루오로메틸)-13,19-디옥사-3,4,18-트리아자트리시클로[12.3.1.12,5]노나데카-1(18),2,4,14,16-펜타엔-6-올의 결정질 형태를 제조하는 방법
WO2023154291A1 (en) 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN119947720A (zh) 2022-05-16 2025-05-06 弗特克斯药品有限公司 治疗囊性纤维化的方法
WO2024056798A1 (en) 2022-09-15 2024-03-21 Idorsia Pharmaceuticals Ltd Macrocyclic cftr modulators
JP2025530377A (ja) 2022-09-15 2025-09-11 イドルシア・ファーマシューティカルズ・リミテッド 大環状ｃｆｔｒ調節剤とｃｆｔｒコレクター及び／又はｃｆｔｒポテンシエーターとの合剤
KR20240069924A (ko) 2022-11-11 2024-05-21 삼성디스플레이 주식회사 표시 장치 및 이를 포함하는 전자 기기
WO2025186214A1 (en) 2024-03-05 2025-09-12 Idorsia Pharmaceuticals Ltd Macrocyclic cftr modulators

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU2005210474B2 (en) 2004-01-30 2011-07-07 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding cassette transporters
US7977322B2 (en) * 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
JP5143738B2 (ja) 2005-08-11 2013-02-13 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子の調節物質
US20120232059A1 (en) 2005-11-08 2012-09-13 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette Transporters
DK2774925T3 (en) 2005-11-08 2017-02-27 Vertex Pharma Heterocyclic modulators of ATP binding cassette transporters
ES2398319T3 (es) 2005-12-28 2013-03-15 Vertex Pharmaceuticals Incorporated Derivados de 1-(benzo[D][1,3]dioxol-5-il)-N-(fenil)ciclopropano-carboxamida y compuestos relacionados como moduladores de transportadores de casetes de unión a ATP para el tratamiento de la fibrosis quística
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
EP2007756B1 (en) * 2006-04-07 2015-08-26 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
CN101715450B (zh) 2006-11-03 2013-03-13 沃泰克斯药物股份有限公司 作为cftr调控剂的氮杂吲哚衍生物
US8563573B2 (en) * 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
AU2008251504B2 (en) 2007-05-09 2013-07-18 Vertex Pharmaceuticals Incorporated Modulators of CFTR
DK2217572T3 (da) 2007-11-16 2014-02-03 Vertex Pharma Isoquinoliner som modulatorer af ATP-bindingskassettetransportører
CN101998854A (zh) 2007-12-07 2011-03-30 沃泰克斯药物股份有限公司 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的制剂
CN102245573B (zh) 2008-02-28 2013-11-20 沃泰克斯药物股份有限公司 作为cftr调节剂的杂芳基衍生物
JP5622285B2 (ja) 2008-03-31 2014-11-12 バーテックスファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓｉｎｃｏｒｐｏｒａｔｅｄ Ｃｆｔｒモジュレーターとしてのピリジル誘導体
WO2011008931A2 (en) 2009-07-15 2011-01-20 Cystic Fibrosis Foundation Therapeutics, Inc. Arylpyrimidine compounds and combination therapy comprising same for treating cystic fibrosis & related disorders
CN102892764B (zh) * 2010-03-25 2016-07-06 弗特克斯药品有限公司 (r)-1(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)-n-(1-(2,3-二羟基丙基)-6-氟-2-(1-羟基-2-甲基丙-2-基)-1h-吲哚-5-基)环丙烷甲酰胺的固体形式
RU2014106611A (ru) * 2011-07-22 2015-08-27 Актелион Фармасьютиклз Лтд Производные гетероциклических амидов в качестве антагонистов р2х7 рецептора
CA2942386A1 (en) 2014-03-13 2015-09-17 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
BR112018007165A2 (pt) * 2015-10-09 2019-01-22 AbbVie S.à.r.l. novos compostos para tratamento da fibrose cística
CN108463223A (zh) * 2015-10-09 2018-08-28 艾伯维公司 用于治疗囊性纤维化的增效剂-校正剂组合

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