AR118124A2 - Proceso para la preparación de un inhibidor de pde4 - Google Patents
Proceso para la preparación de un inhibidor de pde4Info
- Publication number
- AR118124A2 AR118124A2 ARP200100438A ARP200100438A AR118124A2 AR 118124 A2 AR118124 A2 AR 118124A2 AR P200100438 A ARP200100438 A AR P200100438A AR P200100438 A ARP200100438 A AR P200100438A AR 118124 A2 AR118124 A2 AR 118124A2
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- indicated above
- meanings indicated
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 16
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- -1 methanesulfonyl halide Chemical class 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Proceso para la preparación de compuestos que poseen actividad inhibitoria de fosfodiesterasa (PDE4) de fórmula (1). La presente también se relaciona con el proceso para el aislamiento por cristalización del compuesto (1) y su uso para la preparación de composiciones farmacéuticas para inhalación en combinación con transportadores o vehículos adecuados. La presente también se relaciona con solvatos y formas cristalinas de un compuesto de fórmula (1). El producto sintetizado es adecuado para el uso en aplicaciones farmacéuticas por ejemplo en el tratamiento de enfermedades respiratorias. Reivindicación 1: Un proceso para preparar un compuesto de fórmula (1) caracterizado porque n es 0 ó 1, en donde el proceso comprende: (a) hacer reaccionar un compuesto de fórmula (2) en donde n es 0 ó 1, con un compuesto de fórmula (3) en donde X se selecciona de -NHSO₂Me y -NO₂ y Z se selecciona de OH, cloro, bromo, alcoxi C₁₋₆ lineal o ramificado, ariloxi, arilalcoxi, alquilcarboniloxi C₁₋₆, arilcarboniloxi y arilo C₁₋₆alquilcarboniloxi, para obtener un compuesto de fórmula (1) en donde n es 0 ó 1 o un compuesto de fórmula (4) en donde n tiene los significados indicados anteriormente; y, cuando se obtiene un compuesto de fórmula (4) en la etapa (a): (b) reducir a un compuesto correspondiente de fórmula (5) en donde n es 0 ó 1, y se hace reaccionar con haluro de metanosulfonilo para obtener un compuesto de fórmula (1) en donde n tiene los significados indicados anteriormente; y en donde el compuesto de fórmula (2) se obtiene de acuerdo con la etapa (c3) mediante: (c3) hacer reaccionar un intermedio de fórmula (6) con un intermedio de fórmula (7) en donde R es un grupo alquilo lineal o ramificado C₁₋₆ o un grupo arilalquilo y n tiene los significados indicados anteriormente, para obtener directamente un compuesto de fórmula (8) y posteriormente reduciéndolo enantioselectivamente para obtener un compuesto de fórmula (2) en donde n tiene los significados indicados anteriormente; y en donde todos los compuestos de fórmula (1), (2), (4), (5) o (8), en donde n es 1, pueden obtenerse oxidando los compuestos correspondientes en donde n es 0.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13189784 | 2013-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR118124A2 true AR118124A2 (es) | 2021-09-22 |
Family
ID=49385193
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140103938A AR098128A1 (es) | 2013-10-22 | 2014-10-20 | Proceso para la preparación de un inhibidor de pde4 |
| ARP200100438A AR118124A2 (es) | 2013-10-22 | 2020-02-17 | Proceso para la preparación de un inhibidor de pde4 |
| ARP210101431A AR122183A2 (es) | 2013-10-22 | 2021-05-27 | Proceso para la preparación de una forma cristalina de un inhibidor de pde4, forma cristalina, composición farmacéutica para inhalación, usos y solvato |
