AR119971A1 - Derivados de piridazin-3(2h)-ona fusionados con azol - Google Patents
Derivados de piridazin-3(2h)-ona fusionados con azolInfo
- Publication number
- AR119971A1 AR119971A1 ARP200102558A ARP200102558A AR119971A1 AR 119971 A1 AR119971 A1 AR 119971A1 AR P200102558 A ARP200102558 A AR P200102558A AR P200102558 A ARP200102558 A AR P200102558A AR 119971 A1 AR119971 A1 AR 119971A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently selected
- halo
- alkyl
- unsubstituted
- substituted
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000001424 substituent group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- -1 cyano, hydroxy Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1), un tautómero de este, o una sal farmacéuticamente aceptable del compuesto o tautómero, donde: a es un enlace simple, b es un enlace doble, X¹ es NR¹N, y tanto (i) X² es N y X³ es CR³C o (ii) X² es CR² y X³ se selecciona entre N y CR³C; o a es un enlace doble, b es un enlace simple, X³ es NR³N, y tanto (i) X¹ es N y X² es CR² o (ii) X¹ es CR¹C y X² se selecciona entre N y CR²; n se selecciona entre 0 y 1; R¹C, R², R³C y R⁴ se seleccionan cada uno independientemente entre (a) hidrógeno; y (b) alquilo C₁₋₆ y cicloalquilo C₃₋₈, cada uno sin sustituir o sustituido con 1 a 3 sustituyentes independientemente seleccionados de halo; R¹N y R³N se seleccionan cada uno independientemente entre alquilo C₁₋₆, cicloalquilo C₃₋₈ y arilo C₆₋₁₀, cada uno sin sustituir o sustituido con 1 a 3 sustituyentes independientemente seleccionados de halo; R⁵ se selecciona entre hidrógeno y alquilo C₁₋₆, y R⁶ se selecciona entre alquilo C₁₋₆ y cicloalquilo C₃₋₈; o R⁵ y R⁶, junto con el nitrógeno y los átomos de carbono a los cuales cada uno está respectivamente unido, forman un anillo heterocíclico C₃₋₆, siendo el anillo heterocíclico monocíclico y con un átomo en el anillo que es un heteroátomo, X⁷ se selecciona entre N y CR⁷; R⁷ se selecciona entre (a) hidrógeno, halo, ciano, hidroxi y amino; y (b) alquilo C₁₋₆ y alcoxi C₁₋₆, cada uno sin sustituir o sustituido con 1 a 3 sustituyentes independientemente seleccionados de halo; R⁸ y R⁹ se seleccionan cada uno independientemente entre (a) hidrógeno, halo, ciano, hidroxi y amino; y (b) alquilo C₁₋₆ y alcoxi C₁₋₆, cada uno sin sustituir o sustituido con 1 a 3 sustituyentes independientemente seleccionados de halo; o R⁸ y R⁹, junto con los átomos de carbono a los cuales están unidos, forman un anillo heterocíclico C₄₋₅, el anillo heterocíclico tiene uno o dos átomos en el anillo que son heteroátomos, estando cada uno de los heteroátomos independientemente seleccionados entre N, O y S; R¹⁰ y R¹¹ se seleccionan cada uno independientemente entre (a) hidrógeno, halo, ciano, hidroxi y amino; y (b) alquilo C₁₋₆ y alcoxi C₁₋₆, cada uno sin sustituir o sustituido con 1 a 3 sustituyentes independientemente seleccionados de halo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962901052P | 2019-09-16 | 2019-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR119971A1 true AR119971A1 (es) | 2022-01-26 |
Family
ID=72670806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200102558A AR119971A1 (es) | 2019-09-16 | 2020-09-15 | Derivados de piridazin-3(2h)-ona fusionados con azol |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US12370192B2 (es) |
| EP (1) | EP4031552B1 (es) |
| JP (1) | JP7566888B2 (es) |
| KR (1) | KR20220063228A (es) |
| CN (1) | CN114728975A (es) |
