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AR117877A1 - Rhabdovirus recombinante que codifica ccl21 - Google Patents

Rhabdovirus recombinante que codifica ccl21

Info

Publication number
AR117877A1
AR117877A1 ARP200100181A ARP200100181A AR117877A1 AR 117877 A1 AR117877 A1 AR 117877A1 AR P200100181 A ARP200100181 A AR P200100181A AR P200100181 A ARP200100181 A AR P200100181A AR 117877 A1 AR117877 A1 AR 117877A1
Authority
AR
Argentina
Prior art keywords
ccl21
recombinant rhabdovirus
coding
recombinant
rhabdovirus coding
Prior art date
Application number
ARP200100181A
Other languages
English (en)
Inventor
Guido Wollmann
John Edward Park
Tobias Nolden
Patrik Erlmann
Klaus Erb
Philipp Mueller
Original Assignee
Vira Therapeutics Gmbh
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vira Therapeutics Gmbh, Boehringer Ingelheim Int filed Critical Vira Therapeutics Gmbh
Publication of AR117877A1 publication Critical patent/AR117877A1/es

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/766—Rhabdovirus, e.g. vesicular stomatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C12N2760/20041—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241—Use of virus, viral particle or viral elements as a vector
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Abstract

Virus oncolíticos y, en particular, un rhabdovirus recombinante, tal como un virus de estomatitis vesicular que codifica en su genoma una proteína CCL21. Asimismo, el uso del virus recombinante en el tratamiento del cáncer, y también métodos para producir tales virus.
ARP200100181A 2019-01-25 2020-01-24 Rhabdovirus recombinante que codifica ccl21 AR117877A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19153668 2019-01-25

Publications (1)

Publication Number Publication Date
AR117877A1 true AR117877A1 (es) 2021-09-01

Family

ID=65443625

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200100181A AR117877A1 (es) 2019-01-25 2020-01-24 Rhabdovirus recombinante que codifica ccl21

Country Status (25)

Country Link
US (2) US11707495B2 (es)
EP (1) EP3914275A1 (es)
JP (2) JP7331136B2 (es)
KR (2) KR20250067177A (es)
CN (1) CN113710260A (es)
AR (1) AR117877A1 (es)
AU (2) AU2020211350B2 (es)
BR (1) BR112021013876A2 (es)
CA (1) CA3123494A1 (es)
CL (1) CL2021001845A1 (es)
CO (1) CO2021009271A2 (es)
CR (1) CR20210403A (es)
DO (1) DOP2021000156A (es)
EA (1) EA202191997A1 (es)
EC (1) ECSP21051111A (es)
IL (1) IL284832A (es)
JO (1) JOP20210199A1 (es)
MX (1) MX2021008927A (es)
NZ (1) NZ777277A (es)
PE (1) PE20212084A1 (es)
PH (1) PH12021551756A1 (es)
SA (1) SA521422601B1 (es)
SG (1) SG11202106760QA (es)
TW (1) TWI894135B (es)
WO (1) WO2020152306A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4013459B1 (en) 2019-08-16 2025-07-23 Mayo Foundation for Medical Education and Research Chimeric vesiculoviruses and methods of use
PE20230784A1 (es) 2020-05-19 2023-05-11 Boehringer Ingelheim Int Moleculas de fijacion para el tratamiento de cancer
IL299723A (en) * 2020-07-10 2023-03-01 Boehringer Ingelheim Int A process for the production of purified rabies virus from cell culture
KR20230069956A (ko) * 2020-09-14 2023-05-19 베링거 인겔하임 인터내셔날 게엠베하 이종 프라임 부스트 백신
JP7762791B2 (ja) * 2021-07-09 2025-10-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 水疱性口内炎ウイルスのレスキュー
WO2025132695A1 (en) * 2023-12-19 2025-06-26 Boehringer Ingelheim International Gmbh Recombinant rhabdovirus encoding for a gasdermin

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153510B1 (en) 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
FR2737730B1 (fr) 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
DE60330966D1 (de) 2002-07-26 2010-03-04 Canada Natural Resources Rekombinante vesicular stomatitis viren als impstoff gegen virale hämorrhagische fieber
EP2439273B1 (en) 2005-05-09 2019-02-27 Ono Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
PT2007883E (pt) 2006-04-20 2012-02-17 Wyeth Llc Processos de purificação para o isolamento do vírus da estomatite vesicular purificado de cultura de células
PE20110220A1 (es) 2006-08-02 2011-04-11 Novartis Ag DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
EP2085092A1 (en) 2008-01-29 2009-08-05 Bayer Schering Pharma Aktiengesellschaft Attenuated oncolytic paramyxoviruses encoding avian cytokines
ES2639857T3 (es) 2008-02-11 2017-10-30 Cure Tech Ltd. Anticuerpos monoclonales para el tratamiento del tumor
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
US10265357B2 (en) * 2008-10-08 2019-04-23 Viratherapeutics Gmbh Compositions, methods and uses for treating solid tumors using LCMV-GP-VSV pseudotype vectors
DE102008050860A1 (de) * 2008-10-08 2010-04-15 Dorothee Von Laer LCMV-GP-VSV-Pseudotypvektoren und tumorinfiltrierende Virenproduzentenzellen zur Therapie von Tumoren
FR2944292B1 (fr) 2009-04-08 2013-08-23 Sanofi Pasteur Procede de purification du virus rabique
JP2013540700A (ja) 2010-08-09 2013-11-07 サイバツクス・インコーポレイテツド 病気を予防するための方法および組成物
US8859541B2 (en) 2012-02-27 2014-10-14 Boehringer Ingelheim International Gmbh 6-alkynylpyridines
US9278978B2 (en) 2013-08-23 2016-03-08 Boehringer Ingelheim International Gmbh 6-Alkynyl Pyridine
US9249151B2 (en) 2013-08-23 2016-02-02 Boehringer Ingelheim International Gmbh Bis-amido pyridines
CN104628679B (zh) 2013-11-08 2018-02-09 江苏恩华药业股份有限公司 Bitopertin的合成方法及其中间体
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
AR101479A1 (es) 2014-08-11 2016-12-21 Boehringer Ingelheim Int Derivados de 6-alquinil-piridina
US20160361360A1 (en) * 2015-06-12 2016-12-15 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
EP4378957A3 (en) 2015-07-29 2024-08-07 Novartis AG Combination therapies comprising antibody molecules to pd-1
US20210322545A1 (en) * 2016-02-24 2021-10-21 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
JP7208492B2 (ja) * 2016-03-10 2023-01-19 シージー オンコロジー， インコーポレイテッド 併用療法によって固形腫瘍又はリンパ系腫瘍を処置する方法
RS61510B1 (sr) 2016-05-18 2021-03-31 Boehringer Ingelheim Int Anti pd-1 i anti-lag3 antitela za lečenje kancera
CA3024653A1 (en) * 2016-05-19 2017-11-23 Turnstone Limited Partnership Pseudotyped oncolytic rhabdoviruses and their use in combination therapy
EP3246410A1 (en) 2016-05-19 2017-11-22 Klinikum rechts der Isar der Technischen Universität München Vsv/ndv hybrid viruses for oncolytic therapy of cancer
WO2018161038A1 (en) * 2017-03-03 2018-09-07 Obsidian Therapeutics, Inc. Il12 compositions and methods for immunotherapy

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