| ARP210101430A AR122182A2 (es) | 2013-10-22 | 2021-05-27 | Procesos para la preparación de compuestos intermediarios de un inhibidor de pde4 y dichos compuestos intermediarios |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140103938A AR098128A1 (es) | 2013-10-22 | 2014-10-20 | Proceso para la preparación de un inhibidor de pde4 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210101431A AR122183A2 (es) | 2013-10-22 | 2021-05-27 | Proceso para la preparación de una forma cristalina de un inhibidor de pde4, forma cristalina, composición farmacéutica para inhalación, usos y solvato |
| ARP210101430A AR122182A2 (es) | 2013-10-22 | 2021-05-27 | Procesos para la preparación de compuestos intermediarios de un inhibidor de pde4 y dichos compuestos intermediarios |
Country Status (29)
| Country | Link |
|---|---|
| US (7) | US9434691B2 (es) |
| EP (5) | EP3293176B1 (es) |
| JP (5) | JP6458957B2 (es) |
| KR (3) | KR102287598B1 (es) |
| CN (5) | CN110256338A (es) |
| AR (4) | AR098128A1 (es) |
| AU (1) | AU2014339136C1 (es) |
| BR (1) | BR112016008161B1 (es) |
| CA (3) | CA3115570C (es) |
| CY (1) | CY1123811T1 (es) |
| DK (3) | DK3293176T3 (es) |
| ES (3) | ES2980505T3 (es) |
| FI (1) | FI3587400T3 (es) |
| HR (3) | HRP20240783T1 (es) |
| HU (3) | HUE046637T2 (es) |
| IL (4) | IL285528B2 (es) |
| LT (2) | LT3293176T (es) |
| MX (4) | MX389002B (es) |
| MY (1) | MY182559A (es) |
| PH (3) | PH12020500162B1 (es) |
| PL (3) | PL3293176T3 (es) |
| PT (3) | PT3060551T (es) |
| RS (2) | RS65452B1 (es) |
| RU (1) | RU2682660C9 (es) |
| SG (4) | SG10202112587RA (es) |
| SI (3) | SI3060551T1 (es) |
| TW (3) | TWI685486B (es) |
| UA (2) | UA127453C2 (es) |
| WO (1) | WO2015059050A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2600830T1 (en) | 2010-08-03 | 2018-05-31 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising a phosphodiesterase inhibitor |
| JP6458957B2 (ja) | 2013-10-22 | 2019-01-30 | チエシ ファルマスティスィ エス．ピー．エー． | Ｐｄｅ４阻害剤の製造方法 |
| EP3487501A1 (en) * | 2016-07-20 | 2019-05-29 | Allergan, Inc. | Methods, compositions, and compounds for treatment of dermatological and ocular conditions |
| JP7361584B2 (ja) * | 2018-12-19 | 2023-10-16 | 高砂香料工業株式会社 | アミドの還元によるアミンの製造方法 |
| JP6780763B2 (ja) | 2018-12-25 | 2020-11-04 | トヨタ自動車株式会社 | 内燃機関の制御装置 |
| US11149615B2 (en) | 2018-12-25 | 2021-10-19 | Toyota Jidosha Kabushiki Kaisha | Control device for internal combustion engine |
| CN111808029A (zh) * | 2020-08-31 | 2020-10-23 | 兰晟生物医药(苏州)有限公司 | 一种pde4抑制剂氯比普兰的制备方法 |
| WO2023117985A1 (en) | 2021-12-21 | 2023-06-29 | Chiesi Farmaceutici S.P.A. | Dry powder formulations filled in an inhaler with improved resistance to humidity |
| JP2025514863A (ja) | 2022-04-27 | 2025-05-09 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｐｄｅ４阻害剤の新規結晶形態 |
| CN115304542B (zh) * | 2022-07-18 | 2024-02-02 | 湖南华纳大药厂手性药物有限公司 | 一种3-羟基吡啶的合成工艺 |
| WO2024027901A1 (en) | 2022-08-02 | 2024-02-08 | Chiesi Farmaceutici S.P.A. | Predictive biomarker of clinical response to a pde4 inhibitor |
| WO2024062006A1 (en) | 2022-09-22 | 2024-03-28 | Chiesi Farmaceutici S.P.A. | Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor |
| CN119947705A (zh) | 2022-09-22 | 2025-05-06 | 奇斯药制品公司 | 用于施用磷酸二酯酶-4抑制剂的胶囊吸入器 |
| EP4590273A1 (en) | 2022-09-22 | 2025-07-30 | Chiesi Farmaceutici S.p.A. | Capsule inhaler for the administration of a phosphodiesterase-4 inhibitor |
| KR20250079386A (ko) | 2023-11-27 | 2025-06-04 | 국립한국해양대학교산학협력단 | 복수의 학습모델을 이용한 이미지 기반의 강도 추정 장치 및 방법 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5935978A (en) * | 1991-01-28 | 1999-08-10 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group |
| CA2414049A1 (en) * | 2000-03-30 | 2001-10-11 | Chirotech Technology Limited | Ruthenium-diphosphine complexes and their use as catalysts |