| AR (1) | AR119971A1 (es) |
| AU (1) | AU2020348675B2 (es) |
| BR (1) | BR112022004819A2 (es) |
| CA (1) | CA3150508A1 (es) |
| CO (1) | CO2022004684A2 (es) |
| CR (1) | CR20220160A (es) |
| DO (1) | DOP2022000057A (es) |
| EC (1) | ECSP22020159A (es) |
| ES (1) | ES2997267T3 (es) |
| HR (1) | HRP20250088T1 (es) |
| HU (1) | HUE069908T2 (es) |
| IL (1) | IL291181B2 (es) |
| JO (1) | JOP20220063A1 (es) |
| MX (1) | MX2022003177A (es) |
| PE (1) | PE20221341A1 (es) |
| PH (1) | PH12022550597A1 (es) |
| PL (1) | PL4031552T3 (es) |
| RS (1) | RS66463B1 (es) |
| TW (1) | TWI873185B (es) |
| WO (1) | WO2021055326A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| EP4031552B1 (en) | 2019-09-16 | 2024-11-06 | Takeda Pharmaceutical Company Limited | Azole-fused pyridazin-3(2h)-one derivatives |
| CN114149371B (zh) * | 2021-11-26 | 2023-08-22 | 首都医科大学 | 四取代吡唑类化合物及其应用 |
| US20250163065A1 (en) * | 2022-03-01 | 2025-05-22 | Shanghaitech University | Pyrrolotriazinone compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof |
| WO2023165262A1 (zh) * | 2022-03-01 | 2023-09-07 | 上海科技大学 | 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用 |
| IT202200024948A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio KV7.2/KV7.3 |
| CN116063179A (zh) * | 2023-02-20 | 2023-05-05 | 南京杰运医药科技有限公司 | 一种4-甲氧基乙酰乙酸甲酯的合成方法 |
| WO2025119351A1 (zh) * | 2023-12-08 | 2025-06-12 | 深圳湾实验室 | Gpr139激动剂 |
| WO2025124544A1 (zh) * | 2023-12-14 | 2025-06-19 | 华润医药研究院（深圳）有限公司 | 3,4-二氢-2H-苯并[b][1,4]二氧杂环庚烷类化合物及其制备方法和医药用途 |
| CN120424068A (zh) * | 2024-02-02 | 2025-08-05 | 上海科技大学 | 稠杂环类化合物与其制备方法、药物组合物及应用 |
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2020
- 2020-09-15 EP EP20781670.3A patent/EP4031552B1/en active Active
- 2020-09-15 ES ES20781670T patent/ES2997267T3/es active Active
- 2020-09-15 CN CN202080079367.0A patent/CN114728975A/zh active Pending
- 2020-09-15 TW TW109131750A patent/TWI873185B/zh active
- 2020-09-15 CA CA3150508A patent/CA3150508A1/en active Pending
- 2020-09-15 US US17/753,803 patent/US12370192B2/en active Active
- 2020-09-15 WO PCT/US2020/050823 patent/WO2021055326A1/en not_active Ceased
- 2020-09-15 HR HRP20250088TT patent/HRP20250088T1/hr unknown
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| US12370192B2 (en) | 2025-07-29 |
| AU2020348675A1 (en) | 2022-04-14 |
| JOP20220063A1 (ar) | 2023-01-30 |
| CN114728975A (zh) | 2022-07-08 |
| IL291181B2 (en) | 2025-09-01 |
| TWI873185B (zh) | 2025-02-21 |
| EP4031552C0 (en) | 2024-11-06 |
| TW202124386A (zh) | 2021-07-01 |
| PL4031552T3 (pl) | 2025-03-17 |
| AU2020348675B2 (en) | 2025-11-20 |
| EP4031552A1 (en) | 2022-07-27 |
| IL291181B1 (en) | 2025-05-01 |
| ECSP22020159A (es) | 2022-05-31 |
| HRP20250088T1 (hr) | 2025-03-28 |
| CR20220160A (es) | 2022-06-16 |
| WO2021055326A1 (en) | 2021-03-25 |
| CO2022004684A2 (es) | 2022-07-08 |
| CA3150508A1 (en) | 2021-03-25 |
| JP7566888B2 (ja) | 2024-10-15 |
| EP4031552B1 (en) | 2024-11-06 |
| RS66463B1 (sr) | 2025-02-28 |
| KR20220063228A (ko) | 2022-05-17 |
| PH12022550597A1 (en) | 2024-03-04 |
| BR112022004819A2 (pt) | 2022-06-07 |
| ES2997267T3 (en) | 2025-02-14 |
| HUE069908T2 (hu) | 2025-04-28 |
| IL291181A (en) | 2022-05-01 |
| PE20221341A1 (es) | 2022-09-13 |
| JP2022548602A (ja) | 2022-11-21 |
| US20230028114A1 (en) | 2023-01-26 |
| MX2022003177A (es) | 2022-04-06 |
| DOP2022000057A (es) | 2022-06-30 |
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