| EP1670742A1 (en) * | 2003-09-12 | 2006-06-21 | Ranbaxy Laboratories Limited | Process for the preparation of roflumilast |
| ES2577303T3 (es) | 2004-04-19 | 2016-07-14 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Procedimientos para la preparación de la forma polimórfica I de hidrogenosulfato de clopidogrel |
| DK1749001T3 (da) * | 2004-04-29 | 2010-06-28 | Aventis Pharma Inc | 3-piperidinylisochroman-5-ol som dopaminagonister |
| KR20070079278A (ko) | 2006-02-01 | 2007-08-06 | 삼성전자주식회사 | 수신자 제한 시스템을 이용하는 디지털 멀티미디어시스템에서 수신기의 채널 전환 시간 단축 장치 및 방법 |
| DE602007012105D1 (de) * | 2006-07-14 | 2011-03-03 | Chiesi Farma Spa | Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren |
| HRP20110464T1 (hr) * | 2006-12-22 | 2011-07-31 | Leo Pharma A/S | Supstituirani acetofenoni korisni kao inhibitori pde4 |
| EP2022783A1 (en) * | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| US20100015430A1 (en) | 2008-07-16 | 2010-01-21 | Outlast Technologies, Inc. | Heat Regulating Article With Moisture Enhanced Temperature Control |
| EP2216327A1 (en) * | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| EP2580195B1 (en) | 2010-06-14 | 2014-12-03 | Chiesi Farmaceutici S.p.A. | Crystal form of glycopyrronium chloride |
| CA2807406C (en) * | 2010-08-03 | 2018-12-11 | Chiesi Farmaceutici S.P.A. | Pharmaceutical formulation comprising a phosphodiesterase inhibitor |
| SI2600830T1 (en) * | 2010-08-03 | 2018-05-31 | Chiesi Farmaceutici S.P.A. | Dry powder formulation comprising a phosphodiesterase inhibitor |
| SI2643322T1 (en) | 2010-11-23 | 2018-01-31 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| WO2012097479A1 (en) * | 2011-01-21 | 2012-07-26 | Abbott Laboratories | Bicyclic inhibitors of anaphastic lymphoma kinase |
| EP2760838B1 (en) * | 2011-09-26 | 2017-05-10 | Chiesi Farmaceutici S.p.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| AR089232A1 (es) * | 2011-12-16 | 2014-08-06 | Chiesi Farma Spa | Potenciacion inducida por inhibidores de pde4 en el tratamiento de la leucemia |
| AR093796A1 (es) * | 2012-12-05 | 2015-06-24 | Chiesi Farm Spa | Derivados del alcohol 1-fenil-2-piridinil alquilico como inhibidores de la fosfodiesterasa |
| CN103304408B (zh) * | 2013-06-05 | 2016-10-05 | 威海迪素制药有限公司 | 罗氟司特中间体3-环丙甲氧基-4-二氟甲氧基苯甲酸的制备 |
| US9427376B2 (en) * | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
| JP6458957B2 (ja) * | 2013-10-22 | 2019-01-30 | チエシ ファルマスティスィ エス．ピー．エー． | Ｐｄｅ４阻害剤の製造方法 |
| KR101591785B1 (ko) | 2013-12-24 | 2016-02-04 | 주식회사 투게더 | 데이터 입력 장치, 이를 이용한 데이터 전송 시스템 및 방법 |
| MA51413A (fr) * | 2017-12-28 | 2021-04-28 | Chiesi Farm Spa | Utilisation de dérivés d'alcool alkylique de 1-phényl-2-pyridinyl pour le traitement de la fibrose kystique |
| WO2023117985A1 (en) * | 2021-12-21 | 2023-06-29 | Chiesi Farmaceutici S.P.A. | Dry powder formulations filled in an inhaler with improved resistance to humidity |
-
2014
- 2014-10-17 JP JP2016519348A patent/JP6458957B2/ja active Active
- 2014-10-17 HU HUE14795565A patent/HUE046637T2/hu unknown
- 2014-10-17 SG SG10202112587RA patent/SG10202112587RA/en unknown
- 2014-10-17 EP EP17192278.4A patent/EP3293176B1/en active Active
- 2014-10-17 SG SG10201903575UA patent/SG10201903575UA/en unknown
- 2014-10-17 CN CN201910622800.XA patent/CN110256338A/zh active Pending
- 2014-10-17 MY MYPI2016000681A patent/MY182559A/en unknown
- 2014-10-17 DK DK17192278.4T patent/DK3293176T3/da active
- 2014-10-17 SG SG10201912852YA patent/SG10201912852YA/en unknown
- 2014-10-17 MX MX2019014408A patent/MX389002B/es unknown
- 2014-10-17 PL PL17192278T patent/PL3293176T3/pl unknown
- 2014-10-17 CN CN201480058065.XA patent/CN105658629B/zh active Active
- 2014-10-17 HR HRP20240783TT patent/HRP20240783T1/hr unknown
- 2014-10-17 UA UAA201909177A patent/UA127453C2/uk unknown
- 2014-10-17 EP EP19183016.5A patent/EP3587400B1/en active Active
- 2014-10-17 ES ES19183016T patent/ES2980505T3/es active Active
- 2014-10-17 RS RS20240463A patent/RS65452B1/sr unknown
- 2014-10-17 PH PH1/2020/500162A patent/PH12020500162B1/en unknown
- 2014-10-17 KR KR1020217004799A patent/KR102287598B1/ko active Active
- 2014-10-17 CN CN202510734070.8A patent/CN120607463A/zh active Pending
- 2014-10-17 SG SG11201603130TA patent/SG11201603130TA/en unknown
- 2014-10-17 SI SI201431364T patent/SI3060551T1/sl unknown
- 2014-10-17 PH PH1/2021/550257A patent/PH12021550257A1/en unknown
- 2014-10-17 CA CA3115570A patent/CA3115570C/en active Active
- 2014-10-17 ES ES17192278T patent/ES2857629T3/es active Active
- 2014-10-17 EP EP20207308.6A patent/EP3798209A1/en active Pending
- 2014-10-17 WO PCT/EP2014/072334 patent/WO2015059050A1/en not_active Ceased
- 2014-10-17 CA CA3115587A patent/CA3115587C/en active Active
- 2014-10-17 RS RS20210247A patent/RS61558B1/sr unknown
- 2014-10-17 IL IL285528A patent/IL285528B2/en unknown
- 2014-10-17 MX MX2016004834A patent/MX370104B/es active IP Right Grant
- 2014-10-17 CN CN202510293709.3A patent/CN120136784A/zh active Pending
- 2014-10-17 HU HUE17192278A patent/HUE053112T2/hu unknown
- 2014-10-17 PT PT147955652T patent/PT3060551T/pt unknown
- 2014-10-17 LT LTEP17192278.4T patent/LT3293176T/lt unknown
- 2014-10-17 CN CN202210366235.7A patent/CN114621139B/zh active Active
- 2014-10-17 PL PL19183016.5T patent/PL3587400T3/pl unknown
- 2014-10-17 LT LTEP19183016.5T patent/LT3587400T/lt unknown
- 2014-10-17 HU HUE19183016A patent/HUE067681T2/hu unknown
- 2014-10-17 EP EP22169035.7A patent/EP4059921A1/en active Pending
- 2014-10-17 UA UAA201604362A patent/UA121853C2/uk unknown
- 2014-10-17 RU RU2016115246A patent/RU2682660C9/ru active
- 2014-10-17 EP EP14795565.2A patent/EP3060551B1/en active Active
- 2014-10-17 HR HRP20192152TT patent/HRP20192152T1/hr unknown
- 2014-10-17 CA CA2928242A patent/CA2928242C/en active Active
- 2014-10-17 ES ES14795565T patent/ES2759514T3/es active Active
- 2014-10-17 AU AU2014339136A patent/AU2014339136C1/en active Active
- 2014-10-17 PT PT171922784T patent/PT3293176T/pt unknown
- 2014-10-17 FI FIEP19183016.5T patent/FI3587400T3/fi active
- 2014-10-17 PL PL14795565T patent/PL3060551T3/pl unknown
- 2014-10-17 KR KR1020217004798A patent/KR102287596B1/ko active Active
- 2014-10-17 BR BR112016008161-7A patent/BR112016008161B1/pt active IP Right Grant
- 2014-10-17 DK DK19183016.5T patent/DK3587400T3/da active
- 2014-10-17 DK DK14795565T patent/DK3060551T3/da active
- 2014-10-17 SI SI201431775T patent/SI3293176T1/sl unknown
- 2014-10-17 US US14/516,976 patent/US9434691B2/en active Active
- 2014-10-17 SI SI201432068T patent/SI3587400T1/sl unknown
- 2014-10-17 IL IL285532A patent/IL285532B2/en unknown
- 2014-10-17 PT PT191830165T patent/PT3587400T/pt unknown
- 2014-10-17 KR KR1020167010773A patent/KR102240865B1/ko active Active
- 2014-10-20 TW TW107133858A patent/TWI685486B/zh active
- 2014-10-20 AR ARP140103938A patent/AR098128A1/es active IP Right Grant
- 2014-10-20 TW TW109102549A patent/TWI720803B/zh active
- 2014-10-20 TW TW103136112A patent/TWI651305B/zh active
-
2016
- 2016-04-14 MX MX2022000030A patent/MX2022000030A/es unknown
- 2016-04-14 MX MX2022000036A patent/MX2022000036A/es unknown
- 2016-04-20 IL IL245220A patent/IL245220A/en active IP Right Grant
- 2016-04-20 PH PH12016500737A patent/PH12016500737B1/en unknown
- 2016-07-22 US US15/217,468 patent/US9890122B2/en active Active
-
2017
- 2017-06-11 IL IL252834A patent/IL252834B/en unknown
- 2017-11-03 US US15/802,737 patent/US10323003B2/en active Active
-
2018
- 2018-10-05 JP JP2018189627A patent/JP2019038813A/ja active Pending
-
2019
- 2019-04-23 US US16/391,952 patent/US10759761B2/en active Active
-
2020
- 2020-02-17 AR ARP200100438A patent/AR118124A2/es active IP Right Grant
- 2020-07-21 US US16/934,527 patent/US11352327B2/en active Active
- 2020-10-14 JP JP2020173216A patent/JP7051970B2/ja active Active
-
2021
- 2021-02-15 CY CY20211100122T patent/CY1123811T1/el unknown
- 2021-03-01 HR HRP20210336TT patent/HRP20210336T1/hr unknown
- 2021-05-27 AR ARP210101431A patent/AR122183A2/es unknown
- 2021-05-27 AR ARP210101430A patent/AR122182A2/es unknown
-
2022
- 2022-02-22 JP JP2022025240A patent/JP7345581B2/ja active Active
- 2022-02-22 JP JP2022025300A patent/JP7534346B2/ja active Active
- 2022-05-06 US US17/738,630 patent/US11981639B2/en active Active
-
2024
- 2024-01-02 US US18/401,832 patent/US20240166605A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR118124A2 (es) | Proceso para la preparación de un inhibidor de pde4 | |
| MX377552B (es) | Proceso para preparar un compuesto antiviral de formula i. | |
| BR112014030365A2 (pt) | síntese de composto antiviral | |
| CR20200276A (es) | Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059) | |
| MY159850A (en) | Tetracyclic compounds | |
| DOP2014000012A (es) | Nuevos compuestos de 4-piperidinilo para uso como inhibidores de la tankirasa | |
| CU24341B1 (es) | Compuestos y composiciones orgánicas inhibidores del ácido graso sintetasa (fasn) útiles para el tratamiento del cáncer, infecciones virales, obesidad y diabetes | |
| MY172860A (en) | Dimethyl-benzoic acid compounds | |
| IN2014MN01521A (es) | ||
| CL2013003056A1 (es) | Compuestos derivados de (fenil o piridin)-etinil-(piridin o pirimidin) sustituido; composición farmacéutica que los comprende; proceso de preparación de esto; y su uso en el tratamiento de la esquizofrenia o enfermedades cognitivas. | |
| NZ711192A (en) | Process for making benzoxazepin compounds | |
| MX2014002988A (es) | Proceso y composicion para inhibir la polimerizacion de compuestos de ciclopentadieno. | |
| PH12015502684B1 (en) | New compounds having triple activities of thrombolysis, antithrombotic and radical scavenging, and synthesis, nano-structure and use thereof | |
| MX2020009462A (es) | Procesos para la preparación de compuestos de pirimidinilciclopentano. | |
| MX355222B (es) | Proceso industrial para la sintesis de acetato de ulipristal y su analogo 4'-acetil. | |
| BR112017003121A2 (pt) | método para a síntese de um óxido de fosfina de hidrogênio heterocíclico | |
| WO2016014864A8 (en) | Hydroxy-(r),(r)-2,2'-bismethylnaltrexones and uses thereof | |
| AR095353A1 (es) | Compuesto | |
| BR112016007646A2 (pt) | forma cristalina anidra de cabazitaxel, uso da forma cristalina anidra de cabazitaxel, composição farmacêutica e processo para o preparo forma cristalina anidra de cabazitaxe | |
| AR102569A1 (es) | Síntesis de inhibidor de pi3k, formas cristalinas y sales del mismo y una composición farmacéutica que lo comprende | |
| MX2021006499A (es) | Proceso de preparacion de un enol eter biciclico. | |
| BR112015030589A8 (pt) | formas polimórficas de fosfato de icotinibe, composição farmacêutica compreendendo as referidas formas e usos das mesmas | |
| WO2013175498A3 (en) | Amido-amine and glycerol based compound and process of preparation | |
| AR115996A2 (es) | Un proceso para preparar intermediarios de síntesis de compuestos de piridona y aza-piridona y dichos intermediarios | |
| UA78494U (ru) | Способ получения двойных полифосфатов магния-цинка |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |